Immunogenic carrier and immunogenic composition
Patent Information
- Application Number
- JP2025550380
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Priority Date
- 2024-10-04
- Filing Date
- 2024-10-04
- Publication Date
- 2026-09-08
AI Technical Summary
Current therapeutic vaccines for cancer treatment require highly immunogenic carriers to break self-tolerance and induce antibody production against target molecules, but existing carriers like Virus-like particles (VLP) and Keyhole limpet hemocyanin (KLH) are expensive, difficult to manufacture, and may contain unwanted peptides from target molecules.
An immunogenic carrier comprising an aminopolysaccharide with 100 or more amino groups per molecule and a protein, where the aminopolysaccharide and protein can be chemically bound or not, is used in conjunction with a short chain peptide to enhance immunogenicity and safety.
The proposed immunogenic carrier system achieves high immunogenicity, cost-effectiveness, and safety by inducing robust antibody production against target proteins, while minimizing the risk of adverse reactions and reducing production costs.