Traditional Chinese medicine composition for treating severe diseases of African swine fever as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating severe African swine fever as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following traditional Chinese medicines: cacumen biotae, cordyceps militaris, fructus forsythiae, myrrh, radix bupleuri, angelica sinensis, dandelion, rhizoma fagopyri dibotryis, folium isatidis, clove, fructus amomi, rhizoma chuanxiong, agastache rugosus, exocarpium citri rubrum and liquidambar formosana hance. The traditional Chinese medicines are ground into 80-100-mesh powder and are uniformly mixed. The dosage forms comprise powder, powder, sniffing agent and oral liquid. The olfactory agent is prepared by soaking powder with white spirit or vinegar for 3-5 hours, baking at 40-100 DEG C to volatilize and release the smell of traditional Chinese medicines, and sick pigs are treated by inhaling the traditional Chinese medicines through breath. The medicine has the effects of moistening lung and clearing heat, detoxifying and diminishing swelling, stopping bleeding and activating blood, relieving cough and asthma, easing pain and refreshing, protecting liver and reinforcing stomach, tonifying qi and yang and the like, and when the medicine is used for treating African swine fever severe illness pigs within 20 days, the cure rate of middle pigs is 71.1%, the cure rate of weaned pigs is 54.54%, and the cure rate of finishing pigs is 43.03%. The medicine has the advantages of safety, environmental protection, simple preparation process, low production cost, reusability and the like.

Description

Technical Field

[0001] The present invention relates to a Chinese medicine composition, in particular to a Chinese medicine composition for treating severe African swine fever, and also to a preparation method and application of the medicine. Background Art

[0002] African swine fever was first reported in Kenya in 1921 and has been prevalent worldwide since 2007, causing a huge impact on the development of the world's animal husbandry. African swine fever enters the pig's body through the upper respiratory tract and oral cavity, infecting the pig's tonsils and nasopharynx, and then the virus spreads rapidly in the body to infect the pig's entire body. This virus is highly lethal to pigs. The mortality rate of young pigs with highly pathogenic strains is as high as more than 90%, and the mortality rate of adult pigs with moderately pathogenic strains is 20-40%. Pigs infected with the strains develop physiological lesions rapidly, showing extremely dangerous symptoms such as lymphocyte necrosis, nasopharyngeal discharge of serous or mucus, inflammation, congestion and bleeding of the spleen, kidney, liver, stomach, and pancreas. Generally, the "six no" phenomena occur: no food or drink, lying flat and weak and not walking, eyes drooping and not opening, ears hot and not fluttering, heartbeat accelerated and uneven, timid tail clamped and not raising head. There is no effective vaccine for preventing African swine fever at home and abroad, and no specific medicine for treating African swine fever. Therefore, in response to the high mortality rate of pig herds, exploring new treatment approaches, new methods, new drugs, and activating the immune capacity of the immune system have become important measures for treating African swine fever.

[0003] As a researcher of pig farming technology, it is my unshirkable responsibility to seek scientific methods and means to minimize the harm caused by African swine fever. According to Chinese patent literature, there are dozens of invention patent applications related to the treatment of African swine fever with traditional Chinese medicine, of which more than ten have been authorized. These inventions have their own merits and characteristics, and have contributed to the early prevention and treatment of African swine fever. However, pigs with severe African swine fever are often "mouth-locked", have no appetite, or even have no appetite at all. Once seriously ill pigs or pigs are unable to drink or take medicine, it is difficult to treat and take medicine. In addition, my country's treasure house of traditional Chinese medicine is very rich, and we need to dig deeper and innovate continuously to give full play to the huge role of traditional Chinese medicine in preventing and treating diseases. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition for treating severe African swine fever in severely sick pigs that are unable to drink or take medicine; at the same time, a preparation method and application of the traditional Chinese medicine composition are provided.

[0005] The technical scheme of the present invention is: a traditional Chinese medicine composition for treating severe African swine fever, comprising the following traditional Chinese medicines in parts by weight: 25-55 parts of Platycladus orientalis leaves, 15-30 parts of Cordyceps sinensis, 15-20 parts of Forsythia suspensa, 6-25 parts of Myrrh, 15-25 parts of Bupleurum, 10-20 parts of Angelica sinensis, 15-30 parts of Taraxacum, 10-15 parts of Atractylodes, 15-25 parts of Ligusticum chuanxiong, 15-30 parts of Fagopyrum scabra, 20-30 parts of Isatis indigotica, 8-15 parts of Cloves, 5-10 parts of Amomum villosum, 5-8 parts of Citrus aurantium, 10-20 parts of Patchouli, 8-15 parts of Citrus aurantium, and 7-12 parts of Smilax glabra.

