Traditional Chinese medicine composition for clearing heat, freeing lung, preventing phlegm from forming and relieving cough and asthma

Abstract

The invention relates to a traditional Chinese medicine composition for clearing heat, freeing lung, preventing phlegm from forming and relieving cough and asthma. The traditional Chinese medicine composition is prepared from 5-10 g of almond, 5-10 g of perillaseed, 5-15 g of radix peucedani, 5-15 g of platycodon grandiflorum, 5-15 g of white mulberry root-bark, 5-15 g of radix scrophulariae, 5-15 g of pericarpium citri reticulatae, 5-15 g of radix ophiopogonis, 5-15 g of scutellaria baicalensis, 10-20 g of fructus forsythiae, 10-20 g of honeysuckle, 1-5 g of coptis chinensis and 5-10 g of liquorice. The traditional Chinese medicine composition is simple in medication and safe in medicine selection, all the medicines are mutually cooperated and mutually prepared to jointly achieve the effects of clearing heat, freeing lung, preventing phlegm from forming, relieving cough and asthma, nourishing yin, moistening lung and the like, the traditional Chinese medicine composition has a good treatment effect on diseases such as upper respiratory tract infection, pneumonia and asthma, the treatment effect is guaranteed, meanwhile, medication safety is guaranteed, and toxic and side effects are avoided.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more specifically to a traditional Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma. Background Art

[0002] Ephedra is an herb included in the "Chinese Pharmacopoeia". It is warm in nature, pungent and slightly bitter in taste. It has the effects of inducing sweat and dispelling cold, promoting lung function and relieving asthma, promoting diuresis and reducing swelling. It can treat colds, chest tightness, cough, wind and water edema, bronchial asthma and other diseases. At present, some Chinese patent medicines with antitussive and antiasthmatic effects available on the market and some compositions reported in patents or literatures all contain ephedra, for example: CN1320902 C discloses a Chinese medicine composition for clearing heat and resolving phlegm, promoting lung function and relieving asthma and a preparation method thereof, wherein the Chinese medicine composition for clearing heat and resolving phlegm, promoting lung function and relieving asthma is composed of 1.5 to 9 parts of ephedra and licorice; 2 to 13 parts of bitter almond, radish seed, scutellaria seed, perilla seed, scutellaria baicalensis, and white mulberry bark; 2.5 to 17 parts of isatis indigotica and houttuynia cordata; and 3.5 to 22 parts of gypsum; CN 101549059 B discloses a medicine for treating bronchial asthma and a preparation method thereof, wherein the medicine for treating bronchial asthma is composed of ephedra, ginkgo, white mulberry bark, scutellaria baicalensis, bitter almond, pinellia, perilla seed, coltsfoot flower, etc.; CN 102552768 A discloses a heat-clearing, phlegm-resolving, asthma-relieving and cough-relieving medicine and its preparation method, wherein the heat-clearing, phlegm-resolving, asthma-relieving and cough-relieving medicine is composed of 480 parts of dried orange peel, 240 parts of ophiopogon japonicus, 240 parts of peucedanum peucedanum, 480 parts of scutellaria baicalensis, 480 parts of phellodendron amurense, 240 parts of licorice, 240 parts of platycodon grandiflorum, 240 parts of mulberry bark, 240 parts of bitter apricot kernel, 240 parts of pinellia ternata, 240 parts of scutellaria baicalensis seeds, 160 parts of arisaema, 360 parts of stemona, 240 parts of ephedra, 240 parts of perilla seeds and 240 parts of trichosanthes seeds; CN105412749 B discloses a medicine for treating pneumonia and asthma in children and its preparation method, wherein the medicine for treating pneumonia and asthma in children is composed of 20-25 grams of Scutellaria baicalensis, 15-20 grams of Forsythia suspensa, 12-20 grams of Apricot kernel, 15-20 grams of Fritillaria thunbergii, 12-15 grams of Coltsfoot flos, 9-15 grams of Ephedra, 12-15 grams of Stemona, 9-12 grams of Belamcanda chinensis, 9-12 grams of Trichosanthes kirilowii, 9-12 grams of Lemongrass seeds, 9-12 grams of Perilla seeds, 9-12 grams of Morus alba bark, 9-12 grams of Platycodon grandiflorum, 9-12 grams of White Sinapis seeds, 9-12 grams of Radish seeds, and 6-9 grams of Licorice. The above-mentioned composition has the effects of clearing away heat, relieving cough, and relieving asthma, and can be used for upper respiratory tract infections, pneumonia, asthma, etc., and has a relatively good therapeutic effect. However, since ephedrine, the main active ingredient of ephedra, can act on multiple systems of the body, especially has serious side effects on the central nervous system and cardiovascular system, the above-mentioned composition is not suitable for children; in addition, by summarizing the existing prescriptions for moistening the lungs, relieving coughs, and relieving asthma (Runfei Zhisou Pills, Qingfei Huatan Pills, Zhisou Huatan Pills, Xiaoer Feike Granules, etc.), it is found that in order to enhance the effect of relieving cough and reducing phlegm, coltsfoot, which has the effects of moistening the lungs and lowering qi, relieving cough and reducing phlegm, is usually added to the existing prescriptions; however, the clepsydra alkali contained in coltsfoot is hepatotoxic, so it is also not suitable for children. Summary of the invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine composition for clearing away heat and promoting lung function, resolving phlegm, relieving cough and relieving asthma. The traditional Chinese medicine composition has simple medication and safe drug selection. The various medicines cooperate with each other and are mutually restrained to jointly exert the effects of clearing heat and promoting lung function, resolving phlegm, relieving cough and relieving asthma, nourishing yin and moistening the lung. The traditional Chinese medicine composition has a good therapeutic effect on upper respiratory tract infection, pneumonia, asthma and the like, and ensures medication safety while ensuring the therapeutic effect and no toxic side effects.

