Multi-anticoagulant combined blood collection tubes used in personalized medication evaluation

Abstract

The present invention discloses a multi-anticoagulant combined blood collection tube used in personalized drug evaluation, comprising a tube body with a accommodating cavity arranged inside; a tube cap; and two or more groups of anticoagulant release devices, each group of anticoagulant release devices comprising a cavity, a connecting hole being provided on the side wall of the cavity, a sealing component being movably installed in the cavity, the sealing component and a part of the inner wall of the cavity defining a sealed reagent cavity, the reagent cavity being loaded with anticoagulant, the sealing component reciprocating along the inner wall of the cavity to control the reagent cavity to be connected with the connecting hole, the sealing component being connected with a pull rod, wherein the types of anticoagulants loaded in each group of anticoagulant release devices are different. When in use, different anticoagulant release devices can be selected to mix the appropriate anticoagulant with the blood sample, thus solving the technical problem that only a certain specific blood collection tube can be used for different detection items, so that the multi-anticoagulant combined blood collection tube of this embodiment can be applied to different detection items.

Description

Technical Field

[0001] The present invention relates to the technical field of blood collection, in particular to a multi-anticoagulant combined blood collection tube used in personalized medication evaluation. Background Art

[0002] Blood drug concentration testing is guided by the principle of pharmacokinetic analysis to determine the concentration of drugs in the blood to evaluate the efficacy or determine the dosing regimen, so as to individualize the dosing regimen and improve the level of drug treatment to achieve safe, effective and reasonable clinical use of drugs. Different types of anticoagulants can be used in different blood test items by combining blood samples.

[0003] As we all know, different blood collection tubes are selected for different testing projects, and the main difference lies in the different types of anticoagulants added to different blood collection tubes. Since the demand for different types of blood collection tubes is difficult to estimate, in actual work, some specific types of blood collection tubes are used in large quantities, resulting in insufficient preparation of certain specific types of blood collection tubes, which directly affects the patient's blood collection and delays the patient's condition, or a certain type of blood collection tube is used less, resulting in an excessive inventory and a waste of resources. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a multi-anticoagulant combined blood collection tube used in personalized medication evaluation, wherein the blood collection tube is configured with more than two groups of anticoagulants, and when used, a suitable anticoagulant can be selected according to actual needs to be mixed with the blood sample, and the operation is simple and convenient.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to certain embodiments of the present invention comprises: a tube body, wherein a receiving cavity with an upper opening is provided inside the tube body; a tube cap, which is arranged at the upper part of the tube body and blocks the upper opening of the receiving cavity, wherein the tube cap is provided with a sampling port connected to the receiving cavity; two or more groups of anticoagulant release devices, which are arranged on the tube cap, wherein all the anticoagulant release devices are independent of each other, wherein each group of the anticoagulant release devices comprises a cavity, wherein a communicating hole connected to the receiving cavity is provided on the side wall of the cavity, wherein a sealing component is movably installed in the cavity, wherein the sealing component and a part of the inner wall of the cavity define a sealed reagent cavity, wherein the reagent cavity is loaded with anticoagulant, wherein the sealing component moves along the inner wall of the cavity to control the communication between the reagent cavity and the communicating hole, wherein the sealing component is connected with a pull rod, wherein the other end of the pull rod is movably extended to the outer peripheral wall of the tube cap; wherein the types of anticoagulants loaded in each group of the anticoagulant release devices are different.

[0007] In certain embodiments of the present invention, the pull rod is movably installed in the cavity along a direction parallel to the upper end surface of the tube body.

[0008] In certain embodiments of the present invention, a pull ring is provided at one end of the pull rod that movably extends to the outer peripheral wall of the tube cap.

[0009] In some embodiments of the present invention, each of the pull rings has a different color.

[0010] In some embodiments of the present invention, a protective cap is further included. The protective cap is detachably mounted on the upper portion of the tube cap, and the protective cap is provided with a peripheral edge covering the outer periphery of all the pull rings.

[0011] In certain embodiments of the present invention, the protective cap and the tube cap are provided with at least one set of connecting structures, and the connecting structure includes connecting columns and connecting holes that are matched and connected to each other, one of the connecting columns and the connecting holes is provided on the tube cap, and the other is provided on the protective cap.

