Stable compositions of dihydroartemisinin

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By combining fatty alcohol polyoxyethylene ether carboxylic acid or its salt with dihydroartemisinin to form a stable micelle structure, the solubility and stability issues of dihydroartemisinin in aqueous media are solved, enabling its effective application in cosmetics.

CN121059461APending Publication Date: 2025-12-05SHANGHAI JAHWA UNITED

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Patent Information

Application Number: CN202410712894.0
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2024-06-03
Publication Date: 2025-12-05

Application Information

Patent Timeline

03 Jun 2024

Application

CN202410712894.0

05 Dec 2025

Publication

CN121059461A

IPC: A61K8/86; A61K8/49; A61Q5/02; A61Q19/10; A61Q5/00; A61Q17/00

CPC: A61K8/86; A61K8/498; A61K8/4993; A61Q5/02; A61Q19/10; A61Q5/006; A61Q17/005; A61K2800/262

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Application Domain

Cosmetic preparations Hair cosmetics

Technology Topics

Dihydroartemisinin Carboxylic acid

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AI Technical Summary

Technical Problem

Dihydroartemisinin is poorly soluble in water and other aqueous media, and its molecule contains a special peroxide group, making it unstable to heat and easily decomposed by moisture, heat, and reducing substances, which limits its application in cosmetics.

Method used

By combining fatty alcohol polyoxyethylene ether carboxylic acid or its salt with dihydroartemisinin, a stable micelle structure is formed, which solubilizes and slowly releases dihydroartemisinin, thereby improving its solubility and stability in aqueous systems.

Benefits of technology

It enhances the solubility and stability of dihydroartemisinin in aqueous systems, expanding its application in cosmetics, especially its effectiveness in anti-dandruff products.

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Abstract

The present invention provides a stable composition comprising, based on the total weight of the composition: 0.01-1 wt% of dihydroartemisinin; 0.1-30% by weight of fatty alcohol polyoxyethylene ether carboxylic acid or a salt thereof; and an aqueous carrier acceptable in the personal care field. The invention also relates to a personal care product comprising said composition.

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