[0006] Furthermore, the weight proportions of the Chinese medicine composition are: 45 parts of Platycladus orientalis leaves, 25 parts of Cordyceps sinensis, 18 parts of Forsythia suspensa, 18 parts of Myrrha, 23 parts of Bupleurum, 18 parts of Angelica sinensis, 25 parts of Taraxacum, 18 parts of Atractylodes, 23 parts of Ligusticum chuanxiong, 25 parts of Fagopyrum scabra, 27 parts of Isatis indigotica, 18 parts of Cloves, 8 parts of Amomum villosum, 7 parts of Citrus aurantium, 18 parts of Patchouli, 22 parts of Citrus aurantium, and 11 parts of Folium Smilacis Glabrae.

[0007] Furthermore, the weight proportions of the Chinese medicine composition are as follows: 35 parts of Platycladus orientalis leaves, 20 parts of Cordyceps militaris, 23 parts of Forsythia suspensa, 12 parts of Myrrh, 18 parts of Bupleurum, 13 parts of Angelica sinensis, 18 parts of Taraxacum officinale, 12 parts of Atractylodes macrocephala, 17 parts of Chuanxiong, 20 parts of Fagopyrum scabra, 22 parts of Isatis indigotica, 10 parts of Cloves, 8 parts of Amomum villosum, 6 parts of Citrus aurantium, 13 parts of Patchouli, 10 parts of Citrus aurantium, and 8 parts of Fructus liquidambar.

[0008] A method for preparing a Chinese medicine composition for treating severe African swine fever comprises the following steps: 1) Weigh each Chinese medicine raw material according to the formula; 2) Crush the weighed Chinese medicine raw materials into 80-100 mesh, mix evenly, and pack, inspect and put into storage.

[0009] The dosage form of the Chinese medicine composition includes but is not limited to: powder, pulverulent, olfactory agent, and oral liquid.

[0010] Furthermore, the particles of the olfactory agent are 100 meshes with a fineness of less than 50 microns. For every 80 grams of the medicine, 650 ml of 53-degree liquor or 9-degree white vinegar is added and soaked for 3-5 hours; then the mixture is baked at 40-100°C to release the odor of the Chinese medicine composition. The pigs inhale the gas and odor of the Chinese medicine through breathing, thereby achieving the purpose of Chinese medicine odor therapy.

[0011] The application of the Chinese medicine composition for treating severe African swine fever is that the medicine is used to treat severely ill fattening pigs, pregnant sows, and boars; another formula of the medicine is used to treat severely ill middle-aged pigs; and the third formula of the medicine is used to treat severely ill weaned piglets and suckling pigs.

[0012] The dosage, administration method and duration of Chinese herbal odor therapy are as follows. One course of treatment is 7 days. The first step is to soak 80 grams of the Chinese medicine composition in 650 ml of 53°C liquor for 4 hours, and then place it in an electric oven at 40°C for 96 hours to allow the sick pigs to inhale the Chinese medicine gas; The second step is to add 80 grams of the Chinese medicine composition to the first step, add 650 milliliters of 55-degree liquor, and heat it to 41-100°C, so that the liquor can boil and accelerate the release of the Chinese medicine ingredients into the air for the sick pigs to inhale, until the liquor molecules and water molecules of the 160 grams of Chinese medicine composition soaked in the oven are dried up; The third step is to set the temperature of the electric oven to 50-60℃ and bake for 24 hours until the baked Chinese medicine composition is dried, cooked, and charred but not carbonized; after 7 consecutive days of olfactory treatment, the sick pigs have recovered some physical strength and appetite, and the pigs will gnaw on the baked Chinese medicine composition, and the efficacy of the medicine will be fully exerted.

[0013] Silkworm Cordyceps is a kind of Cordyceps, which is cultivated by artificial cultivation using silkworm larvae as culture medium. The nutritional value of silkworm Cordyceps is higher than that of Cordyceps militaris and is similar to wild Cordyceps. The inventor successfully cultivated silkworm Cordyceps and obtained patent CN201310245503.0, which solved the problem of shortage of wild Cordyceps and high price.

[0014] The beneficial effect of the medicine of the present invention is that the components and dosage of the Chinese medicine composition of the present invention are based on the dialectical formulation of Chinese veterinary prescriptions, combined with the pathogenesis of severe African swine fever and clinical symptoms, under the guidance of the theory of syndrome differentiation and treatment of traditional Chinese medicine, after a large number of comparative tests, a highly applicable prescription is obtained after a large number of clinical verifications. The test results show that the cure rate of middle-aged pigs with severe African swine fever is 71.1% within 20 days after the olfactory agent of the present invention is used to treat pigs with severe African swine fever; the cure rate of weaned piglets is 54.54%, and the cure rate of fattening pigs reaches 43.03%. It is proved that the present invention has a unique therapeutic effect on severe African swine fever.