[0012] In certain embodiments of the present invention, the sealing assembly includes a first sealing plug, an outer peripheral wall of the first sealing plug is in sealing contact with an inner peripheral wall of the cavity, and the first sealing plug is connected to the pull rod.

[0013] In certain embodiments of the present invention, the sealing assembly includes a second sealing plug, the outer peripheral wall of the second sealing plug is in sealing contact with the inner peripheral wall of the cavity, and the first sealing plug and the second sealing plug are installed on the pull rod at intervals, wherein the first sealing plug, the second sealing plug and part of the inner wall of the cavity jointly define the reagent chamber.

[0014] In certain embodiments of the present invention, the sampling port is opened in the middle of the tube cap, and all the anticoagulant release devices are evenly arranged on the tube cap around the sampling port.

[0015] In certain embodiments of the present invention, each group of the anticoagulant release device includes a guide tube, an inlet end of the guide tube is connected to the connecting hole, and an outlet end of the guide tube faces the bottom of the accommodating cavity.

[0016] The beneficial effects of the multi-anticoagulant combined blood collection tubes of certain embodiments of the present invention are as follows: by configuring more than two groups of anticoagulant release devices in the tube cap, each group of anticoagulant release devices is loaded with a different type of anticoagulant. Therefore, when in use, different anticoagulant release devices can be selected to mix the appropriate anticoagulant with the blood sample, thereby solving the technical problem that only a certain type of blood collection tube can be used for different detection items, so that the multi-anticoagulant combined blood collection tube of this embodiment can be suitable for different detection items, solving the problem of insufficient stock of certain specific types of blood collection tubes or excessive stock of certain specific types of blood collection tubes. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0018] Figure 1 This is a schematic diagram of the structure of a multi-anticoagulant combined blood collection tube according to some embodiments of the present invention;

[0019] Figure 2 for Figure 1 The schematic diagram of the structure when the protective cap and the tube cap of the multi-anticoagulant combined blood collection tube are separated;

[0020] Figure 3 for Figure 1 The schematic diagram of the structure of the anticoagulant release device in the multi-anticoagulant combined blood collection tube shown in;

[0021] Figure 4 for Figure 1 A top view of the multi-anticoagulant blood collection tube with the protective cap removed. DETAILED DESCRIPTION

[0022] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.

[0023] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., and orientations or positional relationships indicated are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0024] In the description of the present invention, "several" means one or more, "more" means more than three, "greater than", "less than", "exceed", etc. are understood to exclude the number itself, and "above", "below", "within", etc. are understood to include the number itself. If there is a description of "first", "second", etc., it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0025] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0026] Reference Figures 1 to 4 The multi-anticoagulant combined blood collection tube used in the personalized medication evaluation of certain embodiments of the present invention includes a roughly cylindrical tube body 100. It should be noted that the shape of the tube body 100 can also be set to a rectangular parallelepiped, triangular prism, polygonal prism, sphere or other shapes, which can be determined according to needs. The interior of the tube body 100 is provided with a receiving chamber 110 with an open upper portion, that is, the interior of the tube body 100 is hollow and the lower end of the tube body 100 is sealed, and the upper end of the tube body 100 is provided with an opening connected to the interior thereof, and a tube cap 200 is installed on the upper portion of the tube body 100, the tube cap 200 blocks the upper opening of the receiving chamber 110, and the tube cap 200 is provided with a sampling port 210 connected to the receiving chamber 110; the tube cap 200 is provided with four groups of anticoagulant release devices 300, and it can be understood that the number of the anticoagulant release devices 300 can also be set to two groups, three groups or more groups, and is not limited to four groups, and can be determined according to actual needs, and all the anticoagulant release devices 300 can be used. 00 are independent of each other, each group of anticoagulant release devices 300 includes a cavity 310, the side wall of the cavity 310 is provided with a connecting hole 320 connected to the accommodating cavity 110, a sealing component is movably installed in the cavity 310, and the sealing component and the part of the inner wall of the cavity 310 define a sealed reagent cavity 330. Specifically, the sealing component and the part of the inner wall of the cavity 310 are enclosed together to form a sealed space, which is the reagent cavity 330. Different types of anticoagulants (not shown in the figure) are loaded in the reagent cavity 330 of each group of anticoagulant release devices 300. In this embodiment, the types of anticoagulants loaded in the four groups of anticoagulant release devices 300 are all different. The types of anticoagulants in this embodiment can be sodium citrate, ethylenediaminetetraacetic acid, sodium oxalate, EDTA and heparin, etc. It should be noted that the types of anticoagulants can also be set to other types, not limited to the types listed above.

