Blue light filtering eye lenses

Abstract

The present invention discloses an ophthalmic lens for filtering blue light, which has a value of less than 2 db*. The ophthalmic lens comprises a blue light filtering compound and a substrate, wherein the db* = (b*)1 – (b*)0, where (b*)1 is the b* value of the ophthalmic lens and (b*)0 is the b* value of a control group lens.

Description

Technical Field

[0001] This invention relates to an ophthalmic lens for filtering blue light, and more particularly to an ophthalmic lens for filtering blue light that is non-yellowish or colorless and transparent. Background Technology

[0002] With the rapid development of technology, the relationship between electronic products and people has become increasingly close, occupying a very important position in daily life. However, the display components of most electronic products, such as LCD screens and mobile phone screens, need to have a richer color rendering in the visible light spectrum to make the products more acceptable to consumers. Therefore, most of these products emit a lot of blue light.

[0003] Blue light, or blue light emission, generally refers to light with wavelengths between 380nm and 460nm, possessing relatively high energy compared to other visible light sources. When using electronic devices, blue light can penetrate the eye and reach the retina. Prolonged exposure to blue light can lead to the death of pigment epithelial cells, causing vision damage. Therefore, prolonged exposure to blue light while using electronic devices can cause irreversible damage to the eyes.

[0004] To reduce or avoid the damage to human eyes caused by blue light exposure, many blue light filtering lenses and products have been launched on the market, such as blue light protection glasses and blue light filtering films. Most existing blue light filtering lenses are made by adding substances with blue light filtering properties to the lens substrate to block blue light from directly shining into the user's eyes. However, common blue light filtering materials, because they filter out blue light from visible light, also give the lenses a yellowish appearance, resulting in poor product appeal and reducing consumers' willingness to purchase. Summary of the Invention

[0005] One object of the present invention is to provide an eye lens that filters blue light without being yellowish or is colorless and transparent.

[0006] To achieve the above objectives, the present invention proposes an ophthalmic lens for filtering blue light, having a value of less than 2 db*. The ophthalmic lens comprises a blue light filtering compound and a substrate, wherein the db* = (b*)1 – (b*)0, where (b*)1 is the b* value of the ophthalmic lens, and (b*)0 is the b* value of a control group lens.

[0007] To achieve the above objectives, the present invention proposes an ophthalmic lens for filtering blue light, having a db* value of less than 2 and a blue light blocking rate between 10% and 60%. The ophthalmic lens comprises a blue light filtering compound and a substrate, wherein the db* = (b*)1 – (b*)0, where (b*)1 is the b* value of the ophthalmic lens, and (b*)0 is the b* value of a control group lens.

[0008] The b* value is the value of the lens on the blue-yellow coordinate axis in the CIELAB color space.

[0009] In some specific embodiments of the present invention, the blue light filtering compound is 0.4 to 10%, 1 to 10%, or 5 to 10% by weight.

[0010] According to the present invention, the ophthalmic lens described above may have a thickness of 0.04 to 2.00 mm, or a thickness of 0.04 to 1.80 mm, or a thickness of 0.04 to 1.50 mm.

[0011] To achieve the above objectives, the present invention provides an ophthalmic lens for filtering blue light, wherein the thickness of the ophthalmic lens is between 0.04 and 1.5 mm, the blue light blocking rate of the ophthalmic lens is between 10 and 60%, and the ophthalmic lens comprises a substrate and a blue light filtering compound having structural formula (A):

[0012]

[0013] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0014] In some specific embodiments of the present invention, the blue light filtering compound comprises 0.4% to 10% by weight.

