Sulfonamide active molecule as well as preparation method and application thereof

By preparing sulfonamide-based active molecules based on natural products, the problem of difficult-to-measure micro-region viscosity of epidermal repair fluid has been solved, realizing visualized control and efficient modulation of viscosity, which is suitable for large-scale chemical production.

CN121378149APending Publication Date: 2026-01-23JINGGANGSHAN UNIVERSITY
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Patent Information

Application Number
CN202511791049.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-01
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing technologies make it difficult to accurately measure and modulate the micro-viscosity of epidermal repair fluids. Traditional viscometers cannot effectively detect changes in the low viscosity range, and existing molecular probes rely on artificially synthesized chemical raw materials, which are complex to prepare and unsuitable for large-scale production.

Method used

A sulfonamide-based active molecule was developed and prepared by the condensation reaction of sulfadiazine reconstituted from natural products and 4-hydroxynonenal. It has a freely rotatable conjugated bridging structure and can release light signals of different intensities at different viscosities, enabling visualized micro-area viscosity detection.

Benefits of technology

It enables visualized control of the viscosity of epidermal repair fluid, providing real-time, in-situ detection. It is suitable for large-scale chemical preparation and is not affected by the components added to the epidermal repair fluid. It has high sensitivity and is suitable for measuring different viscosities.

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Abstract

The invention belongs to the technical field of repair liquid detection, and provides a sulfonamide active molecule and a preparation method and application thereof.The active molecule tool is obtained based on natural product unsaturated aldehyde derivatives and sulfadiazine functional molecules through reconstruction, flexible conjugated single and double bonds capable of freely rotating exist in the molecular structure of the active molecule tool, and the flexible conjugated single and double bonds can be used for detecting the sulfonamide active molecule tool. The relatively flexible conjugated structure can freely rotate in a dilute solution, rotation in a thick solution is inhibited, and optical signals with different intensities are shown, so that control of the thickness of the epidermis repair liquid becomes visual, and real-time, in-situ and visual detection support can be provided for process development of the epidermis repair liquid. And the development of the chromogenic function of the microcell viscosity measuring agent cannot be influenced by common macromolecular proteins and auxiliaries (such as panthenol, ceramide, hyaluronic acid, vitamin C and derivatives thereof) contained in various epidermal repair liquids, so that the microcell viscosity measuring agent is particularly suitable for measuring the microcell viscosity of the epidermal repair liquid.
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