Dual-purpose maintenance system for coring and extracorporeal maintenance of the heart

Abstract

The application relates to a dual-purpose maintenance system for taking out a heart and maintaining the heart extracorporeally, which comprises a perfusion pipeline assembly and an organ box. The design that the organ box is communicated with a blood storage container and is switched can support the no-stop-taking-out and transportation operation of the heart. In the conversion process, the pipeline does not need to be replaced, the heat ischemic injury and ischemia-reperfusion injury of the heart are reduced.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a dual-purpose maintenance system for heart harvesting and extracorporeal cardiac maintenance. Background Technology

[0002] With the development of medical technology, heart transplantation has become an effective treatment for end-stage heart disease. Before the heart transplant surgery, the preservation effect of the donor heart directly affects the success rate of the heart transplant surgery.

[0003] Currently, in the process of heart transplantation, it is usually necessary to first stop the heart from beating, transfer it to an organ transport platform, and then re-perfusion and restart it. This can lead to ischemic injury and reperfusion injury to the heart, which in turn affects organ quality, the number of usable organs, and the post-transplant outcome. Summary of the Invention

[0004] Based on the aforementioned deficiencies in the prior art, the purpose of this invention is to provide a dual-purpose maintenance system for heart retrieval and extracorporeal heart maintenance. This dual-purpose maintenance system provides perfusion function to the heart during both the heart retrieval and extracorporeal maintenance stages, supports off-beat heart retrieval and transport operations, reduces thermal ischemia-reperfusion injury and ischemia-reperfusion injury to the heart, and improves the utilization rate of heart donors.

[0005] Therefore, the present invention provides the following technical solution.

[0006] A dual-purpose maintenance system for heart harvesting and extracorporeal cardiac maintenance includes: a perfusion tubing assembly for perfusing the heart; the perfusion tubing assembly includes a first tubing and a second tubing; one end of the first tubing is connected to a vein of the heart; and one end of the second tubing is connected to the aorta of the heart.

[0007] An organ cassette for holding a heart removed from a donor; the organ cassette has a collection tank connector, and the perfusion tubing assembly includes a blood storage container disposed on a first tubing; the collection tank connector is connected to the blood storage container via a recovery tube.

[0008] The first pipeline and the recovery pipeline are respectively controllably connected to or shut off from the blood storage container.

[0009] Preferably, the perfusion tubing assembly includes a fourth control valve disposed between the organ box and the blood storage container, the fourth control valve being used to control the connection or closure of the first tubing and the blood storage container.

[0010] Preferably, the fourth control valve is a three-way valve, and both the recovery pipe and the first pipe are connected to the blood storage container through the fourth control valve.

[0011] Preferably, the organ box is provided with a first connecting part and a second connecting part, wherein the first connecting part can be detachably connected to the first conduit connected to the vein of the heart; and the second connecting part can be detachably connected to the second conduit connected to the aorta of the heart.

[0012] Preferably, the first pipeline is provided with a first mounting part, and the second pipeline is provided with a second mounting part. The first mounting part is used to be detachably connected to the first connecting part, and the second mounting part is used to be detachably connected to the second connecting part.

[0013] Preferably, one of the first mounting portion and the first connecting portion is constructed as a snap-fit ​​protrusion structure, and the other is constructed as a slot structure;

[0014] One of the second mounting part and the second connecting part is constructed as a snap-fit ​​protrusion structure, and the other is constructed as a slot structure.

[0015] Preferably, a first airbag is provided on the outer periphery of one end of the first conduit, the first airbag being placed inside the vein; and the first airbag has a first working state of not closing the vein and a second working state of completely closing the vein;

[0016] The outer periphery of one end of the second conduit is provided with a second airbag, which is used to be placed inside the aorta, and the second airbag has a third working state in which the aorta is not closed and a fourth working state in which the aorta is completely closed.

[0017] Preferably, the outer periphery of one end of the first conduit and / or the second conduit is provided with a plurality of slots, the slots being used to engage with a suture to ligate the vein and / or aorta.

[0018] Preferably, the perfusion tubing assembly includes an oxygenation device, a centrifugal pump, a perfusion device, and a drug supply device; the oxygenation device is used to oxygenate the blood, the centrifugal pump is used to drive the blood flow within the perfusion tubing assembly, the perfusion device is used to inject perfusion fluid into the blood, and the drug supply device is used to inject drugs into the blood.