[0015] To achieve the above objectives, the present invention provides an ophthalmic lens for filtering blue light, which is prepared by a method comprising the following steps: mixing a blue light filtering compound and a substrate to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 0.4 to 10.0%, and the weight percentage of the substrate is 90.0 to 99.6%; adding the mixed solution into a molding die; and causing the mixed solution in the molding die to undergo a copolymerization reaction to obtain the ophthalmic lens, wherein the ophthalmic lens has a db* value less than or equal to 2, wherein db* = (b*)1 – (b*)0, (b*)1 is the b* value of the ophthalmic lens, and (b*)0 is the b* value of a control group lens.

[0016] To achieve the above objectives, the present invention provides a blue light filtering ophthalmic lens, which is prepared by a method comprising the following steps: mixing a blue light filtering compound and a substrate to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 0.4 to 10.0%, and the weight percentage of the substrate is 90.0 to 99.6%; adding the mixed solution to a molding die; and causing the mixed solution in the molding die to undergo a copolymerization reaction to obtain the ophthalmic lens; wherein the ophthalmic lens has a blue light blocking rate of between 10 and 60%; and wherein the blue light filtering compound is a compound having structural formula (A):

[0017]

[0018] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0019] When preparing the blue light filtering ophthalmic lens of the present invention, a substrate of 90.0 to 90.6% by weight may be used.

[0020] According to the present invention, the substrate as described above may contain a hydrophilic substance, a polymerization initiator, a crosslinking agent, or a combination thereof.

[0021] The hydrophilic substances include, but are not limited to, one or more of the following: 2-hydroxyethylmethacrylate (HEMA), 2-methylpropenoic acid (MAA), acrylic acid (AA), N-vinyl-2-pyrrolidone (NVP), N,N-dimethylacrylamide (DMAA), glycerol methacrylate (GMA), and 2-(dimethylamino)ethyl methacrylate (DEAEMA).

[0022] The polymerization initiator includes, but is not limited to, thermal initiators or photoinitiators.

[0023] The thermal initiator includes, but is not limited to, one or a combination of one or more of 2,2'-azobisisobutyronitrile (AIBN), azobisisoheptanenitrile (ADVN), and benzoyl peroxide (BPO).

[0024] The photoinitiator includes, but is not limited to, one or a combination of phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0025] The crosslinking agent includes, but is not limited to, one or more of the following: ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacrylate (TrEGDMA), tetraethylene glycol dimethacrylate (TEGDMA), polyethylene glycol dimethacrylate (PEGDMA), propylene-terminated ethylene oxide dimethylsiloxane-ethylene oxide ABA block copolymer, and trimethylolpropane trimethacrylate (TMPTMA).

[0026] Additionally, the substrate may also contain a non-hydrophilic material. This non-hydrophilic material includes, but is not limited to, one or a combination of one or more of the following: (3-methacryloyloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methyl (Methyl di(trimethylsiloxy)silylpropylglyceryl methacrylate, SIGMMA), 3-(Methacryloyloxy)-propyltris(trimethylsiloxy)-silane (TRIS), and polydimethylsiloxane (PDMS).

[0027] According to the present invention, the blue light filtering compound as described above can be a compound having structural formula (A):

[0028]

[0029] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0030] The ophthalmic lens of the present invention is preferably a contact lens, such as a soft contact lens, a rigid contact lens, an in-line ophthalmic lens, or an artificial lens. Attached Figure Description

[0031] Figure 1 Display the transmittance (T%) of lenses 12-16 at various wavelengths. Detailed Implementation

[0032] Unless otherwise specified, all technical and scientific terms used herein have the meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0033] Unless otherwise specified, the term "one" as used in this article refers to at least one (one or more) quantity.

[0034] In one aspect, the present invention provides an ophthalmic lens for filtering blue light, having a value of less than 2 db*. The ophthalmic lens comprises a blue light filtering compound and a substrate, wherein the db* = (b*)1 – (b*)0, where (b*)1 is the b* value of the ophthalmic lens and (b*)0 is the b* value of a control group lens.

