Preparation method of 5-bromo-2-substituted pyrimidine compound

Through the one-step reaction method of 2-bromomalondialdehyde and amidine compounds, the problems of cumbersome operation, high cost and high risk in the synthesis of 5-bromo-2-substituted pyrimidine compounds in the existing technology are solved, achieving low cost and simplicity. The preparation method of the process is suitable for industrial production.

CN110642788AInactive Publication Date: 2020-01-03GUANGZHOU UNIVERSITY
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Patent Information

Application Number
CN201911016288.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2019-10-24
Publication Date
2020-01-03
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing synthesis method of 5-bromo-2-substituted pyrimidine compounds has the problems of cumbersome operation, high cost, high risk and expensive raw material cost, making it difficult to apply in industrial production.

Method used

A one-step reaction method between 2-bromomalondialdehyde and amidine compounds is used to prepare 5-bromo-2-substituted pyrimidine compounds. Low-priced raw materials are used to promote the reaction through protonic acid catalysis and molecular sieves to simplify the process flow.

Benefits of technology

A simple, safe, and low-cost preparation method is achieved, which reduces production costs, simplifies post-processing steps, and improves synthesis efficiency.

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Abstract

The invention discloses a preparation method of a 5-bromo-2-substituted pyrimidine compound. The 5-bromo-2-substituted pyrimidine compound is obtained through a one-step reaction by using 2-bromomalonaldehyde and an amidine compound as raw materials. The method has the advantages of simple operation, safety, short use time, and low cost, the preparation process is simplified, the synthesis cost isreduced, a new and efficient way for synthesis of the 5-bromo-2-substituted pyrimidine compound is provided, and the method can be applied to scale production in the pharmaceutical and chemical industry.
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