Preparation method and application of traumatic injury seven-centimeter preparation based on raw material granularity control

By controlling the specific particle size range of the medicinal materials in the Die Da Qi Li preparation, the problems of slow dissolution of active ingredients and high production energy consumption have been solved, achieving a balance between improved bioavailability and industrialized production.

CN121371052APending Publication Date: 2026-01-23CHONGQING HILAN PHARM CO LTD
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Patent Information

Application Number
CN202511920387.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-18
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

In the existing production process of Die Da Qi Li Pian (a traditional Chinese medicine for traumatic injuries), the coarse particle size of the medicinal materials leads to slow dissolution of the active ingredients and low bioavailability; while excessively fine grinding results in high energy consumption, large equipment wear and tear, poor material flowability, and affects the stability of the preparation and the yield.

Method used

By precisely controlling the specific particle size range of key medicinal ingredients—80-120 mesh for Panax notoginseng, 60-100 mesh for Dragon's Blood, and 60-200 mesh for other medicinal materials—the mixture is made into a traditional Chinese medicine preparation for traumatic injuries, avoiding the problems of high energy consumption and poor material flowability caused by ultrafine grinding.

Benefits of technology

This achieves full dissolution of the active pharmaceutical ingredients, improves bioavailability, reduces production costs, and ensures formulation stability and suitability for industrial production.

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Abstract

The invention relates to a preparation method and application of a traumatic injury Qicentimeter preparation based on raw material granularity control, and the traumatic injury Qicentimeter preparation is prepared from the following medicinal raw materials in parts by mass: 0.8 part of artificial musk, 8 parts of pseudo-ginseng, 16 parts of dragon's blood, 48 parts of safflower, 40 parts of cinnabar, 80 parts of wine-processed angelica sinensis, 32 parts of vinegar-processed myrrh, 1.6 parts of borneol, 32 parts of vinegar-processed frankincense and 40 parts of catechu. The preparation method of the pseudo-ginseng preparation comprises the following steps: S1, raw material pretreatment and crushing: crushing the medicinal raw materials, and controlling the crushing granularity of pseudo-ginseng to be 80-120 meshes; the crushing granularity of the dragon's blood is controlled between 60 meshes and 100 meshes; s2, total mixing and preparation: mixing the crushed medicinal raw materials to obtain a mixture, and preparing the mixture into the traumatic injury seven-centimeter preparation. On the basis of the specific preparation, under the condition of not adopting a complex process, the bioavailability and the industrial preparation feasibility are synchronously improved only by accurately controlling the specific crushing particle size range of the key medicines.
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