[0035] On the other hand, the present invention provides an ophthalmic lens for filtering blue light, having a db* value of less than 2 and a blue light blocking rate between 10 and 60%, the ophthalmic lens comprising a blue light filtering compound and a substrate, wherein the db* = (b*)1 – (b*)0, the (b*)1 being the b* value of the ophthalmic lens, and the (b*)0 being the b* value of a control group lens.

[0036] For example, the control group lens was a lens without added blue light filtering compound.

[0037] The b* value is the value of the lens on the blue-yellow axis in the CIELAB color space. For relevant definitions of the CIELAB color space, please refer to, for example, US 5,751,845 or US 2019 / 0151161.

[0038] In some specific embodiments of the present invention, the weight percentage of the blue light filtering compound is 0.4% to 10%.

[0039] According to the present invention, the weight percentage of the blue light filtering compound may be 0.4 to 10%, 1 to 10%, 1.5 to 10%, 2 to 10%, 2.5 to 10%, 3 to 10%, 3.5 to 10%, 4 to 10%, 4.5 to 10%, or 5 to 10%.

[0040] According to the present invention, the ophthalmic lens as described above may have a thickness of 0.04 to 2 mm, 0.04 to 1.95 mm, 0.04 to 1.90 mm, 0.04 to 1.85 mm, 0.04 to 1.80 mm, 0.04 to 1.75 mm, 0.04 to 1.70 mm, 0.04 to 1.65 mm, 0.04 to 1.60 mm, 0.04 to 1.55 mm, or 0.04 to 1.50 mm.

[0041] As mentioned above, eye lenses may have a blue light blocking rate of 10 to 60%, 20 to 60%, 30 to 60%, 40 to 60%, or 50 to 60%.

[0042] In another aspect, the present invention provides an ophthalmic lens for filtering blue light, wherein the thickness of the ophthalmic lens is between 0.04 and 1.5 mm, the blue light blocking rate of the ophthalmic lens is between 10 and 60%, and the ophthalmic lens comprises a substrate and a blue light filtering compound having structural formula (A):

[0043]

[0044] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0045] In some specific embodiments of the present invention, the weight percentage of the blue light filtering compound is 0.4% to 10%.

[0046] On the other hand, the present invention provides an eye lens for filtering blue light, which is prepared by a method comprising the following steps: mixing a blue light filtering compound and a substrate to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 0.4 to 10.0%, and the weight percentage of the substrate is 90.0 to 99.6%; adding the mixed solution into a molding die; and causing the mixed solution in the molding die to undergo a copolymerization reaction to obtain the eye lens, wherein the eye lens has a db* value less than or equal to 2, wherein the db* = (b*)1 – (b*)0, the (b*)1 being the b* value of the eye lens, and the (b*)0 being the b* value of a control group lens.

[0047] For example, the control group lens is a lens without added blue light filtering compound. The b* value is the value of the lens on the blue-yellow coordinate axis in the CIELAB color space.

[0048] On the other hand, the present invention provides an ophthalmic lens for filtering blue light, which is prepared by a method comprising the following steps: mixing a blue light filtering compound and a substrate to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 0.4 to 10.0%, and the weight percentage of the substrate is 90.0 to 99.6%; adding the mixed solution into a molding die; and causing the mixed solution in the molding die to undergo a copolymerization reaction to obtain the ophthalmic lens; wherein the ophthalmic lens has a blue light blocking rate of between 10 and 60%; and wherein the blue light filtering compound is a compound having structural formula (A):

[0049]

[0050] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0051] When preparing the blue light filtering ophthalmic lens of the present invention, a substrate of 90.0 to 90.6% by weight may be used.

[0052] According to the present invention, the substrate as described above may contain a hydrophilic substance, a non-hydrophilic substance, a polymerization initiator, a crosslinking agent, or a combination thereof.

