Cerebral infarction treatment support system

Abstract

The cerebral infarction treatment support system (100) comprises a detection device (10), a display unit (30) and an image control unit (20), wherein the image control unit (20) comprises: a receiving unit (21) which receives at least one of first information (41) generated by the detection device (10) and second information (42) associated with a susceptibility gene generated based on the first information (41); and an image output unit (22) which outputs at least one of the received first information (41) and second information (42) to the display unit (30).

Description

Technical Field

[0001] The present invention relates to a cerebral infarction treatment auxiliary system and a cerebral infarction treatment auxiliary method, and in particular to a cerebral infarction treatment auxiliary system and a cerebral infarction treatment auxiliary method for auxiliary diagnosis and treatment of acute cerebral infarction patients. Background Art

[0002] Conventionally, there is known a device for assisting diagnosis and treatment of patients with acute cerebral infarction. This device is disclosed in Patent Gazette No. 4509531.

[0003] The above-mentioned Patent Gazette No. 4509531 discloses an acute cerebral infarction diagnosis and treatment auxiliary device assembled in an X-ray computed tomography device. The acute cerebral infarction diagnosis and treatment auxiliary device of the above-mentioned Patent Gazette No. 4509531 provides a contrast-enhanced image and a cerebral blood flow image, and displays a first ROI identified based on the contrast-enhanced image and a second ROI identified based on the cerebral blood flow image in a superimposed manner on the CT image, wherein the contrast-enhanced image is an image obtained by threshold processing or cluster analysis processing of the above-mentioned CT image taken by non-contrast CT photography, and the cerebral blood flow image is an image obtained by processing continuous images taken by dynamic CT photography and quantitatively represents the blood flow dynamics of capillaries in brain tissue.

[0004] Prior art literature

[0005] Patent Literature

[0006] Patent Document 1: Japanese Patent No. 4509531 Summary of the invention

[0007] Problem that the invention aims to solve

[0008] Patients in the acute stage of cerebral infarction are typically diagnosed and treated according to the following process (1) to (4).

[0009] (1) A CT (Computed Tomography) image or an MRI (Magnetic Resonance Imaging) image is captured of the patient's head as described in Japanese Patent No. 4509531.

[0010] (2) Based on the captured images, diagnosis such as determination of the type of cerebral infarction and identification of the location of thrombus is performed.

[0011] (3) Attempts to use drug treatment such as thrombolytic agents to dissolve blood clots.

[0012] (4) Perform catheter-based treatment (intravascular treatment) to retrieve thrombus as needed.

[0013] There are three types of cerebral infarction: cardiogenic cerebral embolism, lacunar cerebral infarction, and atherothrombotic cerebral infarction. In addition, there are many types of treatment devices used in catheter treatment of cerebral infarction, and they are selected according to the type of cerebral infarction suffered.

[0014] However, there are the following problems: In the past, doctors visually judged the type of cerebral infarction based on CT images or MRI images, which required proficiency and was difficult to determine the type of cerebral infarction. In addition, sometimes the doctor who determined the type of cerebral infarction was different from the doctor who was to perform catheter treatment. The urgency of the treatment of patients with cerebral infarction is high, so there is no time to prepare written documents, etc., and there is a high possibility that the type of cerebral infarction is verbally communicated to the doctor performing the treatment. There are the following problems: the reliability is low in the case of verbal communication, and there is no means to reconfirm the type of cerebral infarction when selecting catheter treatment of the treatment device.

[0015] Therefore, when diagnosing or treating acute cerebral infarction, it is desired to present auxiliary information that helps doctors identify the type of cerebral infarction separately from image information such as CT and MRI.

[0016] The present invention is made to solve the problems mentioned above. One purpose of the present invention is to provide a cerebral infarction treatment assistance system and a cerebral infarction treatment assistance method that can present auxiliary information that helps doctors determine the type of cerebral infarction when diagnosing or treating acute cerebral infarction.

[0017] Solutions for solving problems

[0018] In order to achieve the above-mentioned purpose, the inventors of the present application have found out after in-depth research that whether a person has a specific gene as a susceptibility gene for determining the type of cerebral infarction has a significant correlation, thereby reaching the following invention. That is, the cerebral infarction treatment support system of the first aspect of the present invention comprises: a detection device, which measures a biological sample collected from a patient and generates first information whether the biological sample has a susceptibility gene related to cerebral infarction; a display unit, which is configured in at least one of a catheter room and a film reading room, the catheter room is configured with a vascular X-ray imaging device, and the film reading room is configured with an image viewing terminal for radiological diagnostic images or MRI images; and an image control unit, which controls the display unit, wherein the image control unit includes: a receiving unit, which receives at least one of the first information generated by the detection device and the second information associated with the susceptibility gene generated based on the first information; and an image output unit, which outputs at least one of the received first information and the second information to the display unit.

[0019] In the present specification, the second information is information related to cerebral infarction that can be derived from the first information on whether or not a susceptibility gene related to cerebral infarction is present and medical knowledge related to the susceptibility gene.

[0020] The second aspect of the present invention is a method for assisting the treatment of cerebral infarction, comprising the following steps: measuring a biological sample collected from a patient to generate first information indicating whether the biological sample has a susceptibility gene related to cerebral infarction; receiving at least one of the generated first information and second information associated with the susceptibility gene generated based on the first information; and outputting at least one of the received first information and the second information to a display unit, wherein the display unit is configured in at least one of a catheter room and a reading room, the catheter room being equipped with a vascular X-ray imaging device, and the reading room being equipped with an image viewing terminal for radiological diagnostic images or MRI images.

[0021] Effects of the Invention

[0022] In the cerebral infarction treatment support system of the first aspect and the cerebral infarction treatment support method of the second aspect, according to the above-mentioned structure, when treating a patient with acute cerebral infarction, at least one of the first information of whether the patient has a susceptibility gene related to cerebral infarction and the second information generated based on the first information can be displayed on a display unit arranged in a film reading room, and the film reading room is used to determine the type of cerebral infarction, determine the location of the existence of thrombus, etc. Therefore, if at least one of the first information and the second information is displayed when diagnosing the type of cerebral infarction, determining the location of the existence of thrombus, etc., the doctor can determine the type of cerebral infarction based on the information of the presence or absence of susceptibility gene that cannot be obtained from the image information in addition to reading the film based on the previous CT image or MRI image. In addition, if at least one of the first information and the second information is displayed on a display unit arranged in a catheter room for treating a patient with cerebral infarction, the doctor who actually performs the treatment can select a treatment device for catheter treatment corresponding to the type of cerebral infarction based on the information of the presence or absence of susceptibility gene. As described above, when diagnosing or treating acute cerebral infarction, auxiliary information that helps a doctor to identify the type of cerebral infarction can be presented. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram showing the overall structure of the cerebral infarction treatment support system.

[0024] Figure 2 It is a schematic diagram showing a configuration example of a detection device.

[0025] Figure 3 (A) to (F) are diagrams for explaining the detection results of the detection device.

[0026] Figure 4 It is a diagram for explaining the second information.

[0027] Figure 5 is a schematic diagram showing types of treatment devices.

[0028] Figure 6 is a diagram showing examples of first information and second information.

[0029] Figure 7 It is a diagram showing a configuration example of a cerebral infarction treatment support system.

[0030] Figure 8 This is a flowchart for explaining the flow of treatment for patients with acute cerebral infarction.

[0031] Fig. 9 is a flow chart showing a method for assisting treatment of cerebral infarction.

[0032] Fig.10 This is a schematic diagram for explaining information cooperation between each server and instrumental treatment equipment (modality) in the cerebral infarction treatment support system.

[0033] Fig.11 This is a schematic diagram for explaining the process of sending the first information and / or the second information to the X-ray imaging device.

[0034] Fig.12 is a flowchart illustrating a process of sending first information and / or second information.

[0035] Fig.13 is a flowchart showing a process of deleting the first information.

[0036] Fig.14 : is a flowchart showing a process of transmitting the second information together with the CT image or the MRI image.

[0037] Fig.15 It is a block diagram showing the structure of a blood vessel imaging device.

[0038] Fig.16 This is a diagram showing an example of a blood vessel imaging device.

[0039] Fig.17 It is a diagram for explaining the generation of a superimposed image.

[0040] Fig.18 It is a diagram for explaining reconstruction of blood vessel image data.

[0041] Fig.19 This is a flowchart showing the operation of the angiography apparatus. DETAILED DESCRIPTION

[0042] Hereinafter, embodiments of the present invention will be described with reference to the drawings.

[0043] Reference Figure 1 The structure of a cerebral infarction treatment support system 100 according to one embodiment will be described.

[0044] The cerebral infarction treatment support system 100 is a system for supporting the diagnosis and treatment of patients with acute cerebral infarction. The cerebral infarction treatment support system 100 is set in a medical facility such as a hospital, for example. The cerebral infarction treatment support system 100 is configured to diagnose and provide information useful for diagnosis and treatment to doctors and the like when treating patients with acute cerebral infarction who are transported to the facility. The cerebral infarction treatment support system 100 can provide auxiliary information different from medical images to doctors and the like separately from medical images (X-ray images, CT images, MRI images, etc.) used in the diagnosis and treatment of patients with acute cerebral infarction.

[0045] The cerebral infarction treatment support system 100 includes at least a gene detection device 10 , an image control unit 20 , and a display unit 30 .

[0046] The detection device 10 is configured to measure a biological sample 2 collected from a patient 1 and generate first information 41 indicating whether the biological sample 2 contains a susceptibility gene associated with cerebral infarction. The detection device 10 is installed in, for example, an examination room of a medical facility such as a hospital.

[0047] The biological sample 2 is a liquid collected from the patient 1 and contains at least the genomic DNA of the patient 1. The biological sample 2 includes, for example, specimens such as blood and saliva collected from the patient 1. In addition, blood includes any one of whole blood, plasma and serum. The specimen may also be tissues and cells such as hair, nails, skin, and mucous membranes. In addition to the specimen, the biological sample 2 may also contain components used in the determination of the detection device 10. The biological sample 2 may contain, for example, a dissolving solution for eluting genes from the specimen, a reaction solution for amplifying genes, etc. The reaction solution is designed to specifically react with a susceptibility gene related to cerebral infarction as the detection object. In this specification, the biological sample is a concept that includes not only the specimen itself collected from the patient 1, but also a prepared sample prepared from the specimen and other components.

[0048] Susceptibility genes associated with cerebral infarction are significantly correlated with the possibility of suffering from a specific type of cerebral infarction. That is, the presence of a susceptibility gene associated with cerebral infarction in biological sample 2 indicates that the possibility of suffering from a type of cerebral infarction associated with the susceptibility gene is significantly higher or lower than when the susceptibility gene is not present. The susceptibility gene associated with cerebral infarction may be a mutation or gene polymorphism of a specific gene. The first information 41 indicates whether a mutation or gene polymorphism of such a gene exists in the DNA in biological sample 2.

[0049] The first information 41 is information that can at least determine whether there is a susceptibility gene related to cerebral infarction. The first information 41 can be, for example, binary information indicating either "there is a susceptibility gene related to cerebral infarction (positive)" or "there is no susceptibility gene related to cerebral infarction (negative)". The first information 41 can be information indicating that the mutation or gene polymorphism of the susceptibility gene is either "there are 2 (mutant homozygous)", "there is 1 (mutant / wild type heterozygous)" or "there is no (wild type homozygous)".