[0004] To achieve the above object, the present invention adopts the following technical solutions:

[0005] A traditional Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma, the traditional Chinese medicine composition comprises 5-10g of apricot kernel, 5-10g of perilla seed, 5-15g of peucedanum, 5-15g of platycodon, 5-15g of mulberry bark, 5-15g of scrophularia, 5-15g of tangerine peel, 5-15g of ophiopogon, 5-15g of scutellaria, 10-20g of forsythia, 10-20g of honeysuckle, 1-5g of coptis root and 5-10g of liquorice.

[0006] As a preferred embodiment of the present invention, the traditional Chinese medicine composition is composed of 5g of almond, 5g of perilla seed, 10g of peucedanum, 10g of platycodon, 10g of mulberry bark, 10g of Scrophularia, 10g of tangerine peel, 10g of Ophiopogon japonicus, 10g of Scutellaria baicalensis, 15g of Forsythia suspensa, 15g of honeysuckle, 3g of Coptis chinensis and 6g of liquorice.

[0007] The Chinese medicine composition provided by the present invention has strict compatibility between the drug components, safe drug selection, and each drug cooperates and controls with each other to jointly exert the effects of clearing away heat and promoting lung function, resolving phlegm, relieving cough and relieving asthma, nourishing yin and moistening the lungs, etc. It has good therapeutic effects on upper respiratory tract infection, pneumonia, asthma and the like, especially for common febrile asthma in children. Therefore, the Chinese medicine composition can be used in the preparation of drugs for treating upper respiratory tract infection, pneumonia and asthma in children.

[0008] As a preferred embodiment of the present invention, the drug is an oral preparation; wherein the oral preparation is selected from any one of powders, granules, tablets, capsules, decoctions or pills.

[0009] As a further preferred embodiment of the present invention, the preparation method of the decoction is: mix the above 13 herbs, add water and boil twice, filter, combine the two filtrates, cool and package, and obtain the decoction.