[0053] The hydrophilic substances include, but are not limited to, 2-hydroxyethylmethacrylate (HEMA), 2-methylpropenoic acid (MAA), acrylic acid (AA), N-vinyl-2-pyrrolidone (NVP), N,N-dimethylacrylamide (DMAA), glycerol methacrylate (GMA), 2-(dimethylamino)ethyl methacrylate (DEAEMA), and one or more other equivalent compounds.

[0054] The polymerization initiator includes, but is not limited to, a thermal initiator or a photoinitiator. It should be understood that the thermal initiator can initiate a chemical reaction (polymerization) between the substrate and the blue light filtering compound when heated, while the photoinitiator can initiate a chemical reaction (polymerization) between the substrate and the blue light filtering compound when illuminated.

[0055] The thermal initiator includes, but is not limited to, one or a combination of one or more of 2,2'-azobisisobutyronitrile (AIBN), azobisisoheptanenitrile (ADVN), and benzoyl peroxide (BPO).

[0056] The photoinitiator includes, but is not limited to, one or a combination of phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0057] Preferably, the substrate may further comprise a crosslinking agent. The crosslinking agent includes, but is not limited to, ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacrylate (TrEGDMA), tetraethylene glycol dimethacrylate (TEGDMA), polyethylene glycol dimethacrylate (PEGDMA), propylene-terminated ethylene oxide dimethylsiloxane-ethylene oxide ABA block copolymer, trimethylolpropane trimethacrylate (TMPTMA), and one or more other equivalent compounds.

[0058] In addition, the substrate may further comprise a non-hydrophilic substance. The non-hydrophilic substance includes, but is not limited to, (3-methacryloyloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methyl (Methyl di(trimethylsiloxy)silylpropylglyceryl methacrylate, SIGMMA), 3-(Methacryloyloxy)-propyltris(trimethylsiloxy)-silane (TRIS), polydimethylsiloxane (PDMS), other equivalent compounds, or a combination of one or more of these substances.

[0059] For example, the substrate may have three forms: containing hydrophilic substances, containing non-hydrophilic substances, or containing both hydrophilic and non-hydrophilic substances.

[0060] According to the present invention, the blue light filtering compound as described above can be a compound having structural formula (A):

[0061]

[0062] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0063] According to the present invention, the blue light filtering compound may be a compound having structural formula (A):

[0064]

[0065] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0066] According to certain embodiments of the present invention, an ophthalmic lens having a value of less than 2 dB* is prepared by a method comprising the following steps: mixing a blue light filtering compound and a substrate to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 1 to 10% and the weight percentage of the substrate is 90 to 99%; adding the mixed solution to a molding die; and causing the mixed solution in the molding die to undergo a copolymerization reaction to obtain the ophthalmic lens.

[0067] The prepared ophthalmic lenses may have a thickness of 0.04 to 2 mm, 0.04 to 1.95 mm, 0.04 to 1.90 mm, 0.04 to 1.85 mm, 0.04 to 1.80 mm, 0.04 to 1.75 mm, 0.04 to 1.70 mm, 0.04 to 1.65 mm, 0.04 to 1.60 mm, 0.04 to 1.55 mm, or 0.04 to 1.50 mm.

[0068] In addition, the prepared ophthalmic lenses may have a blue light blocking rate of 10 to 60%, 20 to 60%, 30 to 60%, 40 to 60%, or 50 to 60%.

[0069] According to the present invention, the blue light filtering compound used in the preparation of ophthalmic lenses may be a compound having the structural formula (A):

[0070]

[0071] Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

[0072] The blue light filtering compound used in this invention may have the structural formula (A1):

[0073]

[0074] The blue light filtering compound used in this invention may have the structural formula (A2):

[0075]

[0076] It contains an unsaturated vinyl group.

[0077] The ophthalmic lens of the present invention is preferably a contact lens, such as a soft contact lens, a rigid contact lens, an in-line ophthalmic lens, or an artificial lens.

[0078] The following examples are used to further illustrate the implementation of the present invention, and are illustrative rather than limiting.

