A radiation blocking and sterilization dual-function composite agent and its preparation method and application

Abstract

The present invention belongs to the field of radiation protection and disinfection and sterilization technology, and specifically relates to a radiation blocking and sterilization dual-functional composite agent, and its preparation method and application. The radiation blocking and sterilization dual-functional composite agent at least contains a neutron protection compound, a nuclear ray protection compound and a sterilization compound, and the composite agent is a liquid preparation. The present invention provides a radiation blocking and sterilization dual-functional composite agent for the first time, which can be used for air spray purification or wet wipes impregnation liquid, etc., so as to remove radioactive dust and aerosols in the air, and wipe dust from nuclear contaminated operating tables and hospital ward doors and windows and other nuclear contaminated areas. At the same time, the sterilization component in the composite agent can kill bacteria, viruses and prevent corrosion, and can be applied to a variety of nuclear facility environments and scenes, so it has good practical application value.

Description

Technical Field

[0001] The invention belongs to the technical field of radiation protection and sterilization, and specifically relates to a dual-functional composite agent for radiation blocking and sterilization, and a preparation method and application thereof. Background Art

[0002] The information disclosed in the background of the invention is only intended to enhance the understanding of the overall background of the invention and should not be necessarily regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art.

[0003] There are a lot of radioactive dust, aerosols and other pollutants in the environment of the radiology department of medical institutions. Compared with the medical imaging department and radiotherapy department, the personal radiation dose monitoring data of radiation workers in the nuclear medicine department is 4 to 10 times that of other departments, and it is urgent to carry out research on nuclear protection products in nuclear medicine workplaces. In addition to the hazards of radioactive dust, aerosols, etc., the working environment of the radiology department and other places in the hospital need to be sterilized and disinfected regularly. Therefore, the development of products with both sterilization and nuclear radiation protection functions in the working environment of the radiology department has both high scientific research value and strong practical application value.

[0004] The radioactive substances in the environment of the radiology department mainly include beta rays (99%) and gamma rays (1%) emitted by medical nuclides such as iodine 131 (I-131), technetium 99 (Tc-99) and fluorine 18 (18-F). In addition to the nuclear pollution caused by the use of radioactive drugs, the neutrons produced when the cyclotron is used to prepare radioactive isotopes in the hospital are another major source of radiation pollution. Therefore, hospital nuclear radiation protection products need to protect against neutron and radiation hazards at the same time.

[0005] The inventors have found that the least toxic and most commonly used neutron protection material is boron 10, but there has been no report on the compounding of other chemical element compounds with boron 10 compounds and bactericides based on boron 10 compounds; and the most commonly used radiation protection element known to be lead is lead. However, lead can only be added to nuclear radiation protection products as a solid sample. If lead is used in liquid products, it will cause serious harm to the surrounding environment and human body, and non-toxic or low-toxic alternative elements must be found. Therefore, how to configure liquid nuclear radiation protection products while also having a sterilization function is still a technical problem that needs to be solved in this field. Summary of the invention

[0006] In view of the shortcomings of the prior art, the purpose of the present invention is to provide a radiation blocking and sterilization dual-function composite agent and its preparation method and application, so that it can be used as a wet wipes impregnation liquid and an air spray liquid raw material to remove nuclear radiation dust, aerosols, bacteria, viruses, etc. in the air and on the surface of objects in a nuclear contaminated environment. Based on the above research results, the present invention is completed.

[0007] In order to achieve the above technical objectives, the technical solution provided by the present invention is as follows:

[0008] In a first aspect of the present invention, a radiation blocking and sterilization dual-function composite agent is provided, wherein the composite agent at least comprises a neutron protection compound, a nuclear radiation protection compound and a sterilization compound; the composite agent is a liquid preparation;

[0009] Wherein, the neutron protection compound is boric acid or a soluble non-toxic compound containing boron 10 element; further, the neutron protection compound can also be boric acid.

