A combined recipe for invigorating spleen and tranquilizing mind

Abstract

This invention relates to the field of traditional Chinese medicine technology, and in particular to a combined formula for strengthening the spleen and calming the mind. The formula includes a daytime spleen-strengthening formula and a nighttime calming formula. The daytime spleen-strengthening formula includes: Astragalus membranaceus 10-30g, Codonopsis pilosula 10-20g, Atractylodes macrocephala 10-20g, Angelica sinensis 6-12g, Citrus reticulata 6-10g, Cimicifuga foetida 3-6g, Bupleurum chinense 6-15g, Pinellia ternata 6-12g, Scutellaria baicalensis 6-15g, Agrimonia pilosa 15-35g, Ziziphus jujuba var. spinosa 10-20g, and Glycyrrhiza uralensis 3-10g. The nighttime calming formula includes: Bupleurum chinense 6-15g, Paeonia lactiflora 10-20g, Os draconis 15-35g, Ostrea gigas 15-35g, Ziziphus jujuba var. spinosa 10-30g, Polygonum multiflorum vine 15-30g, Pinellia ternata 6-12g, Scutellaria baicalensis 6-15g, Codonopsis pilosula 10-20g, Poria cocos 10-20g, Atractylodes macrocephala 10-20g, Albizia julibrissin 5-10g, Ziziphus jujuba var. spinosa 10-20g, and Glycyrrhiza uralensis 3-10g. This combined formula for strengthening the spleen and calming the mind is applied at different times, day and night: The daytime formula for strengthening the spleen targets the pathogenesis of "qi deficiency and failure of clear yang to rise" during the day, using the method of tonifying the middle and replenishing qi to boost function and improve daytime energy and physical strength; The nighttime formula for calming the mind targets the pathogenesis of "liver stagnation, floating yang, and disturbed mind" at night, using the method of heavy calming to guide yang into yin and promote sleep.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a combined formula for strengthening the spleen and calming the mind. Background Technology

[0002] Insomnia is a subjective experience of dissatisfaction with sleep duration and / or quality caused by difficulty falling asleep, frequent awakenings, or difficulty falling back asleep, which affects daytime social functioning. It has become a major public health problem. Long-term insomnia can seriously harm the physical and mental health of patients. According to the "2024 White Paper on Sleep Health of Chinese Residents" released by the Chinese Sleep Research Society, the average sleep duration of Chinese residents is 6.75 hours, with half of the residents sleeping less than 64%, 64% experiencing poor sleep quality, and 59% experiencing insomnia symptoms. Only 19% of the population has no sleep disorders whatsoever. Decreased sleep quality often leads to daytime fatigue, lethargy, poor concentration, and mood swings, and in severe cases, can significantly impact daily life. Currently, insomnia is increasingly affecting younger people. Studies show that the prevalence of insomnia among Chinese adolescents varies considerably across different research methods, but as many as 54.15% of adolescents suffer from insomnia. Insomnia is not only an independent disease but can also be an early symptom of other illnesses, thus requiring serious attention in clinical practice. Furthermore, insomnia is often comorbid with anxiety, depression, substance dependence, and cognitive impairment, with a comorbidity rate as high as 46%–68%, severely impacting patients' memory, mood, social function, and quality of life. Currently, most Western medicine treatments for insomnia use addictive sleeping pills. While these drugs may have a noticeable effect in the short term, long-term use can lead to serious adverse reactions, dependence, and addiction. Rebound insomnia and withdrawal symptoms can occur upon discontinuation, causing irreversible harm to health. Traditional Chinese medicine (TCM) has made tireless efforts in the treatment of insomnia over the years. TCM treatments for insomnia are effective, with fewer adverse reactions, and offer advantages over Western medicine in terms of safety, dependence, and long-term efficacy.

[0003] Currently, Western medicines used clinically to treat insomnia are mainly divided into five categories: benzodiazepines, non-benzodiazepines (or Class Z drugs), antihistamines, dual appetite receptor antagonists, and melatonin agonists. There are more than 20 types of benzodiazepines, such as estazolam, diazepam, and alprazolam; non-benzodiazepines, such as zopiclone, eszopiclone, and zaleplon; antihistamines, such as chlorpheniramine maleate tablets, cetirizine hydrochloride dispersible tablets, and ephedrine-diphenhydramine tablets; dual appetite receptor antagonists, such as leboresen; and melatonin agonists, such as melatonin, rameltein, and agomelatine. In addition, some antipsychotics are used clinically to treat insomnia caused by depression and mental disorders, such as chlorpromazine, sulpiride, and amitriptyline. These types of drugs have a rapid onset of action in the short term, but long-term use can easily lead to adverse reactions such as dependence, addiction, drowsiness, delirium, ataxia, cognitive decline, and sleep-related behavioral disorders.

[0004] Traditional Chinese medicine (TCM) is based on a holistic approach, addressing the root cause of disease through individualized diagnosis and treatment by analyzing the etiology and pathogenesis. TCM emphasizes starting from the patient's constitution, focusing on harmonizing Yin and Yang and improving overall health to restore mental tranquility and ultimately cure insomnia. Furthermore, TCM treatment for insomnia has relatively few side effects and is less likely to lead to drug dependence, offering unique safety and sustainability advantages in long-term treatment. However, currently, TCM lacks highly effective and safe compound preparations specifically targeting "liver stagnation and spleen deficiency type" insomnia that also address the different symptoms during the day and night.