[0019] Preferably, it further includes a dialysis tubing assembly, with its two ends respectively connected to the perfusion tubing assembly, for selectively dialyzing the blood in the perfusion tubing assembly;

[0020] The dialysis tubing assembly includes:

[0021] Dialysis tubing, having an inlet and an outlet end connected to the infusion tubing assembly,

[0022] A dialysis device, which is installed on the dialysis tubing, is used for dialysis of blood;

[0023] The infusion pipeline assembly also includes a first control valve located between the inlet end and the outlet end.

[0024] Preferably, the dialysis apparatus includes a dialysis filter, a dialysate container, and a third drive pump. The dialysis filter is disposed on the dialysis line and is connected to the dialysate container through a circulation line. The third drive pump is used to drive the dialysate to circulate in the circulation line.

[0025] Preferably, the dialysis apparatus includes a dialysis filter, a dialysate container, and a third drive pump. The dialysis filter is disposed on the dialysis line and is connected to the dialysate container through a circulation line. The third drive pump is used to drive the dialysate to circulate in the circulation line.

[0026] The present invention has the following technical effects:

[0027] This invention provides a dual-purpose maintenance system for heart retrieval and extracorporeal cardiac maintenance. Through the design of connecting and switching between the organ cassette and the blood storage container, it supports continuous heart retrieval and transport. During the switching process, it eliminates the need for multiple replacements of the heart's connecting tubing, reducing thermal ischemia-reperfusion injury and ischemia-reperfusion injury to the heart. Furthermore, during organ transplantation, the liver or kidney is harvested first, requiring the injection of large amounts of medication to maintain cardiac function. This results in residual medication in the heart, potentially causing damage. By perfusing the heart within the donor's body before retrieval, the damage caused by the injected medication can be repaired, improving the utilization rate of the heart donor.

[0028] In a preferred embodiment, selective dialysis of the blood within the perfusion tubing assembly via the dialysis tubing assembly can control the levels of cardiac metabolic products in the blood, improve cardiac perfusion, and thus increase the utilization rate of cardiac donors. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the dual-purpose maintenance system in the first embodiment of the present invention;

[0030] Figure 2 This is a schematic diagram of the dual-purpose maintenance system in the second embodiment of the present invention;

[0031] Figure 3 This is a schematic diagram of the dual-purpose maintenance system in the third embodiment of the present invention;

[0032] Figure 4 This is an enlarged cross-sectional view of one end of the first pipeline in one embodiment of the present invention;

[0033] Figure 5 This is an enlarged view of one end of the first pipeline in another embodiment of the present invention;

[0034] Figure 6 This is a partial assembly structure diagram of the housing, the first pipeline, and the second pipeline of the present invention;

[0035] Figure 7 This is a partial three-dimensional structural diagram of the first pipeline of the present invention;

[0036] Figure 8 This is a three-dimensional structural diagram of the box body of the present invention.

[0037] Explanation of reference numerals in the attached figures

[0038] 1. Injection piping assembly;

[0039] 11. First pipeline; 111. First airbag; 112. First mounting part; 1121. Snap-fit ​​section; 1122. Abutment section; 113. Gas passage; 114. Through hole; 115. Slot; 12. Second pipeline; 121. Second mounting part; 13. Blood storage container; 14. Oxygenation device; 15. Centrifugal pump; 16. Infusion device; 17. Drug supply device; 18. First control valve; 19. Fourth control valve;

[0040] 2. Dialysis tubing assembly;

[0041] 21. Dialysis tubing; 22. Dialysis apparatus; 221. Dialysis filter; 222. Dialysis fluid container; 223. First peristaltic pump; 224. Second peristaltic pump; 225. Circulation tubing; 23. Third control valve; 24. Second drive pump;

[0042] 3. Organ box;

[0043] 31. First connecting part; 32. Second connecting part; 33. Liquid collection tank connector; 34. Box body;

[0044] 4. Recycling pipe;

[0045] 5. Cleaning components;

[0046] 51. Cleaning pipeline; 52. First drive pump; 53. Second control valve; 54. Filling fluid container;

[0047] 6. Metabolic sensors. Detailed Implementation

[0048] To make the technical solution and beneficial effects of the present invention more apparent and understandable, a detailed description is provided below by listing specific embodiments. Unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application pertains.

[0049] In the description of this invention, unless otherwise expressly defined, the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "height," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the purpose of simplifying the description of this invention and do not indicate that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. That is, they should not be construed as limiting this invention.