[0050] The cerebral infarction treatment support system 100 can generate second information 42 related to the diagnosis or treatment of cerebral infarction based on the first information 41 of whether there is a susceptibility gene related to cerebral infarction. As the second information 42, for example, it can be information indicating the type of cerebral infarction that is significantly associated with the susceptibility gene related to cerebral infarction. In addition, for example, patients with susceptibility genes sometimes also show characteristics (traits) that are prone to cerebral infarction. Characteristics that are prone to cerebral infarction refer to, for example, the tendency of blood vessels in the brain to be thin and the tendency of blood vessel walls to be fragile. The second information 42 is secondary information generated by taking the first information 41 of whether there is a susceptibility gene related to cerebral infarction as primary information and taking into account other medical knowledge. The second information 42 does not need to be generated by the detection device 10. The second information 42 can be generated by, for example, a computer or server that can obtain the first information 41 from the detection device 10 via a network.

[0051] The image control unit 20 acquires at least one of the first information 41 generated by the detection device 10 and the second information 42 associated with the susceptibility gene generated based on the first information 41. The image control unit 20 controls the display unit 30 to display at least one of the acquired first information 41 and the second information 42. The image control unit 20 includes, for example, a computer configured to be able to communicate with the detection device 10 and the display unit 30.

[0052] More specifically, the image control unit 20 includes a receiving unit 21 and an image output unit 22. The receiving unit 21 receives at least one of the first information 41 generated by the detection device 10 and the second information 42 associated with the susceptibility gene generated based on the first information 41. The receiving unit 21 can communicate directly with the detection device 10, for example, by wire or wirelessly. The receiving unit 21 can communicate with the detection device 10, for example, via a network. The receiving unit 21 does not need to receive information from the detection device 10, as long as it can access a device that stores the first information 41 generated by the detection device 10 and the second information 42 generated based on the first information 41 via a network.

[0053] The image output unit 22 outputs at least one of the received first information 41 and the second information 42 to the display unit 30. The image output unit 22 is electrically connected to the display unit 30 via a wired or wireless method. Figure 1 , an example is shown in which the image control unit 20 is installed outside the image reading room 901 and outside the catheter room 902. Figure 1 In the example of FIG. 9 , the image control unit 20 issues at least one of the first information 41 and the second information 42 to the display unit 30 provided in the image reading room 901 and the display unit 30 provided in the catheterization room 902 .

[0054] The display unit 30 is a monitor for displaying information. The display unit 30 is arranged in at least one of the catheter room 902, which is equipped with a vascular X-ray imaging device, and the image reading room 901, which is equipped with an image viewing terminal for radiological diagnostic images or MRI images. The image control unit 20 outputs the received information (the first information 41 and / or the second information 42) to the display unit 30. The display unit 30 displays the information (the first information 41 and / or the second information 42) output from the image control unit 20.

[0055] In the cerebral infarction treatment support system 100 , at least during treatment or diagnosis of the patient 1 , information (at least one of the first information 41 and the second information 42 ) output from the image control unit 20 is displayed on the display unit 30 .

[0056] For patients with acute cerebral infarction, CT images or MRI images for diagnosis are taken by a CT device or MRI device in the hospital, and the diagnosis is performed in the image reading room 901 in the hospital. In the cerebral infarction treatment support system 100, for example, when diagnosing the patient 1, information received by the image control unit 20 is output to the display unit 30 provided in the image reading room 901. The image reading room 901 is a room equipped with a radiation diagnosis device (X-ray imaging device, CT device, etc.) or an image viewing terminal (PC) for diagnostic images such as MRI.

[0057] After diagnosis, in the treatment stage of cerebral infarction patients, for example, catheter treatment is performed on the infarction site in the cerebral blood vessels. In the cerebral infarction treatment support system 100, for example, when catheter treatment is performed on the patient 1, information received by the image control unit 20 is output to the display unit 30 provided in the catheter room 902. The catheter room 902 is a room where a blood vessel X-ray imaging device used in the catheter treatment is provided.

[0058] In this way, the display unit 30 is disposed in at least one of the catheter room 902 and the image reading room 901 in the hospital. The cerebral infarction treatment support system 100 may include other display units in addition to the display unit 30 of the catheter room 902 and the display unit 30 of the image reading room 901. Such a display unit 30 may be, for example, a display unit of a portable information terminal such as a tablet terminal carried by a doctor or the like.

[0059] (Detection device)

[0060] The detection device 10 detects a susceptibility gene (detection target gene) related to cerebral infarction from the biological sample 2. Detecting the susceptibility gene means detecting a specific base sequence in the genomic DNA contained in the biological sample 2. The detection device 10 generates first information 41 as a detection result indicating whether the biological sample 2 has a susceptibility gene related to cerebral infarction.

[0061] The susceptibility gene detected by the detection device 10 is not limited to one (one type). When the presence or absence of susceptibility genes related to multiple cerebral infarctions is significantly correlated with the possibility of suffering from any type of cerebral infarction, the first information 41 may indicate the presence or absence of each of the multiple susceptibility genes.

[0062] The detection device 10, for example, amplifies the detection target gene of the biological sample 2. The detection device 10, for example, binds the detection target gene to a marker substance. The detection device 10, for example, detects a susceptibility gene related to cerebral infarction by detecting the marker substance bound to the detection target gene. The marker substance is not particularly limited as long as it generates a signal that can be detected in the detection device 10, and for example, includes a fluorescent substance (fluorescent marker). In this case, the detection device 10 irradiates the biological sample 2 with excitation light and detects the fluorescence generated from the marker substance.

[0063] exist Figure 2 In the configuration example, the detection device 10 is a gene amplification detection device that amplifies the detection target gene by using the PCR (Polymerase Chain Reaction) method to perform detection. The detection device 10 includes a container mounting unit 11, a detection unit 12, a temperature adjustment unit 13, and a data processing unit 14.

[0064] The container mounting portion 11 is configured to be able to place a sample container 3 containing a biological sample 2. The sample container 3 is a light-transmitting reaction container, and may be a so-called PCR tube, a PCR well plate, or the like.

[0065] The temperature adjustment unit 13 is configured to adjust the temperature of the biological sample 2 by heating and / or cooling the sample container 3 provided on the container mounting unit 11. The temperature adjustment unit 13 performs a thermal cycle process for periodically raising and lowering the temperature of the biological sample 2. Through the thermal cycle process, the detection target gene (susceptibility gene related to cerebral infarction) in the biological sample 2 is amplified.

[0066] The detection unit 12 includes a light source 12a and a light detector 12b. The light source 12a includes, for example, an LED (light emitting diode) element, which is used to generate excitation light for a fluorescent probe contained in the biological sample 2. The light source 12a irradiates the biological sample 2 in the sample container 3 provided in the container loading unit 11 with the excitation light. The fluorescent probe contained in the biological sample 2 is excited by the irradiation of the excitation light and generates fluorescence. The light detector 12b is configured to detect the fluorescence generated from the fluorescent probe contained in the biological sample 2. The light detector 12b outputs a detection signal corresponding to the fluorescence intensity generated from the biological sample 2. The light detector 12b includes, for example, a photomultiplier tube (PMT) or a photodiode.

[0067] Here, in Figure 2 In the structural example, the detection device 10 is configured to perform a gene amplification process on a biological sample 2 containing a specimen 2a and a reaction solution 2c, wherein the specimen 2a contains blood or saliva collected from a patient 1, and the reaction solution 2c contains a component for suppressing the influence of inhibitory substances in the specimen 2a. That is, the detection device 10 is a direct PCR device that performs a PCR process on a biological sample 2 prepared without a purification process to purify DNA from the specimen 2a. "Direct PCR" refers to the case where a PCR process is performed without a DNA purification process. The reaction solution 2c containing a component for suppressing the influence of inhibitory substances contains a PCR enzyme, a fluorescent probe, a primer, and a component for suppressing the influence of inhibitory substances in the specimen 2a. As a component for suppressing the influence of inhibitory substances, for example, it is preferable to use an Ampdirect (registered trademark) buffer produced by Shimadzu Corporation.

[0068] In addition, the detection device 10 is configured to implement a real-time PCR method in which a labeling substance is used for labeling during the gene amplification process. That is, the detection device 10 does not label the amplification product after the gene amplification is performed by PCR, but specifically binds the fluorescent probe to the detection target gene (susceptibility gene related to cerebral infarction) during the gene amplification by PCR.

[0069] exist Figure 2In the structural example, first, the specimen 2a collected from the patient 1 is mixed with the cell lysate 2b. The mixture of the specimen 2a and the cell lysate 2b is mixed with the reaction solution 2c in the sample container 3. The reaction solution 2c contains PCR enzyme, fluorescent probe, primers and components for suppressing the influence of inhibitory substances in the specimen 2a. In this way, the biological sample 2 is prepared. By using the components for suppressing the influence of inhibitory substances, PCR treatment can be performed without performing DNA (deoxyribonucleic acid) purification treatment. The detection unit 12 detects the fluorescence indicating the presence of the detection target gene during the gene amplification process through real-time PCR treatment, and outputs the detection signal corresponding to the fluorescence intensity to the data processing unit 14.

[0070] The data processing unit 14 is composed of a computer having a processor 14a such as a CPU (Central Processing Unit), a storage unit 14b storing a program 15 for gene analysis, and a communication unit 14c. The storage unit 14b includes a volatile and / or non-volatile storage device. The communication unit 14c includes a communication interface that can be connected to a network of a medical facility such as a hospital.

[0071] The processor 14a acquires the detection signal output from the detection unit 12. The processor 14a analyzes the detection signal by executing the program 15 stored in the storage unit 14b. The processor 14a generates the first information 41 whether the biological sample 2 has a susceptibility gene related to cerebral infarction through the analysis. The processor 14a sends the first information 41 to the server 50 via the network through the communication unit 14c. The first information 41 may also be sent directly to the image control unit 20.

[0072] Furthermore, the biological sample 2 collected from the patient 1 is provided with the patient information 45. The patient information 45 includes unique identification information for specifying the patient 1. For example, the detection device 10 provides the patient information 45 of the patient 1 from whom the biological sample 2 was collected to the first information 41.

[0073] In addition, Figure 2 2 shows an example in which a prepared sample mixed with a specimen 2a, a cell lysate 2b, and a reaction solution 2c is supplied to the detection device 10 as the biological sample 2, but instead, for example, a biological sample 2 containing only the specimen 2a may be supplied to the detection device 10. In this case, the detection device 10 may also be configured to include a mechanism for dispensing the cell lysate 2b and the reaction solution 2c into the sample container 3 containing the biological sample 2, and to prepare a sample for measurement in the detection device 10.

[0074] In addition, the susceptibility gene associated with cerebral infarction can be a single nucleotide polymorphism (SNP; Single Nucleotide Polymorphism) in the base sequence of a specific gene. The detection method of SNP can use, for example, RFLP (restriction fragment length polymorphism) method, PCR-SSCP (single-strand DNA conformation polymorphism analysis) method, ASO (Allele Specific Oligonucleotide: allele specific oligonucleotide) hybridization method, sequence method, ARMS (Amplification Refracting Mutation System: amplification refracting mutation system) method, denaturing gradient gel electrophoresis (Denaturing Gradient Gel Electrophoresis) method, RNAse A cleavage method, DOL (Dye-labeled Oligonucleotide Ligation: dye-labeled oligonucleotide ligation) method, TaqMan PCR method, primer extension method, invasion method, etc. The detection device 10 is Figure 2 In addition to the illustrated configuration examples, a device capable of implementing any of the above-described detection methods may be used.

[0075] (Susceptibility gene associated with cerebral infarction)

[0076] Susceptibility genes associated with cerebral infarction include, for example, the RNF213 p.R4810K gene polymorphism.

[0077] RNF213 (Ring finger protein 213) (GenBank accession number NM_001256071.1) is present in the human chromosome region 17q25.3.

