Polyamino acid and preparation method and application thereof

Through the design of specific polyamino acid structures, a controllable hydrogel is formed, which solves the problem of polyamino acid hydrogels causing inflammatory reactions in the body, improves the effects of drug delivery and immunotherapy, and improves biocompatibility and degradation sex.

CN109824890AInactive Publication Date: 2019-05-31CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
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Patent Information

Application Number
CN201910108638.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2019-02-03
Publication Date
2019-05-31
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing polyamino acid hydrogels cause large inflammatory reactions in the body, which affects their application in drug delivery and immunotherapy.

Method used

Using a specific polyamino acid structure, the amino-terminated polyethylene glycol monomethyl ether reacts with L- or D-amino acid-N-endocarboxylic anhydride in a solvent to form a polyamino acid with hydrophilic and hydrophobic segments, forming nanometer-sized physical gel, and the gel-forming properties can be controlled through temperature, pH, light and electricity.

Benefits of technology

It achieves a smaller inflammatory response in the body, improves the effect of drug delivery and immunotherapy, and controls gel properties through temperature responsiveness to improve biocompatibility and degradability.

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Abstract

The invention provides a polyamino acid, having a structure shown as the formula (I) or formula (II). One end of the polyamino acid is provided with hydrophilic polyethylene glycol monomethyl ether; the other end of the polyamino acid is provided with hydrophobic poly-L-alanine, poly-L-valine, poly-L-glycine, poly-L-leucine, poly-D-alanine, poly-D-valine, poly-D-glycine or poly-D-leucine. The amphiphilic polyamino acid with hydrophilic chain segments and hydrophobic chain segments can form nano physical gel in water, which gelatinizes at a certain temperature, and therefore, the physical gel can act as a carrier material for drug delivery, control and release. After hydrogel of the polyamino acid is subcutaneously injected, great inflammatory response may be caused; the inflammatory response generate a series of inflammatory factors to stimulate T cells, DC cells and other cells to generate a series of immune responses, thereby arriving at immunotherapy.
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