Application of CD14 gene / protein as target spot in screening drugs or vaccines for preventing or treating African swine fever virus infection
By targeting CD14 gene/protein, inhibiting the adsorption, internalization and replication of ASFV, the problem of difficulty in effectively preventing or treating African swine fever virus infection in the prior art is solved, and the effective inhibition of ASFV and theoretical support for vaccine development is achieved.
CN120193070APending Publication Date: 2025-06-24LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES(LANZHOU BRANCH CENTER OF CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENTER)
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Patent Information
- Application Number
- CN202510360300.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-25
- Publication Date
- 2025-06-24
AI Technical Summary
Technical Problem
The prior art is difficult to effectively prevent or treat African swine fever virus infection, especially in terms of antigen selection and combination and the safety of vaccines.
Method used
By targeting CD14 gene/protein, using siRNA, antibodies, recombinant proteins and other means, it inhibits the adsorption, internalization and replication of ASFV, and screens drugs or vaccines for preventing or treating African swine fever virus infection.
Benefits of technology
Effectively inhibiting the replication and infection of ASFV in host cells, providing new targets and methods for the development of safe and effective ASF vaccines and therapeutic drugs.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of biology, and particularly relates to application of CD14 gene / protein as a target spot to screening of drugs for preventing or treating African swine fever virus infection, the inventor uses host protein CD14 as a research object to explore the influence of the host protein CD14 on ASFV infected host cells, and research results show that the CD14 protein can promote adsorption, internalization and replication of ASFV, and the CD14 gene / protein can be used for preparing drugs for preventing or treating ASFV infection. The siRNA, the antibody and the recombinant protein of the CD14 can inhibit ASFV infected cells, and vaccines or drugs for preventing or treating African swine fever virus infection can be screened or anti-African swine fever CD14 knockout pigs can be screened by taking the CD14 gene / protein as a target spot. The invention enriches the cognition of the host protein for regulating and controlling ASFV infection, provides theoretical support for the research and development of safe and effective ASF vaccines, and has important significance for the clinical treatment and prevention and control of African swine fever.
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