[0010] The nuclear radiation protection compound is selected from non-toxic or low-toxic soluble compounds containing elements including but not limited to bismuth, tungsten, tantalum, lanthanum, and cerium, and is further selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride, and cerium chloride.

[0011] The bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide.

[0012] The second aspect of the present invention provides a method for preparing the above-mentioned radiation blocking and sterilization dual-function composite agent, the preparation method comprising:

[0013] S1. Dispersing the neutron protection compound into water, adding a stabilizer and stirring to obtain liquid A;

[0014] S2, adding the nuclear radiation protection compound to the solution A obtained in step S1, and dissolving by ultrasonic stirring to obtain solution B;

[0015] S3, adding the bactericidal compound into liquid B and stirring to obtain the product.

[0016] The third aspect of the present invention provides the use of the above-mentioned radiation blocking and sterilization dual-functional composite agent in the preparation of sterilization and nuclear radiation protection products.

[0017] Beneficial technical effects of one or more of the above technical solutions:

[0018] The above technical solution provides for the first time a dual-functional composite product of radiation blocking and sterilization. The product can be used for air spray purification or wet wipes impregnation liquid to remove radioactive dust and aerosols in the air, and to wipe dust from nuclear contaminated areas such as nuclear contaminated operating tables and hospital ward doors and windows. At the same time, the bactericidal components in the composite can kill bacteria, viruses and have multiple functions such as preservation. It can be used in a variety of nuclear facility environments and scenarios, and therefore has good practical application value. DETAILED DESCRIPTION

[0019] It should be noted that the following detailed descriptions are all illustrative and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present invention belongs.

[0020] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0021] The present invention is further described in conjunction with specific examples. The following examples are only for explaining the present invention and are not intended to limit the content thereof. If the specific experimental conditions are not specified in the examples, they are usually carried out according to conventional conditions or the conditions recommended by the reagent company; the reagents and consumables used in the following examples, unless otherwise specified, can all be obtained from commercial sources.

[0022] In a typical embodiment of the present invention, a radiation blocking and sterilization dual-function composite agent is provided, wherein the composite agent at least comprises a neutron protection compound, a nuclear radiation protection compound and a sterilization compound; the composite agent is a liquid preparation.

[0023] Among them, the neutron protection compound is boric acid or a soluble non-toxic compound containing boron 10 element; further, since the abundance of boron-10 and boron-11 in natural boron element is 19.78% and 80.22% respectively, a high dose of natural boron element can be used instead of boron-10 as a neutron protection material, so the neutron protection compound can also be boric acid.

[0024] The nuclear radiation protection compound is selected from non-toxic or low-toxic soluble compounds containing elements including but not limited to bismuth, tungsten, tantalum, lanthanum, and cerium, and is further selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride, and cerium chloride.

[0025] The bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide.

[0026] It should be noted that when the nuclear radiation protection compound is selected from a soluble compound containing bismuth, the bactericidal compound can be selected from sodium benzoate, but it is not suitable to use ammonium and amino-containing bactericides (such as benzalkonium chloride, benzethonium chloride and benzalkonium bromide, etc.) because their compounding is prone to precipitation problems. Analysis of the problem of precipitation formed by ammonium bactericides is that ammonium or amine groups are ionized in water to generate weakly alkaline hydroxide ions, which react with soluble compounds containing bismuth (such as potassium bismuth citrate) to cause the precipitation of bismuth. Therefore, it is not suitable to use ammonium and amino-containing bactericides.

[0027] Wherein, the mass ratio of the neutron protection compound, the nuclear radiation protection compound and the sterilization compound is 0.5-10:0.05-100:0.01-0.5, further such as 0.5-5:0.05-1:0.01-0.2.

[0028] The solvent of the composite agent is water, further deionized water.

