A traditional chinese medicine composition for dispelling phlegm-dampness, dissipating pulmonary nodules and reducing abnormal lung tumor markers
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Patents
- Current Assignee / Owner
- 董峰
- Filing Date
- 2024-10-18
- Publication Date
- 2026-07-10
Abstract
Description
TECHNICAL FIELD
[0001] The application belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for eliminating phlegm and dampness, dispersing pulmonary nodules and reducing the level of abnormal lung tumor markers. BACKGROUND
[0002] With the improvement of living standards and the awareness of prevention and health care, in recent years, regular physical examination is becoming more and more popular. As a result, the detection rate of lung nodules and lung tumor markers (such as squamous cell carcinoma antigen, cytokeratin 19 fragment, neuron-specific olfactory enzyme, and gastrin releasing peptide precursor) in physical examination has also increased greatly. In most cases, lung nodules and / or lung tumor markers are detected in physical examination, and the body has no special discomfort. Western medicine has no targeted treatment drugs and treatment methods for this, and only follow-up is advised. However, lung nodules and / or lung tumor markers can cause great psychological burden, even anxiety and fear, affecting normal life and work.
[0003] Traditional Chinese medicine believes that the lung governs qi and controls respiration, governs water and regulates the blood vessels. The basic operation form of lung qi is to spread, release, purify and descend. The lung lobes are delicate and cannot tolerate invasion of cold, heat, dryness and dampness. If phlegm and blood stasis cause the body fluid to be unable to be normally distributed, lung nodules are easily formed. The inventors found in medical practice that most patients with lung nodules have a history of excessive phlegm and poor expectoration, which is consistent with the TCM syndrome of lung phlegm and dampness. Based on this understanding, the inventors combined traditional Chinese medicine theory and summarized a traditional Chinese medicine composition with the functions of eliminating phlegm and dampness and dispersing lung nodules. Surprisingly, the lung tumor markers closely related to lung nodules that are abnormally elevated in patients are also reduced. SUMMARY
[0004] Therefore, the application provides a traditional Chinese medicine composition for eliminating phlegm and dampness, dispersing lung nodules and reducing the level of abnormal lung tumor markers, as well as a preparation method and application thereof.
[0005] The application adopts the following technical solutions:
[0006] A traditional Chinese medicine composition for eliminating phlegm and dampness, dispersing lung nodules and reducing the level of abnormal lung tumor markers is composed of the following medicinal materials:
[0007] Herba Lycopodii 30-40 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 20-30 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 3-4 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 10-12 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 15-20 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 1-2, Herba Lycopodii 10-11 parts by weight, Herba Lycopodii 6-7 parts by weight, Herba Lycopodii 15-20 parts by weight.
[0008] Preferably, the traditional Chinese medicine composition for removing phlegm and dispelling lung nodules is composed of the following medicinal materials:
[0009] Herba Lycopodii 30-40 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 20-30 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 3-4 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 10-12 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 15-20 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 1-2, Herba Lycopodii 10-11 parts by weight, Herba Lycopodii 6-7 parts by weight, Herba Lycopodii 15-20 parts by weight.
[0010] More preferably, the traditional Chinese medicine composition for removing phlegm and dispelling lung nodules is composed of the following medicinal materials:
[0011] Herba Lycopodii 30-40 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 20-30 parts by weight, Herba Lycopodii 10-20 parts by weight, Herba Lycopodii 3-4 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 10-12 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 15-20 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-9 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 6-8 parts by weight, Herba Lycopodii 1-2, Herba Lycopodii 10-11 parts by weight, Herba Lycopodii 6-7 parts by weight, Herba Lycopodii 15-20 parts by weight.
[0012] Preferably, the Ganoderma lucidum is Ganoderma lucidum.
[0013] Preferably, the Fructus Aurantii is Fructus Aurantii Immaturus Roasted with Wheat Bran.
[0014] It is another object of the present application to provide use of the above-mentioned Chinese medicine composition in the preparation of a medicament for treating lung nodules caused by phlegm-dampness.
[0015] It is another object of the present application to provide use of the above-mentioned Chinese medicine composition in the preparation of a medicament for treating abnormal elevation of serum lung tumor markers.
