Collagen peptide with anti-aging effect and preparation method and application thereof

The novel collagen peptide Sa1, constructed using gene recombination technology, solves the safety and functional limitations of natural collagen, achieving antioxidant and anti-aging effects in skincare products and demonstrating significant skin improvement efficacy.

CN121293373BActive Publication Date: 2026-07-03DEZHOU KANGZE BIOPHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202511524664.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-10-24
Publication Date
2026-07-03
Estimated Expiration
2045-10-24

AI Technical Summary

Technical Problem

In existing technologies, natural collagen extracted from animals carries the risk of immunogenicity and viral contamination, while single-type recombinant collagen cannot mimic the synergistic effect of multiple collagens in the natural extracellular matrix, thus limiting its application effectiveness.

Method used

By using gene recombination technology, the effective active sequences of human type III and type XVII collagen are spliced ​​and recombined to construct a novel collagen peptide Sa1, which has antioxidant properties. The purified peptide was obtained by expression in Pichia pastoris and can be applied to skin care products and other fields.

Benefits of technology

The novel collagen peptide Sa1 has good safety and significant antioxidant effects. It can promote the absorption of collagen in the skin, improve skin elasticity, delay skin aging, and has no cytotoxicity.

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Abstract

This invention belongs to the field of cosmetic technology, specifically relating to a collagen peptide with anti-aging effects, its preparation method, and its application. The amino acid sequence of the collagen peptide is shown in SEQ ID NO.1, and the nucleotide sequence is shown in SEQ ID NO.2. This invention constructs and expresses a collagen peptide Sa1 by recombining the effective sequences of human type III and XVII collagen. This collagen peptide Sa1 exhibits significant antioxidant effects, is non-cytotoxic, and has good safety. Skincare products containing collagen peptide Sa1 can promote the absorption of collagen in the skin, effectively exert antioxidant effects, thereby improving skin elasticity and delaying skin aging.
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