[0015] The various components of the Chinese medicine composition of the present invention can ensure the volatilization of medicinal gas and the exudation of medicinal flavor to the maximum extent through the use of olfactory agents, so that sick pigs can inhale the gaseous components of the Chinese medicine that inactivate viruses through the respiratory tract and exhale the removed residual toxic components. After a two-way circulation, individual pigs can continuously resist, degrade, and even kill the virus in the fastest, easiest, and most direct way and under the conditions.

[0016] The establishment of the drug of the present invention gives full play to the holistic concept that has been formed in my country for thousands of years, and the scientific formulation is effective in treating severe African swine fever. African swine fever is caused by viruses, and the plague carries the disease. The plague is the source of disasters and the epidemic is harmful. For the disaster of plague, ancient my country had a profound analysis and understanding, and formed a systematic scientific theory of curing plague and breaking the epidemic with traditional Chinese medicine, and its complete and effective treatment strategy, which is highly consistent with modern medicine, pharmacy, and prevention of viruses and epidemics. China successfully treated swine fever a thousand years earlier than foreign countries. According to the principle of yin and yang balance emphasized by traditional Chinese medicine, the African swine fever causes the pigs to have high fever, cough, vomiting, bloody diarrhea, serous mucus, bleeding, bloody stool, bloody urine, not eating, not drinking water... All the symptoms of infection, plus the test of biochemical indicators, at least dozens of items, more than a hundred items, can be summarized as the dialectical treatment strategies and prescriptions such as clearing away heat and detoxification, softening and dispersing nodules, reducing swelling and relieving pain, regulating the five internal organs, replenishing blood and qi, moistening the lungs and relieving cough, stopping diarrhea and promoting body fluid. Severely ill pigs or pigs are often "mouth-locked", with no appetite, or even no appetite at all. The method of medication has become a decisive factor. Therefore, comprehensive dialectics, in-depth dialectics, and more flexible dialectics are required. Although pigs or pigs have appetite disorders and the cause is determined, there are still internal causes that can be found, used, and controlled, that is, taking advantage of the fact that although pigs or pigs have difficulty breathing, they are generally breathing continuously. Therefore, using breathing has become the best means and the best way to treat serious diseases. Therefore, Chinese medicine chooses to administer medicine through breathing, so that there is gas output, smell can overflow, the smell is strong, and there is hope for detoxification.

[0017] The Chinese medicine of the present invention is divided into monarch, minister, adjuvant and messenger, all of which are used to promote the weighting and strengthening of the efficacy of Chinese medicine. Platycladus orientalis leaves, silkworm Cordyceps, Forsythia suspensa, and Myrrh are monarch drugs; Bupleurum, Angelica sinensis, Taraxacum officinale, Atractylodes macrocephala, Chuanxiong, Golden Fagopyrum, and Isatis indigotica are minister drugs; adjuvant drugs include cloves, Amomum villosum, Citrus aurantium, Patchouli, and Citrus aurantium; and Smilax glabra is the messenger. Platycladus orientalis is a tree species unique to China. Among them, leaves, seeds, and branches are used as medicine, which have irreplaceable effects of clearing away heat and detoxifying, calming, unblocking qi and blood, relaxing the mind, stabilizing emotions, cooling blood and stopping bleeding, dispelling wind and dampness, moistening the lungs and relieving cough, and enhancing immune function. All of its effects are special needs for the treatment of severe African swine fever. Therefore, it is unquestionable as the first choice of monarch drug. Silkworm Cordyceps is obtained by silkworms infected with Xuefeng Cordyceps (invention patent has been obtained). The main effects are to treat heat toxins, dispel wind and calm the nerves. Therefore, it has a good effect on pigs seriously infected with African swine fever or pigs that are afraid of wind, light, and curled up in fear. In particular, the products infected with Xuefeng Cordyceps, when baked at a certain temperature, emit a long-lasting and strong fragrance, which has a unique effect on activating the immune function of animal pigs. Forsythia and myrrh have always been known as "holy medicine" and "wonderful medicine" respectively for the treatment of swelling, pain and inflammation. For the treatment of plague, fever, cough, blood circulation and pain relief, the effect of forsythia paired with myrrh is so amazing that it is extremely active and naturally effective. As ministerial drugs, bupleurum, angelica, golden buckwheat, and isatis indigotica have therapeutic effects on the main high-risk symptoms of African swine fever, such as fever, antiviral, blood circulation and blood tonification, and clearing swelling, pain and inflammation. For the compatibility of multiple Chinese medicines with the same effect, the weighted effect will inevitably appear. In addition to their own unique effects, the adjuvants such as clove, amomum villosum, fragrant fruit, patchouli, and orange peel have multiple functions, such as abundant gas production, strong overflowing flavor, unique fragrance, strong vitality, invigorating the spleen and stomach, protecting the liver and strengthening the kidneys. In other words, the "adjuvant" medicine can not only protect the "king", but also help the "minister" at the same time, and can also show its own ability in the treatment of severe African swine fever, forming a powerful trend. Lulutong is worthy of its name as a medicine. It has meridians everywhere, blood circulation everywhere, and organs all over the body, sending the "king", welcoming the "minister", and protecting the "adjuvant". Obviously, the foundation of the king, minister, assistant and messenger is solid, the formula is reasonable, and the use value is constantly increasing. From the perspective of the origin of the medicine, the pigs can exhale under the action of the relevant Chinese medicine to remove a large amount of toxins and reduce fever; from the perspective of the medicinal properties, inhaling the smell of Chinese medicine can detoxify and relieve pain; from the perspective of the theory of medicine, the breathing process is the process of transporting and transforming the medicine, which can reflect a new way and method of using the medicine; from the perspective of the efficacy, time is used as a measure of the smell of the medicine, which is objective and true. Especially in the use space of the Chinese medicine composition of the present invention, the east, west, south and north are all led by the monarch medicine alliance; the minister medicine is active in all directions; the adjuvant medicine is effective up and down, and the effect is twice the result with half the effort; the medicine is allowed to reach inside and outside, and the defeat of the disease will be strongly promoted. In addition, it is also critical to choose the right method and time node of the administration method.