[0005] Therefore, existing technologies need to be improved. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the purpose of this invention is to provide a combined formula for strengthening the spleen and calming the mind, which aims to solve the problem that existing traditional Chinese medicine lacks a highly effective and safe compound preparation for insomnia of "liver stagnation and spleen deficiency type" that also takes into account the different symptoms during the day and night.

[0007] The technical solution of the present invention is as follows: In a first aspect, the present invention provides a combined formula for strengthening the spleen and calming the mind, comprising a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein... The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10-30 parts, Codonopsis pilosula 10-20 parts, Atractylodes macrocephala 10-20 parts, Angelica sinensis 6-12 parts, Citrus reticulata 6-10 parts, Cimicifuga foetida 3-6 parts, Bupleurum chinense 6-15 parts, Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Agrimonia pilosa 15-35 parts, Ziziphus jujuba 10-20 parts, Glycyrrhiza uralensis 3-10 parts; The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 6-15 parts, Paeonia lactiflora 10-20 parts, raw dragon bone 15-35 parts, raw oyster shell 15-35 parts, stir-fried jujube seed 10-30 parts, Polygonum multiflorum vine 15-30 parts, ginger-processed Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Codonopsis pilosula 10-20 parts, Poria cocos 10-20 parts, Atractylodes macrocephala 10-20 parts, Albizia julibrissin flower 5-10 parts, jujube 10-20 parts, prepared licorice root 3-10 parts.

[0008] Optionally, the daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

[0009] Beneficial Effects: This invention provides a combined formula for strengthening the spleen and calming the mind, along with its preparation method. This combined formula for strengthening the spleen and calming the mind addresses the issue at different times of day and night: the daytime formula (strengthening the spleen, replenishing qi, and raising yang): targeting the pathogenesis of "qi deficiency and failure of clear yang to rise" during the day, it uses the method of replenishing qi to boost function and improve daytime energy and physical strength; the nighttime formula (soothing the liver, nourishing blood, and calming the mind): targeting the pathogenesis of "liver stagnation, floating yang, and disturbed mind" at night, it uses the method of calming the mind to guide yang into yin and promote sleep. This treatment method avoids the contradiction of a single formula causing "excessive dispersion during the day and insufficient descent at night," making it highly targeted. On the other hand, it addresses both the root cause and the symptoms, regulating the middle jiao: both formulas contain the herbs "ginger-processed pinellia, scutellaria, codonopsis, jujube, and prepared licorice," which are essentially the framework of "Banxia Xiexin Tang," having the effect of harmonizing cold and heat and promoting the smooth flow of qi in the middle jiao. This suggests that the patient likely suffers from a core pathogenesis of "impaired middle jiao pivot function and spleen and stomach dysfunction," which is both the source of qi deficiency and the root cause of internal phlegm-heat. Regulating the middle jiao day and night lays the foundation for the smooth ascending, descending, entering, and exiting of qi throughout the body. Detailed Implementation

[0010] This invention provides a combined formula for strengthening the spleen and calming the mind, and its preparation method. To make the objectives, technical solutions, and effects of this invention clearer and more explicit, the invention is further described in detail below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0011] Insomnia is a strong area of ​​expertise for Traditional Chinese Medicine (TCM). TCM is based on a holistic approach, addressing the root cause of disease through individualized diagnosis and treatment based on the differentiation of its etiology and pathogenesis. TCM emphasizes starting with the patient's constitution, focusing on harmonizing Yin and Yang and improving overall health to restore mental tranquility and ultimately cure insomnia. Furthermore, TCM treatment for insomnia has relatively few side effects, is less likely to cause drug dependence, and offers unique advantages in terms of safety and sustainability in long-term treatment.

[0012] Insomnia patients with liver stagnation and spleen deficiency often present with daytime fatigue, lethargy, irritability, dizziness, bitter taste in the mouth, chest and rib distension, poor appetite, abdominal distension, loose stools or difficulty defecating; at night, they have difficulty falling asleep, experience light sleep with frequent awakenings, vivid dreams, and may also experience irritability, anxiety, and restless thoughts. Their tongue is reddish or pale red with teeth marks on the edges, and the coating is thin white or thin yellow; their pulse is wiry and thready. Modern urban dwellers who suffer from chronic fatigue, high stress, and excessive thinking often have a constitution characterized by "mixed deficiency and excess, mixed cold and heat, and imbalance of qi and blood."

[0013] Based on this, this embodiment provides a combined formula for strengthening the spleen and calming the mind, including a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10-30 parts, Codonopsis pilosula 10-20 parts, Atractylodes macrocephala 10-20 parts, Angelica sinensis 6-12 parts, Citrus reticulata 6-10 parts, Cimicifuga foetida 3-6 parts, Bupleurum chinense 6-15 parts, Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Agrimonia pilosa 15-35 parts, Ziziphus jujuba 10-20 parts, Glycyrrhiza uralensis 3-10 parts; The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 6-15 parts, Paeonia lactiflora 10-20 parts, raw dragon bone 15-35 parts, raw oyster shell 15-35 parts, stir-fried jujube seed 10-30 parts, Polygonum multiflorum vine 15-30 parts, ginger-processed Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Codonopsis pilosula 10-20 parts, Poria cocos 10-20 parts, Atractylodes macrocephala 10-20 parts, Albizia julibrissin flower 5-10 parts, jujube 10-20 parts, prepared licorice root 3-10 parts.

