Composition as well as preparation method and application thereof in preparation of antibacterial agent

By mixing and optimizing the extracts of yellow peel and olive in a specific ratio, the resulting composition solves the problem of limited antibacterial effect of single plant extracts, achieving a significant reduction in minimum inhibitory concentration and an improvement in antibacterial effect, making it suitable for the preparation of antibacterial agents.

CN121336852APending Publication Date: 2026-01-16PINGJIANG JINZAI FOOD CO LTD
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Patent Information

Application Number
CN202511459519.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-13
Publication Date
2026-01-16

AI Technical Summary

Technical Problem

In existing technologies, the antibacterial effects of single plant extracts are limited, with issues such as high effective concentrations and long durations of action, and an increased risk of drug resistance. There are few studies on the synergistic antibacterial effects of extracts from yellow peel and olive, and their optimal ratio and mechanism of action are not yet clear.

Method used

The preparation method of the composition was optimized by mixing the extract of yellow peel and olive extract in a specific ratio and processing them by ultrasonic extraction and macroporous resin column elution. In particular, the composition obtained by using a 1:1 ratio and a D101 type macroporous resin column and elution with 53% and 77% ethanol solutions showed a significant synergistic antibacterial effect.

Benefits of technology

It significantly reduced the minimum inhibitory concentration, decreased the amount of antimicrobial agent used, improved the antimicrobial effect against Staphylococcus aureus and Escherichia coli, and reduced the risk of bacterial resistance.

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Abstract

The invention relates to the technical field of natural products, and particularly discloses a composition as well as a preparation method and application thereof in preparation of an antibacterial agent. The composition comprises a clausena lansium extract and an olive extract, the clausena lansium extract is extracted by taking clausena lansium peel as a raw material; the olive extract is obtained by extracting olive fruits serving as raw materials. Researches show that the minimum inhibitory concentration of the composition obtained by combining the clausena lansium extract prepared by the method and the olive extract is greatly smaller than that of the single clausena lansium extract or olive extract. Therefore, when the composition disclosed by the invention is used as an antibacterial agent, the use amount of the antibacterial agent can be greatly reduced; the important application value is realized.
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