[0018] In addition, the raw materials of the medicine of the present invention are widely available and have abundant output. Taking pine and cypress as an example, the planting area in Dongkou and Longhui counties of Hunan Province is as much as 120,000 mu. The raw materials of traditional Chinese medicine related to the present invention are low in cost and have a reasonable and stable market price, which can ensure the long-term supply of the medicine of the present invention at a low price and the significant effect of the present invention in treating severe diseases of highly pathogenic African swine fever.

[0019] The Chinese medicine of the present invention selectively combines traditional technology with modern advanced technology, and uses a unique and efficient way. It can exert its medicinal effect in pigs or pig groups at a speed that turns into gas and flavor, awakening the spleen and stomach, nourishing the heart and lungs, and strongly protecting the liver and benefiting the stomach, which is bound to show good therapeutic effects.

[0020] The Chinese medicine of the present invention is indirectly administered under platform conditions according to the severe status of susceptible animal pig herds and pigs, and can show the benefits of centralized or decentralized administration, group administration or individual administration, ensuring zero obstacles and zero dead ends in the treatment process, and comprehensively benefiting animal pig herds and pig farmers.

[0021] The Chinese medicine of the present invention has a good therapeutic effect on pigs with severe African swine fever. Obviously, it is also effective in treating pigs or pigs infected by low or medium pathogenic strains. The preventive effect of the present invention has not been systematically and accurately compared. DETAILED DESCRIPTION

[0022] The following examples are used to illustrate the present invention in detail but are not intended to limit the scope of the present invention.

[0023] Example 1. Preparation and use of the drug of the present invention A. Weigh the following Chinese medicinal raw materials by weight: 45 parts of Platycladus orientalis leaves, 25 parts of Cordyceps sinensis, 18 parts of Forsythia suspensa, 18 parts of Myrrha, 23 parts of Bupleurum, 18 parts of Angelica sinensis, 25 parts of Taraxacum, 18 parts of Atractylodes, 23 parts of Ligusticum chuanxiong, 25 parts of Fagopyrum scabra, 27 parts of Isatis indigotica, 18 parts of Cloves, 8 parts of Amomum villosum, 7 parts of Citrus aurantium, 18 parts of Patchouli, 22 parts of Citrus aurantium, and 11 parts of Folium Smilacis Glabrae.

[0024] B. Grind the raw drug materials by weight in step A into 100 mesh and mix them evenly to prepare powders.