[0079] Example 1: Preparation of ophthalmic lenses with different raw materials and ratios

[0080] Lenses 1 to 11 were prepared according to the raw materials and their weight ratios shown in Table 1 below.

[0081] Table 1. Raw material weight ratio table

[0082]

[0083] HEMA is 2-hydroxyethyl methacrylate, EGDMA is ethylene glycol dimethacrylate, and AIBN is 2,2'-azobisisobutyronitrile.

[0084] Taking lens 2 as an example, 0.40% by weight of a compound with structural formula (A), 99.20% by weight of HEMA, 0.20% by weight of EGDMA, and 0.20% by weight of AIBN were prepared. The prepared raw materials were filtered, mixed thoroughly, and placed into a molding die. Then, heating or light exposure was applied to induce a copolymerization reaction in the raw materials within the molding die. After the reaction was complete, the lens was removed from the molding die and used for subsequent analysis.

[0085] Example 2: Analysis of Blue Light Filtering Capability

[0086] The average blue light transmittance (%) of lenses 1 to 11 prepared in Example 1 in the wavelength range of 380 to 460 nm was measured using an ultraviolet-visible spectrometer (e.g., an Agilent Cary 60 spectrometer), and their respective blue light blocking rates (%) were calculated. The blue light blocking rate was then used as a parameter to evaluate the blue light filtering ability of the lenses.

[0087] First, immerse the lens to be tested in standard saline solution for at least 30 minutes to equilibrate. Carefully remove the 1cm diameter quartz colorimetric tube, rinse it three times with pure water, and then three times with standard saline solution. Wipe the outside of the quartz tube clean with lens paper, and check the tube wall for dirt or fingerprints. If present, repeat the cleaning steps until clean, or replace the quartz colorimetric tube. Carefully place the lens into the colorimetric tube, and cut it to a suitable square size as needed. Turn on the spectrometer and software. The wavelength for lens transmittance testing is the blue light wavelength range of 380–460nm. Set the measurement range to 380–460nm and the spectral scanning bandwidth to 1nm. Add 8 / 8 full of standard saline solution to the colorimetric tube and perform blank calibration on the set spectrometer. Remove the colorimetric tube, carefully place the lens in, and ensure that the center of the lens is located where the light source of the spectrometer passes. Measure the lens transmittance (T%) at 380–460nm and save the measurement results. Calculate the corresponding blue light filtering capability value using the following formulas 1 and 2:

[0088]

[0089] Blue light blocking rate (%) = 100 - average blue light transmittance (2)

[0090] The measurements and calculations of lenses 1 to 11 are recorded in Table 2 below.

[0091] Table 2. Blue Light Filtering Capability Values

[0092]

[0093] As shown in Table 2, lens 1 still has a slight blue light blocking rate (about 0.4%) even without the addition of any blue light filtering material.

[0094] In cases where a contrasting yellow dye is added as a blue light filtering material, adding even a small amount (approximately 0.1%) would cause the lens to appear yellow, thus failing to meet the objectives of this invention. Therefore, the proportion of the yellow dye was reduced in lenses 7-11 (see Table 1), and tests were conducted to determine if the desired blue light filtering effect was still achieved. The results showed that using 0.01 to 0.1% of the yellow dye could achieve a blue light blocking rate of 6% to 22%.

[0095] Generally speaking, a lens must have a blue light blocking rate of at least 10% to be considered to have a blue light filtering effect.

[0096] In lenses using yellow dyes, lenses 7 and 8 have a blue light blocking rate of less than 10%, while lenses 9 to 11 have a blue light blocking rate of more than 10%. Lenses 2 to 6, which use compounds with structural formula (A), have a blue light blocking rate of approximately 10% to approximately 60%.

[0097] Example 3: Transparency Analysis

[0098] First, perform standard calibration on the colorimeter (e.g., a colorimeter of model MSEZ-4000S). After calibration, point the lens at a control group lens (lens 1 prepared in Example 1), press the measurement button, and the colorimeter will display the absolute color values ​​of the control group lens: L*, a*, b*.