[0016] In the present application, the "abnormal elevation of serum lung tumor markers" refers to the detection result of serum tumor markers exceeding the normal reference value.
[0017] It is another object of the present application to provide use of the above-mentioned Chinese medicine composition in the preparation of a medicament for treating lung nodules caused by phlegm-dampness and abnormal elevation of serum lung tumor markers.
[0018] The lung nodules caused by phlegm-dampness are characterized by the presence of scattered round dense shadows with clear or blurred edges and a diameter less than or equal to 3 cm in lung imaging, pale red tongue, yellow greasy or thick yellow fur or white fur, and slow and slippery or soft pulse.
[0019] The patient can also have one or more of the following symptoms: chest tightness, fatigue, easy sweating, loose or constipated stool, throat discomfort, excessive sputum or poor expectoration.
[0020] Preferably, the lung tumor markers are selected from one or more of squamous cell carcinoma antigen, cytokeratin 19 fragment, neuron-specific olidase, and progastrin-releasing peptide.
[0021] Preferably, the above-mentioned medicament is a clinically acceptable preparation.
[0022] Further preferably, the preparation is an oral preparation selected from a decoction, a tablet, a capsule, a powder, a pill, or a granule.
[0023] As a preferred embodiment, the present application provides a preparation method of a decoction for treating lung nodules caused by phlegm-dampness and / or abnormal elevation of serum lung tumor markers, using the Chinese medicine composition of the present application as raw material, comprising the following steps:
[0024] I. Prepare each medicinal material according to weight parts;
[0025] II. Powder the Radix Notoginseng, and reserve; crush the Colla Carapacis et Natrii Asparagi, and soak in 5-10 times the weight of water for 20-30 minutes; mix the other medicinal materials except for Radix Notoginseng, and soak in 5-10 times the weight of water for 20-30 minutes;
[0026] III. After soaking, transfer the vinegar-soaked turtle shell and soaking water to a suitable container, add calcined pumice, bring to a boil over high heat, then reduce to low heat and simmer for 20-30 minutes; add the soaked mixed herbs, and if necessary, add water to make the water level 1-3cm above the herbs, bring to a boil over high heat, then reduce to low heat and simmer for 20-30 minutes, then filter while hot; keep the dregs in the container, add water to make the water level 1-3cm above the herbs, bring to a boil over high heat, then reduce to low heat and simmer for 20-30 minutes, then filter while hot; combine the two filtrates to obtain the herbal decoction;
[0027] IV. Divide the decoction of medicinal materials obtained in step III into 200-300 ml portions. Divide the Panax notoginseng powder into corresponding portions. Take one portion of Panax notoginseng powder with one portion of the decoction of medicinal materials (twice a day, one portion each time).
[0028] If an automatic decoction machine is used to prepare the decoction described in this invention, the specific operation can be as follows:
[0029] Prepare each herb according to weight proportions; grind Panax notoginseng into powder and set aside; put all the herbs except Panax notoginseng into an automatic decoction machine and decoct 1-2 times, then bag the resulting herbal decoction, each bag containing about 100 ml; divide the Panax notoginseng powder into corresponding portions, and take one portion of Panax notoginseng powder with one bag of herbal decoction; take one bag twice a day.
[0030] The decoction obtained by the above preparation method is equivalent to 100-200 grams of medicinal materials (all medicinal materials except Panax notoginseng) per serving (or per bag); correspondingly, each serving of Panax notoginseng powder is 1.5-3 grams.