[0029] In another specific embodiment of the present invention, the radiation blocking and sterilization dual-function composite agent may also contain common auxiliary materials such as stabilizers, and the stabilizer may be ethylene glycol; the stabilizer can effectively improve the stability of the above active ingredients. The content of ethylene glycol in the composite agent is 0.1-1% (w / w).

[0030] In another specific embodiment of the present invention, a method for preparing the above-mentioned radiation blocking and sterilization dual-function composite agent is provided, and the preparation method comprises:

[0031] S1. Dispersing the neutron protection compound into water, adding a stabilizer and stirring to obtain liquid A;

[0032] S2, adding the nuclear radiation protection compound to the solution A obtained in step S1, and dissolving by ultrasonic stirring to obtain solution B;

[0033] S3, adding the bactericidal compound into liquid B and stirring to obtain the product.

[0034] Wherein, in the step S1, the mass ratio of the neutron protection compound to water is 1:5-1000; further 1:10-100; and the water is deionized water.

[0035] The stabilizer may be ethylene glycol.

[0036] In another specific embodiment of the present invention, there is provided the use of the above-mentioned dual-functional composite agent of radiation blocking and sterilization in the preparation of sterilization and nuclear radiation protection products.

[0037] The sterilization and nuclear radiation protection product can be any product containing the above-mentioned composite agent, such as air spray, wet wipes, and devices, equipment and systems (such as sprayers) carrying the above-mentioned composite agent, etc., and no specific limitation is made here; at the same time, the above-mentioned product can be used in any nuclear contaminated environment, especially in the environment where radioactive dust, aerosols, bacteria, viruses and other pollutants exist, including but not limited to medical institutions, scientific research institutions, nuclear power plants, etc. with radiation sources (such as corresponding nuclear devices and equipment).

[0038] The present invention is further explained by the following examples, but they are not intended to limit the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The test methods for the specific conditions in the following examples are usually carried out under normal conditions.

[0039] Example 1

[0040] 0.2g of potassium bismuth citrate was added to 100mL of deionized water, stirred and dissolved, 2g of boric acid was added to the solution, stirred and dissolved, a clear and transparent solution was obtained, 0.8g of ethylene glycol was added, stirred and dispersed, and 0.05g of benzethonium chloride was added. A large amount of white precipitate was found to be generated during the stirring and dissolving process, indicating that potassium bismuth citrate, boric acid, ethylene glycol and benzethonium chloride cannot be combined to obtain a stable dual-functional composite preparation for sterilization and nuclear radiation protection.

[0041] Example 2

[0042] 0.2g of potassium bismuth citrate was added to 100mL of deionized water, stirred and dissolved, 2g of boric acid was added to the solution, stirred and dissolved, a clear and transparent solution was obtained, 0.8g of ethylene glycol was added and stirred and dispersed, and 0.05g of chlorhexidine gluconate was added. A large amount of white precipitate was found to be generated during the stirring and dissolving process, indicating that potassium bismuth citrate, boric acid, ethylene glycol and chlorhexidine gluconate cannot be combined to obtain a stable dual-functional composite preparation for sterilization and nuclear radiation protection.

[0043] Example 3

[0044] 0.2g of potassium bismuth citrate was added to 100mL of deionized water, stirred and dissolved, 2g of boric acid was added to the solution, stirred and dissolved, a clear and transparent solution was obtained, 0.8g of ethylene glycol was added and stirred and dispersed, and 0.05g of benzalkonium chloride was added. A large amount of white precipitate was found to be generated during the stirring and dissolving process, indicating that potassium bismuth citrate, boric acid, ethylene glycol and benzalkonium chloride cannot be combined to obtain a stable dual-functional composite preparation for sterilization and nuclear radiation protection.

[0045] Example 4

[0046] 0.2g of potassium bismuth citrate was added to 100mL of deionized water, stirred and dissolved, 2g of boric acid was added to the solution, stirred and dissolved, a clear and transparent solution was obtained, 0.8g of ethylene glycol was added and stirred and dispersed, and 0.05g of benzalkonium bromide was added. A large amount of white precipitate was found to be generated during the stirring and dissolving process, indicating that potassium bismuth citrate, boric acid, ethylene glycol and benzalkonium bromide cannot be combined to obtain a stable dual-functional composite preparation for sterilization and nuclear radiation protection.