[0099] Next, the measuring lens is aimed at a test group of lenses (one of lenses 2 to 11 prepared in Example 1), and the above test is repeated. At this time, the colorimeter will display the absolute color values ​​of the test group of lenses: L*, a*, b*.

[0100] Based on the positive and negative values ​​of the color difference data, we can determine the color difference between the experimental group lenses and the control group lenses: L* represents black and white, a positive L* value indicates that the experimental group lenses are whiter than the control group lenses, and a negative value indicates that they are blacker; a* represents red and green, a positive a* value indicates that the experimental group lenses are redder than the control group lenses, and a negative value indicates that they are greener; b* represents yellow and blue, a positive b* value indicates that the experimental group lenses are yellower than the control group lenses, and a negative value indicates that they are bluer.

[0101] In this invention, it was discovered that whether a lens appears yellowish can be determined by the db* value calculated using the following formula 3:

[0102] (db*) 试验组镜片 =(b*) 试验组镜片 –(b*) 对照组镜片 (3)

[0103] The measured and calculated values ​​of lenses 1 to 11, and their comparison with the lens appearance color and blue light blocking rate, are shown in Table 3 below.

[0104] Table 3. Color Difference Values ​​ / Appearance Color / Blue Light Blocking Rate Comparison

[0105]

[0106]

[0107] Lens 1 contains no added blue light filtering material, appears transparent and colorless to the naked eye, and has a b* value of 0.00, representing yellow-green information. Lens 1 is used as a control group lens.

[0108] Lenses 7 to 11 are made using yellow dye. Among them, although lenses 7 to 8 appear transparent and colorless, their blue light blocking rate is less than 10% (see Table 2), and they do not have the required blue light filtering ability; while lenses 9 to 11 have a blue light blocking rate greater than 10% (see Table 2), but as shown in Table 3, their appearance appears yellowish upon visual inspection.

[0109] Lenses 2 to 6 are made using compounds with structural formula (A). They are all transparent and colorless when viewed visually, and their db* values ​​are between 0.08 and 0.87. Furthermore, lens 8, with a db* value of 2.01, still appears transparent and colorless. It can be inferred that lenses with a db* value less than 2 will appear non-yellowish or transparent and colorless.

[0110] Example 4: Other Examples

[0111] Table 4 below provides relevant parameters for lenses 12 to 16 in other embodiments of the present invention.

[0112] Table 4. Relevant parameters for lenses 12-16

[0113]

[0114] in addition, Figure 1 Display the transmittance (T%) of lenses 12-16 at various wavelengths.

[0115] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of the present invention. All equivalent variations and modifications made in accordance with the shape, structure, features and spirit described in the claims of the present invention should be included within the scope of the claims of the present invention.

Claims

1. An ophthalmic lens for filtering blue light, characterized in that, The ophthalmic lens has a blue light blocking rate of 10% to 60% for wavelengths in the range of 380–460 nm. The lens has a db* value of less than or equal to 2. It comprises a blue light filtering compound having structural formula (A) and a substrate. The weight percentage of the blue light filtering compound is 0.4% to 10%, and the weight percentage of the substrate is 90.0% to 99.6%. The db* value is defined as (b*)1 – (b*)0, where (b*)1 is the b* value of the ophthalmic lens, and (b*)0 is the b* value of a control group lens containing the substrate but without the blue light filtering compound. The structural formula (A) is: (A)， Wherein R1 is hydrogen, a straight-chain or branched alkyl group from C1 to C10, an aralkyl group from C6 to C15, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a straight-chain or branched alkylene group from C1 to C10, a straight-chain or branched alkylene group from C1 to C10 with hydroxyl substitution, or a straight-chain or branched alkylene group from C1 to C10 interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a straight-chain or branched alkyl group from C1 to C10, or a straight-chain or branched alkenyl group from C3 to C10.

