A membrane-protected micro-solid phase extraction device based on carboxylated covalent organic framework materials and its application

By carboxylation modification of the covalent organic frame material TpBD, a membrane-protected micro-solid-phase extraction device for heterocyclic amine enrichment in baked goods was prepared, which solved the problems of low extraction efficiency and poor adsorbent stability in the prior art, and achieved efficient and accurate detection of heterocyclic amines.

CN115639290BActive Publication Date: 2025-04-01SOUTH CHINA UNIV OF TECH +1
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Patent Information

Application Number
CN202211292034.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-10-21
Publication Date
2025-04-01
Estimated Expiration
2042-10-21

AI Technical Summary

Technical Problem

The prior art When detecting trace amounts of heterocyclic amine compounds in baked goods, the extraction efficiency is low and the accuracy is poor, and the adsorbent materials used are reduced in stability in complex matrix environments, which affects the efficiency and accuracy of the detection.

Method used

By carboxylation modification of the covalent organic frame material TpBD, a carboxylated covalent organic frame material was prepared and placed in a polypropylene microporous filter membrane to form a membrane-protected microsolid phase extraction device for efficient enrichment and detection of heterocyclic amines in food.

Benefits of technology

It realizes rapid and efficient enrichment and detection of heterocyclic amines in baked goods, with short adsorption equilibrium time and large adsorption amount, and strong affinity of the material for heterocyclic amines, reducing detection costs and labor costs.

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Abstract

The invention discloses a membrane-protected micro-solid phase extraction device based on a carboxylated covalent organic framework material and an application thereof. The preparation of the covalent organic framework material comprises the following steps: (1) using trialdehyde phloroglucinol and 3,3'-dihydroxybenzidine as organic ligands, and preparing the covalent organic framework material by a solvent thermal method under the catalytic action of acetic acid; (2) uniformly mixing the covalent organic framework material prepared in step (1) with a succinic anhydride solution and a catalyst 4-methylaminopyridine, collecting a solid reaction product after condensation and reflux, and preparing the carboxylated covalent organic framework material. The membrane-protected micro-solid phase extraction device using the covalent organic framework material as an adsorbent of the invention has a permanent porosity and an ordered crystalline structure, has a strong affinity for heterocyclic amine compounds, has a short adsorption equilibrium time, and has a large adsorption amount, can greatly simplify the sample pretreatment steps, and shortens the detection time and labor cost.
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