[0014] It should be noted that the spleen-strengthening formula in this embodiment is based on the classic formula "Buzhong Yiqi Tang" and modified to aim at invigorating qi and raising yang, while also clearing heat and resolving dampness. The principal herb, Astragalus membranaceus, greatly invigorates the qi of the spleen and lungs, consolidates the exterior, and raises yang, making it a key qi-tonifying herb. The assistant herbs, Codonopsis pilosula and Atractylodes macrocephala, enhance the qi-tonifying and spleen-strengthening effects of Astragalus membranaceus; Codonopsis pilosula invigorates the middle jiao and replenishes qi, while Atractylodes macrocephala dries dampness and strengthens the spleen. The adjuvant herb, Angelica sinensis, nourishes blood and harmonizes the nutritive qi, providing a foundation for qi, thus invigorating both qi and blood. Tangerine peel regulates qi and harmonizes the stomach, preventing the tonifying herbs from stagnating the qi mechanism. Cimicifuga foetida and Bupleurum chinense are key ingredients, acting as a light and dispersing agent to assist the principal herb in raising the sunken clear yang qi. The key modification of Pinellia ternata and Scutellaria baicalensis is based on the principle of "Banxia Xiexin Tang," using pungent and bitter herbs to open and descend, harmonize the stomach, and clear damp-heat in the middle jiao (in the Lingnan region, dampness and heat are often present, so pure tonification is not advisable). Agrimonia pilosa is a special herb used. Known colloquially as "the herb of exhaustion," it possesses strengthening, astringent, and restorative properties, assisting in replenishing qi and alleviating fatigue. The accompanying herbs, jujube and roasted licorice root, tonify the spleen and stomach, harmonizing the effects of the other herbs; the roasted licorice root also benefits qi. This formula, based on replenishing the middle jiao and boosting qi, cleverly incorporates ginger, pinellia, and scutellaria to clear damp-heat in the middle jiao, and uses agrimony to enhance its restorative and fatigue-fighting effects, allowing yang qi to rise during the day and improving energy levels.

[0015] Moreover, the nighttime calming formula in this embodiment is adapted from the combined approach of "Bupleurum and Dragon Bone and Oyster Shell Decoction" and "Ziziphus Jujuba Seed Decoction," focusing on soothing the liver and nourishing blood, calming the mind, and harmonizing the spleen and stomach. The principal herbs, Bupleurum and White Peony, are the core ingredients for soothing and softening the liver. Bupleurum soothes the liver, relieves depression, and regulates Qi, while White Peony nourishes blood, astringes Yin, and softens the liver, relieving spasms. The two herbs, one dispersing and the other astringing, harmonize liver Qi. Raw Dragon Bone and Raw Oyster Shell are the core ingredients for calming the mind, their mass sinking and calming the mind, suppressing liver Yang, and restraining the restless spirit. The assistant herbs, Fried Ziziphus Jujuba Seed and Polygonum Multiflorum Vine, nourish blood and calm the mind. Ziziphus Jujuba Seed nourishes heart Yin, benefits liver blood, and calms the mind, while Polygonum Multiflorum Vine (also known as Night-blooming Polygonum Multiflorum Vine) nourishes blood, calms the mind, and unblocks the meridians. Both are essential herbs for treating insomnia due to deficiency and restlessness. Poria cocos calms the mind and soothes the spirit, and also... This formula strengthens the spleen and eliminates dampness; Albizia julibrissin flower relieves depression and calms the mind, making it an excellent remedy for depression and insomnia; the adjuvant herbs, Pinellia ternata and Scutellaria baicalensis, echo the daytime formula, clearing phlegm and heat, harmonizing the stomach and relieving nausea, targeting "restless sleep due to stomach disharmony" and liver and gallbladder stagnation; Codonopsis pilosula, Atractylodes macrocephala, and jujube strengthen the spleen and replenish qi. The inclusion of this group of herbs in the nighttime formula aims to "see liver disease, know that the liver transmits to the spleen, and first strengthen the spleen," preventing liver qi from overpowering the spleen, and also replenishing qi and blood to nourish the heart and spirit; the guiding herb, Glycyrrhiza uralensis, harmonizes all the herbs, and when combined with Paeonia lactiflora, it can transform yin with its sour and sweet properties, relieving urgency and harmonizing the middle jiao. This formula uses multiple methods—soothing the liver, nourishing blood, clearing heat, calming the mind, and tonifying the spleen—in a well-structured manner. Its aim is to allow the hyperactive yang qi at night to subside and the restless mind to calm down, thereby improving sleep.