[0025] Method of use of the drug of the present invention: for treating severely ill African swine fever pigs, 400-800 grams of the powder is used for fattening pigs, administered by breathing, and used for 5-7 consecutive days. The dosage, administration method and administration time of Chinese medicine odor treatment are as follows The first step is to weigh 80 grams of the Chinese medicine composition and soak it in 650 ml of 53-degree liquor for 3-5 hours. Then pour it into an electric oven tray or barrel, set it to 40℃ and bake it for 96 hours continuously, so that the wine molecules carry the Chinese medicine molecules to volatilize. The second step is to add another 80 grams of the Chinese medicine composition, use 650 ml of 9℃ white vinegar, and bake it in a 41-100℃ oven for 48 hours until the Chinese medicine composition is dried, so that more acetic acid molecules can pull out more drug molecules and release them, so that sick pigs can inhale them into their bodies. The third step is to set the electric oven to 50℃ and bake the Chinese medicine composition for 24 hours until the Chinese medicine particles are dried and fully matured and coked, but not carbonized, to ensure that the smell of the Chinese medicine is released more thoroughly. The fourth step is to allow the pigs that are gradually recovering to eat the matured Chinese medicine freely.

[0026] Example 2: Preparation and use of the drug of the present invention A. Weigh the Chinese medicine raw materials according to the following weight parts: 35 parts of Platycladus orientalis leaves, 20 parts of Cordyceps sinensis, 23 parts of Fructus Forsythiae, 12 parts of Myrrha, 18 parts of Radix Bupleuri, 13 parts of Radix Angelicae Sinensis, 18 parts of Herba Taraxaci, 12 parts of Rhizoma Atractylodis Macrocephalae, 17 parts of Rhizoma Chuanxiong, 20 parts of Fagopyrum scabrae, 22 parts of Folium Isatidis, 10 parts of Caryophyllus caryophyllus, 8 parts of Fructus Amomi, 6 parts of Fragrant Fruit, 13 parts of Patchouli, 10 parts of Dalbergia citratae, and 8 parts of Fructus Ligustici Liquidambar.

[0027] B. Mix the raw medicinal materials in each weight ratio obtained in step A thoroughly and evenly, crush them into 100 meshes, and prepare them into powder for later use.

[0028] The drug of the present invention is used for treating a pig herd or pigs with severe African swine fever. There are 5 to 10 pigs in the herd, and 400 to 800 grams of the powder is used for continuous use for 5 to 7 days. The administration method is similar to the above. However, there are certain differences in the use of auxiliary materials for pigs at different stages. Compared with fattening pigs and middle-aged pigs, suckling pigs and weaned piglets have relatively weak physiological and psychological tolerance to drugs, especially alcohol auxiliary materials. Therefore, white vinegar has both a stimulating effect and is relatively mild, and can also carry the release and diffusion of the smell and taste of traditional Chinese medicine to meet the olfactory needs of pigs.

[0029] Example 3. Preparation and use of the drug of the present invention A. Weigh the Chinese medicine raw materials according to the following weight proportions 35 parts of Platycladus orientalis leaves, 20 parts of Cordyceps sinensis, 13 parts of Fructus Forsythiae, 11 parts of Myrrha, 16 parts of Radix Bupleuri, 13 parts of Radix Angelicae Sinensis, 18 parts of Herba Taraxaci, 12 parts of Rhizoma Atractylodis Macrocephalae, 17 parts of Rhizoma Chuanxiong, 20 parts of Fagopyrum scabrae, 18 parts of Folium Isatidis, 10 parts of Cloves, 8 parts of Fructus Amomi, 5 parts of Citrus aurantium, 12 parts of Patchouli, 8 parts of Exfoliated Orange, 7 parts of Fructus Liquidambar formosanae.

[0030] B. Grind the raw materials of Chinese medicine weighed in step A into 100 mesh and mix evenly to prepare powder.

[0031] The method of using the drug of the present invention is as follows: 400-800 grams of the powder of the powder preparation is used for weaned piglets for 5-7 consecutive days. The administration method is similar to that of Example 1.

[0032] Treatment efficacy trials The clinical efficacy and beneficial effects of the drug of the present invention are further described below through experiments.

[0033] Chinese medicine composition comparative example 1 A traditional Chinese medicine composition for treating severe African swine fever, wherein the main medicines are Radix Isatidis, Houttuynia Cordata, Baical Skullcap Root, and Terminalia Terminalia; the auxiliary medicines are Dendrobium Officinale, Flos Lonicerae, Safflower, Andrographis Paniculata, Licorice, Salvia Miltiorrhiza, and Fructus Arctii; the adjuvant medicines are Flos Sophorae, Sanguisorba Officinalis, Puffball, Folium Artemisiae Argyi, and Herba Smilacis Glabrae is used as the adjuvant.