[0031] The *Suwen* (Plain Questions) chapter "On the Essential Principles of Medicine" states: "The herb that controls the disease is called the 'ruler,' the herb that assists the 'ruler' is called the 'minister,' and the herb that responds to the 'minister' is called the 'guide.'" "One 'ruler' and two 'ministers' represent a small system. Two 'rulers,' three 'ministers,' and five 'guides' represent a medium system. One 'ruler,' three 'ministers,' and nine 'guides' represent a large system." The herbs in a prescription can be categorized according to their roles: ruler, minister, assistant, and guide herbs, referred to as ruler, minister, assistant, and guide. In the herbal composition described in this invention, Agrimonia pilosa is the ruler; Hedyotis diffusa, Chrysanthemum indicum, and Taraxacum mongolicum are ministers; Coix lacryma-jobi, Trichosanthes kirilowii, Panax notoginseng powder, Bambusa textilis, Poria cocos, Citrus reticulata peel, Citrus aurantium (stir-fried with wheat bran), Acorus tatarinowii, Curcuma longa, Ganoderma lucidum, Scutellaria barbata, Pinellia ternata, and Prunella vulgaris are assistants; and Stemona japonica (honey-processed), Fritillaria thunbergii, Cinnamomum cassia, Scolopendra subspinipes, Turtle shell (processed with vinegar), Bombyx mori (stir-fried), and Pumice are guides. Each herb performs its specific function and works synergistically.
[0032] The principal herb is Agrimonia pilosa, which is bitter and astringent in taste, neutral in nature, and enters the heart and liver meridians. Its functions include astringing and stopping bleeding, treating malaria, stopping dysentery, detoxifying, and tonifying deficiency. Agrimonia pilosa tonifies deficiency and treats sores and toxins, serving as the overarching principle of this formula and thus the principal herb. The principal herb is used in large, concentrated doses to work together with the other herbs to overcome pathogenic factors.
[0033] The main ingredients are: Hedyotis diffusa, wild chrysanthemum, and dandelion.
[0034] Oldenlandia, bitter, sweet, cold, stomach, large intestine, small intestine, heat- clearing and detoxifying, wetness- removing and stranguria- relieving, especially good for treating various types of inflammation. The inventor found in clinical practice that Oldenlandia can treat many diseases if properly matched.
[0035] Wild chrysanthemum, bitter, pungent, slightly cold, liver, heart, heat-clearing and detoxifying, liver- soothing. Wild chrysanthemum is pungent and dispersing, clear and clear, and its gas is clear and floating. It has the effect of dispersing lung heat, but the dispersing ability of surface evil is not strong, and it is often used to relieve fever, headache, cough and other symptoms caused by warm evil invading the lung in the early stage of warm disease.
[0036] Dandelion, bitter, sweet, cold, liver, stomach, heat-clearing and detoxifying, swelling and knot-removing, wetness-removing and stranguria- relieving, for boils, mastitis, scrofula, lung abscess, intestinal abscess, red eyes, sore throat, hot and painful stranguria.
[0037] The wild chrysanthemum in the three ministerial drugs disperses the lung, which helps the Oldenlandia and the dandelion to show their swelling and knot-removing, heat-clearing and detoxifying, and wetness-removing and abscess-removing effects in the lungs. The combined power of knot-removing, wetness-removing and abscess-removing helps the monarch to eliminate lung diseases. The ministerial drug is light in nature, which is in line with the description in the classic of traditional Chinese medicine that "the upper part is like a feather, which is not light and cannot be lifted." That is, to treat diseases of the upper part (lungs in the upper part), light- natured drugs must be used to directly reach the disease site.
[0038] Sauce: yiyi, melon, three seven powder, bamboo, Fuling, dried tangerine peel, bran fried fructus aurantii, alocasia, jude, half branch orchid, half summer grass.
[0039] Yiyiren, sweet, light, cool, spleen, stomach, lung, water-removing and dampness-removing, spleen- strengthening and diarrhea- stopping, removing and knot-removing, for edema, difficulty urinating, spleen deficiency, diarrhea, dampness, joint stiffness, lung abscess, intestinal abscess, warts, cancer.
[0040] Melon, sweet, slightly bitter, cold, lung, stomach, large intestine, heat-clearing and phlegm-removing, chest- expanding and knot-removing, dryness-removing and intestine- smoothing, for lung heat cough, phlegm turbidity, chest pain, lung abscess, mastitis, intestinal abscess.
[0041] Sanqi, sweet, slightly bitter, warm, liver, stomach, blood- stasis-removing and blood- stopping, swelling-removing and pain- stopping.
[0042] Bamboo, sweet, slightly cold, lung, stomach, heart, gallbladder, heat-clearing and phlegm-removing, removing and stopping vomiting.
