A method and system for judging spontaneous breathing trigger under a non-invasive ventilation mode for neonates

Abstract

The present invention proposes a method and system for determining the triggering of spontaneous breathing in a neonatal non-invasive ventilation mode, the method comprising the following steps: 1) obtaining the expiratory pressure data Lastp of the subject at time t0; t0 ; 2) The airway pressure value monitored by the pressure sensor is low-pass filtered to obtain low-pass data FilterData t0 ; 3) According to the above two data, the predicted value of the expiratory pressure data at time t1 is obtained PLastp t1 ; 4) Repeat steps 1) to 3) until N expiratory pressure data and expiratory pressure data prediction values are obtained, and go to step 5); 5) Draw the actual expiratory pressure line Pn based on the expiratory pressure data; 6) Draw the expiratory pressure baseline line P based on the expiratory pressure data prediction value; 7) If the difference between the expiratory pressure baseline line and the actual expiratory pressure line is greater than the preset trigger value, it is determined that the person being tested has triggered spontaneous breathing.

Description

Technical Field

[0001] The present invention belongs to the technical field of ventilators, and in particular relates to a method and system for determining spontaneous breathing triggering in a neonatal non-invasive ventilation mode. Background Art

[0002] Spontaneous breathing refers to a person's normal breathing, that is, breathing without any auxiliary equipment or external pressure. It is a basic physiological behavior of the human body. It mainly exhales waste gas from the body and inhales oxygen from the outside through the elastic contraction of the lungs, so as to achieve the purpose of absorbing oxygen and expelling carbon dioxide.

[0003] A ventilator is a device that replaces, controls, or alters normal physiological breathing, increasing lung ventilation, improving respiratory function, reducing the work of breathing, and conserving cardiac reserve capacity. Ventilators offer a variety of ventilation modes, one of which is Positive End Expiratory Pressure (PEEP). This technique maintains a constant pressure in the airway at the end of expiration while providing intermittent positive pressure ventilation. It plays an important role in treating respiratory distress syndrome, non-cardiogenic pulmonary edema, and pulmonary hemorrhage.

[0004] In a ventilator, determining whether the patient has triggered spontaneous breathing is a very important function. When the ventilator determines that the patient has triggered spontaneous breathing, the patient can be given mechanical ventilation. This can achieve good synchronization between man and machine and the patient will have better treatment.

[0005] The most commonly used spontaneous breathing triggering methods currently use the set expiratory pressure value as a benchmark. The set trigger level or pressure trigger condition is compared with the benchmark to determine whether to trigger spontaneous breathing. The specific process is as follows:

[0006] 1) Use the expiratory pressure value as the baseline value;

[0007] 2) Airway pressure value monitored by the pressure sensor during exhalation;

[0008] 3) Determine whether the difference between the read pressure value and the reference value meets the pressure trigger level or pressure trigger condition within a certain period of time;

[0009] 4) If the conditions are met, perform mechanical ventilation.

[0010] This judgment method uses expiratory pressure as a benchmark, and requires too high an expiratory pressure during the patient's spontaneous breathing. The patient cannot guarantee that the same expiratory pressure will be generated during each spontaneous breathing, which may lead to spontaneous breathing not being triggered or being triggered incorrectly, resulting in human-machine asynchrony. Summary of the Invention

[0011] The purpose of the present invention is to overcome the defects of the prior art and propose a method and system for determining the triggering of spontaneous breathing in a neonatal non-invasive ventilation mode.

[0012] To achieve the above objectives, the present invention proposes a method for determining spontaneous breathing triggering in a neonatal non-invasive ventilation mode, the method comprising:

[0013] Step 1) Obtain the exhalation pressure data Lastp of the subject at time t0 t0 ;

[0014] Step 2) The airway pressure value monitored by the pressure sensor is processed by low-pass filtering to obtain low-pass data FilterData t0 ;

[0015] Step 3) Obtain the predicted value of the expiratory pressure data PLastp at time t1 based on the above two data t1 ;

[0016] Step 4) Repeat steps 1) to 3) until N expiratory pressure data and expiratory pressure data prediction values are obtained, and then go to step 5);

[0017] Step 5) drawing an actual expiratory pressure line Pn based on the expiratory pressure data;

[0018] Step 6) drawing an expiratory pressure baseline P according to the predicted value of the expiratory pressure data;

[0019] Step 7) If the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than a preset trigger value, it is determined that the subject has triggered spontaneous breathing.

[0020] As an improvement to the above method, step 3) includes:

[0021] The predicted value of expiratory pressure data at time t1, PLastp, is obtained according to the following formula: t1 :

[0022] PLastp t1 =0.98×Lastp t0 +0.02×FilterData t0 .

[0023] As an improvement to the above method, the trigger value preset in step 7) is 0.2× the trigger level.

[0024] As an improvement to the above method, the trigger level is adjustable from 1 to 10 levels, and the smaller the trigger level, the higher the sensitivity.