[0050] In this invention, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating the relative importance of the indicated features or the number of indicated technical features. Therefore, a feature specified as "first" or "second" can explicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two; "several" means at least one; unless otherwise expressly defined.

[0051] In this invention, unless otherwise explicitly defined, the terms "installation," "connection," "linking," "fixing," and "setting," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral molding; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can also refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0052] In this invention, unless otherwise explicitly defined, the terms "above," "on top of," "over," "above," "below," "below," "below," or "below" for "first feature above second feature" can refer to the first and second features being in direct contact, or to the first and second features being in indirect contact through an intermediate medium. Furthermore, "above," "over," and "below" for "first feature above second feature" can mean the first feature is directly above or diagonally above the second feature, or simply indicates that the horizontal height of the first feature is higher than the horizontal height of the second feature. Similarly, "below," "below," and "below" for "first feature below second feature" can mean the first feature is directly below or diagonally below the second feature, or simply indicates that the horizontal height of the first feature is lower than the horizontal height of the second feature.

[0053] The following is based on Figures 1 to 8 The dual-purpose maintenance system of the present invention will be described in detail.

[0054] First Implementation Method

[0055] according to Figure 1 , Figures 4 to 8The dual-purpose maintenance system according to the first embodiment of the present invention will be described.

[0056] In this embodiment, such as Figure 1 As shown, the dual-purpose maintenance system is used for heart retrieval and extracorporeal cardiac maintenance. It includes a perfusion tubing assembly 1, a dialysis tubing assembly 2, and an organ cassette 3. The organ cassette 3 is used to hold the heart retrieved from the donor. After the heart is connected to the dual-purpose maintenance system, the perfusion tubing assembly 1 is used to perfuse the heart. The perfusion tubing assembly 1 includes a first tubing 11 and a second tubing 12. One end of the first tubing 11 is connected to a vein in the heart, and one end of the second tubing 12 is connected to the aorta in the heart. Blood flows out from the vein in the heart and is then perfused through the aorta, supporting the blood supply to the heart and enabling it to beat normally. The organ cassette 3 has a collection tank connector 33. The perfusion tubing assembly 1 includes a blood storage container 13 disposed on the first tubing 11. The collection tank connector 33 is connected to the blood storage container 13 via a recovery pipe 4, through which blood from the organ cassette 3 is introduced into the blood storage container 13.

[0057] When the dual-purpose maintenance system is used for heart retrieval, the first conduit 11 is first connected to the vein of the heart located in the donor body, and the second conduit 12 is connected to the aorta of the heart located in the donor body. At this time, the dual-purpose maintenance system is used to perfuse the heart located in the donor body. Then, the heart is retrieved. After the heart is retrieved, it is placed in the organ box 3, and the first conduit 11 connected to the vein of the heart and the second conduit 12 connected to the aorta of the heart are assembled with the organ box 3. At this time, the heart outside the body can be maintained by the dual-purpose maintenance system.

[0058] By employing the above technical solution, a dual-purpose maintenance system provides perfusion to the heart during both the heart retrieval and extracorporeal maintenance stages. The design, which allows for connection and switching between the organ cassette and the blood storage container, supports continuous heart retrieval and transport. During the switching process, multiple replacements of the heart's connecting tubing are unnecessary, reducing thermal ischemia-reperfusion injury and ischemia-reperfusion injury. Furthermore, during organ transplantation, the liver or kidney is harvested first, requiring the injection of large amounts of medication to maintain the heart's vitality. This results in residual medication that can damage the heart. Perfusion of the heart within the donor's body before retrieval can repair the damage caused by the injected medication, thereby improving the utilization rate of the heart donor.

[0059] In one implementation, such as Figure 1As shown, the organ box 3 is provided with a first connecting part 31 and a second connecting part 32. The first connecting part 31 can be detachably connected to a first conduit 11 connected to a vein of the heart; the second connecting part 32 can be detachably connected to a second conduit 12 connected to the aorta of the heart. After the heart is harvested, the heart is placed in the organ box 3, and the first conduit 11 connected to the vein of the heart is connected to the first connecting part 31, and the second conduit 12 connected to the aorta of the heart is connected to the second connecting part 32, so as to facilitate rapid assembly.