[0016] It has the following advantages: Firstly, it treats patients at different times of the day and night: the daytime formula (strengthening the spleen, replenishing qi, and raising yang) targets the pathogenesis of "qi deficiency and failure of clear yang to rise" during the day, using the method of tonifying the middle and replenishing qi to boost function and improve daytime energy and physical strength; the nighttime formula (soothing the liver, nourishing blood, and calming the mind) targets the pathogenesis of "liver stagnation, floating yang, and disturbed mind" at night, using the method of calming the mind to guide yang into yin and promote sleep. This treatment method avoids the contradiction of "excessive dispersion when taken during the day and insufficient descent when taken at night" with a single formula, and is highly targeted. Secondly, it addresses both the root cause and the symptoms, regulating the middle jiao: both formulas contain the herbs "ginger-processed pinellia, scutellaria, codonopsis, jujube, and prepared licorice," which are actually the framework of "Banxia Xiexin Tang," and have the effect of harmonizing cold and heat and smoothing the middle jiao. This suggests that the patient may have a core pathogenesis of "impaired middle jiao pivot and spleen and stomach dysfunction," which is both the source of qi deficiency and the root cause of internal phlegm and heat. By regulating the middle jiao day and night, the foundation is laid for the ascending, descending, entering, and exiting of qi throughout the body.

[0017] This embodiment proposes the idea of ​​"time-based medication" for insomnia caused by liver stagnation and spleen deficiency. It breaks down the function of a large compound formula into two sub-formulas with clearly defined targets and different timings of administration, achieving precise treatment. 1. The daytime spleen-strengthening formula (modified Buzhong Yiqi Tang) aims to strengthen the spleen and stomach, invigorate qi and raise yang, laying the material foundation for "calming the mind." During the day, when the body's yang qi is abundant and functions are active, it concentrates its efforts to repair and enhance the function of the "qi and blood production department" (spleen and stomach), generating sufficient qi and blood to store "energy" and "raw materials" for sleep at night. 2. The nighttime calming formula (modified Chaihu Shaoyang Longmu Tang) aims to harmonize the liver and gallbladder, calm yang, nourish blood and calm the mind, directly guiding sleep. At night, when the body's yang qi enters yin and needs quiet, it calms the liver and calms yang, clears heat and eliminates irritability to "remove evil disturbances," and nourishes blood and calms the heart, harmonizing the heart and kidneys to "support the body's vital energy and ensure peace," directly promoting high-quality sleep. This embodies the principles of chronomedicine: strictly adhering to the "correspondence between man and nature" and the body's circadian rhythm. During the day, replenishing Qi aligns with the rising Yang energy to aid bodily functions; at night, nourishing Yin and calming the mind aligns with the receding Yang energy to aid rest. This approach is physiologically sound, yielding twice the results with half the effort, and seamlessly integrates the treatment processes. Through this precise "day and night treatment, harmonizing the heart and spleen" combined formula design, the aim is to systematically address insomnia in a way that better suits the body's natural rhythms, ultimately achieving the ideal state of health where one is "energetic during the day and sleeps soundly at night."

[0018] In one specific embodiment, the daytime spleen-strengthening formula includes the following components: Astragalus membranaceus 15 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

[0019] The following is the preparation method for the daytime spleen-strengthening formula (modified Buzhong Yiqi Decoction): 1. Sorting and cleaning: Place all medicinal slices in a clean container and remove impurities and non-medicinal parts. Rinse quickly once with room temperature drinking water (≤30 seconds) to remove dust and prevent loss of active ingredients.

[0020] 2. Soaking: Place the washed herbs in a non-metallic decoction pot (ceramic, glass, or stainless steel pot is recommended), and add cold water until the water level is about 3-5 cm above the surface of the herbs. Soaking time: 40-60 minutes (until the herbs have fully absorbed water and expanded).

[0021] 3. First decoction (first decoction): After bringing to a boil over high heat, reduce to a simmer and cook for 25-30 minutes. Note: Agrimonia pilosa, jujubes, etc., should be decocted together with the other herbs; ginger-processed Pinellia ternata does not need to be decocted first.

[0022] 4. Filtering: Filter the solution through an 80-mesh stainless steel sieve or double-layered gauze, and collect the solution in a clean container.

[0023] 5. Second decoction (re-decoction): Add an appropriate amount of hot water (about 3 times the initial volume of the herbs) to the dregs, bring to a boil over high heat, then reduce to low heat and simmer for another 20 minutes.

[0024] 6. Combine the medications: After filtering the second decoction, mix it with the first decoction, keeping the total volume between 300-400 mL.

[0025] The following is the preparation method for a nighttime calming formula (modified Chai Shao Long Mu Tang): 1. Sorting and cleaning: Same as the daytime formulation. Note: Raw pork bones and raw oysters must be checked for mud and impurities, and should not be washed for too long (to avoid dissolving and losing active ingredients).

[0026] 2. Decoction of mineral-based medicines first (key step): Add raw dragon bone and raw oyster shell to a pot, either alone or first, along with about 800 mL of cold water. Bring to a boil over high heat, then reduce to a simmer and cook for 20-30 minutes. Meanwhile, soak the other herbs (except for stir-fried jujube seeds and mimosa flowers) in another container of cold water.

[0027] 3. Decoction of all herbs together: Add the other soaked herbs (including Bupleurum, White Peony Root, Ginger-processed Pinellia, Scutellaria, Codonopsis, Poria, Atractylodes, Polygonum multiflorum, Jujube, and Prepared Licorice) along with the soaking water to the pre-decocted dragon bone and oyster shell liquid. Bring to a boil over high heat, then reduce to low heat and simmer for 30 minutes.

