Method for synthesizing chlorantraniliprole key intermediate

By using 2,3-dichloropyridine as the starting material, combined with solid phosgene acyl chloride and phosphorus pentabromide, the synthesis process of chlorantraniliprole intermediate is simplified, which solves the problems of expensive reagents and numerous steps in the existing methods. problems and achieve more environmentally friendly and efficient industrial production.

CN102311424AInactive Publication Date: 2012-01-11WENZHOU UNIV
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Patent Information

Application Number
CN201010228404.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2010-07-05
Publication Date
2012-01-11
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing synthesis method of the key intermediate of chlorantraniliprole, 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxyl chloride, involves the use of expensive reagents, harsh low-temperature conditions, and numerous steps. And the problem of low yield makes it difficult to be suitable for industrial production.

Method used

Using 2,3-dichloropyridine as the starting material, through hydrazination, cyclization, bromination, oxidation, hydrolysis and acid chlorination, combined with solid phosgene acid chloride and phosphorus pentabromide, it replaces the traditional high temperature and high pressure reaction and simplifies steps and improve yields.

Benefits of technology

It achieves a more environmentally friendly and efficient intermediate synthesis, reduces production wastewater, improves product quality, and is suitable for industrial production.

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Abstract

The invention relates to a method for synthesizing 3-bromine-1-(3-chloropyridine-2-yl)-1H-5-formyl chloride, and relates to a method for synthesizing a key intermediate of chlorantraniliprole serving as a disinfestant. In the method, 2,3-dichloro-pyridine serving as a raw material is subjected to hydrazine, cyclization, bromination, oxidation, hydrolysis and acyl chloride to form the intermediate. The innovation of the method is that phosphorous oxybromide serving as a bromination reagent which is used currently is replaced by phosphorus pentabromide in the bromination process, and thionyl chloride is replaced by environment-friendly solid phosgene in the acyl chloride process. The method has the characteristics of environment friendliness, little waste water and waste gas, few waste residue, and high synthetic yield and products have good quality.
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