[0078] The RNF213 p.R4810K gene polymorphism is a single nucleotide polymorphism (SNP) of 73097G>A in the nucleotide sequence represented by SEQ ID NO: 2. The detection device 10 detects the SNP of 73097G>A in the biological sample 2.

[0079] Sequence number 2 is a partial nucleotide sequence of human chromosome 17 DNA containing the mysterin gene and genes in its surrounding regions [FLJ3520, NPTX1, CARD14 and Raptor (KIAA1303)], which corresponds to nucleotides 43560001-43795000 of Contig#NT010783.15 registered in NCBI.

[0080] In the nucleotide sequence represented by sequence number 2, in addition to the SNP at position 73097 (73097G>A) which is G or A, there may also be a SNP at position 4766 (4766T>C) which is T or C, a SNP at position 120764 (120764G>A) which is G or A, a SNP at position 152917 (152917G>A) which is G or A, and a SNP at position 232102 (232102G>A) which is G or A.

[0081] In this specification, the position of the SNP is recorded based on the position of the nucleotide in the nucleotide sequence represented by sequence number 2. For example, "SNP at position 73097" refers to the SNP in the nucleotide at position 73097 in the nucleotide sequence represented by sequence number 2. In the case of recording as "73097G>A" etc., the base of the major allele (in this case, G) is recorded before the symbol ">", and the base of the minor allele (in this case, A) is recorded after the symbol ">".

[0082] In addition, in this specification, unless otherwise specified, the nucleotide sequence is recorded as a DNA sequence, but when the polynucleotide is RNA (ribonucleic acid), thymine (T) is appropriately replaced with uracil (U). In addition to the continuous partial sequence of the nucleotide sequence represented by SEQ ID NO: 2 or its complementary sequence, the polynucleotide may also include any additional sequence.

[0083] The following has been clarified through the research of the inventors of the present invention: RNF213 p.R4810K polymorphism increases the risk of ischemic stroke (i.e., atherothrombotic cerebral infarction) caused by aortic atherosclerosis. The inventors of the present application have filed a patent application based on this insight. Regarding the applications of the inventors of the present application with application numbers 2018-233549 and PCT / JP2018 / 045915, the entire disclosures of these applications are incorporated into this specification by reference.

[0084] Figure 3 (A)~ Figure 3 (F) illustrates the detection result of RNF213 p.R4810K gene polymorphism detected by the detection device 10. Figure 3 (A)~ Figure 3 In any of the graphs (F) of , the vertical axis represents the signal intensity (fluorescence intensity) of the detection signal of the detection device 10 , and the horizontal axis represents the number of cycles of the PCR process of the detection device 10 .

[0085] Figure 3(A) shows the detection results of the wild-type positive control of the RNF213 gene. Figure 3 (B) shows the detection results of the mutant positive control of the RNF213 gene. The wild type refers to the base sequence without the p.R4810K gene polymorphism, and the mutant type refers to the base sequence with the p.R4810K gene polymorphism. The positive control is obtained by synthesizing DNAs of each sequence of the wild type and the mutant type. Figure 3 (C) shows the results of positive control detection of a heterozygote in which one allele of RNF213 is wild-type and the other is mutant. Figure 3 (D) shows the test results obtained using blood collected from the subject. Figure 3 (E) shows the test results obtained using saliva collected from the subject. Figure 3 (F) shows the detection result of the negative control for verifying the determination result of the detection device 10. The negative control is a sample containing neither the wild type nor the mutant type of the RNF213 gene.

[0086] exist Figure 3 In (A), the intensity of the fluorescent signal generated by the fluorescent probe that specifically binds to the wild-type RNF213 gene (referred to as the wild-type signal 16) increases, while the intensity of the fluorescent signal generated by the fluorescent probe that specifically binds to the mutant-type RNF213 gene (referred to as the mutant-type signal 17) does not change. Figure 3 In (B), the intensity of the wild-type signal 16 does not change, while the intensity of the mutant signal 17 increases. Figure 3 In (C), the intensities of both the wild-type signal 16 and the mutant-type signal 17 increase. Therefore, according to the detection result of the detection device 10, the presence or absence of the RNF213p.R4810K gene polymorphism can be determined based on the change in the intensity of the mutant-type signal 17.

[0087] according to Figure 3 (D) and Figure 3 (E) confirmed that the same signal intensity change as that of the positive control can be obtained from the blood sample and the saliva sample actually collected from the subject. Figure 3 (F) confirmed that there was no nonspecific amplification and that specific amplification and labeling of the target gene was achieved.

[0088] According to the above content, Figure 2The data processing unit 14 shown determines the presence or absence of a susceptibility gene (RNF213 p.R4810K gene polymorphism) related to cerebral infarction based on the intensity change of the mutant signal 17. The data processing unit 14 produces first information 41 corresponding to the determination result. That is, in the detection result, when the intensity of the signal (mutant signal 17) derived from the marker substance annotated to the susceptibility gene related to cerebral infarction increases, the data processing unit 14 generates the first information 41 indicating that there is a susceptibility gene related to cerebral infarction. In the detection result, when the intensity of the signal (mutant signal 17) derived from the marker substance annotated to the susceptibility gene related to cerebral infarction does not increase, the data processing unit 14 generates the first information 41 indicating that there is no susceptibility gene related to cerebral infarction.

[0089] As a criterion for determining whether there is a susceptibility gene in the test result, for example, a threshold value is set for the signal intensity. For example, the data processing unit 14 obtains the difference between the signal intensity at the start of the PCR process and the signal intensity at the end of the PCR process, and determines that there is a susceptibility gene when the obtained difference exceeds the threshold value. Alternatively, it can be simply determined that there is a susceptibility gene when the signal intensity of the mutant signal 17 exceeds the threshold value.

[0090] Susceptibility genes associated with cerebral infarction may also be genes other than the RNF213 p.R4810K gene polymorphism. According to genetic research in recent years, the correlation between cardiogenic cerebral infarction and PITX2 (human chromosome region 4q25) and ZFHX3 (human chromosome region 16q22) as related genes has been shown. The correlation between lacunar cerebral infarction and ALDH2 (human chromosome region 12q24) and the like as related genes has been shown. Susceptibility genes associated with cerebral infarction may include one or more of these genes. Susceptibility genes associated with cerebral infarction can be genes that show a significant correlation with specific cerebral infarction, and are not limited to the above genes.

[0091] (Second message)

[0092] Next, the second information 42 will be described. Figure 4 In the example shown, the second information 42 includes at least one of information 42a related to the type of cerebral infarction, information 42b related to the cerebral blood vessels of the patient 1, and information 42c (hereinafter referred to as "device information 42c") indicating a treatment device that is recommended or not recommended for catheter treatment of cerebral infarction of the patient 1. The second information 42 is generated to the user in the form of a message (text), for example.

[0093] The information 42a related to the type of cerebral infarction is information indicating the type of cerebral infarction significantly associated with the susceptibility gene detected based on the first information 41. The types of cerebral infarction are classified into three types: cardiogenic cerebral embolism, lacunar cerebral infarction, and atherothrombotic cerebral infarction. The presence of the susceptibility gene, for example, indicates that the possibility of suffering from a certain type of cerebral infarction is significantly high or significantly low. The information 42a related to the type of cerebral infarction can be a message indicating the type of cerebral infarction with a significantly high or significantly low possibility of suffering from the disease.

[0094] The information 42b related to the cerebrovascular vessels of the patient 1 is information on the morphology or properties of the cerebrovascular vessels of the patient 1 estimated based on the presence or absence of the susceptibility gene. In the case of the susceptibility gene, the information 42b related to the cerebrovascular vessels of the patient 1 can be, for example, information indicating that the cerebrovascular vessels tend to be thick or thin. In the case of the susceptibility gene, the information 42b related to the cerebrovascular vessels of the patient 1 can be, for example, information indicating that the cerebrovascular vessels tend to be tough (not easily damaged) or fragile (easy to be damaged).

[0095] The device information 42c is information indicating the type or shape of a treatment device that is an option for the catheter treatment.

[0096] The therapeutic device used in catheter treatment of cerebral infarction has Figure 5 The thrombus recovery device 5a, thrombus suction device 5b, and percutaneous angioplasty device 5c are shown. The thrombus recovery device 5a has a spiral wire for winding to recover the thrombus. The thrombus suction device 5b is a hollow tube and is configured to remove the thrombus by suctioning the thrombus into the inside. The percutaneous angioplasty device 5c has a balloon catheter and a stent.

[0097] The device information 42c can be, for example, a message indicating a treatment device that is recommended or not recommended for use among the thrombus retrieval device 5a, the thrombus suction device 5b, and the percutaneous angioplasty device 5c.

[0098] For example, in the presence of RNF213 p.R4810K gene polymorphism, the possibility of suffering from atherothrombotic cerebral infarction is significantly increased. In addition, in the presence of this gene polymorphism, the relatively thick blood vessels in the brain, which are the infarction sites caused by atherothrombotic cerebral infarction, tend to be thinner than the same sites in the group without this gene polymorphism. Moreover, the relatively thick blood vessels in the brain also tend to be thinner than in normal situations, so if a thrombus recovery device that is easy to contact with blood vessels is used, it is possible that reocclusion occurs due to endothelial damage of the occluded blood vessels.

[0099] So, as an example, Figure 6As shown, when the first information 41 indicates the presence of the RNF213 p.R4810K gene polymorphism, the information 42a related to the type of cerebral infarction includes a message that the type of cerebral infarction suffered by the patient 1 from whom the biological sample 2 was collected is "highly likely to be atherothrombotic cerebral infarction". The information 42b related to the cerebral blood vessels of the patient 1 includes a message that the "cerebral blood vessels of the patient 1 from whom the biological sample 2 was collected tend to be thin". The device information 42c includes a message that "the use of the thrombus retrieval device 5a is not recommended" and / or a message that "the use of the thrombus aspiration device 5b or the percutaneous angioplasty device 5c is recommended". The device information 42c may also include a message that "the use of a treatment device with a smaller diameter than usual is recommended".

[0100] In addition, Figure 2 In the structural example, the cerebral infarction treatment support system 100 includes a server 50, which is connected to the detection device 10 and the image control unit 20 in a manner that can communicate with each other and stores the first information 41. The server 50 is as follows Figure 4 As shown, the second information 42 is generated based on the first information 41 .

[0101] As described above, the server 50 has a second information generation table 51 for generating the second information 42 corresponding to the content of the first information 41 (presence / absence of a susceptibility gene). The second information generation table 51 is a data table that records the presence or absence of a specific susceptibility gene in association with the content of the second information 42 that should be generated corresponding to the presence or absence of the susceptibility gene. After acquiring the first information 41 from the detection device 10, the server 50 generates the second information 42 based on the second information generation table 51 and with reference to the second information 42 corresponding to the content of the first information 41. The second information 42 is associated with the first information 41 or the patient information 45 assigned to the first information 41. The patient information 45 assigned to the first information 41 may also be assigned to the second information 42.

[0102] Regarding the generation of the second information 42, in addition to the case where the second information 42 is generated by the server 50 in the hospital, the second information 42 may be generated in a cloud server or the like via the Internet. The detection device 10 may also generate the second information 42 while generating the first information 41. The server 50 includes, for example, at least one of a radiology information system server connected to the network in the hospital and a medical image management system server connected to the network in the hospital. Here, the radiology information system server is referred to as a RIS (Radiology Information Systems) server 52 (refer to Figure 7) is a server that mainly executes the processing of the system for performing examinations using radiation equipment and managing the examination results. The medical image management system server is a server that collects and records medical image data. The medical image management system server processes medical image data based on the DICOM specification, which is a standard specification, and is therefore also called a DICOM server 53 (see Figure 7 ).