[0028] 4. Add the medication later: Add the roasted jujube seeds (crushed) 12-15 minutes before turning off the heat. Add the mimosa flowers 5 minutes before turning off the heat (to prevent excessive loss of volatile components).

[0029] 5. Filtering: Filter the first decoction using gauze or a sieve and collect the liquid.

[0030] 6. Second decoction: Add hot water (about 3 times the initial volume) to the dregs of the medicine, bring to a boil, then simmer for 20 minutes, and filter again.

[0031] 7. Combine the drug solution and concentrate: After combining the two doses, the solution can be concentrated to 200-300 mL (for easy single or divided doses at night).

[0032] The following are general precautions for both daytime spleen-strengthening formulas and nighttime calming formulas: 1. Do not use metal decoction utensils: Iron, aluminum, and copper pots will react with flavonoids such as Scutellaria baicalensis and Bupleurum chinense, affecting the efficacy and color of the medicine.

[0033] 2. Ginger-processed Pinellia ternata is a processed product and does not need to be decocted first; raw dragon bone and raw oyster shell must be crushed and decocted first; stir-fried jujube seeds must be crushed.

[0034] 3. Water for decocting medicine: Use purified water or boiled tap water, and avoid using tap water containing chlorine directly.

[0035] 4. Storage method: Refrigerate the decoction on the same day (2-8℃). Discard any decoction not taken within 12 hours. It is recommended to decoct and use it fresh each day.

[0036] The present invention will be further described below through specific embodiments.

[0037] Example 1 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0038] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried Ziziphus jujuba var. spinosa 15g, Polygonum multiflorum vine 15g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0039] This embodiment describes a method of using a combined formula for strengthening the spleen and calming the mind: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0040] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0041] One hundred patients diagnosed with liver stagnation and spleen deficiency type insomnia were randomly divided into four groups of 25 patients each. There were no statistically significant differences in baseline data (age, course of disease, severity of insomnia, fatigue score, etc.) (P>0.05). The trial lasted for four weeks with uniform diet and rest interventions, with only the medications differing.

[0042] Experimental grouping: 1. Combined prescription: Take the spleen-strengthening prescription during the day and the calming prescription at night (the prescription of Example 1 of this invention); 2. Single-dose spleen-strengthening formula: Take only the spleen-strengthening formula during the day, one dose each in the morning and evening; 3. Single-dose calming formula: Take only the nighttime calming formula daily, one dose each in the morning and evening; 4. Positive control group: The patients took routine clinical medications for treating insomnia caused by liver stagnation and spleen deficiency (such as Guipi Pill + Jiawei Xiaoyao Pill, according to the instructions).

[0043] Test indicators and results: 1. Improvement effect of daytime fatigue (using the Chronic Fatigue Scale (CFS) score, with a maximum score of 50 points. The higher the score, the more severe the fatigue. The higher the score reduction rate after treatment, the more significant the improvement). Table 1 Comparison of daytime fatigue scores and reduction rates before and after treatment in each group

[0044] Note: The p-values ​​in the intergroup comparison column are statistical results compared with the combined formulation. The combined formulation was superior to the other groups in improving daytime fatigue (P<0.01), and the difference was statistically significant.

[0045] 2. Improvement in nighttime sleep quality (using the Pittsburgh Sleep Quality Index (PSQI) score, with a maximum score of 21 points. The higher the score, the worse the sleep. The higher the score reduction rate after treatment and the more significant the increase in sleep duration, the better the sleep quality. Sleep latency and the number of nighttime awakenings were also recorded.) Table 2 Comparison of sleep quality indicators after treatment in each group

[0046] Note: Intergroup comparisons show that the combined formula significantly improved all sleep indicators compared to the other three groups, with a more significant improvement in nighttime sleep quality.

[0047] 3. Overall therapeutic effect (referring to the "Standards for Diagnosis and Efficacy Evaluation of Diseases and Syndromes in Traditional Chinese Medicine" for judging the efficacy of treatment for insomnia due to liver stagnation and spleen deficiency: Cured: Symptoms disappear, PSQI ≤ 3 points, CFS ≤ 10 points; Markedly effective: Symptoms significantly improve, PSQI / CFS reduction rate ≥ 50%; Effective: Symptoms improve, PSQI / CFS reduction rate ≥ 30%; Ineffective: The above standards are not met; Total effective rate = (Cure + Markedly effective + Effective) / Total number of cases × 100%) Table 3 Comparison of clinical efficacy among groups

[0048] Note: The combined formula had the highest total effective rate (96.0%) and cure rate (56.0%) among all groups, and the difference compared with the other three groups was statistically significant (P<0.01), indicating that the combined formula had better overall efficacy.

[0049] 4. Occurrence of adverse reactions (statistically count the number of adverse reactions such as gastrointestinal discomfort, dizziness, dry mouth, and rash during the trial, and calculate the incidence rate of adverse reactions) Table 4 Comparison of adverse reaction occurrences in each group

[0050] Note: The incidence of adverse reactions in the combined formulation (2.0%) was significantly lower than that in the other three groups (P<0.05). All adverse reactions were mild and transient, and no serious adverse events occurred, indicating that the combined formulation had higher drug safety and fewer adverse reactions.