[0043] Fuling, sweet, light, heart, lung, spleen, kidney, water-removing and dampness-removing, spleen- strengthening, heart- soothing, for edema, dizziness, spleen deficiency, diarrhea, heart- soothing, insomnia.
[0044] Dried tangerine peel, bitter, warm, spleen, lung, qi- regulating and spleen- strengthening, dampness-removing and phlegm-removing.
[0045] Fructus Aurantii Immaturus (Fried with Wheat Bran): Bitter, pungent and sour in taste, it pertains to the spleen and stomach meridians, and functions to regulate qi, relieve stagnation, dissipate distension, and arrest phlegm and fluid retention.
[0046] Rhizoma Acori Tatarinowii, pungent and bitter in taste, warm in nature, it returns to the heart and stomach meridians, and functions to open the orifices, dissipate phlegm, and dry dampness.
[0047] Radix Anemarrhenae, bitter and pungent in taste, cold in nature, it returns to the heart, lung, liver, and kidney meridians, and functions to clear heat and resolve toxin, and to clear heat and resolve toxin.
[0048] Ganoderma lucidum, sweet in taste, and neutral in nature, it returns to the heart, lung, liver, and kidney meridians, and functions to tonify qi and calm the spirit, and to relieve cough and asthma. The product is sweet and neutral, and can tonify and warm the lung, and relieve cough and asthma. It is often used to treat phlegm-dampness syndrome, and is especially effective for treating cold and cough with excessive phlegm, and for treating phlegm-dampness and deficiency-cold syndromes.
[0049] Herba Houttuyniae, bitter and pungent in taste, cold in nature, it returns to the lung, liver, and kidney meridians, and functions to clear heat and resolve toxin, and to clear heat and resolve toxin.
[0050] Rhizoma Pinelliae (Prepared), pungent in taste, warm in nature, it returns to the spleen, stomach, and lung meridians, and functions to dry dampness and resolve phlegm, to arrest vomiting, and to dissipate phlegm and resolve mass.
[0051] Folium Spireae, bitter and pungent in taste, cold in nature, it returns to the liver and gallbladder meridians, and functions to clear liver heat, to clear heat and resolve toxin, and to clear heat and resolve toxin.
[0052] The invention is based on the Chinese medicine classic saying that "all diseases are caused by phlegm", and believes that nodules and lung tumor markers are caused by phlegm-dampness. The auxiliary medicines form a combined force in the aspects of promoting water excretion and dampness elimination, heat clearing and phlegm resolving, and mass resolving and abscess resolving, and have a special and powerful effect.
[0053] Medicines: honeyed Radix Stachyuri, Rhizoma Bletillae, Ramulus Cinnamomi, Eupompha perniciosa, vinegar calcined Carapax Trionycis, fried Eupolyphaga, and calcined Concha Haliotidis.
[0054] Radix Stachyuri, sweet and bitter in taste, slightly warm in nature, it returns to the lung meridian, and after being honeyed, it can even more effectively moisten the lung, lower qi, and relieve cough. It is often used to treat yin deficiency and laborious cough.
[0055] Rhizoma Bletillae, bitter in taste, cold in nature, it returns to the lung and heart meridians, and functions to clear heat and resolve phlegm, to relieve cough, to resolve toxin and resolve mass, and to resolve abscess. It is often used to treat wind-heat cough, phlegm-fire cough, lung abscess, breast abscess, scrofula, and sore.
[0056] Ramulus Cinnamomi, pungent and sweet in taste, warm in nature, it returns to the heart, lung, and bladder meridians, and functions to sweat and disperse, to warm and unblock meridians, to assist yang and transform qi, and to treat wind-cold invasion, blood stagnation, phlegm-dampness, water retention, and palpitation.
[0057] Eupompha perniciosa, pungent and warm in taste, it returns to the liver meridian, and functions to extinguish wind and relieve convulsion, to unblock collaterals and relieve pain, and to attack toxin and resolve mass. It is often used to treat sores, scrofula, and the like.
[0058] E JIAOJIANG, functions to nourish yin and suppress yang, soften and resolve mass; vinegar has the effect of astringe, detoxify, dispel blood stasis and relieve pain, and can enhance the effect of drug into the liver to resolve accumulation, soften and resolve mass.