[0103] Image control unit 20 (see Figure 1 ) For example, the image control unit 20 is configured to receive at least the second information 42 from the server 50. The image control unit 20 outputs at least the received second information 42 to the display unit 30 for display. The image control unit 20 may also receive both the first information 41 and the second information 42 and display them on the display unit 30. The image control unit 20 may also display only the first information 41 on the display unit 30, in which case, the cerebral infarction treatment support system 100 may not generate the second information 42.

[0104] (Configuration example of cerebral infarction treatment support system)

[0105] Figure 7 A more specific configuration example of the cerebral infarction treatment support system 100 is shown. The cerebral infarction treatment support system 100 can be configured as a part or the whole of the in-hospital network.

[0106] The hospital network is connected to radiation equipment such as a CT apparatus 101 and an MRI apparatus 102, and a detection apparatus 10. The hospital network is connected to various portable terminals 103 such as a tablet information terminal, and various servers such as a RIS server 52 and a DICOM server 53. In addition, the hospital network is connected to a blood vessel X-ray imaging apparatus 70 installed in a catheter room 902 and an image viewing terminal 80 installed in a film reading room 901.

[0107] The catheter room 902 is provided with a vascular X-ray imaging device 70, a catheter device 104, and the like. During treatment, a treatment device 5 to be used is prepared. The vascular X-ray imaging device 70 is a vascular imaging device that performs fluoroscopic imaging of blood vessels. The vascular X-ray imaging device 70 detects X-rays irradiated from an X-ray source using an X-ray detector and images them. The vascular X-ray imaging device 70 includes a first control device 71 that performs control processing of the device and a first display unit 72 that displays the captured X-ray image. During catheter treatment, the vascular X-ray imaging device 70 performs fluoroscopic imaging of the catheter and treatment device 5 introduced into the blood vessel in the form of a moving image, and displays it on the first display unit 72. In addition, the details of the vascular X-ray imaging device 70 will be described later.

[0108] The image viewing terminal 80 provided in the image reading room 901 is, for example, a PC (personal computer), and includes a second control device 81 and a second display unit 82 constituting a main body of the PC. In the image reading room 901, doctors and the like use the image viewing terminal 80 to view medical images obtained by photographing the patient 1, and perform identification of the thrombus site, diagnosis, and decision on a treatment plan for the cerebral infarction patient 1. The medical images include CT images photographed by the CT device 101 and MRI images photographed by the MRI device.

[0109] exist Figure 7 In the configuration example, the image control unit 20 includes a first control unit 71 provided in the blood vessel X-ray imaging device 70 provided in the catheter room 902. The first control unit 71 includes a receiving unit 21 and an image output unit 22. The display unit 30 includes a first display unit 72 provided in the catheter room 902 for displaying an X-ray image 73 of the blood vessel X-ray imaging device 70.

[0110] Specifically, the first control device 71 is configured to output at least one of the received first information 41 and the second information 42 and the X-ray image 73 of the patient 1 captured by the vascular X-ray imaging device 70 to the first display unit 72 when the catheter treatment is performed on the patient 1 in the catheter room 902. As a result, when the patient 1 is treated in the catheter room 902, the information (at least one of the first information 41 and the second information 42) received by the image control unit 20 is displayed.

[0111] In addition, Figure 7 In the configuration example, the image control unit 20 includes a second control device 81 provided in the image reading terminal 80 provided in the image reading room 901. The second control device 81 includes a receiving unit 21 and an image output unit 22. The display unit 30 includes a second display unit 82 provided in the image reading room 901 for displaying the screen of the image reading terminal 80.

[0112] Specifically, the second control device 81 is configured to receive at least one of the first information 41 and the second information 42 and the CT image 6 or the MRI image 7 of the patient 1 when diagnosing the patient 1 in the image reading room 901, and output the received information to the second display unit 82. As a result, when the patient 1 is diagnosed in the image reading room 901, the information (at least one of the first information 41 and the second information 42) received by the image control unit 20 is displayed.

[0113] In addition, the first information 41 and the second information 42 are assigned to the patient information 45 as described above, or are recorded in the server 50 (RIS server 52 or DICOM server 53) in association with the patient information 45. In addition, the patient information 45 is assigned to the X-ray image 73, the CT image 6, and the MRI image 7 captured by the vascular X-ray imaging device 70 at the time of imaging. Based on the patient information 45, it can be recognized that these images and the first information 41 and the second information 42 are acquired from the same patient 1.

[0114] Therefore, in the above-mentioned configuration example, the image control unit 20 receives an image of the patient 1 to which the patient information 45 is assigned, and outputs at least one of the first information 41 and the second information 42 having the same patient information 45 and the image to the display unit 30. The image of the patient 1 includes any one of the X-ray image 73, the CT image 6, and the MRI image 7 captured by the vascular X-ray imaging device 70, and may also include other medical images.

[0115] The cerebral infarction treatment support system 100 may be configured to provide at least one of the first information 41 and the second information 42 to a doctor or the like when performing a postoperative evaluation or confirming the progress of treatment after treating the cerebral infarction patient 1 .

[0116] (Patient treatment process)

[0117] Next, refer to Figure 8 The treatment process for acute cerebral infarction patient 1 is briefly described.

[0118] First, a patient 1 who is estimated to have suffered a cerebral infarction is transported to a hospital as an emergency patient.

[0119] After being transported in, the patient information 45 and triage information are input into the in-hospital network system. The triage information is information indicating the priority of the treatment sequence determined based on the severity of the symptoms of the patient 1. In addition, the sample 2a is obtained from the patient 1.

[0120] In the imaging room, a CT image 6 or an MRI image 7 is imaged of a patient 1 using a CT device 101 or an MRI device 102. While imaging the patient 1, a biological sample 2 is prepared from a specimen 2a and supplied to a detection device 10. The cerebral infarction treatment support system 100 detects a susceptibility gene using the detection device 10 while imaging the patient 1.

[0121] Next, in the image reading room 901, the patient 1 is diagnosed based on the captured CT image 6 or MRI image 7. The image control unit 20 performs a diagnosis based on the patient information 45 (see Figure 6), at least one of the first information 41 and the second information 42 is displayed together with the image of the patient 1. Based on the provided information, the doctor or the like diagnoses that the patient 1 has suffered from cerebral infarction, identifies the site of the thrombus, and decides on a treatment plan.

[0122] According to the treatment policy, for example, a first treatment is performed. The first treatment is to administer a thrombolytic agent to the patient 1. If the cerebrovascular blood flow is not sufficiently improved by the administration of the thrombolytic agent, a second treatment is performed as needed. The second treatment is catheter therapy.

[0123] During catheter treatment, the image control unit 20 causes at least one of the first information 41 and the second information 42 to be compared with the X-ray image 73 (see FIG. 1 ) of the patient 1 based on the patient information 45. Figure 7 The doctor in charge of treatment selects the treatment device 5 with reference to the provided information, and performs the catheter treatment while referring to the X-ray image 73 in the blood vessel.

[0124] (Operation of the cerebral infarction treatment support system)

[0125] Next, refer to Fig. 9 The operation of the cerebral infarction treatment support system 100 is described below. The cerebral infarction treatment support method of this embodiment is implemented by the cerebral infarction treatment support system 100. Figure 2 Regarding the first information 41, the second information 42 and the patient information 45, refer to Figure 4 and Figure 6 .

[0126] In step 91 , the detection device 10 measures the biological sample 2 collected from the patient 1 , and generates the first information 41 on whether the biological sample 2 contains a susceptibility gene related to cerebral infarction.

[0127] In step 92 , the detection device 10 adds the patient information 45 of the patient 1 to the first information 41 generated based on the biological sample 2 collected from the patient 1 who was transported in as an emergency.

[0128] In step 93, the second information 42 can be generated based on the first information 41. When the second information 42 is not to be displayed, step 93 is unnecessary.

[0129] In step 94, the receiving unit 21 (see Figure 1 , Figure 7 ) receives at least either the first information 41 or the second information 42.

[0130] In step 95, the image output unit 22 (see Figure 1 , Figure 7) The image control unit 20 outputs at least one of the first information 41 and the second information 42 received by the image control unit 20 to the display unit 30 for display. The image control unit 20 receives the first information 41 of the patient 1 from whom the biological sample 2 is collected based on the patient information 45, and outputs it to the display unit 30 (refer to Figure 1 , Figure 7 ).

[0131] The first information 41 and / or the second information 42 may be displayed only during treatment of the patient 1 or during diagnosis of the patient 1. In particular, it is necessary to treat the acute phase of cerebral infarction patient 1 in a short time. Therefore, it is also necessary to consider the possibility that the generation of the first information 41 is not completed when diagnosing the patient 1, when the detection of the susceptibility gene takes time. Even in this case, in the present embodiment, the received information is displayed on the display unit 30 together with the patient information 45 at least before the treatment of the patient 1. The doctor performing the treatment can refer to the first information 41 and / or the second information 42 to select the treatment device 5.

[0132] (Other structural examples of cerebral infarction support system)

[0133] Next, refer to Fig.10 and Fig.11 A cerebral infarction treatment support system 200 of another configuration example will be described. The cerebral infarction treatment support system 200 implements the cerebral infarction treatment support method of the present embodiment.

[0134] exist Fig.10 In the configuration example of FIG. 2 , the cerebral infarction treatment support system 200 includes a detection device 210, a server 250, and a medical treatment device 105. The server 250 is an example of the “management unit” of the present invention.

[0135] The server 250 includes a RIS server 252, a DICOM server 253, and a hospital information system server connected to a network within the hospital. Here, the hospital information system server is referred to as an HIS (Hospital Information Systems) server 254, which includes, for example, an automatic acceptance system, an electronic medical record management system, a medical accounting system, a medical appointment system, a pharmacy management system, etc. The HIS server 254 is configured to store patient information 245. In addition, the RIS server 252 and the DICOM server 253 are respectively connected to the RIS server 52 (see Figure 7 ) and DICOM server 53 (refer to Figure 7 ) has the same structure, so detailed description is omitted.

[0136] The instrument treatment device 105 includes a vascular X-ray imaging device 270 (see Fig.11)、Image browsing terminal 80 (refer to Fig.11 )、CT device 101 (refer to Figure 7 ) and MRI apparatus 102 (refer to Figure 7 ) etc. In this specification, "instrumental treatment equipment" refers to the general term for these medical imaging equipment. In addition, the vascular X-ray imaging device 270 has the same structure as the vascular X-ray imaging device 70, so the detailed description is omitted. In addition, the vascular X-ray imaging device 270 is an example of the "device used in the treatment of patients" of the present invention.

[0137] (Gene association information)

[0138] The detection device 210 measures the biological sample 2 collected from the patient 1 and generates gene-related information 240 associated with the susceptibility gene related to cerebral infarction. In addition, the gene-related information 240 includes first information 241 indicating whether the biological sample 2 has the susceptibility gene related to cerebral infarction and second information 242 associated with the susceptibility gene generated based on the first information 241.

[0139] (First information and second information)

[0140] The server 250 is configured to generate second information 242 associated with the susceptibility gene based on the first information 241 included in the gene-related information 240 generated by the detection device 210. In addition, the first information 241 is associated with the first information 41 (see Figure 4 ). That is, the first information 241 includes the patient information 245 and the information on the presence / absence of gene polymorphism. In addition, the patient information 245 is the same as the patient information 45 (refer to Figure 4 ) includes identification information 245a. Identification information 245a is unique information that can identify patient 1. Identification information 245a includes, for example, a patient identification number. In addition, second information 242 is the same as second information 42 (refer to Figure 4 That is, the second information 242 includes at least one of the information 42a related to the type of cerebral infarction, the information 42b related to the cerebral blood vessels of the patient 1, and the information 42c indicating the treatment device recommended or not recommended for the catheter treatment of the cerebral infarction of the patient 1.