[0010] Advantages and beneficial effects of the present invention:

[0011] (1) The Chinese medicine composition provided by the present invention is simple in dosage and safe in drug selection. The various herbs cooperate with each other and control each other. Among them, almond is bitter in taste and warm in nature, and is mainly used to descend qi and relieve cough; perilla seed can descend qi and resolve phlegm, relieve cough and relieve asthma. The combination of the two herbs can enhance the effects of descending qi and resolving phlegm, relieving cough and relieving asthma; scutellaria baicalensis can disperse wind evil, and bitterness can purge lung qi, cold can be cleared from the upper part, and descending can remove phlegm; platycodon can promote lung function and eliminate phlegm, relieve throat and discharge pus. The combination of the two herbs can disperse external evil and clear phlegm heat from the inside, so that lung adverse reaction can be relieved and cough can be stopped; mulberry bark has the effects of purging lung and relieving asthma, promoting diuresis and reducing swelling; scutellaria baicalensis can clear away heat and dampness, purge fire and detoxify. The combination of the two herbs can enhance the effects of clearing lung heat and purging lung fire. The above six herbs are used together to play the role of clearing heat and resolving phlegm. , relieving cough and relieving asthma; Honeysuckle has a light texture and a fragrant smell, which can not only clear the heat of the qi, but also detoxify the blood; Forsythia suspensa is light and floats upward, and is good at going to the upper part of the body to relieve heart fire; Coptis chinensis is bitter and cold in nature, and can clear away heat and dampness, relieve fire and detoxify. These three medicines work synergistically to enhance the effects of clearing heat and detoxifying; both Xuanshen and Ophiopogon japonicus have the effects of nourishing yin and moistening dryness, moistening the lungs and relieving cough, and at the same time can restrain the excessive effects of the above-mentioned heat-clearing drugs; Tangerine peel has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm; Licorice can nourish the spleen and stomach, moisten the lungs and detoxify, and harmonize various medicines. The two can harmonize the medicinal properties and enhance the effects of strengthening the spleen and resolving phlegm; the above-mentioned medicines are used together to play the effects of clearing heat and promoting lung function, resolving phlegm and relieving cough and asthma, nourishing yin and moistening the lungs.

[0012] (2) The spleen is the source of phlegm, and the lungs are the organs that store phlegm. Dysfunction of these organs will affect the metabolism of water-damp phlegm, causing phlegm to accumulate and accumulate in the lungs, which in turn causes phlegm and qi to collide and cause asthma. The Chinese medicine composition provided by the present invention can not only strengthen the spleen and resolve phlegm, but also nourish yin and moisten the lungs, regulate the functions of the internal organs, and take into account both the symptoms and the root causes.

[0013] (3) The Chinese medicine composition provided by the present invention has strict compatibility between the drug components, and has good therapeutic effects on upper respiratory tract infection, pneumonia, asthma and the like, especially for the common febrile asthma in children. DETAILED DESCRIPTION

[0014] The present invention discloses a Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the scope of protection of the present invention.

[0015] Example 1

[0016] The present embodiment provides a traditional Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma, and the traditional Chinese medicine composition is composed of 5g of almond, 5g of perilla seed, 10g of peucedanum, 10g of platycodon, 10g of mulberry bark (also known as double peel), 10g of Scrophularia, 10g of tangerine peel, 10g of Ophiopogon japonicus (also known as Cundong), 10g of Scutellaria baicalensis, 15g of Forsythia suspensa, 15g of honeysuckle, 3g of Coptis chinensis and 6g of liquorice.

[0017] The Chinese medicine composition provided in this embodiment can be made into an oral preparation when actually used; the oral preparation includes powders, granules, tablets, capsules, decoctions or pills, etc. Among the above dosage forms, decoctions have the advantages of fast absorption and rapid effect, so decoctions are preferred. The preparation method of the decoction is: mix the above 13 herbs, add water to cover the herbs after washing, soak for 1 hour, boil for 30 minutes, filter, add water again, boil for 20 minutes, filter, combine the two filtrates and concentrate, cool and package to obtain (the above decoction is concentrated to finally obtain 100 ml of liquid medicine).

