Immortalized cardiac stem cells for cardiac repair

Immortalized neonatal cardiac stem cells with specific markers address the limitations of c-kit+ cells by enhancing cardiac repair and function through anti-inflammatory and pro-angiogenic conditioned medium, overcoming issues of non-cardiogenic progenitors and senescence.

JP7817160B2Active Publication Date: 2026-02-18SECRETOME THERAPEUTICS INC +1
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Patent Information

Application Number
JP2022528334
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-11-15
Filing Date
2020-11-13
Publication Date
2026-02-18
Estimated Expiration
2040-11-13

AI Technical Summary

Technical Problem

Current cardiac stem cell therapies, particularly those using c-kit+ cells, are limited by the presence of non-cardiogenic progenitor cells and senescence, which can contribute to cardiac injury and inadequate cardiac repair.

Method used

Development of immortalized neonatal cardiac stem cells (Im-nCSCs) with specific surface markers, such as CD90+, CD105+, CD117+, and CD73+, and a method to isolate and culture these cells without antibody selection, followed by immortalization using hTERT gene expression, to produce conditioned medium with anti-inflammatory, anti-fibrotic, and pro-angiogenic properties.

Benefits of technology

The Im-nCSCs enhance cardiac repair, regeneration, and remodeling by promoting myocardial tissue repair, reducing inflammation and fibrosis, and improving cardiac function through secreted factors.

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Abstract

Embodiments of the present disclosure relate to compositions and methods of use related to certain immortalized cells, including cardiac muscle stem cells, obtained from pediatric or neonatal individuals. In certain embodiments, the immortalized cells, or conditioned medium derived from the cells, or a partial or entire secretome thereof, are provided to an individual in need thereof in an effective amount, either alone or in combination with cardiac muscle stem cells.
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