[0059] Chao Jiangcan, salty and pungent in taste, neutral in nature, and meridian into liver, lung, stomach, functions to calm wind and stop convulsion, dispel wind and relieve pain, and resolve phlegm and resolve mass.
[0060] Calcined sea sponges, salty, cold, lung and kidney, functions to clear lung and resolve phlegm, soften and resolve mass, diuresis and relieve, for phlegm and cough, old phlegm accumulation, scrofula, goiter.
[0061] Make medicine focus on softening, detoxification, and removing stubborn phlegm, so as to form a force for resolving mass. DETAILED DESCRIPTION
[0062] The following specific examples are described in the present application. Those skilled in the art can understand that these examples are only for illustration of the present application, and do not limit the scope of the present application in any way.
[0063] The experimental methods in the following examples are as follows, unless otherwise specified. The medicinal materials, reagent materials and the like used in the following examples are commercially available, unless otherwise specified. Example 1 A kind of traditional Chinese medicine composition and a kind of decoction
[0064] The medicinal material composition of the traditional Chinese medicine composition described in this embodiment is as follows:
[0065] Xianhecao 30g, Baihuashexiao 10g, Yekuhua 6g, Pugongying 6g, Yiyiren 20g, Gualou 10g, Sanqi 3g, Zhuzu 6g, Fuling 10g, Chenpi 6g, Zhishicheng 6g, Shichanglian 6g, Fubanxia 6g, Xiacukui 15g, Mibubu 6g, Zhebeimu 6g, Guizhi 6g, Guogong 1, E JIAOJIANG 10g, Chao Jiangcan 6g, Calcined sea sponges 15g.
[0066] The above traditional Chinese medicine composition is used as raw material to obtain the decoction of this embodiment by water decocting twice, and the specific operation is as follows:
[0067] I. Prepare each medicinal material according to weight;
[0068] II. Sanqi powder, ready for use; take E JIAOJIANG and crush it, soak it in 100g water for 20-30 minutes, mix the other medicinal materials except Sanqi, and soak them in water for 20-30 minutes;
[0069] III. After the soaking is completed, the vinegar turtle shell is transferred to a suitable decocting sand pot together with the soaking water, and calcined pumice is added. After being boiled with a large fire, the fire is turned to small and the decoction is continued for 20 minutes. The soaked mixed medicinal materials are added, and if necessary, water is added to make the water level 2 cm higher than the medicinal materials. After being boiled with a large fire, the fire is turned to small and the decoction is continued for 30 minutes. The decoction is filtered while hot. The residue is retained in the sand pot, and water is added to make the water level 2 cm higher than the medicinal materials. After being boiled with a large fire, the fire is turned to small and the decoction is continued for 20 minutes. The decoction is filtered while hot. The two filtrates are combined to obtain the medicinal material water decoction.
[0070] IV. The medicinal material water decoction (one day's amount) obtained in step III is divided into three portions (about 300 ml each), and the notoginseng powder is also divided into three portions. One portion of the notoginseng powder is taken with one portion of the medicinal material water decoction.
[0071] Dosage and method of use: three times a day, one portion each time, and taken with one portion of the notoginseng powder.
[0072] A traditional Chinese medicine composition and a decoction
[0073] The medicinal material composition of the traditional Chinese medicine composition described in this example is as follows:
[0074] Herba monochori 50 g, oldenlandia 30 g, chrysanthemum indicum 12 g, herba taraxaci 12 g, coix 50 g, trichosanthes 30 g, notoginseng 6 g, bamboo shavings 12 g, poria 15 g, tangerine peel 10 g, fructus aurantii immaturus (roasted with wheat flour) 12 g, rhizoma alocasia 12 g, curcuma 10 g, red ginseng 10 g, herba barbata 12 g, pinellia 12 g, prunella 30 g, honey root 10 g, fritillaria 12 g, cassia bark 10 g, centipede 2, vinegar turtle shell 15 g, fried silkworm chrysalis 9 g, calcined pumice 30 g.
[0075] The above-mentioned traditional Chinese medicine composition is used as raw material to obtain the decoction (one day's amount) of this example by water decoction twice, and the specific operation is basically the same as that of example 1.
