Acoustic resonance synthesis method of 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine

The synthesis of 1,4-dicarboxy-2,3,5,6-tetrahydroxypiperazine at room temperature using acoustic resonance enhancement technology solved the problems of long synthesis time and low yield, achieving a highly efficient synthesis effect.

CN121800728APending Publication Date: 2026-04-07XIAN MODERN CHEM RES INST
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Patent Information

Application Number
CN202311790316.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-12-25
Publication Date
2026-04-07

AI Technical Summary

Technical Problem

The synthesis of 1,4-dicarboxy-2,3,5,6-tetrahydroxypiperazine in the existing technology is time-consuming and yields are low, especially the aldehyde-amine condensation reaction time, which is more than 2 hours and the yield is about 80%, indicating room for improvement.

Method used

Acoustic resonance enhancement technology was used to carry out the reaction of formamide, glyoxal and alkaline solution at room temperature, which shortened the reaction time to 5-10 minutes and increased the yield to 90%. The alkaline solution used included sodium hydroxide, potassium hydroxide or triethylamine.

Benefits of technology

The reaction time was significantly shortened and the yield was increased, achieving efficient synthesis that can be completed at room temperature without additional heating or cooling.

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Abstract

The invention belongs to the field of organic synthesis, and particularly discloses an acoustic resonance synthesis method of 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine, which comprises the following steps: under acoustic resonance and room temperature conditions, formamide, glyoxal and alkali liquor are subjected to a reaction for 5-10 min to synthesize 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine, and the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine is subjected to a reaction for 5-10 min to obtain the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine. The acceleration of acoustic resonance is 196-980 m / s < 2 >, and the alkali liquor is selected from a sodium hydroxide aqueous solution, a potassium hydroxide aqueous solution or triethylamine. According to the present invention, the alkali-catalyzed aldehyde amine condensation reaction is achieved by using acoustic resonance reinforcement, the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine is rapidly and efficiently synthesized, the reaction time is substantially shortened, the product yield is improved, and the method has broad industrial application prospects.
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