Thermosensitive fluorescent material based on aggregation-induced emission, and preparation method and application thereof

By combining tetrastyrene glycolic acid with compounds such as stearoyl lysolecithin to form an aggregation-induced emission temperature-sensitive fluorescent material, and forming nanoparticles through a thin film hydration method, the fluorescence changes of existing temperature-sensitive polymer materials are solved. The problem of insufficiently sensitive characteristics enables efficient temperature responsiveness and wide application.

CN106588975AInactive Publication Date: 2017-04-26HUNAN UNIV OF SCI & TECH
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Patent Information

Application Number
CN201611112262.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2016-12-06
Publication Date
2017-04-26
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing temperature-sensitive polymer materials are not sensitive enough in fluorescence change characteristics under temperature stimulation, and are difficult to form suitable nanoparticle forms, which limits their application in the fields of biomedicine and chemical sensors.

Method used

Tetrastyrene glycolic acid is combined with compounds such as stearoyl lysolecithin, and through the action of condensation agents and organic bases, an aggregation-induced emission type temperature-sensitive fluorescent material is formed, and nanoparticles are formed through ultrasonic film hydration method. The particle size is within 50-85nm, enhance fluorescence intensity and temperature responsiveness.

Benefits of technology

An efficient temperature-responsive fluorescent material has been realized. The fluorescence intensity gradually weakens as the temperature increases. The nanoparticle form expands the application range and environmental adaptability of the material.

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Abstract

The invention discloses a thermosensitive fluorescent material based on aggregation-induced emission, and a preparation method and an application thereof. The thermosensitive fluorescent material with a structure as shown in a formula I in the specification is prepared by using tetraphenylethylene glycolic acid as a raw material through condensation with stearoyl lyso-phosphocholine MSPC. The fluorescent material provided by the invention is compounded with phosphatidyl cholines (like DPPC, DSPC and DAPC) and DSPE-PEG 2000 to form a thermosensitive nanometer fluorescent material. The thermosensitive nanometer fluorescent material is composed of the following raw materials in percentages by mass: 5 to 30% of a fluorescent material I, 60 to 90% of phosphatidyl choline and 1 to 10% of DSPE-PEG 2000. A film hydration method is utilized to ultrasonically form nanometer particles which have a particle size in a range of 50 to 85 nm. The thermosensitive nanometer fluorescent material provided by the invention has good temperature response capability and has potential application values in the field of drug release.
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