[0034] The above Chinese medicine composition is calculated by weight: 45 parts of Radix Isatidis, 25 parts of Houttuynia, 18 parts of Scutellaria, 18 parts of Terminalia chebula, 23 parts of Dendrobium, 18 parts of Flos Lonicerae, 25 parts of Carthamus tinctorius, 18 parts of Andrographis paniculata, 23 parts of Licorice, 27 parts of Salvia miltiorrhiza, 25 parts of Fructus Arctiae, 27 parts of Sophora japonica, 18 parts of Radix Sanguisorbae, 8 parts of Puffball, 7 parts of Folium Artemisiae Argyi, 18 parts of Eclipta prostrata, and 11 parts of Fructus Ligustri Lucidi. The above Chinese medicine raw materials by weight are crushed to 100 mesh and mixed evenly to prepare powder.

[0035] Chinese medicine composition comparative example 2 The Chinese medicine composition for treating severe African swine fever comprises the following parts by weight: 35 parts of Radix Isatidis, 20 parts of Houttuynia, 23 parts of Scutellaria, 12 parts of Terminalia chebula, 18 parts of Dendrobium, 13 parts of Honeysuckle, 18 parts of Carthamus tinctorius, 12 parts of Andrographis paniculata, 17 parts of Licorice, 20 parts of Salvia miltiorrhiza, 22 parts of Fructus Arcti, 10 parts of Sophora japonica, 8 parts of Sanguisorba officinalis, 6 parts of Puffball, 13 parts of Artemisia argyi, 10 parts of Eclipta prostrata, and 8 parts of Fructus Ligustri Lucidi. The Chinese medicine raw materials in the above parts by weight are crushed into 100-mesh microparticle powder to prepare the composition.

[0036] Chinese medicine composition comparative example 3 A Chinese medicine composition for treating severe African swine fever comprises the following parts by weight: 35 parts of Radix Isatidis, 20 parts of Houttuynia Cordata, 13 parts of Scutellaria Baicalensis, 11 parts of Terminalia Terminalia, 16 parts of Dendrobium Officinale, 13 parts of Flos Lonicerae, 18 parts of Carthamus Tinctorius, 12 parts of Andrographis Paniculata, 17 parts of Licorice, 20 parts of Salvia Miltiorrhizae, 18 parts of Fructus Arctiae, 10 parts of Flos Sophorae, 8 parts of Sanguisorba Officinalis, 5 parts of Puffball, 12 parts of Folium Artemisiae Argyi, 8 parts of Eclipta Prostrata, and 7 parts of Fructus Liquidambar. The Chinese medicine composition is prepared by crushing to 100-mesh microparticle powder.

[0037] Test Example 1 of the present invention In 2021, 59 white Rock fattened pigs weighing 90-110 kg were found in a fattening pig farm in a certain township of Dongkou County, Hunan Province. The disease began to occur on July 5, with symptoms of fever up to 41°C, continuous vomiting, severe dry cough, corneal congestion, white foam with a small amount of blood in the corners of the mouth, mucus flowing out of the nostrils, fear of wind, light, and people, pulling the body and not walking, widespread bleeding, bleeding spots on the pores of the waist and back, prominent closed mouth, no drinking water, and no eating. The rapid test strip was diagnosed as positive for African swine fever, which was consistent with the severe manifestations caused by the highly pathogenic African swine fever strain, and the test results from the site, pens, feces and urine were also positive. In this regard, the dead horse is treated as a living horse. The 59 seriously ill pigs were divided into 6 groups according to their weight. Among them, the test group and the control group are divided into 3 groups, group 1 weighs 90-95 kg, group 2 weighs 96-100 kg, and group 3 weighs 101-110 kg. There are 29 pigs in the test group, and groups 1-3 are given the olfactory preparation according to the dosage and method of Example 1 of the present invention; the control group has a total of 30 pigs, which are groups 4-6, and the olfactory preparation is given according to the dosage and method of the aforementioned comparative example 1. 7 days of uninterrupted breathing administration treatment. Observe and record the treatment situation at any time. On the 8th day, the number of deaths of sick pigs within 7 days was counted, and the deaths in the test group were 4, 5, and 6, respectively. The deaths in the control group were 7, 8, and 8, respectively. On the 20th day, the number of survivors was counted, and the survival of the test group was 4, 5, and 4, a total of 13, and the survival rate (%) was 60, 55, and 40. After 20 days, the cure rate reached 44.8%.

[0038] In the control group, there were 30 fattening pigs that were put into the pen for treatment, and only 2 survived after 20 days, with a cure rate of 6.66%. It can be seen that the drug of the present invention has a significant effect on the treatment of severe highly pathogenic African swine fever.

[0039] Cure evaluation criteria: body temperature returns to normal, bleeding stops, vomiting stops, the patient starts drinking water and eating, and each meal takes 4-6 minutes to finish. The patient breathes evenly, has normal excretion of feces and urine, sleeps quietly, the fur becomes shiny again, the mental state is full, the eyes are clear and bright, there is no more bleeding, the blood spots in the pores of the waist, back and abdomen disappear, and the daily weight gain is around 450-700 grams.

