COMPOSITIONS AND METHODS FOR ENZYME INTERNALIZATION
CY1125696T1Undetermined Publication Date: 2026-04-17REGENERON PHARMACEUTICALS INC
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Patent Information
- Application Number
- CY20221100683T
- Authority / Receiving Office
- CY · CY
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2016-08-25
- Filing Date
- 2022-10-17
- Publication Date
- 2026-04-17
- Estimated Expiration
- 2042-10-17
Abstract
Disclosed are compositions and methods for the treatment of lysosomal storage diseases. Also disclosed are biotherapeutic complexes comprising an internalization effector binding domain and lysosomal replacement enzyme activity. The biotherapeutic complexes are capable of entering cells, sequestering in the lysosome, and delivering the replacement enzyme activity to the lysosome.
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