[0025] On the other hand, the present invention provides a system for determining the triggering of spontaneous breathing in a neonatal non-invasive ventilation mode, the system comprising:

[0026] The exhalation pressure data acquisition module is used to obtain the exhalation pressure data Lastp of the subject at time t0. t0 ;

[0027] The low-pass processing module is used to obtain low-pass data FilterData by low-pass filtering the airway pressure value monitored by the pressure sensor t0 ;

[0028] The expiratory pressure data prediction value acquisition module is used to obtain the expiratory pressure data prediction value PLastp at time t1 based on the above two data t1 ;

[0029] A pressure line drawing module is used to repeat the processing of the above three modules until N expiratory pressure data and expiratory pressure data prediction values are obtained; draw an actual expiratory pressure line Pn based on the expiratory pressure data; draw an expiratory pressure baseline line P based on the expiratory pressure data prediction value; and

[0030] The trigger judgment module is used to judge that the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than a preset trigger value, and then determine that the subject has triggered spontaneous breathing.

[0031] As an improvement to the above system, the processing of the expiratory pressure data prediction value acquisition module includes:

[0032] The predicted value of expiratory pressure data at time t1, PLastp, is obtained according to the following formula: t1 :

[0033] PLastp t1 =0.98×Lastp t0 +0.02×FilterData t0 .

[0034] As an improvement to the above system, the trigger value preset by the trigger judgment module is 0.2×trigger level.

[0035] As an improvement to the above system, the trigger level is adjustable from 1 to 10 levels, and the smaller the trigger level, the higher the sensitivity.

[0036] Compared with the prior art, the advantages of the present invention are:

[0037] Since the method of the present invention determines a specific trend during the exhalation phase, it accurately determines the patient's spontaneous breathing and can effectively prevent false triggering or non-triggering. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 This is a flow chart of the method for determining spontaneous breathing triggering in the neonatal non-invasive ventilation mode of the present invention;

[0039] Figure 2 It is a schematic diagram of the actual exhalation pressure line and the exhalation pressure baseline line drawn by the method of the present invention. DETAILED DESCRIPTION

[0040] The present invention improves the spontaneous breathing triggering of the non-invasive nasal synchronized intermittent positive pressure ventilation mode for neonates. By using the expiratory pressure of each respiratory cycle as a benchmark, the inspiratory effort during spontaneous breathing is taken as a trend and compared with the expiratory pressure. This allows for a good comparison with the pressure triggering conditions to prevent false triggering or non-triggering.

[0041] The technical solution of the present invention is described in detail below with reference to the accompanying drawings and embodiments.

[0042] Example 1

[0043] like Figure 1 As shown, embodiment 1 of the present invention proposes a method for determining the triggering of spontaneous breathing in a neonatal non-invasive ventilation mode, the method comprising:

[0044] Step 1) Obtain the exhalation pressure data Lastp of the subject at time t0 t0 ;

[0045] Step 2) The airway pressure value monitored by the pressure sensor is processed by low-pass filtering to obtain low-pass data FilterData t0 ;

[0046] Step 3) Obtain the predicted value of the expiratory pressure data PLastp at time t1 based on the above two data t1 ;

[0047] Step 4) Repeat steps 1) to 3) until N expiratory pressure data and expiratory pressure data prediction values are obtained, and then go to step 5);

[0048] Step 5) drawing an actual expiratory pressure line Pn based on the expiratory pressure data;

[0049] Step 6) drawing an expiratory pressure baseline P according to the predicted value of the expiratory pressure data;

[0050] Step 7) If the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than a preset trigger value, it is determined that the subject has triggered spontaneous breathing.

[0051] The specific analysis is as follows:

[0052] In the exhalation phase, this method uses low-pass filtering to obtain the predicted exhalation pressure data value PLastp at time t1 according to the following formula: t1 :

[0053] PLastp t1=0.98×Lastp t0 +0.02×FilterData t0

[0054] Find the baseline P of the exhalation pressure and make the difference between the baseline and the current pressure value Pn, such as Figure 2 When the difference is greater than the trigger level multiplied by 0.2cmH2O (P-Pn>0.2*trigger level), it means that the patient has triggered spontaneous breathing. The trigger level is adjustable from 1 to 10. The smaller the value, the more sensitive the trigger. For example: when the trigger level is 1, the trigger parameter is 0.2cmH2O, when the trigger level is 2, the trigger parameter is 0.4cmH2O, and so on. The maximum trigger parameter is 2cmH2O.

[0055] Adjust the neonatal pediatric ventilator to SNIPPV (nasal synchronized intermittent positive pressure ventilation) mode, and set the parameters as follows: IPAP (inspiratory pressure) = 20 cmH2O, Ti (inspiratory time) = 1 s, f (respiratory rate) = 17 bpm, EPAP (expiratory pressure) = 5 cmH2O, FIO2 (oxygen concentration) = 40%, set the Trigger (trigger level), pull the simulated lung to trigger spontaneous breathing, and observe whether the neonatal pediatric ventilator triggers spontaneous breathing.