[0027] The sealing component reciprocates along the inner wall of the cavity 310 to control whether the reagent chamber 330 is connected to the connecting hole 320 . The sealing component is connected to a pull rod 340 , and the other end of the pull rod 340 movably extends to the outer peripheral wall of the tube cap 200 .

[0028] Since the sealing component is movably installed in the cavity 310, when the sealing component moves in the cavity 310, the volume of the reagent cavity 330 will change or the position of the reagent cavity 330 in the cavity 310 will change. If the sealing component moves in the cavity 310, the volume of the reagent cavity 330 will increase and cover the connecting hole 320, and the reagent cavity 330 will be connected with the connecting hole 320. Alternatively, when the sealing component moves in the cavity 310, the reagent cavity 330 moves in the cavity 310, and the reagent cavity 330 moves to a position that overlaps with the connecting hole 320, the reagent cavity 330 will be connected with the connecting hole 320. It can be understood that the sealing component moves in the reverse direction in the cavity 310 and causes the volume of the reagent chamber 330 to shrink. The reagent chamber 330 does not cover the connecting hole 320. At this time, the reagent chamber 330 is disconnected from the connecting hole 320, or the sealing component moves in the reverse direction in the cavity 310, causing the reagent chamber 330 to move away from the connecting hole 320 in the cavity 310. The reagent chamber 330 and the connecting hole 320 no longer overlap. At this time, the reagent chamber 330 is no longer connected to the connecting hole 320.

[0029] When the multi-anticoagulant blood collection tube of this embodiment is not in use, the reagent chambers 330 in the four groups of anticoagulant release devices 300 are loaded with different types of anticoagulants. After the multi-anticoagulant blood collection tube is used for blood collection, a suitable type of anticoagulant is selected and the pull rod 340 of one group of anticoagulant release devices 300 is pulled accordingly. The pull rod 340 drives the sealing component to move in the cavity 310. The sealing component moves along the inner wall of the cavity 310 and connects the reagent chamber 330 with the connecting hole 320. At this time, the suitable anticoagulant loaded in the reagent chamber 330 can pass through the connecting hole 320 and enter the accommodating chamber 110, so that the anticoagulant is mixed with the blood.

[0030] By adopting the above structure, four groups of anticoagulant release devices 300 are configured in the tube cap 200, and the types of anticoagulants loaded in each group of anticoagulant release devices 300 are different. Therefore, when in use, different anticoagulant release devices 300 can be selected to mix the appropriate anticoagulant with the blood sample, which solves the technical problem that only a certain specific blood collection tube can be used for different detection items, so that the multi-anticoagulant combined blood collection tube of this embodiment can be applied to different detection items, and solves the problem of too little stock of certain specific types of blood collection tubes or too much stock of certain specific types of blood collection tubes.

[0031] In order to facilitate the production of blood collection tubes for multiple anticoagulants, in certain embodiments of the present invention, the pull rod 340 is movably installed in the cavity 310 along a direction parallel to the upper end surface of the tube body 100. By adopting the above structure, the anticoagulant release device 300 can be arranged inside the tube cap 200 along a direction parallel to the end surface of the tube cap 200, which helps to reduce the thickness of the tube cap 200, and at the same time facilitates the production of blood collection tubes for multiple anticoagulants, which helps to reduce production costs.

[0032] Reference Figure 2 and Figure 3 In order to facilitate the user to operate the pull rod 340, in some embodiments of the present invention, a pull ring 341 is provided at one end of the pull rod 340 that is movably extended to the outer peripheral wall of the tube cap 200. When using a multi-anticoagulant combined blood collection tube, the user can apply force to the pull ring 341 and pull the pull rod 340 to move, which is more convenient to operate.

