Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine for treating hypertension early-stage kidney damage and a preparation method thereof. The traditional Chinese medicine for treating hypertension early-stage kidney damage disclosed by the invention mainly comprises radix rehmanniae preparata, fructus corni, yam, cortex eucommiae, radix salviae miltiorrhizae and tortoise shell, and is prepared into various common preparations by the traditional technology of traditional Chinese medicine. The traditional Chinese medicine for treating hypertension early-stage kidney damage disclosed by the invention can effectively relieve the kidney fibrosis progress of the patient suffering hypertension early-stage kidney damage, reduces the kidney burden of the patient, and effectively controls the disease progression; in combination with the oral hypotensor benazepril, a synergistic effect is realized for the blood pressure reducing effect; and compared with the oral hypotensor benazepril only, the traditional Chinese medicine disclosed by the invention takes effect quickly in reducing blood pressure, and the final blood pressure reducing effect is better. Compared with the prior art, the invention has outstanding substantial characteristics and obvious progress.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating hypertensive early kidney damage and a preparation method thereof. Background technique

[0002] The prevalence of hypertension among adults in my country is 18.8%, and there are currently about 160 million hypertensive patients. Since the kidney is one of the main target organs damaged by hypertension, there are data showing that the number of patients with chronic renal insufficiency due to kidney damage caused by high blood pressure is increasing year by year, so how to prevent and treat kidney damage in hypertension, especially early kidney damage , Delaying the development of the disease has very important clinical significance.

[0003] At present, it is believed that growth factors play an important role in hypertensive renal damage, among which transforming growth factor-β1 (transforming growth factor-beta 1, TGF-β1), connective tissue ...

Examples

Embodiment 1

[0044] Rehmannia glutinosa 500g Dogwood 500g Dioscorea 800g

[0045] Eucommia 500g Salvia 800g Tortoise shell 800g

[0046] Take all 6 medicinal materials, add water to extract twice, add 31200g water for the first time, extract for 1 hour, add 31200g water for the second time, extract for 1 hour; combine the extracts, concentrate to an extract with a relative density of 1.20 at 80°C, Add ethanol until the volume percentage concentration of alcohol content is 50%, stir evenly, let stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.20 at 80°C to obtain the active ingredient of the present invention.

Embodiment 2

[0048] Rehmannia glutinosa 3000g Cornus officinalis 3000g Dioscorea 4000g

[0049] Eucommia 3000g Salvia 3000g Tortoise shell 4000g

[0050] Take all 6 medicinal materials, add water to extract twice, add 240000g water for the first time, extract for 1-3 hours, add 240000g water for the second time, extract for 2 hours; combine the extracts, concentrate to 80 °C when the relative density is 1.30 ointment, add ethanol until the volume percentage concentration of alcohol content is 65%, stir evenly, let it stand for 24 hours, filter, and when the filtrate is concentrated to 80°C, the relative density is 1.30 to obtain the active ingredient of the present invention ;

[0051] The active ingredient is mixed with an appropriate amount of sucrose, made into granules, and dried to obtain the granules of the present invention.

Embodiment 3

[0053] Rehmannia glutinosa 2500g Cornus officinalis 2500g Dioscorea 2000g

[0054] Eucommia 2500g Salvia 2500g Tortoise shell 2000g

[0055] Take all 6 medicinal materials, add water to extract twice, add 140000g water for the first time, extract for 2 hours, add 110000g water for the second time, extract for 1.5 hours; combine the extracts, concentrate to an extract with a relative density of 1.25 at 80°C, Add ethanol until the volume percentage concentration of alcohol content is 56%, stir evenly, let stand for 24 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.25 at 80°C to obtain the active ingredient of the present invention;

[0056] The active ingredient is mixed with an appropriate amount of sucrose and preservatives, and water is added to 3000g to obtain the oral liquid of the present invention.

technical field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating hypertensive early kidney damage and a preparation method thereof. Background technique

[0002] The prevalence of hypertension among adults in my country is 18.8%, and there are currently about 160 million hypertensive patients. Since the kidney is one of the main target organs damaged by hypertension, there are data showing that the number of patients with chronic renal insufficiency due to kidney damage caused by high blood pressure is increasing year by year, so how to prevent and treat kidney damage in hypertension, especially early kidney damage , Delaying the development of the disease has very important clinical significance.

[0003] At present, it is believed that growth factors play an important role in hypertensive renal damage, among which transforming growth factor-β1 (transforming growth factor-beta 1, TGF-β1), connective tissue ...

Examples

Embodiment 1

[0044] Rehmannia glutinosa 500g Dogwood 500g Dioscorea 800g

[0045] Eucommia 500g Salvia 800g Tortoise shell 800g

[0046] Take all 6 medicinal materials, add water to extract twice, add 31200g water for the first time, extract for 1 hour, add 31200g water for the second time, extract for 1 hour; combine the extracts, concentrate to an extract with a relative density of 1.20 at 80°C, Add ethanol until the volume percentage concentration of alcohol content is 50%, stir evenly, let stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.20 at 80°C to obtain the active ingredient of the present invention.

Embodiment 2

[0048] Rehmannia glutinosa 3000g Cornus officinalis 3000g Dioscorea 4000g

[0049] Eucommia 3000g Salvia 3000g Tortoise shell 4000g

[0050] Take all 6 medicinal materials, add water to extract twice, add 240000g water for the first time, extract for 1-3 hours, add 240000g water for the second time, extract for 2 hours; combine the extracts, concentrate to 80 °C when the relative density is 1.30 ointment, add ethanol until the volume percentage concentration of alcohol content is 65%, stir evenly, let it stand for 24 hours, filter, and when the filtrate is concentrated to 80°C, the relative density is 1.30 to obtain the active ingredient of the present invention ;

[0051] The active ingredient is mixed with an appropriate amount of sucrose, made into granules, and dried to obtain the granules of the present invention.

Embodiment 3

[0053] Rehmannia glutinosa 2500g Cornus officinalis 2500g Dioscorea 2000g

[0054] Eucommia 2500g Salvia 2500g Tortoise shell 2000g

[0055] Take all 6 medicinal materials, add water to extract twice, add 140000g water for the first time, extract for 2 hours, add 110000g water for the second time, extract for 1.5 hours; combine the extracts, concentrate to an extract with a relative density of 1.25 at 80°C, Add ethanol until the volume percentage concentration of alcohol content is 56%, stir evenly, let stand for 24 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.25 at 80°C to obtain the active ingredient of the present invention;

[0056] The active ingredient is mixed with an appropriate amount of sucrose and preservatives, and water is added to 3000g to obtain the oral liquid of the present invention.

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