[0060] In one implementation, such as Figures 6 to 8 As shown, the first conduit 11 has a first mounting portion 112, and the second conduit 12 has a second mounting portion 121. The first mounting portion 112 is detachably connected to the first connecting portion 31, and the second mounting portion 121 is detachably connected to the second connecting portion 32. Specifically, the first mounting portion 112 is connected to the outer peripheral wall of the first conduit 11, and the second mounting portion 121 is located on the outer peripheral wall of the second conduit 12. Before heart retrieval, one end of the first conduit 11 is connected to a vein of the heart, and one end of the second conduit 12 is connected to the aorta of the heart to achieve intracorporeal perfusion of the heart. Then, the heart and the portions of the first conduit 11 and the second conduit 12 located in the donor body are removed, the heart is placed in the organ box 3, and the first mounting portion 112 is connected to the first connecting portion 31, and the second mounting portion 121 is connected to the second connecting portion 32 to achieve extracorporeal perfusion of the heart. The assembly of the first conduit 11 and the second conduit 12 with the organ box 3 is simple and facilitates rapid operation.

[0061] In one embodiment, a left ventricular drainage tube (not shown in the figure) is also included, one end of which is connected to the left ventricle of the heart, and the other end extends into the organ box 3. During the perfusion of the heart outside the body, blood may leak from the left ventricle, and the residual blood from the left ventricle is introduced into the organ box 3 through the left ventricular drainage tube.

[0062] In one embodiment, one of the first mounting portion 112 and the first connecting portion 31 is configured as a snap-fit ​​protrusion, and the other is configured as a snap-fit ​​groove; one of the second mounting portion 121 and the second connecting portion 32 is configured as a snap-fit ​​protrusion, and the other is configured as a snap-fit ​​groove. After the heart is removed, the first tube 11 and the second tube 12 are assembled with the organ box 3 by snap-fit, which is convenient for assembly and disassembly.

[0063] Furthermore, such as Figure 6 and Figure 8 As shown, the organ box 3 includes a box body 34 and a lid (not shown in the figure). The lid is used to cover the box body 34 to close it. Openings are provided on both side walls of the box body 34 to form a first connecting portion 31 and a second connecting portion 32, respectively. Figure 6 and Figure 7As shown, the first mounting part 112 is sleeved on the outer periphery of the tube body of the first pipeline 11. The first mounting part 112 includes a snap-fit ​​section 1121 and two abutment sections 1122, which are respectively connected to the two ends of the snap-fit ​​section 1121. When the first pipeline 11 is detachably connected to the organ box 3 through the first mounting part 112, the snap-fit ​​section 1121 snaps into the first connecting part 31, and the two abutment sections 1122 abut against the inner and outer surfaces of the side wall of the box body 34, respectively. After the box cover is closed, the first mounting part 112 cannot move in either the horizontal or vertical direction, thus realizing the assembly between the first pipeline 11 and the organ box 3, which is convenient for loading and unloading. The second mounting part 121 has the same structure as the first mounting part 112, and the assembly principle of the second pipeline 12 and the organ box 3 is the same as that of the first pipeline 11 and the organ box 3, which will not be described again here.

[0064] In one implementation, such as Figure 4 As shown, a first airbag 111 is provided on the outer periphery of one end of the first conduit 11. The first airbag 111 is used to be placed inside the vein. The first airbag 111 has a first working state of not closing the vein and a second working state of completely closing the vein. An air passage 113 is provided inside the tube wall of the first conduit 11, and multiple through holes 114 are provided at the connection between the air passage 113 and the first airbag 111. When the heart and the dual-purpose maintenance system are connected, the first airbag 111 of the first conduit 11 is inserted into the vein. At this time, the first airbag 111 has the first working state of not closing the vein. The air passage 113 inflates the first airbag 111 through the through holes 114, so that the first airbag 111 expands to close the connection between the first conduit 11 and the vein, preventing external bleeding from the vein. At this time, the first airbag 111 has the second working state of completely closing the vein. This method can quickly close the outer wall of the conduit and the inner wall of the blood vessel.

[0065] A second air bladder (not shown in the figure) is provided on the outer periphery of one end of the second conduit 12. The second air bladder is used to place inside the aorta, and the second air bladder has a third working state in which the aorta is not closed and a fourth working state in which the aorta is completely closed. The connection structure and method between the second conduit 12 and the aorta are the same as those between the first conduit 11 and the vein, and will not be described again here.