[0076] A traditional Chinese medicine composition and a decoction
[0077] The medicinal material composition of the traditional Chinese medicine composition described in this example is as follows:
[0078] Herba monochori 45 g, oldenlandia 25 g, chrysanthemum indicum 10 g, herba taraxaci 10 g, coix 40 g, trichosanthes 25 g, notoginseng 5 g, bamboo shavings 10 g, poria 15 g, tangerine peel 10 g, fructus aurantii immaturus (roasted with wheat flour) 10 g, rhizoma alocasia 10 g, curcuma 9 g, red ginseng 9 g, herba barbata 10 g, pinellia 10 g, prunella 25 g, honey root 9 g, fritillaria 10 g, cassia bark 9 g, centipede 2, vinegar turtle shell 12 g, fried silkworm chrysalis 8 g, calcined pumice 25 g.
[0079] The above-mentioned traditional Chinese medicine composition is used as raw material to obtain the decoction (one day's amount) of this example by water decoction twice, and the specific operation is basically the same as that of example 1.
[0080] A traditional Chinese medicine composition and a decoction
[0081] The medicinal material composition of the traditional Chinese medicine composition described in this embodiment is as follows:
[0082] Herba Agrimoniae 40 g, Herba Hedyotis Diffusae 20 g, Flos Chrysanthemi Indici 9 g, Herba Taraxaci 9 g, Radix Euryalis 30 g, Fructus Trichosanthis 20 g, Radix Notoginseng 4 g, Rhizoma Bamboo 9 g, Poria 12 g, Pericarpium Citri Reticulatae 9 g, Fructus Aurantii Immaturus (Fried with Wheat Flour) 9 g, Rhizoma Acori Graminei 9 g, Radix Curcumae 8 g, Sclerotium Gordoniae 8 g, Herba Violae 9 g, Rhizoma Pinelliae 9 g, Herba Prunellae 20 g, Radix Stachy 8 g, Radix Bletillae 9 g, Ramulus Cinnamomi 8 g, Centipede 1, Vinegar Carapax Trionycis 11 g, Fried Bombyx Batryticatus 7 g, Calcined Selenite 20 g.
[0083] The above-mentioned traditional Chinese medicine composition is water-decocted twice to obtain the decoction (one-day amount) of this embodiment, and the specific operation is basically the same as that of Embodiment 1.
[0084] Clinical practice example The typical medical records of the traditional Chinese medicine composition of the present application in the clinical treatment of lung nodules and abnormal elevation of serum lung tumor markers Patient 1. Miss Feng XX, 61 years old, serum detection of neuron-specific enolase (NSE) 102.00 ng / ml (reference value 0-16.3 ng / ml) on March 6, 2017. The patient complained of chest tightness, fatigue, constipation, and sputum. The tongue was pale red with yellow and greasy fur, and the pulse was slippery and floating.
[0085] The decoction of Embodiment 1, 1 dose per day, three times a day, for four weeks. On April 15, 2017, serum detection of neuron-specific enolase (NSE) 16.25 ng / ml (reference value 0-16.3 ng / ml). The patient complained of chest tightness, fatigue, and sputum, which improved significantly, and the two excretions were adjusted. The tongue was pale red with white and greasy fur, and the pulse was slippery and floating.
[0086] Patient 2. Miss Li XX, 48 years old, chest CT showed multiple small nodules in the right upper lobe, multiple lymph node shadows in the mediastinum, and multiple accessory spleen nodules (possibly) on June 8, 2017. The patient complained of chest tightness, fatigue, easy sweating, constipation, and throat discomfort. The tongue was pale red with yellow and greasy fur, and the pulse was slippery and floating.
[0087] The decoction of Embodiment 2, 1 dose per day, three times a day, for four weeks. On August 8, 2017, the chest CT showed no abnormal enhanced density shadow in the lungs (right lung nodules disappeared), no enlarged lymph nodes in the mediastinum, and no thickening of the bilateral pleura. The tongue was bright red with white and greasy fur, and the pulse was floating and number. The patient complained of chest tightness and other symptoms improved significantly, and the two excretions were adjusted.