[0051] In summary, the spleen-strengthening and mind-calming combined formula of this embodiment of the invention adopts a day-night dosing regimen. Compared with single-drug administration and conventional clinical medication, it shows significant advantages in improving daytime fatigue, enhancing nighttime sleep quality, and overall efficacy (P<0.01), and the incidence of adverse reactions is significantly reduced (P<0.05), confirming the synergistic effect and toxicity reduction of dosing at different times.

[0052] Animal experimental data (rat model of insomnia due to liver stagnation and spleen deficiency): 1. Experimental animals: 80 SPF-grade SD rats, half male and half female, weighing 200±20g, were acclimatized for 1 week; 2. Modeling method: A rat model of insomnia due to liver stagnation and spleen deficiency was established by chronic restraint stress combined with dietary indiscretion: rats were restrained for 6 hours (9:00-15:00) daily for 21 consecutive days; at the same time, they were fasted every other day but allowed free access to water. Successful modeling was determined by the following: rats exhibited reduced activity, reduced food intake, slow weight gain, and circadian rhythm disorder (reduced nighttime activity and prolonged sleep latency), and abnormal serum serotonin (5-HT) and dopamine (DA) levels (characteristic indicators of insomnia due to liver stagnation and spleen deficiency).

[0053] 3. Grouping and Administration: After successful model establishment, rats were randomly divided into 4 groups of 20 each. A blank control group (normal rats, without model establishment, administered physiological saline by gavage) was also included. The drug administration volume was 10 mL / kg, and the administration was repeated for 14 days. 4. Model control group: administered physiological saline by gavage; 5. Combined prescription: Daytime administration of spleen-strengthening decoction via gavage, and nighttime administration of calming decoction via gavage (equivalent doses calculated based on body surface area); 6. Single-herb mixed group: Mix the herbs of the spleen-strengthening formula and the calming formula, decoct them in water, and administer them by gavage once in the morning and once in the evening (the total dosage is the same as the combined formula). 7. Positive drug group: Gui Pi Wan decoction was administered by gavage (equivalent dose was calculated based on body surface area).

[0054] The detection indicators and results are as follows: 1. General condition and weight changes Model control group: Rats showed persistently reduced activity, decreased food intake, slow weight gain, and no improvement in circadian rhythm disorder; Single-drug combination group: The general condition of rats improved slightly, their weight increased slowly, and their circadian rhythm disorder was partially relieved; Positive drug group: The rats' general condition improved, their weight gain was faster than that of the model group, and their diurnal rhythm disorder was alleviated; Combined formulation: The activity level and food intake of rats returned to near those of the blank control group, and their weight gain was significantly faster than that of other model groups (P<0.01). Their nocturnal activity and sleep rhythm basically returned to normal.

[0055] 2. Sleep-related indicators (sleep duration and sleep latency in rats were measured using a polysomnography system) Table 5 Comparison of sleep phase indices among different groups of rats

[0056] Note: Compared with the model control group, the single-drug combination group, and the positive control group, the combined group of rats showed significantly prolonged slow-wave sleep duration and rapid eye movement sleep duration (P<0.01), and significantly shortened sleep latency (P<0.01), with sleep phase indices approaching those of the blank control group. The results indicate that the timed administration regimen has a significantly better effect on improving sleep structure than the single-drug combination regimen.

[0057] 3. Serum neurotransmitters and immune indicators (core indicators of liver stagnation and spleen deficiency): The levels of 5-HT (a key neurotransmitter for calming the nerves), DA (a neurotransmitter for mood regulation), cortisol (a stress indicator), and IL-6 (an inflammatory factor associated with spleen deficiency) in serum were measured. The results showed: The combined formula significantly increased serum 5-HT levels and decreased DA and cortisol levels in model rats (P<0.01), and its effect in regulating neurotransmitter disorders was better than that of the single-formula mixture group and the positive control group. The combined formula significantly reduced serum IL-6 levels in model rats (P<0.01) and improved the inflammatory response caused by spleen deficiency, with better results than other model groups; All indicators were close to those of the blank control group, confirming that the combined formula can correct the pathological state of insomnia due to liver stagnation and spleen deficiency from the neurological and immune levels.

[0058] In summary, the combined formulation of Example 1 of this invention can significantly improve the general condition, body weight and diurnal rhythm of rats with liver stagnation and spleen deficiency insomnia, correct neurotransmitter disorders, reduce stress and inflammatory markers, and has a significant regulatory and repairing effect on the pathological state of liver stagnation and spleen deficiency insomnia. 2. Key advantages: The efficacy of the combined formulation with timed administration is significantly better than that of the mixed administration of equal amounts of medicinal materials, which proves the originality and synergistic effect of the "day and night timed treatment" scheme of this invention. It is not a simple superposition of medicinal materials, but a precise prescription design based on the human body's circadian rhythm.

