Application of butyrolactone compounds to preparation of antituberculosis drugs

Butyrolactone compounds isolated from marine microorganisms have significant inhibitory activity against Mycobacterium tuberculosis tyrosine phosphatase, which solves the problem of difficulty in effectively targeting this enzyme with existing anti-tuberculosis drugs and provides new opportunities for the development of anti-tuberculosis drugs. direction.

CN107286120AInactive Publication Date: 2017-10-24OCEAN UNIV OF CHINA
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Patent Information

Application Number
CN201610217872.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2016-04-11
Publication Date
2017-10-24
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Tuberculosis is prone to drug resistance, and it is difficult to effectively target Mycobacterium tuberculosis tyrosine phosphatase in the development of existing anti-tuberculosis drugs, resulting in poor therapeutic effects and a lack of effective new inhibitors.

Method used

Butyrolactone compounds (Formula I-Formula VI) isolated from marine microorganisms, especially have significant inhibitory activity against Mycobacterium tuberculosis tyrosine phosphatase (mPTPB), and serve as potential anti-tuberculosis drug targets.

Benefits of technology

These compounds have significant inhibitory activity against Mycobacterium tuberculosis tyrosine phosphatase, provide a new direction for the development of anti-tuberculosis drugs, and have broad application prospects.

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Abstract

The invention discloses application of butyrolactone compounds derived from Aspergillus terreus and derivatives thereof to preparation of antituberculosis drugs. The compounds expressed by formulae I-VI have high inhibition activity on mycobacterium tuberculosis tyrosine phosphatase and can be used for developing the antituberculosis drugs.
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