[0018] Example 2

[0019] The present embodiment provides a traditional Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma, the composition is composed of 8g of apricot kernel, 8g of perilla seed, 10g of peucedanum, 10g of platycodon, 10g of mulberry bark, 10g of Scrophularia, 10g of tangerine peel, 10g of ophiopogon, 10g of scutellaria, 10g of forsythia, 20g of honeysuckle, 5g of coptis and 10g of liquorice.

[0020] The Chinese medicine composition provided by the present invention is simple in medication, safe in drug selection, and each of the medicines cooperates with each other and is mutually controlled. The above medicines are used together to play the effects of clearing heat and promoting lung function, resolving phlegm, relieving cough and relieving asthma, nourishing yin and moistening the lungs. This prescription has been used in Jilin Children's Hospital for many years. The following clinical data illustrate the therapeutic effect of the decoction described in Example 1 of the present invention, and the specific situation is as follows:

[0021] 1. Clinical data

[0022] A total of 64 children with febrile asthma admitted to Jilin Children's Hospital from April 2022 to December 2023 were selected as the research subjects (the Western medicine diagnostic criteria refer to the "Guidelines for the Diagnosis and Prevention of Bronchial Asthma in Children" revised by the Pediatric Branch of the Chinese Medical Association in 2008, and the TCM diagnostic criteria refer to the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes" of the State Administration of Traditional Chinese Medicine in 1994). They were randomly divided into a study group and a control group, with 32 cases in each group; the study group had 15 males and 17 females, aged 1 to 12 years old; the control group had 16 males and 16 females, aged 1 to 12 years old. There was no statistically significant difference in the general data between the two groups, and they were comparable. Patients with severe or critical asthma and liver and kidney damage were excluded.

[0023] 2. Treatment Methods

[0024] The two groups of children were given standardized treatment based on their symptoms, signs and physical and chemical test results. Patients with bacterial infections were given antibiotics to control the infection; patients with viral infections were given antiviral drugs; when there was mycoplasma or chlamydia infection, erythromycin or azithromycin was given for treatment; when patients had high fever, they were given antipyretic and analgesic treatment; when they had shortness of breath, they were given oxygen therapy.

[0025] Control group: In addition to the above treatment, terbutaline sulfate nebulized inhalation solution (2ml: 5mg / vial × 20 vials, AstraZeneca AB) was given, 2.5mg (1ml) for children under 20kg, 5mg (2ml) for children over 20kg, plus budesonide inhalation suspension (2ml: 0.5mg / vial × 30 vials, AstraZeneca Pty Ltd) 0.25 (1ml)-0.5mg (2ml), nebulizer inhalation treatment, twice a day, for 5 days.

[0026] Study group: on the basis of the above treatment, the decoction described in Example 1 was added (10 ml once per year old, 2-3 times a day, specification: 100 ml per bottle, under 1 year old is calculated as 1 year old, 1 year old is calculated as 2 years old, 2 years old is calculated as 3 years old, and so on; specific usage and dosage are: under 1 year old: 5 ml once, 3 times a day; 2 to 3 years old: 15 ml once, 2 times a day; 4 to 6 years old, 30 ml once, 2 times a day; 7 to 10 years old, 60 ml once, 2 times a day; over 10 years old, 70 ml once, 2 times a day, treatment for 5 days.

[0027] 3. Observation indicators

[0028] Cure: Symptoms and wheezing disappear, breath sounds in both lungs are clear, and occasional mild attacks can resolve on their own.

[0029] Markedly effective: The frequency and severity of asthma attacks were significantly reduced compared to before, the breath sounds of both lungs were clear, or wheezing could be heard occasionally.

[0030] Effective: Symptoms are alleviated and wheezing is reduced.

[0031] Ineffective: Asthma attacks still occur and there is no obvious improvement in clinical symptoms.

[0032] 4. Treatment Outcomes

[0033] The comparison of the overall clinical efficacy between the two groups of children is shown in Table 1.