[0066] In another embodiment, a plurality of slots are provided on the outer periphery of one end of the first conduit 11 and / or the second conduit 12. These slots are used to engage with a suture to ligate the vein and / or aorta, thereby achieving the effect of quickly sealing the outer wall of the conduit and the inner wall of the blood vessel. Figure 5As shown, taking the first conduit 11 as an example, a specific explanation is given. One end of the first conduit 11 is provided with multiple slots 115. After the first conduit 11 is inserted into a vein, the connection between the first conduit 11 and the vein is ligated by wrapping a suture around the slots 115 to prevent external bleeding from the vein. The connection structure and method between the second conduit 12 and the aorta are the same as those between the first conduit 11 and the vein, and will not be described again here.

[0067] In one implementation, such as Figure 1 As shown, the perfusion tubing assembly 1 includes an oxygenation device 14, a centrifugal pump 15, a perfusion device 16, and a drug supply device 17. The oxygenation device 14 is used to oxygenate the blood, the centrifugal pump 15 is used to drive the blood flow within the perfusion tubing assembly 1, the perfusion device 16 is used to introduce perfusion fluid into the blood, and the drug supply device 17 is used to introduce drugs into the blood. The centrifugal pump 15 is located between the blood storage container 13 and the oxygenation device 14, and the perfusion device 16 and the drug supply device 17 are located between the oxygenation device 14 and the second tubing 12. When the blood in the blood storage container 13 flows to the position of the pipe corresponding to the oxygenation device 14, the oxygenation device 14 oxygenates the blood, increasing the oxygen content in the blood. Then the blood continues to flow until it reaches the position of the perfusion device 16 and the drug supply device 17, where it is perfused and infused with drugs before flowing into the second tubing 12.

[0068] Of course, there can be one or more drug supply devices 17. Preferably, such as Figures 1 to 3 As shown, there are two drug supply devices 17, which are used to supply anticoagulants and drug solutions (such as nutrient solutions, electrolyte solutions, etc.) respectively.

[0069] Furthermore, the perfusion device 16 includes a perfusion pump and a perfusion tank (not shown in the figure), the perfusion pump being used to drive the perfusion fluid in the perfusion tank to flow to the blood conduit.

[0070] Furthermore, the drug supply device 17 includes a drug pump and a drug tank (not shown in the figure), the drug pump being used to drive the drug liquid in the drug tank to flow to the blood conduit.

[0071] In one implementation, such as Figure 1 As shown, the dual-purpose maintenance system also includes a dialysis tubing assembly 2, with both ends connected to the perfusion tubing assembly 1. The dialysis tubing assembly 2 is used to selectively dialyze the blood within the perfusion tubing assembly 1. By selectively dialyzing the blood within the perfusion tubing assembly 1 using the dialysis tubing assembly 2, the levels of cardiac metabolic products in the blood can be controlled, improving cardiac perfusion and thus increasing the utilization rate of cardiac donors.

[0072] The dialysis tubing assembly 2 includes a dialysis tubing 21 and a dialysis device 22. The dialysis tubing 21 has an inlet end and an outlet end connected to the perfusion tubing assembly 1. The dialysis device 22 is disposed on the dialysis tubing 21 for dialysis of blood. The perfusion tubing assembly 1 also includes a first control valve 18, which is located between the inlet end and the outlet end. After the blood in the perfusion tubing assembly 1 flows into the dialysis tubing 21, it is dialyzed by the dialysis device 22 to remove harmful and excess metabolic products and electrolytes from the blood. During dialysis, the first control valve 18 can be closed, so that the blood in the first tubing 11 must undergo dialysis before flowing to the second tubing 12, at which point the blood flow rate will decrease. Of course, during dialysis, the first control valve 18 can be opened, and part of the blood in the first tubing 11 flows through the dialysis tubing assembly 2 for dialysis, while the other part of the blood flows directly to the second tubing 12 after passing through the first control valve 18. In this way, the parameters such as the content of metabolic products and ions in the blood flowing into the aorta can be maintained within the qualified range while the blood flow rate is relatively fast.

[0073] Furthermore, such as Figure 1 As shown, the dialysis tubing assembly 2 also includes a second drive pump 24, which is disposed on the dialysis tubing 21. The second drive pump 24 can be a peristaltic pump. Figure 1 and Figure 2 As shown, when the dialysis tubing assembly 2 is undergoing dialysis, the second drive pump 24 operates to drive the blood in the first tubing 11 into the dialysis tubing assembly 2.

