Traditional Chinese medicine capsule for treating cold and wind-cold and preparation method thereof

By designing an outer layer of rapid-release microcapsules and an inner layer of sustained-release microspheres, the problem of instability of perilla leaf oil and ginger volatile oil was solved, achieving rapid disintegration and long-term release, thus improving the efficacy and storage stability of traditional Chinese medicine capsules.

CN121102164APending Publication Date: 2025-12-12SHAANXI KAIYUAN PHARM CO LTD
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Patent Information

Application Number
CN202511605960.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-05
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

Among the existing Chinese medicine capsules for treating colds and flu, the chemical properties of perilla leaf oil and ginger volatile oil are unstable and easily volatilize and oxidize, leading to a rapid decline in efficacy. Moreover, ordinary capsules cannot achieve both rapid and long-lasting release modes.

Method used

The product employs an outer layer of immediate-release microcapsules and an inner layer of sustained-release microspheres. The outer layer of immediate-release microcapsules is composed of perilla leaf oil and ginger volatile oil encapsulated with β-cyclodextrin and then mixed with microcrystalline cellulose and hydroxypropyl methylcellulose. The inner layer of sustained-release microspheres is made of kudzu root extract and other ingredients combined with a composite backbone of hydroxypropyl methylcellulose and ethylcellulose. The outer layer of immediate-release microcapsules rapidly disintegrates in the stomach, while the inner layer of sustained-release microspheres continuously releases nutrients in the intestines. The product is protected by an ethylcellulose isolation layer and a magnesium aluminum silicate anti-caking agent.

Benefits of technology

It achieves high retention rate and rapid disintegration of volatile components, and slow release of long-acting components, thereby improving the bioavailability and storage stability of the drug and ensuring the continuity and stability of the efficacy.

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Abstract

The invention provides a traditional Chinese medicine capsule for treating cold and wind-cold and a preparation method thereof, and relates to the technical field of medical treatment. The traditional Chinese medicine capsule for treating cold and wind-cold comprises an outer-layer quick-release micro-capsule, the outer-layer quick-release micro-capsule is a micro-capsule particle with the particle size of 0.3-0.5 mm, and the outer-layer quick-release micro-capsule is prepared by mixing perilla leaf oil, ginger volatile oil and ephedra extract with microcrystalline cellulose serving as a filler and a disintegrating agent and hydroxypropyl methylcellulose serving as an adhesive after being included by beta-cyclodextrin, and the outer-layer quick-release micro-capsule is a micro-capsule particle with the particle size of 0.3-0.5 mm. The content accounts for 30% of the mass of the total content, and the inner-layer sustained-release pellet is prepared from a kudzu vine root extract, a radix saposhnikoviae extract, a liquorice extract, hydroxypropyl methyl cellulose and an ethyl cellulose composite framework and has the particle size of 0.5-0.8 mm. According to the present invention, the volatile oil is included by the beta-cyclodextrin in the outer layer rapid-release micro-capsule, the volatile oil is rapidly disintegrated within 10-15 min in the stomach, the HPMC K100LV + EC composite skeleton is adopted in the inner layer sustained-release micro-pill, and the sustained-release micro-pill is continuously released within 6-8 h, such that different release paths and time tables are designed for the drug components with different properties;
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