Composition for immunohistochemical staining of PAUF protein comprising Anti-PAUF monoclonal antibody and use thereof
An immunohistochemistry method using a specific anti-PAUF monoclonal antibody addresses the sensitivity and accuracy issues of existing PAUF protein diagnostics, facilitating precise cancer patient identification for targeted therapy.
WO2026141938A1 Publication Date: 2026-07-02PRESTIGE BIOPHARMA IDC CO LTD +1
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Patent Information
- Application Number
- PCT/KR2025/017832
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-12-24
- Filing Date
- 2025-11-03
- Publication Date
- 2026-07-02
AI Technical Summary
Technical Problem
Existing diagnostic methods for PAUF protein expression in cancer cells lack sensitivity and accuracy, hindering the effectiveness of targeted therapy by limiting the identification of patients requiring such treatment.
Method used
Development of an immunohistochemistry (IHC) staining method using an anti-PAUF monoclonal antibody with specific CDR and FR sequences, enhancing sensitivity and clarity for PAUF protein detection.
Benefits of technology
The method provides significantly improved sensitivity and clarity in diagnosing PAUF protein expression, enabling accurate and rapid identification of cancer patients requiring targeted therapy.
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Abstract
The present invention relates to: a composition and kit for immunohistochemistry (IHC) staining, comprising an anti-PAUF monoclonal antibody that specifically binds to a PAUF protein; and an immunohistochemical staining method using same. The present invention exhibits significantly improved staining sensitivity and clarity over conventional PAUF staining methods, thereby providing the advantage of obtaining more accurate and reliable results regarding the expression of the PAUF protein. In addition, the present invention enables accurate staining of a large amount of clinical tissues in a short time by using specialized staining equipment together, thereby providing the advantage of enhancing the reliability of staining results. Accordingly, it is possible to specifically, rapidly, and accurately identify only PAUF within cancer tissues of cancer patients, thereby enabling rapid and efficient cancer diagnosis, and by using this, early cancer diagnosis is possible, thereby enabling early treatment for cancer patients in need of targeted therapy.
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