[0141] exist Fig.10 In the example of FIG. 2 , the HIS server 254 sends the examination request 201 to the detection device 210. When sending the examination request 201, the HIS server 254 also sends the identification information 245a of the patient 1 to be examined.

[0142] The detection device 210 that receives the inspection request 201 performs the inspection and generates the first information 241. The detection device 210 associates the identification information 245a sent together with the inspection request 201 with the generated first information 241. The detection device 210 sends the first information 241 associated with the identification information 245a to the HIS server 254.

[0143] The HIS server 254 manages the first information 241 transmitted from the detection device 210. In addition, managing the first information 241 includes storing the first information 241 in the HIS server 254. In addition, managing the first information 241 includes transmitting the first information 241 to the blood vessel X-ray imaging device 270 or the like.

[0144] The server 250 is configured to generate second information 242 associated with the susceptibility gene based on the first information 241 included in the gene-related information 240 generated by the detection device 210 .

[0145] In the present embodiment, the server 250 is configured to store the identification information 245a of the patient 1. In addition, the server 250 is connected in a manner capable of communicating with the detection device 210. In addition, the server 250 is configured to associate the set identification information 245a of the patient 1 with the stored identification information 245a of the patient 1, and associate at least one of the stored identification information 245a of the patient 1 and the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 with the gene association information 240 for management. In addition, in the present embodiment, the process of setting the identification information 245a of the patient 1 to the gene association information 240 is performed by the detection device 210 that generates the gene association information 240.

[0146] In this embodiment, the server 250 is configured to: Figure 1 ) is associated with the identification information 245a of the patient 1 to associate at least one of the first information 241 and the second information 242 with the patient information 245 of the patient 1 for management. In the present embodiment, the HIS server 254 is configured to associate the second information 242 with the patient information 245. In addition, the HIS server 254 is configured to store the second information 242 in a state of being associated with the patient information 245.

[0147] In addition, the HIS server 254 transmits the imaging request 202 of the patient 1 to the RIS server 252. The RIS server 252 transmits the imaging request 202 to the instrument treatment device 105 based on the received imaging request 202. Specifically, when a request to obtain the CT image 6 of the patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the CT apparatus 101. In addition, when a request to obtain the MRI image 7 of the patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the MRI apparatus 102. Here, the imaging request 202 can include the patient information 245.

[0148] The equipment treatment device 105 (here, the CT apparatus 101 or the MRI apparatus 102 ) that receives the imaging request 202 performs imaging of the patient 1 . After the imaging is completed, the equipment treatment device 105 transmits the acquired image (the CT image 6 or the MRI image 7 ) to the DICOM server 253 .

[0149] The DICOM server 253 stores the transmitted image (CT image 6 or MRI image 7). Here, by matching the patient information 245 included in the imaging request 202 with the patient information 245 stored in the HIS server 254, at least one of the first information 241 and the second information 242 stored in the HIS server 254 and the patient information 245 can be stored in the header of the transmitted image. In addition, the DICOM server 253 transmits imaging completion information 203 indicating that imaging of the image (CT image 6 or MRI image 7) has been completed to the HIS server 254.

[0150] The HIS server 254 that has received the photography completion information 203 stores the fact that the photography of the transmitted photography request 202 has been completed.

[0151] In addition, the instrumentation treatment device 105 acquires the first information 241 , the second information 242 , and the image (the CT image 6 or the MRI image 7 ) by sending requests (requests 204 , 206 , and 207 ) to the server 250 .

[0152] Specifically, when diagnosing cerebral infarction, the image viewing terminal 80 is configured to obtain an image (CT image 6 or MRI image 7) from the DICOM server 253 by operation by a doctor or the like. The image viewing terminal 80 is operated by a doctor or the like to send an image transmission request 204 to the DICOM server 253. The DICOM server 253 that receives the image transmission request 204 sends the image (CT image 6 or MRI image 7) to the image viewing terminal 80. For example, the doctor or the like prepares a diagnosis report 205 related to a stenosis site, etc. based on the image (CT image 6 or MRI image 7) sent to the image viewing terminal 80. The prepared diagnosis report 205 is, for example, sent to the DICOM server 253. The DICOM server 253 stores the sent diagnosis report 205.

[0153] In addition, when treating cerebral infarction, the vascular X-ray imaging device 270 sends a request 206 and a request 207 to the server 250 to obtain at least one of the first information 241 and the second information 242 and an image (CT image 6 or MRI image 7). The vascular X-ray imaging device 270 obtains the information and the image sent from the server 250 in response to the request 206 and the request 207.

[0154] Here, refer to Fig.11 A configuration in which the server 250 transmits at least one of the first information 241 and the second information 242 and an image (the CT image 6 or the MRI image 7 ) to the vascular X-ray imaging apparatus 270 will be described.

[0155] like Fig.11 As shown, the vascular X-ray imaging device 270 is configured to send a request 206 to the RIS server 252 to obtain at least one of the first information 241 and the second information 242 through operation by a doctor or the like. When sending the transmission request 206, the vascular X-ray imaging device 270 also sends the identification information 245a.

[0156] The RIS server 252 that receives the request 206 sends the request 206 and the identification information 245 a to the HIS server 254 .

[0157] The HIS server 254 that has received the request 206 transmits at least either the first information 241 associated with the identification information 245 a or the second information 242 associated with the identification information 245 a to the RIS server 252 based on the received identification information 245 a .

[0158] The RIS server 252 transmits at least one of the received first information 241 and second information 242 to the blood vessel X-ray imaging apparatus 270 .

[0159] Furthermore, the vascular X-ray imaging device 270 transmits a transmission request 207 of an image (CT image 6 or MRI image 7) to the DICOM server 253 based on an operation by a doctor or the like. When transmitting the transmission request 207, the vascular X-ray imaging device 270 also transmits the identification information 245a.

[0160] The DICOM server 253 that has received the transmission request 207 identifies the image (CT image 6 or MRI image 7) of the patient 1 from the stored plurality of images (CT image 6 or MRI image 7) based on the identification information 245a. The DICOM server 253 transmits the identified image (CT image 6 or MRI image 7) to the vascular X-ray imaging apparatus 270 via the RIS server 252.

[0161] That is, the server 250 is configured to associate the second information 242 with the CT image 6 or the MRI image 7 of the patient 1 using the identification information 245a. In addition, the server 250 is configured to send at least one of the first information 241 and the second information 242 to the vascular X-ray imaging device 270. In the present embodiment, the server 250 sends the CT image 6 or the MRI image 7 of the patient 1 and the second information 242 to the vascular X-ray imaging device 270 based on the request 206 and the request 207 from the vascular X-ray imaging device 270.

[0162] In addition, in the present embodiment, the RIS server 252 is configured to send at least one of the first information 241 and the second information 242 to the vascular X-ray imaging apparatus 270. However, when at least one of the first information 241 and the second information 242 is stored in the CT image 6 or the MRI image 7 of the patient 1 stored in the DICOM server 253, it is not necessary for the RIS server 252 to send at least one of the first information 241 and the second information 242. In this case, at least one of the first information 241 and the second information 242 can be stored in the head of the CT image 6 or the MRI image 7 of the patient 1.

[0163] (Sending process of first information and / or second information)

[0164] Next, refer to Fig.12 The process of the server 250 generating the first information 241 and the second information 242 will be described.

[0165] In step 301 , the detection device 210 measures the biological sample 2 collected from the patient 1 and generates gene-related information 240 associated with susceptibility genes related to cerebral infarction. The detection device 210 transmits the generated gene-related information 240 to the server 250 .

[0166] In step 302 , the detection device 210 sets the identification information 245 a of the patient 1 in the gene-related information 240 .

[0167] In step 303 , the server 250 associates the set identification information 245 a of the patient 1 with the identification information 245 a of the patient stored in the server 250 .

[0168] In step 304, the server 250 associates at least one of the identification information 245a of the patient 1 stored in the server 250 and the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 with the gene association information 240 for management. In addition, the gene association information 240 includes first information 241 indicating whether the biological sample 2 has a susceptibility gene related to cerebral infarction and second information 242 related to the susceptibility gene generated based on the first information 241. In the present embodiment, the server 250 associates at least one of the identification information 245a of the patient 1 stored in the server 250 and the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 with at least one of the first information 241 and the second information 242 for management. Specifically, the server 250 associates the second information 242 with the patient information 245 for management.

[0169] In step 305, the server 250 determines whether there is a request 206 from the blood vessel X-ray imaging device 270 to transmit the first information 241 and / or the second information 242. If there is a request 206, the process proceeds to step 306. If there is no request 206, the process ends.

[0170] In step 306, the server 250 transmits at least one of the first information 241 and the second information 242 to the blood vessel X-ray imaging device 270. Thereafter, the process ends.

[0171] (Delete the first message)

[0172] In this embodiment, the HIS server 254 is configured to delete the first information 241 immediately after associating the second information 242 with the patient information 245, or delete the first information 241 after a predetermined period of time, or delete the first information 241 based on the information 208 indicating the end of treatment from the vascular X-ray imaging device 270 (see Fig.10 ) to delete the first information 241, and store the second information 242 in a state of being associated with the patient information 245. In the present embodiment, the HIS server 254 is configured to delete the first information 241 based on the information 208 indicating the end of treatment from the vascular X-ray imaging device 270 after associating the second information 242 with the patient information 245.

[0173] Next, refer to Fig.13 Based on the information 208 indicating the end of treatment (refer to Fig.10 ) is used to delete the first information 241, and the deletion process of the first information 241 is described.

[0174] In step 401, the server 250 determines whether the information 208 indicating the end of treatment is transmitted from the vascular X-ray imaging device 270. If the server 250 receives the information 208 indicating the end of treatment from the vascular X-ray imaging device 270, the process proceeds to step 402. If the server 250 does not receive the information 208 indicating the end of treatment from the vascular X-ray imaging device 270, the server 250 repeats the process of step 401.

[0175] In step 402, the server 250 deletes the first information 241. Thereafter, the process ends.

[0176] (Transmission of Second Information and CT Image or MRI Image)

[0177] Next, refer to Fig.14 A description will be given of a process in which the server 250 transmits the second information 242 and the CT image 6 or the MRI image 7 of the patient 1 to the vascular X-ray imaging apparatus 270 .

[0178] In step 410, the DICOM server 253 determines whether there is a request 207 for sending an image (CT image 6 or MRI image 7) from the vascular X-ray imaging device 270. If there is a request for sending an image, the process proceeds to step 411. If there is no request for sending an image, the process of step 410 is repeated. In addition, when the transmission request 207 is transmitted from the vascular X-ray imaging device 270, the identification information 245a is also transmitted.

[0179] Next, in step 411, the DICOM server 253 (server 250) uses the identification information 245a to associate the second information 242 with the CT image 6 or the MRI image 7 of the patient 1. Specifically, the DICOM server 253 that has received the sending request 207 determines the image (CT image 6 or MRI image 7) of the patient 1 from the stored multiple images (CT image 6 or MRI image 7) based on the identification information 245a, thereby associating the second information 242 with the image (CT image 6 or MRI image 7).

[0180] Next, in step 412, the DICOM server 253 (server 250) transmits the determined image (CT image 6 or MRI image 7) to the vascular X-ray imaging apparatus 270 via the RIS server 252. That is, the DICOM server 253 (server 250) transmits the CT image 6 or MRI image 7 of the patient 1 and the second information 242 to the vascular X-ray imaging apparatus 270 based on the request 206 and the request 207 from the vascular X-ray imaging apparatus 270. Thereafter, the processing ends.