[0059] Example 2 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 10g, Scutellaria baicalensis 15g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0060] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried Ziziphus jujuba var. spinosa 15g, Polygonum multiflorum vine 15g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0061] This embodiment is applicable to hot and humid regions such as Lingnan, and the method of administration is the same as in Embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0062] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0063] Example 3 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 7g, Scutellaria baicalensis 7g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0064] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried Ziziphus jujuba var. spinosa 15g, Polygonum multiflorum vine 15g, ginger-processed Pinellia ternata 7g, Scutellaria baicalensis 7g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0065] This embodiment is applicable to dry areas in the north, and the method of administration is the same as in embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0066] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0067] Example 4 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0068] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried Ziziphus jujuba var. spinosa 15g, Polygonum multiflorum vine 15g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0069] This embodiment is suitable for those with a predominant deficiency of Qi (significant fatigue and weakness), and the method of administration is the same as in Embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0070] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0071] Example 5 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 10g, Scutellaria baicalensis 15g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0072] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 15g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried jujube seed 15g, Polygonum multiflorum vine 15g, ginger-processed Pinellia ternata 10g, Scutellaria baicalensis 10g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0073] This embodiment is suitable for those with a severe liver stagnation (significant irritability and chest tightness), and the method of administration is the same as in embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0074] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0075] Example 6 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15g, Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Angelica sinensis 10g, Citrus reticulata 10g, Cimicifuga foetida 5g, Bupleurum chinense 10g, Pinellia ternata 10g, Scutellaria baicalensis 10g, Agrimonia pilosa 30g, Ziziphus jujuba 15g, Glycyrrhiza uralensis 5g.

[0076] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10g, Paeonia lactiflora 15g, raw dragon bone 30g, raw oyster shell 30g, stir-fried jujube seed 20g, Polygonum multiflorum vine 15g, ginger-processed Pinellia ternata 10g, Scutellaria baicalensis 10g, Codonopsis pilosula 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Albizia julibrissin flower 10g, jujube 15g, and prepared licorice root 5g.

[0077] This embodiment is suitable for those with severe insomnia (significant difficulty falling asleep and frequent awakenings). The method of administration is the same as in embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0078] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0079] Example 7 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10g, Codonopsis pilosula 10g, Atractylodes macrocephala 10g, Angelica sinensis 7g, Citrus reticulata 6g, Cimicifuga foetida 3g, Bupleurum chinense 7g, Pinellia ternata 7g, Scutellaria baicalensis 7g, Agrimonia pilosa 25g, Ziziphus jujuba 10g, Glycyrrhiza uralensis 3g.

[0080] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 7g, Paeonia lactiflora 10g, raw dragon bone 25g, raw oyster shell 25g, stir-fried jujube seed 10g, Polygonum multiflorum vine 10g, ginger-processed Pinellia ternata 7g, Scutellaria baicalensis 7g, Codonopsis pilosula 10g, Poria cocos 10g, Atractylodes macrocephala 10g, Albizia julibrissin flower 7g, jujube 10g, and prepared licorice root 3g.

[0081] This embodiment is suitable for middle-aged and elderly patients (over 60 years old), and its usage method is the same as in embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0082] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL warm, one hour before bedtime (21:00–22:00), once a day. Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. Stir-fried jujube seeds, crushed, are added to the decoction along with the other ingredients of the nighttime calming formula.

[0083] Example 8 A combined formula for strengthening the spleen and calming the mind includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; wherein, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 16.5g, Codonopsis pilosula 16.5g, Atractylodes macrocephala 16.5g, Angelica sinensis 11g, Citrus reticulata 10g, Cimicifuga foetida 5.5g, Bupleurum chinense 12g, Pinellia ternata 10g, Scutellaria baicalensis 12g, Agrimonia pilosa 33g, Ziziphus jujuba 16.5g, Glycyrrhiza uralensis 5.5g.

[0084] The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 12g, Paeonia lactiflora 16.5g, raw dragon bone 33g, raw oyster shell 33g, stir-fried Ziziphus jujuba var. spinosa 16.5g, Polygonum multiflorum vine 16.5g, Pinellia ternata 10g, Scutellaria baicalensis 12g, Codonopsis pilosula 16.5g, Poria cocos 16.5g, Atractylodes macrocephala 16.5g, Albizia julibrissin flower 10g, jujube 16.5g, and prepared licorice root 5.5g.

[0085] This embodiment is applicable to young and middle-aged patients, and the usage method is the same as in embodiment 1: The method of taking the spleen-strengthening formula during the day is to decoct it in water and take it warm between 7:00 and 9:00 every day, 200mL each time, half a dose per day.

[0086] The method of taking the nighttime calming formula is as follows: decoct in water and take 200mL each time, half a dose per day, one hour before bedtime (21:00–22:00). Raw dragon bone and raw oyster shell need to be decocted for 30 minutes first. After crushing the fried jujube seeds, add them to the decoction along with the other ingredients of the nighttime calming formula.