[0040] Test Example 2 of the present invention In 2022, 118 Qianshao Hua pigs weighing 40-80 kg were found in a pig nursery in a town in Dongkou County, Hunan Province. The disease began on June 22, with symptoms of persistent high fever, tense breathing, rapid heartbeat, no eating, bloating, constipation, blood in urine, weak legs, and cramps from time to time. The rapid test strip was diagnosed as positive for African swine fever, which was consistent with the severe symptoms caused by the highly pathogenic African swine fever virus strain. Moreover, the test results from the site pens, feces, and urine were also positive. On June 25, the 118 seriously ill pigs were divided into 6 groups. Among them, the experimental group and the control group were divided into 3 groups, with 20 pigs weighing 40-50 kg in group 1, 19 pigs weighing 51-60 kg in group 2, and 20 pigs weighing 61-80 kg in group 3. A total of 59 pigs in the test groups 1-3 were given the olfactory preparation according to the dosage and method of Example 2 of the present invention; a total of 59 pigs in the control groups 4-6 were given the olfactory preparation according to the dosage and method of the aforementioned comparative example 2. The odor treatment was carried out continuously for 7 days. The treatment situation was observed and recorded at any time. On the 8th day, the number of deaths of sick pigs in the first 7 days was counted. The deaths in the test groups were 4, 3, and 9, respectively. After 20 days, the number of survivors was 15, 17, and 10, a total of 42 pigs, respectively, with a survival rate of 71.2%. After 20 days, the cure rate reached 71.2%.

[0041] Among the 59 sick pigs in the control group, only 11 survived after 20 days, with a cure rate of 18.6%.

[0042] Cure evaluation criteria: body temperature returns to normal, bleeding stops, vomiting stops, the patient starts drinking water and eating, each meal takes 4-6 minutes to finish, breathing is even, feces and urine excretion is normal, sleep is quiet, hair becomes shiny again, mental state is positive, eyes are clear and bright, blood stops flowing, blood spots in the pores of the waist, back and abdomen disappear, and daily weight gain is around 450-700 grams.

[0043] Test Example 3 of the present invention On August 24, 2023, 176 weaned piglets at a piglet transfer station on a farm in Dongkou County, Hunan Province had high fever, tense breathing, bloody diarrhea, listlessness, no water, no food, mutual repulsion and biting, bloodshot eyes and other symptoms. The rapid test strips were diagnosed as positive for African swine fever, and the feces and urine in the field pens were also positive. On August 25, the 176 sick piglets were divided into 6 groups and treated with olfactory agents. Among them, the experimental group and the control group were divided into 3 groups, 1 group weighing 5-7 kg each with 30 heads, 2 groups weighing 8-10 kg each with 30 heads, and 3 groups weighing 11-12 kg each with 28 heads. In the experimental group, 88 heads in groups 1-3 were given the olfactory preparation according to the dosage and method of Example 3 of the present invention; the control group, groups 4-6, and 88 heads were given the olfactory preparation according to the dosage and method of the aforementioned comparative example 3. 7 days of uninterrupted olfactory treatment. The treatment status was observed and recorded at any time. On the 8th day, the mortality rate of pigs in the previous 7 days was counted. The deaths in the experimental groups were 12, 14, and 11 respectively. After 20 days, the survival numbers were 17, 16, and 15 respectively, a total of 48 pigs. The survival rate was 54.5%. After 20 days, the cure rate reached 54.5%.

[0044] In the control group, 88 sick pigs died within 7 days, and only 21 survived after 20 days, with a cure rate of 23.86%.

[0045] Cure evaluation criteria: body temperature returns to normal, breathing is even, bloody diarrhea stops, defecation is normal, drinking and eating are restored, and hunger is strong, eye congestion disappears, eyeballs are flexible and bright, mental state is full, and daily weight gain is about 120-150 grams.

[0046] Alcohol is the olfactory auxiliary material for fattening pigs, pregnant sows and boars. Because alcohol has a strong function in decomposing Chinese medicine and is highly volatile, it can carry more medicinal gas, thicker medicinal flavor and more significant medicinal effect. At the same time, pigs have a strong ability to adapt to the odor released by Chinese medicine compositions, a more sensitive sense of smell, and a greater tolerance to alcohol molecules and drug molecules.