[0181] (Angiography Device)

[0182] The blood vessel X-ray imaging device 270 (see Fig.11 ) For example Fig.15 The angiography apparatus 500 shown in FIG.

[0183] (Structure of angiography device)

[0184] like Fig.15 and Fig.16 As shown, the angiography apparatus 500 of this embodiment includes a table 501 for placing a patient 1 , an imaging unit 502 including an X-ray source 521 and a detection unit 522 , an image processing unit 503 , a control unit 504 , and a display unit 505 .

[0185] The top plate 501 is formed in a rectangular flat plate shape when viewed from above. With respect to the top plate 501, the patient 1 is placed on the top plate in such a manner that the head and feet direction of the patient 1 is the direction along the long side of the rectangle and the left and right direction of the patient 1 is the direction along the short side of the rectangle. In addition, in this specification, the head and feet direction of the patient 1 is referred to as the X direction, the left and right direction of the patient 1 is referred to as the Z direction, and the direction orthogonal to the X direction and the Z direction is referred to as the Y direction.

[0186] The imaging unit 502 is configured such that the X-ray source 521 irradiates the patient 1 with X-rays, and the detection unit 522 detects the X-rays that have passed through the patient 1 .

[0187] like Fig.16 As shown in (b), the X-ray source 521 is installed at the front end of one side of the C-shaped holding portion 523. The X-ray source 521 is applied with voltage by an X-ray tube driving unit (not shown), thereby being able to irradiate X-rays to the patient 1. The X-ray source 521 has a collimator that can adjust the X-ray irradiation field that is the irradiation range of the X-rays.

[0188] The detection unit 522 is mounted on the front end of the other side of the holding unit 523. That is, the detection unit 522 is arranged on the side opposite to the X-ray source 521 across the top plate 501. The detection unit 522 is configured to be arranged facing the X-ray source 521, so that it can detect X-rays that have passed through the patient 1. The detection unit 522 includes, for example, an FPD (Flat Panel Detector).

[0189] like Fig.15 As shown, the image processing unit 503 is a computer including a processor such as a GPU (Graphics Processing Unit) or an FPGA (Field-Programmable Gate Array) configured for image processing. The image processing unit functions as an image processing device by executing an image processing program.

[0190] The image processing unit 503 is configured to generate a fluoroscopic image 520 (see FIG. 5 ) of the patient 1 based on the detection signal output from the detection unit 522. Fig.17 ).

[0191] The control unit 504 is a computer including a CPU (central processing unit), a ROM (Read Only Memory), a RAM (random access memory), and the like.

[0192] The control unit 504 is configured to obtain the CT image 6 or the MRI image 7 from the server 506. The server 506 is connected to the server 250 (see Fig.10 and Fig.11 ) has the same structure, so detailed description is omitted.

[0193] like Fig.15 As shown, the control unit 504 is configured to acquire the CT image 6 or the MRI image 7 of the patient 1 who has undergone fluoroscopy from the server 506 based on the patient information 545 of the patient 1 who has undergone fluoroscopy.

[0194] The control unit 504 is configured to select, from the CT images 6 or MRI images 7 of the patient 1 who has undergone fluoroscopic imaging, the CT image 6 or MRI image 7 having the same spatial coordinates as the fluoroscopic image 520 generated by the image processing unit 503 . Fig.17 1 is a schematic diagram showing a process of generating a superimposed image 530 of the head 550 of the patient 1 . The control unit 504 is configured to control the display unit 505 to superimpose (layer) the fluoroscopic image 520 and the acquired CT image 6 or MRI image 7 .

[0195] like Fig.17 As shown, the control unit 504 is configured to perform the following control: when the treatment position (thrombus site) 511 is associated with the CT image 6 or the MRI image 7, the treatment position 511 is displayed on the display unit 505 together with the superimposed image 530. Fig.17 In FIG. 5 , a mark 531 is marked on the treatment position 511. The mark 531 may be a graphic surrounding the treatment position 511 or may be an arrow.

[0196] The control unit 504 is configured to perform the following control: obtain the gene information 540 that is consistent with the patient information 545 of the patient 1 who has undergone fluoroscopic photography from the server 506. The gene information 540 includes at least one of the first information 541 and the second information 542. In addition, the first information 541 is consistent with the first information 41 (refer to Figure 4 ). That is, the first information 541 includes the patient information 545 and the information on the presence / absence of gene polymorphism. In addition, the second information 542 is the same as the second information 42 (refer to Figure 4 That is, the second information 542 includes at least one of the information 42a related to the type of cerebral infarction, the information 42b related to the cerebral blood vessels of the patient 1, and the information 42c indicating the treatment device recommended or not recommended for the catheter treatment of cerebral infarction of the patient 1.

[0197] The control unit 504 is configured to perform the following control: the gene information 540 is also displayed on the image obtained by superimposing the fluoroscopic image 520 and the CT image 6 or the MRI image 7 displayed on the display unit 505. The control unit 504 is configured to perform control to display the gene information 540 at a position that does not overlap with the treatment position 511. Fig.17 In this way, when the mark 531 indicating the treatment position 511 is displayed, the position that does not overlap with the treatment position 511 is the position that does not overlap with the mark 531 .

[0198] The display unit 505 is a monitor provided in the angiography apparatus 500. Fig.17 As shown in FIG. 5 , the catheter 512 is clearly captured in the perspective image 520, but the blood vessel 513 is not clear. Therefore, by superimposing the CT image 6 or the MRI image 7, a superimposed image 530 is generated in which the catheter 512 and the blood vessel 513 are superimposed. Fig.17 As shown, in the superimposed image 530, in order to make the catheter 512 clear, the pixel value of the blood vessel 513 is inverted. Fig.17 In order to show that the pixel value of the blood vessel 513 is inverted and set to white, the pixel value of the catheter 512 can also be inverted. In addition, the mark 531 indicating the treatment position 511 and the gene information 540 are displayed in the superimposed image. Fig.17In the embodiment, the gene information 540 is represented by characters. By displaying the superimposed image 530, the treatment position 511 and the gene information 540 on the display unit 505 disposed in the angiography device 500, a doctor or the like can confirm the treatment. The displayed gene information 540 is at least one of the first information 541 and the second information 542.

[0199] (Diagnosis process of doctors, etc.)

[0200] When a patient 1 suffering from cerebral infarction is transported to a hospital, a doctor or the like captures a CT image 6 or an MRI image 7 .

[0201] In CT imaging, the imaging unit is moved rotationally to image the patient from multiple directions. Fig.18 As shown in (a), multiple two-dimensional image data are generated in CT photography. Fig.18 (a) shows an image obtained by shooting while moving in the head-to-foot direction (X direction). Fig.18 By reconstructing a plurality of two-dimensional CT images 6 captured continuously as in (b), three-dimensional image data can be generated. The desired CT image 6 can be obtained by cutting the three-dimensional data in any direction. For example, in the case where the blood vessel 513 extends in the head-foot direction, it can also be Fig.18 The reconstructed three-dimensional image data is cut in a direction parallel to the head-foot direction (X direction) as shown in (c).

[0202] In addition, three-dimensional image data can also be generated by reconstructing the MRI image 7. By cutting the generated three-dimensional image data in the extending direction of the blood vessel, an image of the blood vessel 513 can be generated.

[0203] The doctor or the like confirms the treatment position 511 as the treatment position based on the captured CT image 6 or MRI image 7 in the image reading room 901. The doctor or the like selects the treatment position 511 of the CT image 6 or MRI image 7 and marks the treatment position 511, thereby associating the treatment position 511 with the CT image 6 or MRI image 7.

[0204] In the case of the CT image 6, the doctor or the like can identify the treatment position 511 by the CT value which is the absorption value of X-rays. Here, in the case of cerebral infarction, a thrombus is generated in the blood vessel 513 of the treatment position 511. The thrombus has a higher CT value than the blood vessel injected with the contrast agent due to absorption of X-rays, and appears black compared to the blood vessel without thrombus. The doctor or the like determines the treatment position 511 based on the difference in CT values.

[0205] In the case of the MRI image 7, the doctor or the like can determine the treatment position 511 by the detection signal. Since the detection signal is strong in a part with fast blood flow and weak in a part with slow blood flow, the blood vessels with slow blood flow (where cerebral infarction has occurred) appear darker than other blood vessels. Therefore, the doctor or the like determines the treatment position 511.

[0206] After the doctor etc. finishes taking the CT image 6 and the MRI image 7 of the patient 1, he or she starts treatment to remove the blood clot. Fig.17 As shown in FIG. 1 , when a doctor or the like starts fluoroscopy for treatment, a superimposed image 530 formed by superimposing the fluoroscopy image 520 and the CT image 6 or the MRI image 7 and gene information 540 are displayed on the display unit 505. Fig.17 As shown, a mark 531 is marked on the treatment position 511 of the CT image 6 or the MRI image 7, so that even if the doctor who performs treatment is different from the doctor who diagnoses in the image reading room 901, the treatment position 511 can be confirmed. The superimposed image 530 and the gene information 540 are displayed on the display unit 505, so that the doctor can smoothly perform the operation.

[0207] Next, refer to Fig.19 The operation of fluoroscopic imaging by the angiography apparatus 500 will be described.

[0208] In step 601, the angiography device 500 starts angiography by receiving an input from the user. When angiography starts, the angiography device 500 irradiates the patient 1 with X-rays from the X-ray source 521. The detector 522 detects the X-rays that have passed through the patient 1 and outputs a detection signal.

[0209] In step 602 , the image processing unit 503 generates a fluoroscopic image 520 based on the detection signal.

[0210] In step 603 , the control unit 504 performs control to acquire, from the server 506 , the CT image 6 or the MRI image 7 having the same spatial position coordinates as the fluoroscopic image 520 generated in step 602 .

[0211] In step 604 , the control unit 504 performs control to display the fluoroscopic image 520 and the acquired CT image 6 or MRI image 7 on the display unit 505 in a superimposed manner.

[0212] In step 605 , the control unit 504 performs control to acquire gene information 540 that matches the patient information 545 from the server.

[0213] In step 606 , the control unit 504 controls the display unit 505 to display the acquired gene information 540 and a superimposed image 530 in which the fluoroscopic image 520 and the CT image 6 or the MRI image 7 are superimposed.

[0214] (Effects of this embodiment)

[0215] In this embodiment, the following effects can be obtained.

[0216] As described above, the cerebral infarction treatment support system 100 of the present embodiment comprises: a detection device 10, which measures a biological sample 2 collected from a patient 1 and generates first information 41 indicating whether the biological sample 2 has a susceptibility gene related to cerebral infarction; a display unit 30, which is arranged in either a catheter room 902 or a film reading room 901, wherein the catheter room 902 is equipped with a vascular X-ray imaging device 70, and the film reading room 901 is equipped with an image viewing terminal 80 for radiological diagnostic images or MRI images; and an image control unit 20, which controls the display unit 30, wherein the image control unit 20 includes: a receiving unit 21, which receives at least one of the first information 41 generated by the detection device 10 and the second information 42 associated with the susceptibility gene generated based on the first information 41; and an image output unit 22, which outputs at least one of the received first information 41 and the second information 42 to the display unit 30.

[0217] In addition, as described above, the cerebral infarction treatment auxiliary method of this embodiment includes the following steps: measuring the biological sample 2 collected from the patient 1 to generate first information 41 whether the biological sample 2 has a susceptibility gene related to cerebral infarction; receiving at least one of the generated first information 41 and the second information 42 associated with the susceptibility gene generated based on the first information 41; and outputting at least one of the received first information 41 and the second information 42 to the display unit 30, wherein the display unit 30 is configured in at least one of the catheter room 902 and the reading room 901, the catheter room 902 is configured with a vascular X-ray imaging device 70, and the reading room 901 is configured with an image viewing terminal 80 for radiological diagnostic images or MRI images.