[0074] Furthermore, such as Figure 1 As shown, the dialysis apparatus 22 includes a dialysis filter 221, a dialysate container 222, and a third drive pump. The dialysis filter 221 is mounted on the dialysis tubing 21 and is connected to the dialysate container 222 via a circulation tubing 225. The third drive pump drives the dialysate to circulate within the circulation tubing 225. Specifically, there are two third drive pumps: a first peristaltic pump 223 and a second peristaltic pump 224. The first peristaltic pump 223 is located between the outlet of the dialysis filter 221 and the inlet of the dialysate container 222, and the second peristaltic pump 224 is located between the outlet of the dialysate container 222 and the inlet of the dialysis filter 221. During dialysis, the first peristaltic pump 223 and the second peristaltic pump 224 are activated. Blood flows into the dialysis filter 221 and is dialyzed, improving the levels of metabolic substances and electrolytes in the blood before flowing into the aorta. When dialysis is not required, the second peristaltic pump 224 is turned off and the first peristaltic pump 223 is turned on, so that the dialysate in the dialysis filter 221 is recycled into the dialysate container 222. When dialysis is turned off and the second drive pump 24 is turned on, some of the blood in the first tubing 11 flows through the dialysis tubing assembly and then flows to the second tubing 12, but hemodialysis is not performed at this time.

[0075] In one embodiment, the perfusion tubing assembly 1 includes a fourth control valve 19, disposed between the organ box 3 and the blood storage container 13. The fourth control valve 19 controls a first air bladder at one end of the first tubing 11 and a second air bladder at one end of the second tubing 12, thereby sealing the first tubing 11 relative to the venous wall and the second tubing 12 relative to the aortic wall. Simultaneously, it regulates and reduces the perfusion flow rate of the circulatory tubing, maintaining a flow rate only sufficient to supply the coronary arteries of the heart. At this time, other cardiac vessels are clamped with surgical forceps for ex vivo cardiac surgery.

[0076] During heart retrieval, the superior and inferior vena cava, aorta, pulmonary artery, pulmonary veins, and related branches are dissected. The pump speed is reduced to the coronary flow rate (500-700 ml / min), switching from systemic perfusion mode to a mode that supplies blood to the heart only through the coronary arteries. The posterior half of the second conduit 12 (descending aorta) is severed, and its opening is sealed manually, with an anastomosis device, or via balloon closure. The first conduit 11 and the second conduit 12 at the drainage end of the inferior vena cava are attached to the organ cassette 3. The heart is then placed inside the organ cassette 3, and a left ventricular drainage tube is added. Blood circulates through the left ventricular drainage tube and the coronary circulation of the heart within the organ cassette (at this point, the superior and inferior vena cava are sutured).

[0077] At this point, the flow in the first conduit 11 is closed, and the passage in the recovery tube 4 is opened. The first conduit 11 and the recovery tube 4 can be opened and closed separately using control valves, or they can be connected selectively using a three-way valve. In this embodiment, the fourth control valve 19 is used to control the opening and closing of the first conduit 11, and the recovery tube 4 is closed and opened using surgical forceps. In other embodiments, the fourth control valve 19 can be configured as a three-way valve connected to either the first conduit 11 or the recovery tube 4 simultaneously, allowing for switching between the two conduits. This switching is more convenient and stable, preventing both conduits from being open or closed simultaneously. Blood from the ventricles flows out from the organ box 3 through the recovery tube 4, then flows through the blood storage tank 13, maintaining the isolated heart externally through the entire tubing system.

[0078] Specifically, drainage tubes are inserted into the pulmonary artery and left ventricle of the heart. The beating heart pumps blood out of the left ventricle and right atrium. This process recovers blood returning to the right atrium via the coronary veins (pulmonary artery cannulation) and prevents blood accumulation in the left ventricle from causing aortic valve opening and regurgitation; it also prevents blood from flowing back into the left ventricle and accumulating due to aortic insufficiency (left ventricular cannulation). At this point, all remaining cardiac vascular pathways except for the superior and inferior vena cava are sutured. The heart, along with the drainage tubes, is transferred to organ box 3. The aortic perfusion tubing is secured using the slot structure of organ box 3. After the heart is transferred to the patient, the first tubing 11 is opened and the recovery tube 4 is closed, following a procedure similar to that during heart retrieval. The heart is then switched back to its original perfusion state and surgically sutured to the patient, completing the heart transplant.

[0079] Second Implementation Method

[0080] according to Figure 2 The dual-purpose maintenance system according to the second embodiment of the present invention will be described.

[0081] The dual-purpose maintenance system of this embodiment has a similar structure to the dual-purpose maintenance system of the first embodiment. The main differences are described below.

