Traditional Chinese medicine composition with effects of soothing nerves and helping sleep as well as preparation method and application of traditional Chinese medicine composition

By extracting volatile oils from traditional Chinese medicines using supercritical carbon dioxide extraction and HP-β-CD inclusion technology, and combining them with γ-aminobutyric acid, a traditional Chinese medicine composition was formed that solved the problems of large side effects and insufficient efficacy in existing insomnia treatments, achieving the effect of calming the mind and promoting sleep.

CN121197326APending Publication Date: 2025-12-26HANGZHOU HEYON PHARM TECH CO LTD
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Patent Information

Application Number
CN202511510493.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-22
Publication Date
2025-12-26

AI Technical Summary

Technical Problem

Among existing treatments for insomnia, chemical drugs have significant side effects, addictive properties, and rebound effects, while existing traditional Chinese medicine formulas neglect the role of jujube seed oil in the preparation process of jujube seed, resulting in insufficient efficacy.

Method used

The volatile oil in the traditional Chinese medicine composition was extracted using supercritical carbon dioxide extraction and HP-β-CD inclusion technology. Combined with γ-aminobutyric acid and other traditional Chinese medicines such as jujube seed, cypress seed, and astragalus, a composition with calming and sleep-aiding effects was formed.

Benefits of technology

It significantly improves symptoms such as difficulty falling asleep, frequent dreams and easy awakening, and insufficient sleep in insomnia patients, prolongs sleep duration, improves mental state after waking up, and avoids the side effects of chemical drugs.

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Abstract

The invention belongs to the field of biological medicine, and particularly relates to a traditional Chinese medicine composition with nerve soothing and sleep aiding effects, a preparation method and application, the composition is prepared by compounding spina date seed, platycladi seed, astragalus membranaceus, longan aril, medlar, dogwood, tuber fleeceflower stem, bighead atractylodes rhizome, angelica sinensis, poria cocos, polygala tenuifolia, ginseng, lily, elecampane, pericarpium citri reticulatae, liquorice, wheat and gamma-aminobutyric acid. The preparation method comprises the following steps: S1, drying and crushing semen ziziphi spinosae, semen boitae, rhizoma atractylodis macrocephalae, radix angelicae sinensis, radix aucklandiae and pericarpium citri reticulatae, and performing supercritical carbon dioxide extraction to obtain a raw material volatile oil A; s2, crushing astragalus membranaceus, longan aril, wolfberry, dogwood, tuber fleeceflower stem, poria cocos, polygala tenuifolia, ginseng, lily, liquorice and wheat, mixing the crushed materials with medicine residues obtained after the volatile oil is extracted in the step S1, and performing extraction, concentration and drying to obtain raw material powder B; s3, clathrating the volatile oil A obtained in the step S1 with hydroxypropyl beta cyclodextrin, and drying to obtain raw material powder C; s4, mixing the raw material powder B, the raw material powder C and gamma-aminobutyric acid to obtain the traditional Chinese medicine composition. The composition and the preparation thereof can improve the symptoms of lassitude, impatient temperament and irritability caused by difficulty in falling asleep, dreaminess, easy waking and insufficient sleep of an insomnia patient, and can deepen the sleep depth of the patient and prolong the sleep duration.
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