[0218] In the cerebral infarction treatment support system 100 and the cerebral infarction treatment support method of the present embodiment, according to the above-mentioned structure, when treating a cerebral infarction patient 1 in the acute stage, at least one of the first information 41 of whether the patient 1 has a susceptibility gene related to cerebral infarction and the second information 42 generated based on the first information 41 can be displayed on the display unit 30 (second display unit 82) arranged in the image reading room 901, and the image reading room 901 is used to determine the type of cerebral infarction, determine the location of the existence of thrombus, etc. Therefore, if at least one of the first information 41 and the second information 42 is displayed when making a diagnosis such as determining the type of cerebral infarction and determining the location of the existence of thrombus, the doctor can determine the type of cerebral infarction based on the information of the presence or absence of susceptibility gene that cannot be obtained from the image information, in addition to reading the image based on the previous CT image 6 or MRI image 7. Furthermore, if at least one of the first information 41 and the second information 42 is displayed on the display unit 30 (first display unit 72) disposed in the catheter room 902 for treating the patient 1 suffering from cerebral infarction during treatment, the doctor who actually performs the treatment can select a treatment device for catheter treatment corresponding to the type of cerebral infarction based on the information on the presence or absence of the susceptibility gene. Based on the above, auxiliary information that helps the doctor determine the type of cerebral infarction can be presented during the diagnosis or treatment of cerebral infarction in the acute stage.

[0219] In addition, in the above-mentioned embodiment, further effects can be obtained by configuring as follows.

[0220] That is, in the above embodiment, the image control unit 20 is configured to receive at least the second information 42 and output it to the display unit 30, wherein the second information 42 includes at least one of the information 42a related to the type of cerebral infarction, the information 42b related to the cerebral blood vessels of the patient 1, and the information 42c indicating the treatment device recommended or not recommended for the catheter treatment of cerebral infarction of the patient 1. According to such a configuration, the second information 42 derived based on the first information 41 on whether there is a susceptibility gene related to cerebral infarction can present particularly useful auxiliary information to a doctor who diagnoses or treats cerebral infarction in the acute stage.

[0221] In addition, in the above-mentioned embodiment, the detection device 10 assigns the patient information 45 of the patient 1 from whom the biological sample 2 is collected to the first information 41, and the image control unit 20 receives the image of the patient 1 assigned with the patient information 45, and outputs at least one of the first information 41 and the second information 42, and the image to the display unit 30, and the image, the first information 41, and the second information 42 have the same patient information 45. According to such a configuration, an image used for treatment or diagnosis can be associated with the first information 41 and / or the second information 42 through the patient information 45. Therefore, even in an emergency such as when treating or diagnosing the patient 1 with cerebral infarction in the acute stage, these images and information can be collected and reliably provided to the doctor without resorting to unreliable communication means such as oral communication.

[0222] In addition, in the above-mentioned embodiment, the image control unit 20 includes the first control device 71 provided in the vascular X-ray imaging device 70 installed in the catheter room 902, and the display unit 30 includes the first display unit 72 installed in the catheter room 902 and displays the X-ray image 73 of the vascular X-ray imaging device 70. According to such a configuration, the first information 41 and / or the second information 42 can be received by the vascular X-ray imaging device 70 used when performing catheter treatment and displayed on the display unit 30. Therefore, it is not necessary to provide a dedicated device for displaying the first information 41 and / or the second information 42, and the system configuration can be simplified.

[0223] In addition, in the above-mentioned embodiment, the first control device 71 is configured to output at least one of the received first information 41 and the second information 42 and the X-ray image 73 of the patient 1 captured by the vascular X-ray imaging device 70 to the first display unit 72 when the catheter treatment is performed on the patient 1 in the catheter room 902. According to such a configuration, the first information 41 and / or the second information 42 can be displayed together with the X-ray image 73 captured by the catheter during the catheter treatment. Therefore, the first information 41 and / or the second information 42 can be reliably presented to the doctor who actually performs the catheter treatment.

[0224] In addition, in the above-mentioned embodiment, the image control unit 20 includes the second control device 81 provided in the image reading terminal 80 provided in the image reading room 901, and the display unit 30 includes the second display unit 82 provided in the image reading room 901 for displaying the screen of the image reading terminal 80. According to such a configuration, the image reading terminal 80 in the image reading room 901 used when diagnosing the patient 1 suffering from cerebral infarction can receive the first information 41 and / or the second information 42 and display it on the display unit 30. Therefore, it is not necessary to provide a dedicated device for displaying the first information 41 and / or the second information 42, and the system configuration can be simplified.

[0225] In addition, in the above-mentioned embodiment, the second control device 81 is configured to receive at least one of the first information 41 and the second information 42 and the CT image 6 or the MRI image 7 of the patient 1 and output them to the second display unit 82 when diagnosing the patient 1 in the film reading room 901. According to such a configuration, when diagnosing the patient 1 suffering from cerebral infarction, the first information 41 and / or the second information 42 can be displayed together with the CT image 6 or the MRI image 7 used for diagnosis. Therefore, the first information 41 and / or the second information 42 can be reliably presented to the doctor who actually determines the type of cerebral infarction.

[0226] In addition, in the above embodiment, a server 50 is further provided, which is connected to the detection device 10 and the image control unit 20 in a manner that can communicate, and is used to store the first information 41. The server 50 generates the second information 42 based on the first information 41, and the image control unit 20 receives at least the second information 42 from the server 50. According to such a configuration, the second information 42 can be automatically generated based on the first information 41 generated by the detection device 10, and presented to a doctor or the like during treatment or diagnosis. Therefore, even in an emergency such as during treatment or diagnosis of a patient 1 with acute cerebral infarction, useful auxiliary information can be reliably presented to a doctor engaged in diagnosis or treatment.

[0227] In addition, in the above-mentioned embodiment, the server 50 includes at least one of a radiology information system server (RIS server 52) connected to a network within the hospital and a medical image management system server (DICOM server 53) connected to a network within the hospital. According to such a configuration, the second information 42 can be generated by a server (52 or 53) of an existing network constructed within the hospital. In addition, since each of the above-mentioned servers (52 or 53) processes radiological images or medical images, it is possible to easily associate images (CT images 6, MRI images 7, X-ray images 73 during treatment) referred to by doctors during treatment or diagnosis of a patient 1 with cerebral infarction with the second information 42 for management and provision.

[0228] In addition, in the above-mentioned embodiment, the susceptibility gene related to cerebral infarction includes the gene polymorphism of RNF213 p.R4810K. According to such a configuration, the first information 41 of whether the gene polymorphism of RNF213p.R4810K is present to the doctor. Based on the first information 41, the doctor and the like can obtain the following insights useful for treatment and diagnosis: the type of cerebral infarction suffered by the patient 1 is significantly more likely to be atherothrombotic cerebral infarction, and the blood vessel diameter of the main cerebral blood vessels tends to be small, and as a result, the thrombus retrieval device needs to be used with caution during catheter treatment, and even when the thrombus retrieval device is used, it is preferred to use a thrombus retrieval device with a diameter smaller than the usual diameter, etc.

[0229] In addition, in the above-mentioned embodiment, the detection device 10 includes a gene amplification detection device, which is configured to perform a gene amplification process on a biological sample 2 containing a specimen 2a containing blood or saliva collected from a patient 1 and a reaction solution 2c, wherein the specimen 2a contains blood or saliva collected from a patient 1, and the reaction solution 2c contains a component for suppressing the influence of an inhibitory substance in the specimen 2a. According to such a configuration, the detection device 10 can directly measure the biological sample 2 collected from the patient 1 to generate the first information 41 without performing a purification process for removing inhibitory substances in the biological sample 2 to purify the gene. Therefore, compared with the case where the purification process is performed, it is not necessary to perform a part of the pretreatment (purification process) required for the measurement by the detection device 10, so the first information 41 can be generated quickly. Therefore, the above-mentioned structure is particularly useful in the following aspects: the first information 41 can be provided to the doctor as soon as possible in an emergency such as when treating or diagnosing a patient 1 with cerebral infarction in the acute stage.

[0230] In addition, in the above-mentioned embodiment, the detection device 10 includes a gene amplification detection device that performs a real-time PCR method, and the real-time PCR method uses a labeling substance to perform a labeling process during the amplification process of the gene. According to such a configuration, the first information 41 can be generated quickly compared to the usual (non-real-time) PCR method that performs a labeling process after amplification. Therefore, the above-mentioned structure is particularly useful in the following aspects: the first information 41 can be provided to the doctor as soon as possible in an emergency such as when treating or diagnosing the acute phase cerebral infarction patient 1.

[0231] In addition, the above-mentioned embodiment further includes the following steps: assigning the patient information 45 of the patient 1 to the first information 41 generated based on the biological sample 2 collected from the patient 1 transported as an emergency patient, and displaying at least one of the received first information 41 and the second information 42 together with the patient information 45 on the display unit 30 at least before the treatment of the patient 1. According to such a configuration, even in an emergency such as the treatment of the patient 1 with cerebral infarction in the acute stage, the patient 1 can be identified based on the patient information 45 and the first information 41 together with the patient information 45 can be reliably presented to the doctor.

[0232] [Example]

[0233] The present inventors will describe the results (symptoms) obtained by confirming the presence or absence of the RNF213 p.R4810K polymorphism in patients with cerebral infarction.

[0234] The inventors of the present application took MRI images and MRA (Magnetic Resonance Angiography) images of a patient who was urgently transported to the hospital, and confirmed that cerebral infarction had occurred in the main cerebral artery.

[0235] The inventors of the present application used a thrombus suction device 5b to perform a treatment for removing a thrombus in a patient's blood vessel <Cerebral infarction treatment 1>. After performing the cerebral infarction treatment 1, it was found that the patient's blood vessel was reoccluded. Therefore, the inventors of the present application performed a treatment for dilating the blood vessel by placing a stent in the blood vessel using a percutaneous angioplasty device 5c. After performing the cerebral infarction treatment 2, it was found that the patient's blood vessel was reoccluded. Therefore, the inventors of the present application performed a treatment for dilating the blood vessel again using a percutaneous angioplasty device 5c <Cerebral infarction treatment 3>. In addition, an examination was performed to determine whether the patient had the RNF213p.R4810K gene polymorphism. As a result, the patient had the RNF213 p.R4810K gene polymorphism.

[0236] As the main cause of vascular reocclusion, intracranial artery stenosis is known to be associated with vascular narrowing, but in this disease, intracranial artery stenosis is not obvious. Therefore, according to the results of the research conducted by the inventors of the present application, the following conclusions were drawn: patients with RNF213 p.R4810K gene polymorphism tend to have thinner blood vessels (fragility of intracranial vascular endothelium) compared with patients without this gene polymorphism, so it is possible that vascular endothelial disorders may occur due to physical stimulation when using stents to recover thrombi, thereby causing vascular reocclusion. In this way, it was confirmed that the risk of vascular reocclusion is relatively high in patients with RNF213 p.R4810K gene polymorphism and fragile vascular endothelium.

[0237] Therefore, if information on whether the patient has the RNF213 p.R4810K gene polymorphism is provided in advance before treatment as in the above embodiment, the doctor can understand that a treatment device that comes into direct contact with a blood vessel should be avoided, and even when a treatment device that does not come into contact with a blood vessel is used, care should be taken not to apply physical stimulation to the blood vessel. In addition, the above results indicate that genetic information may also be useful for assessing the risk of reocclusion after surgery.