[0087] In summary, this invention provides a combined formula for strengthening the spleen and calming the mind. This combined formula for strengthening the spleen and calming the mind addresses the issue at different times of day and night: the daytime formula (strengthening the spleen, replenishing qi, and raising yang): targeting the pathogenesis of "qi deficiency and failure of clear yang to rise" during the day, it uses the method of replenishing qi to boost function and improve daytime energy and physical strength; the nighttime formula (soothing the liver, nourishing blood, and calming the mind): targeting the pathogenesis of "liver stagnation, floating yang, and disturbed mind" at night, it uses the method of calming the mind to guide yang into yin and promote sleep. This treatment method avoids the contradiction of a single formula causing "excessive dispersion during the day and insufficient descent at night," and is highly targeted. On the other hand, it addresses both the root cause and the symptoms, regulating the middle jiao: both formulas contain the herbs "ginger-processed pinellia, scutellaria, codonopsis, jujube, and prepared licorice," which are essentially the framework of "Banxia Xiexin Tang," having the effect of harmonizing cold and heat and smoothing the middle jiao. This suggests that the patient likely suffers from a core pathogenesis of "impaired middle jiao pivot function and spleen and stomach dysfunction," which is both the source of qi deficiency and the root cause of internal phlegm-heat. Regulating the middle jiao day and night lays the foundation for the smooth ascending, descending, entering, and exiting of qi throughout the body.

[0088] It should be understood that the application of the present invention is not limited to the examples above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A combined formula for strengthening the spleen and calming the mind, characterized in that, This includes a daytime formula for strengthening the spleen and a nighttime formula for calming the mind; among them, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10-30 parts, Codonopsis pilosula 10-20 parts, Atractylodes macrocephala 10-20 parts, Angelica sinensis 6-12 parts, Citrus reticulata 6-10 parts, Cimicifuga foetida 3-6 parts, Bupleurum chinense 6-15 parts, Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Agrimonia pilosa 15-35 parts, Ziziphus jujuba 10-20 parts, Glycyrrhiza uralensis 3-10 parts; The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 6-15 parts, Paeonia lactiflora 10-20 parts, raw dragon bone 15-35 parts, raw oyster shell 15-35 parts, stir-fried jujube seed 10-30 parts, Polygonum multiflorum vine 15-30 parts, ginger-processed Pinellia ternata 6-12 parts, Scutellaria baicalensis 6-15 parts, Codonopsis pilosula 10-20 parts, Poria cocos 10-20 parts, Atractylodes macrocephala 10-20 parts, Albizia julibrissin flower 5-10 parts, jujube 10-20 parts, prepared licorice root 3-10 parts.

2. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

3. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 15 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

4. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 7 parts, Scutellaria baicalensis 7 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 7 parts, Scutellaria baicalensis 7 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

5. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried Ziziphus jujuba var. spinosa 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

6. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 15 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 15 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried jujube seed 15 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

7. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 15 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Angelica sinensis 10 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5 parts, Bupleurum chinense 10 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Agrimonia pilosa 30 parts, Ziziphus jujuba 15 parts, Glycyrrhiza uralensis 5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 10 parts, Paeonia lactiflora 15 parts, raw dragon bone 30 parts, raw oyster shell 30 parts, stir-fried jujube seed 20 parts, Polygonum multiflorum vine 15 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 10 parts, Codonopsis pilosula 15 parts, Poria cocos 15 parts, Atractylodes macrocephala 15 parts, Albizia julibrissin flower 10 parts, jujube 15 parts, and prepared licorice root 5 parts.

8. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 10 parts, Codonopsis pilosula 10 parts, Atractylodes macrocephala 10 parts, Angelica sinensis 7 parts, Citrus reticulata 6 parts, Cimicifuga foetida 3 parts, Bupleurum chinense 7 parts, Pinellia ternata 7 parts, Scutellaria baicalensis 7 parts, Agrimonia pilosa 25 parts, Ziziphus jujuba 10 parts, Glycyrrhiza uralensis 3 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 7 parts, Paeonia lactiflora 10 parts, raw dragon bone 25 parts, raw oyster shell 25 parts, stir-fried jujube seed 10 parts, Polygonum multiflorum vine 10 parts, ginger-processed Pinellia ternata 7 parts, Scutellaria baicalensis 7 parts, Codonopsis pilosula 10 parts, Poria cocos 10 parts, Atractylodes macrocephala 10 parts, Albizia julibrissin flower 7 parts, jujube 10 parts, and prepared licorice root 3 parts.

9. The spleen-strengthening and mind-calming combined formula according to claim 1, characterized in that, The daytime spleen-strengthening formula comprises the following components in parts by weight: Astragalus membranaceus 16.5 parts, Codonopsis pilosula 16.5 parts, Atractylodes macrocephala 16.5 parts, Angelica sinensis 11 parts, Citrus reticulata 10 parts, Cimicifuga foetida 5.5 parts, Bupleurum chinense 12 parts, Pinellia ternata 10 parts, Scutellaria baicalensis 12 parts, Agrimonia pilosa 33 parts, Ziziphus jujuba 16.5 parts, Glycyrrhiza uralensis 5.5 parts. The nighttime calming formula comprises the following components in parts by weight: Bupleurum chinense 12 parts, Paeonia lactiflora 16.5 parts, raw dragon bone 33 parts, raw oyster shell 33 parts, stir-fried Ziziphus jujuba var. spinosa 16.5 parts, Polygonum multiflorum vine 16.5 parts, ginger-processed Pinellia ternata 10 parts, Scutellaria baicalensis 12 parts, Codonopsis pilosula 16.5 parts, Poria cocos 16.5 parts, Atractylodes macrocephala 16.5 parts, Albizia julibrissin flower 10 parts, jujube 16.5 parts, and prepared licorice root 5.5 parts.

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