[0088] Patient 3. Dong XX, male, 55 years old, serum detection of cytokeratin 19 fragment (CYFR21) 3.96 ng / ml (reference value 0-2.08 ng / ml), and carcinoembryonic antigen (CEA) 4.88 ng / ml (reference value <4.70 ng / ml) on September 10, 2015. The tongue was light red with yellowish thick fur, and the pulse was slippery and rapid.
[0089] The decoction of Example 3 was taken one dose per day, three times a day, and continuously taken for four weeks. On February 24, 2016, serum detection of cytokeratin 19 fragment (CYFR21) was 2.07 ng / ml (reference value 0-2.08 ng / ml), and carcinoembryonic antigen (CEA) was 4.07 ng / ml (reference value <4.70 ng / ml). The tongue was light red with thin white fur, and the pulse was slippery.
[0090] Patient 4. Wu XX, female, 47 years old, serum detection of neuron-specific enolase (NSE) 18.240 ng / ml (reference value 0-17 ng / ml) on May 22, 2017. The tongue was bright red with white fur, and the pulse was slippery and rapid.
[0091] The decoction of Example 4 was taken one dose per day, three times a day, and continuously taken for four weeks. On June 29, 2017, serum detection of neuron-specific enolase (NSE) was 12.790 ng / ml (reference value 0-17 ng / ml). The tongue was light red, and the pulse was full and large.
[0092] The inventor has treated about 518 patients with lung nodules and abnormal elevation of serum lung tumor markers using the traditional Chinese medicine composition of the present application, which will not be described here. After treatment, the lung nodules disappeared, and the abnormal tumor markers decreased to normal values, which helped the patients physiologically and psychologically.
[0093] In summary, the present application provides a traditional Chinese medicine composition for eliminating phlegm and dampness and dispersing lung nodules. Clinical practice has proved that the traditional Chinese medicine composition of the present application has a clear effect in treating lung nodules caused by phlegm and dampness, especially lung nodules caused by phlegm and dampness with abnormal elevation of serum lung tumor markers.
Claims
1. A traditional Chinese medicine composition for eliminating phlegm and dampness, dispersing pulmonary nodules, and reducing the levels of abnormal lung tumor markers, comprising the following medicinal materials: Agrimony 30-50 parts by weight, Hedyotis diffusa 10-30 parts by weight, Chrysanthemum indicum 6-12 parts by weight, Taraxacum mongolicum 6-12 parts by weight, Coix lacryma-jobi 20-50 parts by weight, Trichosanthes kirilowii 10-30 parts by weight, Panax notoginseng 3-6 parts by weight, Bambusa textilis 6-12 parts by weight, Poria cocos 10-15 parts by weight, Citrus reticulata 6-10 parts by weight, Citrus aurantium 6-12 parts by weight, Acorus tatarinowii 6-12 parts by weight 6-10 parts by weight of turmeric, 6-10 parts by weight of Ganoderma lucidum, 6-12 parts by weight of Scutellaria barbata, 6-12 parts by weight of processed Pinellia ternata, 15-30 parts by weight of Prunella vulgaris, 6-10 parts by weight of honey-processed Stemona japonica, 6-12 parts by weight of Fritillaria thunbergii, 6-10 parts by weight of Cinnamomum cassia, 1-2 centipedes, 10-15 parts by weight of vinegar-processed turtle shell, 6-9 parts by weight of stir-fried Bombyx mori, and 15-30 parts by weight of calcined pumice.
2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition for eliminating phlegm and dampness and dispersing lung nodules is composed of the following medicinal materials: Agrimonia pilosa 30-45 parts by weight, Hedyotis diffusa 10-25 parts by weight, Chrysanthemum indicum 6-10 parts by weight, Taraxacum mongolicum 6-10 parts by weight, Coix lacryma-jobi 20-40 parts by weight, Trichosanthes kirilowii 10-25 parts by weight, Panax notoginseng 3-5 parts by weight, Bambusa textilis 6-10 parts by weight, Poria cocos 10-15 parts by weight, Citrus reticulata 6-10 parts by weight, Citrus aurantium 6-10 parts by weight, Acorus tatarinowii 6-10 parts by weight, Curcuma longa 6-9 parts by weight, Ganoderma lucidum 6-9 parts by weight, Scutellaria barbata 6-10 parts by weight, Pinellia ternata 6-10 parts by weight, Prunella vulgaris 15-25 parts by weight, Stemona japonica 6-9 parts by weight, Fritillaria thunbergii 6-10 parts by weight, Cinnamomum cassia 6-9 parts by weight, Scolopendra subspinipes 1-2 pieces, Vinegar-processed turtle shell 10-12 parts by weight, Fried Bombyx mori 6-8 parts by weight, Calcined pumice 15-25 parts by weight.
