Perampanel new type crystal A and preparation method thereof
By crystallizing in an acetic acid and water solvent system, a new perampanel crystal form A with characteristic X-ray powder diffraction patterns and thermal analysis properties was prepared, which solved the uncertainty and stability problems of the existing crystal structure and achieved This improves the structural certainty and stability of the drug.
Patent Information
- Application Number
- CN201310606707.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2013-11-26
- Publication Date
- 2014-03-26
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing crystal form of perampanel has structural uncertainty and stability problems, and there is a lack of new crystal forms to meet the needs of drug preparation.
By dissolving perampanel powder in a mixed solvent system of acetic acid and water, and crystallizing using slow volatilization or slow cooling methods, a new crystal form A was prepared, and the results were obtained through X-ray powder diffraction patterns and differential scanning. Calorimetry and thermogravimetric analysis were used to determine its characteristic peaks and heat loss characteristics.
A new crystal form A with characteristic X-ray powder diffraction patterns and thermal analysis properties was successfully prepared, which improved the structural certainty and stability of the drug and provided a new preparation method to meet the clinical needs of the drug.