[0047] The above embodiments are only preferred implementation methods and methods of the present invention. It should be noted that for general technical operators in this technical field, several improvements or even breakthroughs can be made or may be made without violating the technical principles of the present invention. These improvements and breakthroughs should also be considered as the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating severe African swine fever, characterized in that: The traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight: 35-55 parts of Platycladus orientalis leaves, 20-30 parts of Cordyceps sinensis, 15-20 parts of Forsythia suspensa, 10-25 parts of Myrrha, 20-25 parts of Bupleurum, 15-20 parts of Angelica sinensis, 20-30 parts of Taraxacum, 10-15 parts of Atractylodes, 20-25 parts of Ligusticum chuanxiong, 20-30 parts of Fagopyrum scabra, 25-30 parts of Isatis indigotica, 10-15 parts of Cloves, 6-10 parts of Amomum villosum, 5-8 parts of Citrus aurantium, 15-20 parts of Patchouli, 10-15 parts of Citrus aurantium, and 10-12 parts of Smilax glabra.

2. The Chinese medicine composition for treating severe African swine fever according to claim 1, characterized in that: The traditional Chinese medicine composition comprises the following parts by weight: 45 parts of oriental arborvitae leaves, 25 parts of silkworm cordyceps, 18 parts of forsythia, 18 parts of myrrh, 23 parts of bupleurum, 18 parts of angelica, 25 parts of dandelion, 18 parts of atractylodes, 23 parts of ligusticum chuanxiong, 25 parts of golden buckwheat, 27 parts of isatis indigotica, 18 parts of cloves, 8 parts of amomum, 7 parts of caraway, 18 parts of patches, 22 parts of orange peel and 11 parts of rhizoma liquidambar formosana.

3. The Chinese medicine composition for treating severe African swine fever according to claim 2, characterized in that: 35 parts of Platycladus orientalis leaves, 20 parts of Cordyceps sinensis, 23 parts of Fructus Forsythiae, 12 parts of Myrrha, 18 parts of Radix Bupleuri, 13 parts of Radix Angelicae Sinensis, 18 parts of Herba Taraxaci, 12 parts of Rhizoma Atractylodis Macrocephalae, 17 parts of Rhizoma Chuanxiong, 20 parts of Fagopyrum scabrae, 22 parts of Folium Isatidis, 10 parts of Caryophyllus caryophyllus, 8 parts of Fructus Amomi, 6 parts of Fragrant Fruit, 13 parts of Patchouli, 10 parts of Dalbergia citratae, and 8 parts of Fructus Ligustici Liquidambar.

4. A method for preparing a Chinese medicine composition for treating severe African swine fever according to any one of claims 1 to 3, comprising the following steps: 1) Weigh each Chinese medicine raw material according to the weight ratio; 2) Crush the weighed Chinese medicine raw materials into 80-100 mesh, mix evenly, and pack, inspect and put into storage.

5. The method for preparing the Chinese medicine composition according to claim 4, characterized in that: The dosage form of the Chinese medicine composition includes but is not limited to: powder, granules, olfactory agent, and oral liquid.

6. The method for preparing the Chinese medicine composition according to claim 5, characterized in that: The particles of the olfactory agent are 100 meshes with a fineness of less than 50 microns. Every 80 grams of the medicine is added with 650 ml of 53-degree liquor or 9-degree white vinegar and soaked for 3-5 hours; then baked at 40-100° C. to release the odor of the Chinese medicine composition. The sick pig inhales the odor of the Chinese medicine through breathing, thereby achieving the purpose of Chinese medicine treatment.

7. The use of the Chinese medicine composition for treating severe African swine fever as described in claims 1-3, wherein the medicine of claim 1 is used to treat severe fattening pigs, pregnant sows, and boars; the medicine of claim 2 is used to treat severe middle-aged pigs; the medicine of claim 3 is used to treat severe weaned piglets and suckling pigs; The dosage, administration method and duration of Chinese herbal scent therapy are as follows, with 7 days as one course of treatment; The first step is to soak 80 grams of the Chinese medicine composition in 650 ml of 53% liquor for 4-5 hours, and then bake it in an electric oven at 40°C for 96 hours to allow the sick pigs to inhale the smell of the Chinese medicine; The second step is to add 80 grams of the Chinese medicine composition to the first step, add 650 milliliters of 55-degree liquor, heat the oven to 41-100°C and bake for 48 hours, so that the liquor boils to accelerate the release of the Chinese medicine ingredients into the air, and let the sick pigs inhale the smell of the Chinese medicine until the liquor molecules and water molecules of the Chinese medicine composition soaked in the oven are dried up; In the third step, the oven temperature is set at 50-60℃, and the Chinese medicine composition is baked for 24 hours until the baked Chinese medicine is dried, cooked, and charred but not carbonized; after 7 consecutive days of Chinese medicine olfactory treatment, the sick pigs have recovered some physical strength and appetite, and will nibble on the baked Chinese medicine composition, and the efficacy of the medicine is fully exerted.