[0082] In this embodiment, such as Figure 2 As shown, the dual-purpose maintenance system also includes a metabolic sensor 6, used to detect blood parameters (such as ion concentration, toxins, pH, etc.) within the perfusion tubing assembly 1. When the blood parameters detected by the metabolic sensor 6 reach preset values, the dialysis tubing assembly 2 operates to perform dialysis on venous blood, ensuring that parameters such as the content of metabolic products and ions in the blood flowing to the aorta are maintained within acceptable ranges.

[0083] Furthermore, the dual-use maintenance system also includes a control unit (not shown in the figure), which selectively controls the opening and closing of the third drive pump (first peristaltic pump 223 and second peristaltic pump 224) based on the parameters detected by the metabolic sensor 6. When the blood parameters detected by the metabolic sensor 6 reach a preset value, the control unit controls the third drive pump to turn on to start the dialysis device 22. When dialysis is not required, the control unit controls the second peristaltic pump 224 to turn off while the first peristaltic pump 223 remains on for a certain period of time, so that the dialysate in the dialysis filter 221 is recovered into the dialysate container 222, and then the first peristaltic pump 223 is turned off.

[0084] Furthermore, based on the blood parameters detected by the metabolic sensor 6, the perfusion device 16 can adjust the perfusion parameters of the perfusion fluid and / or the drug supply device 17 can adjust the drug supply parameters so that parameters such as the content of nutrients, metabolites and ions in the blood are within the qualified range.

[0085] Third Implementation Method

[0086] according to Figure 3 The dual-purpose maintenance system of the third embodiment of the present invention will be described.

[0087] The dual-purpose maintenance system of this embodiment has a similar structure to the dual-purpose maintenance systems of the first and second embodiments. The main differences are described below.

[0088] In this embodiment, such as Figure 3 As shown, the dual-use maintenance system also includes a cleaning assembly 5, which includes a cleaning line 51, a first drive pump 52, a second control valve 53, and a perfusion fluid container 54. The inlet end of the cleaning line 51 is connected to the perfusion fluid container 54, and the outlet end is connected to the dialysis line 21. The first drive pump 52 and the second control valve 53 are both mounted on the cleaning line 51. The first drive pump 52 can be a peristaltic pump. After use, the dialysis line assembly 2 needs to be cleaned promptly to prevent blood coagulation within it. During cleaning, the second control valve 53 is opened, and the perfusion fluid in the perfusion fluid container 54 flows through the dialysis line 21 and the dialysis device 22 under the driving force provided by the first drive pump 52, flushing away the blood and filling the dialysis line assembly 2 with perfusion fluid. After cleaning, the second control valve 53 is closed.

[0089] Furthermore, such as Figure 3 As shown, a third control valve 23 is provided on the dialysis tubing 21, located between the inlet end of the dialysis tubing 21 and the outlet end of the cleaning tubing 51. When the cleaning assembly 5 cleans the dialysis tubing assembly 2, the third control valve 23 is first closed to flush out the blood in the dialysis tubing assembly 2 and fill the dialysis tubing assembly 2 with perfusion fluid. Then, the third control valve 23 is opened to clean the tubing between the inlet end of the dialysis tubing 21 and the outlet end of the cleaning tubing 51 with perfusion fluid.

[0090] Furthermore, such as Figure 3 As shown, when the cleaning assembly 5 cleans the dialysis tubing assembly 2, the second drive pump 24 operates to accelerate the flow of perfusion fluid from the cleaning assembly 5 to the dialysis tubing assembly 2. When cleaning is complete and the dialysis tubing assembly 2 is in the closed state, the first drive pump 52, the second control valve 53, the third control valve 23, and the second drive pump 24 are closed. When the dialysis tubing assembly 2 is restarted, the first drive pump 52 and the second control valve 53 are closed, and the third control valve 23 and the second drive pump 24 are opened, allowing the blood in the first tubing 11 to flow through the dialysis tubing assembly 2, while the perfusion fluid from the cleaning assembly 5 does not flow to the dialysis tubing assembly 2.

[0091] It should be understood that the above embodiments are exemplary and are not intended to encompass all possible implementations included in the claims. Various modifications and changes can be made to the above embodiments without departing from the scope of this disclosure. Similarly, the various technical features of the above embodiments can be arbitrarily combined to form other embodiments of the present invention that may not be explicitly described. Therefore, the above embodiments only illustrate several implementations of the present invention and do not limit the scope of protection of this patent.