2. The ophthalmic lens as described in claim 1, characterized in that, It has a thickness of 0.04 to 2.00 mm.

3. The ophthalmic lens as described in claim 1, characterized in that, It has a thickness of 0.04 to 1.5 mm.

4. The ophthalmic lens as described in claim 1, characterized in that, The substrate can be a soft contact lens substrate, a rigid contact lens substrate, an in-line ophthalmic lens substrate, or an artificial lens substrate.

5. The ophthalmic lens as described in claim 1, characterized in that, The substrate comprises a hydrophilic substance, a polymerization initiator, a crosslinking agent, or a combination thereof.

6. The ophthalmic lens as described in claim 5, characterized in that, The hydrophilic substance includes one or more of the following: 2-hydroxyethyl methacrylate (HEMA), methacrylic acid (MAA), acrylic acid (AA), N-vinyl-2-pyrrolidone (NVP), N,N-dimethylacrylamide (DMAA), glycidyl methacrylate (GMA), and diethylaminoethyl methacrylate (DEAEMA).

7. The ophthalmic lens as described in claim 5, characterized in that, The polymerization initiator includes thermal initiators or photoinitiators.

8. The ophthalmic lens as described in claim 7, characterized in that, The thermal initiator includes one or more of 2,2'-azobisisobutyronitrile (AIBN), azobisisoheptanenitrile (ADVN), and benzoyl peroxide (BPO).

9. The ophthalmic lens as described in claim 7, characterized in that, The photoinitiator includes one or more of phenylbis(2,4,6-trimethylbenzoyl)-phosphine oxide, 2-hydroxy-2-methyl-1-phenyl-1-propanone.

10. The ophthalmic lens as described in claim 5, characterized in that, The crosslinking agent includes one or more of the following: ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacrylate (TrEGDMA), tetraethylene glycol dimethacrylate (TEGDMA), polyethylene glycol dimethacrylate (PEGDMA), propylene-terminated ethylene oxide dimethylsiloxane-ethylene oxide ABA block copolymer, and trimethylolpropane trimethacrylate (TMPTMA).

11. The ophthalmic lens as described in claim 5, characterized in that, The substrate contains a non-hydrophilic material, which includes one or more of (3-methacryloyloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methyl (SIGMMA), methacryloyloxypropyltris(trimethylsiloxane)silane (TRIS), and polydimethylsiloxane (PDMS).

12. A method for manufacturing an ophthalmic lens that filters blue light, characterized in that, By including the following steps: A blue light filtering compound having structural formula (A) and a substrate are mixed to obtain a mixed solution, wherein the weight percentage of the blue light filtering compound is 0.4% to 10.0%, and the weight percentage of the substrate is 90.0% to 99.6%; the structural formula (A) is: (A)， Wherein R1 is hydrogen, a C1 to C10 straight-chain or branched alkyl group, a C6 to C15 aralkyl group, -R2-X, -O-R2-X, or -N-R2-X; wherein R2 is a C1 to C10 straight-chain or branched alkylene group, a C1 to C10 straight-chain or branched alkylene group containing a hydroxyl group, or a C1 to C10 straight-chain or branched alkylene group interrupted by an ester group, and X is -OH, -OC(O)R3, -NH2, -NC(O)R3, -NCO, -COOH, or -COOR3; wherein R3 is a C1 to C10 straight-chain or branched alkyl group, or a C3 to C10 straight-chain or branched alkenyl group; The mixture is added to a molding die; and The mixed solution in the molding die undergoes a copolymerization reaction to obtain the ophthalmic lens, wherein the ophthalmic lens has a db* value less than or equal to 2, where db* = (b*)1 – (b*)0, (b*)1 is the b* value of the ophthalmic lens, and (b*)0 is the b* value of a control group lens, which contains the substrate and does not contain the blue light filtering compound.

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