3. The traditional Chinese medicine composition according to claim 2, characterized in that, The traditional Chinese medicine composition for eliminating phlegm and dampness and dispersing lung nodules is composed of the following medicinal materials: Agrimony 30-40 parts by weight, Hedyotis diffusa 10-20 parts by weight, Chrysanthemum indicum 6-9 parts by weight, Taraxacum mongolicum 6-9 parts by weight, Coix lacryma-jobi 20-30 parts by weight, Trichosanthes kirilowii 10-20 parts by weight, Panax notoginseng 3-4 parts by weight, Bambusa textilis 6-9 parts by weight, Poria cocos 10-12 parts by weight, Citrus reticulata peel 6-9 parts by weight, Citrus aurantium 6-9 parts by weight, Acorus tatarinowii 6-9 parts by weight, Curcuma longa 6-8 parts by weight, Ganoderma lucidum 6-8 parts by weight, Scutellaria barbata 6-9 parts by weight, Pinellia ternata 6-9 parts by weight, Prunella vulgaris 15-20 parts by weight, Stemona japonica 6-8 parts by weight, Fritillaria thunbergii 6-9 parts by weight, Cinnamomum cassia 6-8 parts by weight, Scolopendra subspinipes 1-2 pieces, Vinegar-processed turtle shell 10-11 parts by weight, Fried Bombyx mori 6-7 parts by weight, Calcined pumice 15-20 parts by weight.
4. The traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, The Ganoderma mentioned is red Ganoderma.
5. The traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, The bitter orange peel mentioned is stir-fried bitter orange peel with wheat bran.
6. The use of the traditional Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for treating pulmonary nodules caused by phlegm and dampness.
7. Use according to claim 6, characterized in that, The lung nodules caused by phlegm and dampness are characterized by: scattered, well-defined or blurred, localized, round, dense shadows with a diameter of 3 cm or less in lung imaging; pale red tongue with a yellow, greasy, or thick yellow coating or a white coating; and a deep, slippery, or soft pulse.
8. Use according to claim 6 or 7, characterized in that, The medicament is a clinically acceptable formulation.
9. Use according to claim 8, characterized in that, The formulation is an oral formulation selected from the group consisting of a decoction, a tablet, a capsule, a powder, a pill or a granule.
10. A method for preparing a decoction for treating pulmonary nodule caused by phlegm-damp, using the traditional Chinese medicine composition according to any one of claims 1 to 5 as raw material, comprising the following steps: I. Preparing each medicinal material according to weight parts; II. Powdering Sanqi, and reserving; crushing and separately soaking Shiquanhu in 5-10 times of water by weight for 20-30 minutes; mixing the other medicinal materials except Sanqi, and separately soaking in 5-10 times of water by weight for 20-30 minutes; III. After completion of soaking, transferring Shiquanhu and the soaking water to a suitable container, adding Huafushi, boiling with a large fire and then continuing to decoct with a small fire for 20-30 minutes; adding the soaked mixed medicinal materials, and supplementing water to make the water level higher than the medicinal materials by 1-3 cm, boiling with a large fire and then continuing to decoct with a small fire for 20-30 minutes, and filtering while hot; retaining the residue in the container, adding water to make the water level higher than the medicinal materials by 1-3 cm, boiling with a large fire and then continuing to decoct with a small fire for 20-30 minutes, and filtering while hot; combining the two filtrates to obtain medicinal material decoction; IV. Dividing the medicinal material decoction obtained in step III into 200-300 ml per portion, and dividing Sanqi powder into corresponding portions, and mixing one portion of Sanqi powder with one portion of medicinal material decoction to be taken orally.