[0056] Example 2

[0057] Example 2 of the present invention proposes a system for determining spontaneous breathing triggering in a neonatal non-invasive ventilation mode, which is implemented based on the method of Example 1. The system includes:

[0058] The exhalation pressure data acquisition module is used to obtain the exhalation pressure data Lastp of the subject at time t0. t0 ;

[0059] The low-pass processing module is used to obtain low-pass data FilterData by low-pass filtering the airway pressure value monitored by the pressure sensor t0 ;

[0060] The expiratory pressure data prediction value acquisition module is used to obtain the expiratory pressure data prediction value PLastp at time t1 based on the above two data t1 ;

[0061] The pressure line drawing module is used to repeat the processing of the above three modules until N expiratory pressure data and expiratory pressure data prediction values are obtained; the actual expiratory pressure line Pn is drawn according to the expiratory pressure data; and the expiratory pressure baseline line P is drawn according to the expiratory pressure data prediction value;

[0062] The trigger judgment module is used to judge that the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than a preset trigger value, and then determine that the subject has triggered spontaneous breathing.

[0063] Verification analysis:

[0064] The following table lists the triggering conditions for different triggering levels using this method and the prior art.

[0065] Trigger Level Is this method triggered? Whether the existing method is triggered 1 trigger False triggering occurs 2 trigger False triggering occurs 5 trigger trigger 10 trigger trigger

[0066] As can be seen from the table, the prior art may cause false triggering when the trigger levels are 1 and 2. This further illustrates that the present method is accurate in judgment, can effectively prevent false triggering or non-triggering, and has the advantage of high sensitivity.

[0067] Finally, it should be noted that the above embodiments are intended only to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions to the technical solutions of the present invention do not depart from the spirit and scope of the technical solutions of the present invention and are intended to be encompassed by the claims of the present invention.

Claims

1. A method for determining spontaneous breathing triggering in a neonatal non-invasive ventilation mode, the method comprising: Step 1) Obtain the exhalation pressure data Lastp of the subject at time t0 t0 ; Step 2) The airway pressure value monitored by the pressure sensor is processed by low-pass filtering to obtain low-pass data FilterData t0 ; Step 3) Obtain the predicted value of the expiratory pressure data PLastp at time t1 based on the above two data t1 ; Step 4) Repeat steps 1) to 3) until N expiratory pressure data and expiratory pressure data prediction values are obtained, and then go to step 5); Step 5) drawing an actual expiratory pressure line Pn based on the expiratory pressure data; Step 6) drawing an expiratory pressure baseline P according to the predicted value of the expiratory pressure data; Step 7) If the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than a preset trigger value, it is determined that the subject has triggered spontaneous breathing; The step 3) comprises: The predicted value of expiratory pressure data at time t1, PLastp, is obtained according to the following formula: t1 : Plastic t1 =0.98×Lastp t0 +0.02×FilterData t0 。 2. The method for determining spontaneous breathing triggering in neonatal non-invasive ventilation mode according to claim 1, characterized in that: The trigger value preset in step 7) is 0.2× the trigger level.

3. The method for determining spontaneous breathing triggering in neonatal non-invasive ventilation mode according to claim 2, characterized in that: The trigger levels include 1-10, and the smaller the trigger level, the higher the sensitivity.

4. A spontaneous breathing trigger judgment system for neonates in non-invasive ventilation mode, characterized in that: The system comprises: The exhalation pressure data acquisition module is used to obtain the exhalation pressure data Lastp of the subject at time t0. t0 ; The low-pass processing module is used to obtain low-pass data FilterData by low-pass filtering the airway pressure value monitored by the pressure sensor t0 ; The expiratory pressure data prediction value acquisition module is used to obtain the expiratory pressure data prediction value PLastp at time t1 based on the above two data t1 ; A pressure line drawing module is used to repeat the processing of the above three modules until N expiratory pressure data and expiratory pressure data prediction values are obtained; draw an actual expiratory pressure line Pn based on the expiratory pressure data; draw an expiratory pressure baseline line P based on the expiratory pressure data prediction value; and The trigger judgment module is used to judge that the difference between the expiratory pressure baseline and the actual expiratory pressure line is greater than the preset trigger value, and then determine that the subject has triggered spontaneous breathing; The processing process of the expiratory pressure data prediction value acquisition module includes: The predicted value of expiratory pressure data at time t1, PLastp, is obtained according to the following formula: t1 : Plastic t1 =0.98×Lastp t0 +0.02×FilterData t0 。 5. The spontaneous breathing trigger judgment system for neonates in non-invasive ventilation mode according to claim 4, characterized in that: The trigger value preset by the trigger judgment module is 0.2×trigger level.

6. The spontaneous breathing trigger judgment system for neonates in non-invasive ventilation mode according to claim 5, characterized in that: The trigger levels include 1-10, and the smaller the trigger level, the higher the sensitivity.

Images