Claims

1. A dual-purpose maintenance system for heart harvesting and extracorporeal cardiac maintenance, characterized in that, include: A perfusion tubing assembly (1) is used to perfuse the heart; the perfusion tubing assembly (1) includes a first tubing (11) and a second tubing (12); one end of the first tubing (11) is used to connect to a vein of the heart; one end of the second tubing (12) is used to connect to the aorta of the heart; Organ box (3) for holding heart removed from donor; organ box (3) has a collection tank connector (33); perfusion line assembly (1) includes blood storage container (13) disposed on first line (11); collection tank connector (33) is connected to blood storage container (13) via recovery pipe (4); The first pipeline (11) and the recovery pipeline (4) are respectively controllably connected to or shut off from the blood storage container (13); The organ box (3) is provided with a first connecting part (31) and a second connecting part (32). The first connecting part (31) can be detachably connected to the first conduit (11) connected to the vein of the heart; the second connecting part (32) can be detachably connected to the second conduit (12) connected to the aorta of the heart.

2. The dual-purpose maintenance system according to claim 1, characterized in that, The perfusion tubing assembly (1) includes a fourth control valve (19) disposed between the organ box (3) and the blood storage container (13), the fourth control valve (19) being used to control the connection or closure of the first tubing (11) and the blood storage container (13).

3. The dual-purpose maintenance system according to claim 2, characterized in that, The fourth control valve (19) is a three-way valve. The recovery pipe (4) and the first pipeline (11) are both connected to the blood storage container (13) through the fourth control valve (19).

4. The dual-purpose maintenance system according to claim 1, characterized in that, The first pipeline (11) is provided with a first mounting part (112), and the second pipeline (12) is provided with a second mounting part (121). The first mounting part (112) is used to be detachably connected to the first connecting part (31), and the second mounting part (121) is used to be detachably connected to the second connecting part (32).

5. The dual-purpose maintenance system according to claim 4, characterized in that, One of the first mounting part (112) and the first connecting part (31) is constructed as a snap-fit ​​protrusion structure, and the other is constructed as a snap-fit ​​groove structure; One of the second mounting part (121) and the second connecting part (32) is constructed as a snap-fit ​​protrusion structure, and the other is constructed as a slot structure.

6. The dual-purpose maintenance system according to any one of claims 1-5, characterized in that, A first airbag (111) is provided on the outer periphery of one end of the first conduit (11), the first airbag (111) is used to be placed inside the vein; and the first airbag (111) has a first working state of not closing the vein and a second working state of completely closing the vein; The outer periphery of one end of the second conduit (12) is provided with a second airbag, which is used to be placed inside the aorta, and the second airbag has a third working state in which the aorta is not closed and a fourth working state in which the aorta is completely closed.

7. The dual-purpose maintenance system according to any one of claims 1-5, characterized in that, The outer periphery of one end of the first conduit (11) and / or the second conduit (12) is provided with a plurality of slots, which are used to engage with a suture to ligate the vein and / or aorta.

8. The dual-purpose maintenance system according to claim 1, characterized in that, The perfusion tubing assembly (1) includes an oxygenation device (14), a centrifugal pump (15), a perfusion device (16), and a drug supply device (17); the oxygenation device (14) is used to oxygenate the blood, the centrifugal pump (15) is used to drive the blood flow in the perfusion tubing assembly (1), the perfusion device (16) is used to inject perfusion fluid into the blood, and the drug supply device (17) is used to inject drugs into the blood.

9. The dual-purpose maintenance system according to claim 1, characterized in that, It also includes a dialysis tubing assembly (2), with its two ends connected to the perfusion tubing assembly (1) for selectively dialyzing the blood in the perfusion tubing assembly (1); The dialysis tubing assembly (2) includes: Dialysis tubing (21), having an inlet and an outlet end connected to the infusion tubing assembly (1), A dialysis device (22) is installed on the dialysis tubing (21) for dialysis of blood; The infusion pipeline assembly (1) also includes a first control valve (18) located between the inlet end and the outlet end.

10. The dual-purpose maintenance system according to claim 9, characterized in that, The dialysis tubing assembly (2) also includes a second drive pump (24), which is disposed on the dialysis tubing (21); The dialysis device (22) includes a dialysis filter (221), a dialysate container (222), and a third drive pump. The dialysis filter (221) is disposed on the dialysis line (21) and is connected to the dialysate container (222) through a circulation line (225). The third drive pump is used to drive the dialysate to circulate in the circulation line (225).

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