[0047] Based on the above precipitation problem caused by the combination of ammonium and amino-containing fungicides with potassium bismuth citrate, boric acid, and ethylene glycol, we analyzed that the problem of precipitation caused by ammonium fungicides is that ammonium or amine groups are ionized in water to generate weakly alkaline hydroxide ions, which react with potassium bismuth citrate to cause the precipitation of bismuth. Therefore, we further adjusted the implementation plan by adjusting the fungicide.

[0048] Example 5

[0049] Add 0.2g of potassium bismuth citrate to 100mL of deionized water, stir and dissolve, add 2g of boric acid to the solution, stir and dissolve to obtain a clear and transparent solution, add 0.8g of ethylene glycol, stir and disperse, add 0.04g of sodium benzoate, stir and dissolve to obtain a clear and transparent solution. This indicates that potassium bismuth citrate, boric acid, ethylene glycol and sodium benzoate can be combined to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. Use 5mL of the preparation to soak a piece of 18cm×21cm non-woven fabric to make a wet wipe, and use the wet wipe to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131 The removal rate of I is 99.7%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.5%.

[0050] Example 5 illustrates that the dual-function composite preparation of sterilization and nuclear radiation protection obtained by compounding potassium bismuth citrate, boric acid, ethylene glycol and sodium benzoate has good performance.

[0051] In order to further explore the feasibility of using other ingredients in combination with anti-nuclear radiation elements to obtain a dual-functional composite preparation for sterilization and anti-nuclear radiation, we further replaced potassium bismuth citrate with sodium tungstate to obtain the following examples.

[0052] Example 6

[0053] Add 0.3g sodium tungstate to 100mL deionized water, stir and dissolve, add 2g boric acid to the solution, stir and dissolve to obtain a clear and transparent solution, add 0.8g ethylene glycol, stir and disperse, add 0.05g benzethonium chloride, stir and dissolve to obtain a clear and transparent solution. This shows that sodium tungstate, boric acid, ethylene glycol and benzethonium chloride can be combined to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. Use 5mL of the composite preparation to soak a piece of 18cm×21cm non-woven fabric to make a wet wipe, and use the wet wipe to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131 The removal rate of I is 95%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.9%.

[0054] Example 7

[0055] The difference between Example 7 and Example 6 is that 0.05g of benzethonium chloride is replaced by 0.05g of chlorhexidine gluconate, and a clear and transparent solution is obtained after stirring and dissolving. This shows that sodium tungstate, boric acid, ethylene glycol and benzethonium chloride can be compounded to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. 5mL of the composite preparation is used to impregnate a piece of 18cm×21cm non-woven fabric to make a wet wipe, and the wet wipe is used to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131 The removal rate of I is 94%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.5%.

[0056] Example 8

[0057] The difference between Example 8 and Example 6 is that 0.05g of benzethonium chloride is replaced by 0.04g of sodium benzoate, and a clear and transparent solution is obtained after stirring and dissolving. This shows that sodium tungstate, boric acid, ethylene glycol and sodium benzoate can be compounded to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. 5mL of the composite preparation is used to impregnate a piece of 18cm×21cm non-woven fabric to make a wet wipe, and the wet wipe is used to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131The removal rate of I is 95%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.4%.

[0058] Examples 6-8 illustrate that sodium tungstate, boric acid, ethylene glycol and ammonium disinfectants or sodium benzoate or chlorhexidine disinfectants can be combined to obtain dual-function composite preparations for sterilization and nuclear radiation protection.

