Construction method and application of fingerprint spectrum of blinding film

By constructing a fingerprint of the slug-ray film and using high-performance liquid chromatography methods to detect and analyze, the problem that the existing technology cannot accurately and comprehensively control the quality of the slug-ray film is solved, and comprehensive detection and quality control of the multi-chemical components of the drug are achieved.

CN116124937BActive Publication Date: 2025-03-25GUANGZHOU BAIYUNSHAN ZHONGYI PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202310027319.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-01-09
Publication Date
2025-03-25
Estimated Expiration
2043-01-09

AI Technical Summary

Technical Problem

The prior art cannot accurately and comprehensively control the quality of the slimming tablets, the thin layer identification accuracy is not high, and the determination elements in the content detection are relatively single, so it cannot fully reflect the material basis of the slimming tablets.

Method used

By constructing a fingerprint of a deficient film, the test samples and reference samples were detected by high-performance liquid chromatography method to generate a standard fingerprint map, and the fingerprint map of the deficient film was obtained through fingerprint map similarity analysis and chromatographic peak identification. The map contains 18 characteristic peaks, identifying the chemical composition of 9 of the chromatographic peaks.

Benefits of technology

It realizes multi-chemical component detection of illustrator tablets, comprehensively reflects the material basis of the drug, improves the accuracy and comprehensiveness of quality control, and ensures the stability, uniformity, effectiveness and controllability of the drug quality.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The present invention relates to the technical field of detection and analysis of components of traditional Chinese medicine, and specifically to a fingerprint spectrum of Zhanyanming tablets and a construction method and quality detection method thereof. The construction method comprises: extracting a test sample of Zhanyanming tablets to obtain a test sample solution; dissolving a reference sample to obtain a reference sample solution; using the same high performance liquid chromatography method to detect the test sample solution and the reference sample solution respectively to obtain a test sample spectrum and a reference spectrum; performing fingerprint spectrum similarity analysis on the test sample spectrum to generate a standard fingerprint spectrum, and identifying the chromatographic peaks of the standard spectrum according to the reference spectrum to obtain the fingerprint spectrum of Zhanyanming tablets. This experiment established the fingerprint spectrum method of Zhanyanming tablets for the first time, and screened a total of 18 characteristic common peaks for quality control and evaluation of Zhanyanming tablets, and can be used to examine production stability and batch consistency. The method is easy to operate, has good repeatability and good stability.
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