Multi-modal screening system and method for senile deaf worker cochlea implantation candidate patients

By using multimodal assessment of DNA telomere length, temporal bone imaging, and electrophysiological signals in patients with age-related hearing loss, this method addresses the shortcomings of existing technologies, enabling scientific and individualized screening for cochlear implantation in these patients and improving the feasibility and effectiveness of the surgery.

CN121096597APending Publication Date: 2025-12-09NINGBO MEDICAL CENT LIHUILI HOSPITACL
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Patent Information

Application Number
CN202511547000.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-28
Publication Date
2025-12-09

AI Technical Summary

Technical Problem

Current technologies fail to adequately incorporate molecular indicators of patients in preoperative screening for cochlear implantation in elderly patients with hearing loss, lack the ability to predict postoperative neural plasticity and auditory adaptation, and struggle to capture the immediate response characteristics of auditory nerve endings to electrical stimulation.

Method used

By acquiring the relative length of telomeres in peripheral blood samples from elderly patients with hearing loss, three-dimensional images of the temporal bone, and electrically evoked compound action potential signals, combined with the width of the oval window and the angle between the horizontal segment of the facial nerve and the promontory, a multimodal assessment was conducted to calculate the cochlear implantation suitability score.

Benefits of technology

This approach enables a comprehensive and objective assessment of the suitability of cochlear implantation in patients with age-related hearing loss, enhancing the scientific rigor and individualization of the screening process, and improving the accuracy of surgical feasibility assessment and the signal-to-noise ratio of neural response signals.

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Abstract

The invention provides a multi-modal screening system and method for candidate patients for cochlear implantation of senile deaf patients. The method comprises the steps that the relative telomere length of leukocyte DNA in peripheral blood sample data of the senile deaf patients and a temporal bone three-dimensional image of the senile deaf patients are obtained; analyzing the temporal bone three-dimensional image to obtain an oval window width and an included angle between a facial nerve level segment and a projia; obtaining an electric evoked compound action potential signal of the auditory nerve of the senile deafness patient under the electric stimulation effect of the preset parameters, and obtaining a filtered electric evoked compound action potential signal; based on the telomere relative length, the oval window width, the included angle and the filtered electric evoked composite action potential signal, candidate patients suitable for cochlear implant implantation are judged; according to the technical scheme provided by the invention, the construction of a comprehensive evaluation system is realized, so that the artificial cochlea implantation fitness of the patient is evaluated more accurately, and the scientificity and reliability of candidate patient screening are improved.
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