[0033] In order to facilitate users to select different types of anticoagulants, in certain embodiments of the present invention, each pull ring 341 has a different color. The color of the pull ring 341 can be set according to the hospital's usage habits). By setting the pull ring 341 to different colors, the anticoagulants in different reagent chambers 330 can be marked, which is convenient for users to select appropriate anticoagulants and is more convenient and quick to use.

[0034] Some unexpected situations may occur during actual use, such as collision, misoperation, etc. before or after use, causing other unselected anticoagulants to be mistakenly released into the receiving chamber 110. Figure 1 , Figure 2 and Figure 4 In certain embodiments of the present invention, the multi-anticoagulant combined blood collection tube further comprises a protective cap 400, which is detachably mounted on the upper part of the tube cap 200, and the protective cap 400 is provided with a surrounding edge 410 covering the outer periphery of all the pull rings 341. Specifically, the protective cap 400 and the tube cap 200 are provided with two sets of connection structures, and it can be understood that the number of connection structures can also be provided with one set, three sets or more sets, which can be determined according to actual needs. The connection structure comprises a connection column 510 and a connection hole 520 that are mutually connected, the connection column 510 is provided on the upper part of the tube cap 200, and the connection hole 520 is provided on the protective cap 400; or the connection column 510 is provided on the lower part of the protective cap 400, and the connection hole 520 is provided on the upper part of the tube cap 200. By inserting the connection column 510 into the connection hole 520, the protective cap 400 and the tube cap 200 can be connected together, so that the protective cap 400 is installed on the tube cap 200. It should be noted that when the connection hole 520 is opened on the upper part of the tube cap 200, the connection hole 520 is a blind hole, that is, the connection hole 520 does not penetrate the tube cap 200, effectively preventing foreign matter from entering the accommodating chamber 110 and contaminating the blood. When the pull ring 341 needs to be pulled, the protective cap 400 can be removed from the tube cap 200, and the user can pull the pull ring 341 at will. When the operation is completed, the protective cap 400 can be reinstalled on the tube cap 200, and the protective cap 400 can cover the pull ring 341 inside it to prevent collision or misoperation, and ensure that the protection pull ring 341 will not be accidentally pulled out before or after the use of the multi-anticoagulant combination blood collection tube.

[0035] It is understandable that in addition to using the connecting column 510 and the connecting hole 520 to connect the protective cap 400 and the tube cap 200 together, other structures can also be used, such as a connecting structure including two magnets, the two magnets are correspondingly arranged on the protective cap 400 and the tube cap 200, and the protective cap 400 can be fixedly installed in the tube cap 200 by the magnetic attraction between the two magnets.

[0036] Reference Figure 1 and Figure 3 In order to simplify the structure of the anticoagulant release device 300, in some embodiments of the present invention, the sealing assembly includes a first sealing plug 350 movably installed in the cavity 310, the outer peripheral wall of the first sealing plug 350 is in sealing contact with the inner peripheral wall of the cavity 310, and the first sealing plug 350 is connected to the pull rod 340. The first sealing plug 350 and the inner wall of one end of the cavity 310 are enclosed to form a reagent cavity 330. When the pull rod 340 pulls the first sealing plug 350 to move in the cavity 310, the volume of the reagent cavity 330 can be changed to cover the connecting hole 320, so that the anticoagulant loaded in the reagent cavity 330 can flow from the connecting hole 320 into the accommodating cavity 110.

[0037] In order to make the anticoagulant in the reagent chamber 330 flow into the receiving chamber 110 better, the sealing assembly further includes a second sealing plug 360 movably installed in the cavity 310, the outer peripheral wall of the second sealing plug 360 is in sealing contact with the inner peripheral wall of the cavity 310, and the first sealing plug 350 and the second sealing plug 360 are installed on the pull rod 340 at intervals. At this time, the first sealing plug 350, the second sealing plug 360 and part of the inner wall of the cavity 310 jointly define the reagent chamber 330. When the pull rod 340 pulls the first sealing plug 350 and the second sealing plug 360 to move synchronously, the reagent chamber 330 can move as a whole inside the cavity 310, so the anticoagulant loaded in the reagent chamber 330 can move as a whole to the connecting hole 320, so that the anticoagulant in the reagent chamber 330 can better pass through the connecting hole 320 and flow into the receiving chamber 110.

