Verfahren für zuverlässiges genetisches testen einer nicht-invasiven präimplantation
Patent Information
- Application Number
- AT2023851091T
- Authority / Receiving Office
- AT · AT
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2023-10-20
- Publication Date
- 2026-06-15
- Estimated Expiration
- 2043-10-20
AI Technical Summary
Current methods for noninvasive preimplantation genetic testing (PGT) face challenges in accurately amplifying and analyzing minute DNA amounts from spent embryo culture medium, leading to high false negatives and false positives, and are affected by maternal contamination and protein content.
The method involves amplifying DNA from spent culture medium using a linear amplification technique, followed by linkage analysis and computational steps to correct for maternal cell contamination and large fragment loss of haplotypes, enabling accurate determination of genetic disease susceptibility in embryos.
This approach significantly improves the accuracy and reliability of noninvasive PGT, reducing false positives and negatives, and providing a more precise assessment of genetic disease susceptibility in embryos, thus aiding in informed reproductive decisions.