[0238] [Modifications]

[0239] In addition, the embodiments disclosed this time should be considered to be illustrative in all aspects and not restrictive. The scope of the present invention is not shown by the description of the above embodiments, but by the claims, and also includes all changes (modifications) within the meaning and scope equivalent to the claims.

[0240] For example, in the above embodiment, the second information 42 includes at least one of the information 42a related to the type of cerebral infarction, the information 42b related to the cerebral blood vessels, and the device information 42c, but the present invention is not limited thereto. The second information 42 may include information other than the above information as long as it is information derived from the first information 41.

[0241] In the above embodiment, an example is shown in which the patient information 45 is added to the first information 41 , but the present invention is not limited thereto. In the present invention, the patient information 45 may not be added to the first information 41 .

[0242] In addition, in the above embodiment, an example is shown in which at least one of the first information 41 and the second information 42 and images such as the CT image 6, the MRI image 7, and the X-ray image 73 are displayed on the display unit 30, but the present invention is not limited thereto. It is also possible to display at least one of the first information 41 and the second information 42 on the display unit 30 without displaying an image.

[0243] In the above embodiment, the detection device 10 is an example of a direct PCR device, but the present invention is not limited thereto. The detection device 10 may perform PCR on the biological sample 2 prepared by purification of DNA from the specimen 2a.

[0244] In addition, in the above embodiment, an example is shown in which the detection device 10 performs a real-time PCR method, but the present invention is not limited to this. The detection device 10 may be configured to perform a non-real-time PCR method.

[0245] [Way]

[0246] It will be understood by those skilled in the art that the above-described exemplary embodiments are specific examples of the following aspects.

[0247] (Item 1)

[0248] A cerebral infarction treatment auxiliary system, comprising:

[0249] A detection device that measures a biological sample collected from a patient and generates first information on whether the biological sample has a susceptibility gene related to cerebral infarction;

[0250] A display unit is arranged in at least one of a catheter room in which a vascular X-ray imaging device is arranged and an image viewing terminal for radiological diagnostic images or MRI images is arranged in the image reading room; and

[0251] an image control unit that controls the display unit,

[0252] Wherein, the image control unit includes:

[0253] a receiving unit that receives at least one of the first information generated by the detection device and second information associated with the susceptibility gene generated based on the first information; and

[0254] An image output unit outputs at least one of the received first information and the received second information to the display unit.

[0255] (Item 2)

[0256] The cerebral infarction treatment assisting system according to item 1, wherein:

[0257] The image control unit is configured to receive at least the second information and output the second information to the display unit.

[0258] The second information includes at least any one of information on the type of cerebral infarction, information on the cerebral blood vessels of the patient, and information indicating a treatment device that is recommended or not recommended for catheter treatment of cerebral infarction in the patient.

[0259] (Item 3)

[0260] The cerebral infarction treatment support system according to item 1 or 2, wherein:

[0261] The detection device adds patient information of the patient from whom the biological sample is collected to the first information,

[0262] The image control unit receives the image of the patient to which the patient information is assigned,

[0263] The image control unit outputs at least one of the first information and the second information and the image to the display unit, and the image, the first information, and the second information have the same patient information.

[0264] (Item 4)

[0265] The cerebral infarction treatment support system according to any one of items 1 to 3, wherein:

[0266] The image control unit includes a first control device provided in the vascular X-ray imaging device installed in the catheterization laboratory.

[0267] The display unit includes a first display unit that is provided in the catheter laboratory and displays an X-ray image of the blood vessel X-ray imaging device.

[0268] (Item 5)

[0269] The cerebral infarction treatment assisting system according to item 4, wherein:

[0270] The first control device is configured to output, to the first display unit, at least one of the received first information and the second information and the X-ray image of the patient captured by the vascular X-ray imaging device when catheter treatment is performed on the patient in the catheter laboratory.

[0271] (Item 6)

[0272] The cerebral infarction treatment support system according to any one of items 1 to 5, wherein:

[0273] The image control unit includes a second control device provided in the image viewing terminal installed in the image reading room.

[0274] The display unit includes a second display unit that is provided in the image reading room and displays a screen of the image viewing terminal.

[0275] (Item 7)

[0276] The cerebral infarction treatment assisting system according to item 6, wherein:

[0277] The second control device is configured to receive at least one of the first information and the second information and a CT image or an MRI image of the patient and output the received information to the second display unit when diagnosing the patient in the image reading room.

[0278] (Item 8)

[0279] The cerebral infarction treatment support system according to any one of items 1 to 7, wherein:

[0280] A server is further provided, the server being connected to the detection device and the image control unit in a manner capable of communicating with the detection device and the image control unit and being used to store the first information.

[0281] The server generates the second information based on the first information,

[0282] The image control unit receives at least the second information from the server.

[0283] (Item 9)

[0284] The cerebral infarction treatment assisting system according to item 8, wherein:

[0285] The server includes at least one of a radiology information system server connected to a network within the hospital and a medical image management system server connected to a network within the hospital.

[0286] (Item 10)

[0287] The cerebral infarction treatment support system according to any one of items 1 to 9, wherein:

[0288] The susceptibility genes associated with cerebral infarction include the gene polymorphism of RNF213 p.R4810K.

[0289] (Item 11)

[0290] The cerebral infarction treatment support system according to any one of items 1 to 10, wherein:

[0291] The detection device includes a gene amplification detection device, which is configured to perform gene amplification processing on the biological sample containing a specimen and a reaction solution, wherein the specimen contains blood or saliva collected from the patient, and the reaction solution contains a component for inhibiting the influence of inhibitory substances in the specimen.

[0292] (Item 12)

[0293] The cerebral infarction treatment support system according to any one of items 1 to 11, wherein:

[0294] The detection device includes a gene amplification detection device that performs a real-time PCR method, wherein the real-time PCR method uses a labeling substance to perform a labeling process during the gene amplification process.

[0295] (Item 13)

[0296] A method for assisting the treatment of cerebral infarction, comprising the following steps:

[0297] measuring a biological sample collected from a patient to generate first information on whether the biological sample contains a susceptibility gene related to cerebral infarction;

[0298] receiving at least either one of the generated first information and second information associated with the susceptibility gene generated based on the first information; and

[0299] outputting at least one of the received first information and the received second information to a display unit,

[0300] The display unit is arranged in at least one of a catheter room and an image reading room. The catheter room is provided with a vascular X-ray imaging device, and the image reading room is provided with an image viewing terminal for radiological diagnostic images or MRI images.

[0301] (Item 14)

[0302] The auxiliary method for treating cerebral infarction according to item 13, wherein:

[0303] The method further includes the steps of: adding patient information of the patient to the first information generated based on the biological sample, wherein the biological sample is collected from the patient transported as suffering from a disease,

[0304] At least before treatment of the patient, at least one of the received first information and the received second information is displayed on the display unit together with the patient information.

[0305] Description of Reference Numerals

[0306] 1: Patient; 2: Biological sample; 2a: Specimen; 2c: Reaction solution; 5: Treatment device; 6: CT image; 7: MRI image; 10: Detection device; 20: Image control unit; 21: Receiving unit; 22: Image output unit; 30: Display unit; 41: First information; 42: Second information; 42a: Information related to the type of cerebral infarction; 42b: Information related to the patient's cerebrovascular vessels; 42c: Device information (information indicating the treatment device); 45: Patient information; 50: Server; 52: Server; 52: RIS server (Radiology Information System Server); 53: DICOM server (Medical Image Management System Server); 70: Vascular X-ray imaging device; 71: First control unit; 72: First display unit; 73: X-ray image; 80: Image viewing terminal; 81: Second control unit; 82: Second display unit; 100: Cerebral infarction treatment support system; 901: Film reading room; 902: Catheter room.

Claims

1. A cerebral infarction treatment auxiliary system, comprising: A detection device that measures a biological sample collected from a patient and generates first information on whether the biological sample has a susceptibility gene related to cerebral infarction; A display unit is arranged in at least one of a catheter room, wherein the catheter room is provided with a vascular X-ray imaging device, and an image viewing terminal for radiological diagnostic images or MRI images is arranged in the image reading room; as well as an image control unit that controls the display unit, in, The image control unit includes: a receiving unit configured to receive at least one of the first information generated by the detection device and second information associated with the susceptibility gene generated based on the first information; as well as An image output unit outputs at least one of the received first information and the received second information to the display unit.

2. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The image control unit is configured to receive at least the second information and output the second information to the display unit. The second information includes at least any one of information on the type of cerebral infarction, information on the cerebral blood vessels of the patient, and information indicating a treatment device that is recommended or not recommended for catheter treatment of cerebral infarction in the patient.

3. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The detection device adds patient information of the patient from whom the biological sample is collected to the first information, The image control unit receives the image of the patient to which the patient information is assigned, The image control unit outputs at least one of the first information and the second information and the image to the display unit, and the image, the first information, and the second information have the same patient information.

4. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The image control unit includes a first control device provided in the vascular X-ray imaging device installed in the catheterization laboratory. The display unit includes a first display unit that is provided in the catheter laboratory and displays an X-ray image of the blood vessel X-ray imaging device.

5. The cerebral infarction treatment assisting system according to claim 4, characterized in that: The first control device is configured to output, to the first display unit, at least one of the received first information and the second information and the X-ray image of the patient captured by the vascular X-ray imaging device when catheter treatment is performed on the patient in the catheter laboratory.

6. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The image control unit includes a second control device provided in the image viewing terminal installed in the image reading room. The display unit includes a second display unit that is provided in the image reading room and displays a screen of the image viewing terminal.

7. The cerebral infarction treatment assisting system according to claim 6, characterized in that: The second control device is configured to receive at least one of the first information and the second information and a CT image or an MRI image of the patient and output the received information to the second display unit when diagnosing the patient in the image reading room.

8. The cerebral infarction treatment assisting system according to claim 1, characterized in that: A server is further provided, the server being connected to the detection device and the image control unit in a manner capable of communicating with the detection device and the image control unit and being used to store the first information. The server generates the second information based on the first information, The image control unit receives at least the second information from the server.

9. The cerebral infarction treatment assisting system according to claim 8, characterized in that: The server includes at least one of a radiology information system server connected to a network within the hospital and a medical image management system server connected to a network within the hospital.

10. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The susceptibility genes associated with cerebral infarction include the gene polymorphism of RNF213 p.R4810K.

11. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The detection device includes a gene amplification detection device, which is configured to perform gene amplification processing on the biological sample containing a specimen and a reaction solution, wherein the specimen contains blood or saliva collected from the patient, and the reaction solution contains a component for inhibiting the influence of inhibitory substances in the specimen.

12. The cerebral infarction treatment assisting system according to claim 1, characterized in that: The detection device includes a gene amplification detection device that performs a real-time PCR method, wherein the real-time PCR method uses a labeling substance to perform a labeling process during the gene amplification process.

13. A method for assisting the treatment of cerebral infarction, comprising the following steps: measuring a biological sample collected from a patient to generate first information on whether the biological sample contains a susceptibility gene related to cerebral infarction; receiving at least one of the generated first information and second information associated with the susceptibility gene generated based on the first information; as well as outputting at least one of the received first information and the received second information to a display unit, The display unit is arranged in at least one of a catheter room and an image reading room. The catheter room is provided with a vascular X-ray imaging device, and the image reading room is provided with an image viewing terminal for radiological diagnostic images or MRI images.

14. The auxiliary method for treating cerebral infarction according to claim 13, characterized in that: The following steps are also included: adding patient information of the patient to the first information generated based on the biological sample collected from the patient transported as suffering from a disease, At least before treatment of the patient, at least one of the received first information and the received second information is displayed on the display unit together with the patient information.

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