Mikrofluidisches system zur steuerung der perfusion, diffusion und sammlung von molekülen über lange zeiträume in einem ex-vivo-hautmodell
Patent Information
- Application Number
- AT2021742150T
- Authority / Receiving Office
- AT · AT
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-07-16
- Filing Date
- 2021-07-16
- Publication Date
- 2026-01-15
- Estimated Expiration
- 2041-07-16
AI Technical Summary
Current ex-vivo skin models for dermal penetration studies face challenges such as tissue destruction, loss of integrity, and inability to mimic native skin vasculature, particularly when using microdialysis or catheter perfusion methods, which often require excision of the hypodermis and result in leaks or overestimation of dermal absorption.
A microfluidic device is implanted through the dermis of an ex-vivo skin explant, allowing for controlled perfusion, diffusion, and collection of molecules, with the device positioned parallel to the epidermis and traversing the skin from side to side, including the hypodermis, to maintain tissue integrity and facilitate long-term culture.
This approach provides a stable ex-vivo skin model that enhances the diffusion of substances of all sizes, maintains tissue integrity, and allows for controlled perfusion and collection of molecules, improving the accuracy of dermal penetration studies and drug absorption analysis.