[0038] Among them, when the anticoagulant naturally flows out along the connecting hole 320, there is a situation where part of the anticoagulant adheres to the outer wall of the cavity 310 or adheres to the inner bottom wall of the tube cap 200. In certain embodiments of the present invention, each group of anticoagulant release devices 300 also includes a guide tube 370, the inlet end of the guide tube 370 is connected to the connecting hole 320, and the outlet end of the guide tube 370 faces the bottom of the containing cavity 110. When the anticoagulant flows into the guide tube 370 from the connecting hole 320, the anticoagulant can directly flow into or drip into the containing cavity 110 under the guidance of the guide tube 370, so as to facilitate the mixing of the anticoagulant and the blood sample.

[0039] Reference Figure 2 and Figure 4In order to facilitate the production of the tube cap 200 and the anticoagulant release device 300, in some embodiments of the present invention, the sampling port 210 is opened in the middle of the tube cap 200, and four groups of anticoagulant release devices 300 are evenly arranged around the sampling port 210 on the tube cap 200. By adopting the above structure, the structure of the tube cap 200 can be made more reasonable, compact, and easy to produce.

[0040] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. A multi-anticoagulant combined blood collection tube used in personalized medication evaluation, characterized in that: include: A tube body, wherein a receiving cavity with an upper opening is arranged inside the tube body; A tube cap is disposed on the upper part of the tube body and blocks the opening of the upper part of the accommodating cavity, and the tube cap is provided with a sampling port connected to the accommodating cavity; Two or more groups of anticoagulant release devices are arranged on the tube cap, and all the anticoagulant release devices are independent of each other. Each group of the anticoagulant release device comprises a cavity, a side wall of the cavity is provided with a connecting hole connected to the accommodating cavity, a sealing component is movably installed in the cavity, the sealing component and a part of the inner wall of the cavity define a sealed reagent cavity, the reagent cavity is loaded with anticoagulant, the sealing component moves along the inner wall of the cavity to control the reagent cavity to be connected with the connecting hole, the sealing component is connected to a pull rod, and the other end of the pull rod is movably extended to the outer peripheral wall of the tube cap; Wherein, the types of anticoagulants loaded in each group of the anticoagulant release devices are different; The sealing assembly comprises a first sealing plug, the outer peripheral wall of the first sealing plug is in sealing contact with the inner peripheral wall of the cavity, and the first sealing plug is connected to the pull rod; The sealing assembly includes a second sealing plug, the outer peripheral wall of the second sealing plug is in sealing contact with the inner peripheral wall of the cavity, and the first sealing plug and the second sealing plug are installed on the pull rod at intervals, wherein the first sealing plug, the second sealing plug and part of the inner wall of the cavity jointly define the reagent chamber.

2. The multi-anticoagulant combined blood collection tube used in the personalized medication evaluation according to claim 1, characterized in that: The pull rod is movably installed in the cavity along a direction parallel to the upper end surface of the tube body.

3. The multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to claim 1, characterized in that: A pull ring is provided at one end of the pull rod that movably extends to the outer peripheral wall of the pipe cap.

4. The multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to claim 3, characterized in that: Each of the pull rings has a different color.

5. The multi-anticoagulant combined blood collection tube used in the personalized medication evaluation according to claim 3 or 4, characterized in that: It also comprises a protection cap which is detachably mounted on the upper part of the tube cap and is provided with a surrounding edge which covers the outer periphery of all the pull rings.

6. The multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to claim 5, characterized in that: The protective cap and the tube cap are provided with at least one set of connection structures, and the connection structures include connection columns and connection holes that are mutually matched and connected. One of the connecting column and the connecting hole is arranged on the tube cap, and the other is arranged on the protection cap.

7. The multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to claim 1, characterized in that: The sampling port is opened in the middle of the tube cap, and all the anticoagulant release devices are evenly arranged on the tube cap around the sampling port.

8. The multi-anticoagulant combined blood collection tube used in personalized medication evaluation according to claim 1, characterized in that: Each group of the anticoagulant release devices comprises a guide tube, the inlet end of the guide tube is connected to the connecting hole, and the outlet end of the guide tube faces the bottom of the accommodating cavity.

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