[0034] Table 1 shows the comparison of the total effective rate of treatment between the two groups of children

[0035] Group Number of cases cure Significant effect efficient invalid Total Effectiveness Control group 32 6 14 3 9 71.9％ Research Group 32 20 9 2 1 <![CDATA[96.8% * ]]>

[0036] Compared with the control group: * P<0.05.

[0037] In addition, the Chinese medicine composition provided by the present invention can also be used to treat pediatric bronchopneumonia, as illustrated below:

[0038] Wan, female, 5.5 years old, coughed and wheezed for 2 days, body temperature 39.4℃, low spirits, dry and wet rales and wheezing in both lungs, X-ray showed "bronchopneumonia", western medicine diagnosed "asthmatic bronchopneumonia", traditional Chinese medicine diagnosed "pneumonia asthma", blood routine test showed mycoplasma infection. Azithromycin, antipyretic treatment and decoction of Example 1 of the present invention were used for treatment for 5 days and the patient recovered.

[0039] Tian Moumou, female, 4 years old, had been coughing for 3 days with yellow sputum, and had an increasing number of fevers per day, with the highest temperature of 38.9°C, lethargy, and moist rales and wheezing in both lungs. Western medicine diagnosed her with "asthmatic bronchopneumonia" and traditional Chinese medicine diagnosed her with "pneumonia asthma and cough". Routine blood tests showed bacterial and viral infections. She was given antibiotics, antiviral drugs, and antipyretic treatment, and was cured after 7 days of treatment using the decoction of Example 1 of the present invention.

[0040] Wei, male, 3 years old, had a cough for a week, and suddenly had shortness of breath, low fever, body temperature of 38°C, pharyngeal congestion, red face, dry and wet rales and wheezing sounds in both lungs, red tongue, yellow tongue coating, X-ray showed "bronchopneumonia", Western medicine diagnosed asthmatic bronchopneumonia, Chinese medicine diagnosed as "pneumonia asthma", blood routine test showed bacterial infection, and he was cured after 5 days of treatment with the decoction of Example 1 of the present invention while being treated with antibiotics.

[0041] Mr. Li, male, 6 years old, had a cold and runny nose 2 days ago, and suddenly came to see a doctor with cough and shortness of breath. Examination showed congestion in the pharynx, red tongue, thin yellow fur, and moist rales and wheezing in both lungs. X-ray showed "bronchopneumonia". Western medicine diagnosed as asthmatic bronchopneumonia. Routine blood test showed viral infection. He was given antiviral drugs and the decoction of Example 1 of the present invention was used for treatment for 5 days and he recovered.

[0042] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma, characterized in that: The traditional Chinese medicine composition consists of 5-10g of apricot kernel, 5-10g of perilla seed, 5-15g of peucedanum, 5-15g of platycodon, 5-15g of mulberry bark, 5-15g of scrophularia, 5-15g of tangerine peel, 5-15g of ophiopogon, 5-15g of scutellaria, 10-20g of forsythia, 10-20g of honeysuckle, 1-5g of coptis root and 5-10g of liquorice.

2. A Chinese medicine composition for clearing away heat, promoting lung function, resolving phlegm, relieving cough and relieving asthma according to claim 1, characterized in that: The traditional Chinese medicine composition consists of 5g of apricot kernel, 5g of perilla seed, 10g of peucedanum, 10g of platycodon, 10g of mulberry bark, 10g of scrophularia, 10g of tangerine peel, 10g of ophiopogon, 10g of scutellaria, 15g of forsythia, 15g of honeysuckle, 3g of coptis root and 6g of liquorice.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of medicines for treating upper respiratory tract infections, pneumonia and asthma in children.

4. The use according to claim 3, characterized in that: The medicine is an oral preparation; wherein the oral preparation is selected from any one of powder, granules, tablets, capsules, decoctions or pills.

5. The use according to claim 4, characterized in that: The preparation method of the decoction is as follows: the 13 herbs are mixed, boiled twice with water, filtered, the two filtrates are combined, cooled and packaged, and the decoction is obtained.