Novel ferroptosis inhibitor and application thereof in preparation of medicine for preventing and / or treating sepsis

By constructing and expressing EfeB and HemH recombinant proteins, binding and transporting iron ions in cells, the problem of poor bioavailability of existing ferrodysfunction inhibitors is solved, and efficient and low toxic ferrodysfunction inhibition is achieved, and inflammation and organ damage caused by sepsis are alleviated.

CN120590495AActive Publication Date: 2025-09-05ZHEJIANG UNIV CITY COLLEGE
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Patent Information

Application Number
CN202511100120.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-07
Publication Date
2025-09-05
Estimated Expiration
2045-08-07

AI Technical Summary

Technical Problem

The existing ferrodysfunction inhibitors have poor bioavailability, high toxicity and low specificity, which cannot effectively inhibit ferrodysfunction in sepsis, resulting in severe inflammatory response and organ damage.

Method used

The functions of EfeB and HemH were predicted through bioinformatic analysis, and the recombinant proteins rEfeB ​​and rHemH were constructed and expressed, binding and transporting free iron ions in the cell, inhibiting iron death.

Benefits of technology

It provides high-purity, low-cytotoxic ferrodysfunction inhibitors, which can effectively reduce the concentration of iron ions in cells, reduce the production of ROS and lipid peroxides, promote GPX4 expression, inhibit iron death, and reduce inflammation and organ damage caused by sepsis.

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Abstract

The invention discloses a novel ferroptosis inhibitor and application thereof in preparation of drugs for preventing and / or treating sepsis, and belongs to the technical field of pharmaceutical preparations and biological medicines. The invention discloses a preparation method of a novel ferroptosis inhibitor, which can be used for developing a high-efficiency and low-toxicity ferroptosis inhibitor. The medicament can be used for preparing a medicament for preventing organ injury related to sepsis, is a potential medicament for treating sepsis, and can inhibit ferroptosis in kidney, liver, lung and cardiomyopathy induced by sepsis and relieve inflammatory response and organ injury. Meanwhile, the invention has the outstanding advantages of strong specificity, high bioavailability, obvious effect and stable preparation method, and has wide application prospects.
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