[0059] Example 9

[0060] The difference between Example 9 and Example 6 is that 0.3g of sodium tungstate is replaced by 0.3g of sodium tantalate, and the other compounds are the same. After stirring and dissolving, a clear and transparent solution is obtained. This shows that sodium tantalate, boric acid, ethylene glycol and benzethonium chloride can be compounded to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. 5mL of the composite preparation is used to impregnate a piece of 18cm×21cm non-woven fabric to make a wet wipe, and the wet wipe is used to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131 The removal rate of I is 90%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.9%.

[0061] Example 10

[0062] The difference between Example 10 and Example 6 is that 0.3g of sodium tungstate is replaced by 0.5g of lanthanum chloride, and the other compounds are the same. After stirring and dissolving, a clear and transparent solution is obtained. This shows that lanthanum chloride, boric acid, ethylene glycol and benzethonium chloride can be compounded to obtain a stable dual-function composite preparation for sterilization and nuclear radiation protection. 5mL of the composite preparation is used to impregnate a piece of 18cm×21cm non-woven fabric to make a wet wipe, and the wet wipe is used to wipe the exposed 131 The activity concentration of I is 3000 Bq / m 3 Stainless steel tabletop in the environment 1m 2 , test the desktop before and after wiping 131 The activity concentration of I was found to be 131 The removal rate of I is 80%. Escherichia coli was cultured on the surface of similar stainless steel material, and the test showed that the removal rate of Escherichia coli by the wet wipes can reach 99.9%.

[0063] Matters not covered by the present invention are known technologies.

[0064] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A radiation blocking and sterilization dual-function composite agent, characterized in that: The composite agent at least comprises a neutron protection compound, a nuclear radiation protection compound and a sterilization compound; the composite agent is a liquid preparation; Wherein, the neutron protection compound is boric acid or a soluble non-toxic compound containing boron 10 element; the non-toxic compound is boric acid; The nuclear radiation protection compound is selected from non-toxic or low-toxic soluble compounds containing bismuth, tungsten, tantalum, lanthanum and cerium elements, and the soluble compound is selected from any one or more of potassium bismuth citrate, ammonium bismuth citrate, sodium tungstate, sodium tantalate, lanthanum chloride and cerium chloride; When the soluble compound is selected from any one or more of potassium bismuth citrate and ammonium bismuth citrate, the bactericidal compound is selected from sodium benzoate; When the soluble compound is selected from any one or more of sodium tungstate, sodium tantalate, lanthanum chloride and cerium chloride, the bactericidal compound is selected from any one or more of sodium benzoate, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium bromide.

2. The radiation blocking and sterilization dual-function composite agent according to claim 1, characterized in that: The mass ratio of the neutron protection compound, the nuclear radiation protection compound and the sterilization compound is 0.5-10: 0.05-100: 0.01-0.

5.

3. The radiation blocking and sterilization dual-function composite agent according to claim 1, characterized in that: The solvent of the composite agent is water.

4. The radiation blocking and sterilization dual-function composite agent as claimed in claim 3, characterized in that: The solvent of the composite agent is deionized water.

5. The radiation blocking and sterilization dual-function composite agent as claimed in claim 1, characterized in that: The radiation blocking and sterilization dual-function compound further contains a stabilizer.

6. The radiation blocking and sterilization dual-function composite agent according to claim 5, characterized in that: The stabilizer is ethylene glycol; the content of the ethylene glycol in the composite agent is 0.1-1%, w / w.

7. The method for preparing the radiation blocking and sterilization dual-function composite agent according to any one of claims 1 to 6, characterized in that: The preparation method comprises: S1. Dispersing the neutron protection compound into water, adding a stabilizer and stirring to obtain liquid A; S2, adding the nuclear radiation protection compound to the solution A obtained in step S1, and dissolving by ultrasonic stirring to obtain solution B; S3, adding the bactericidal compound into liquid B and stirring to obtain the product.

8. The preparation method according to claim 7, characterized in that: In the step S1, the mass ratio of the neutron protection compound to water is 1:5-1000.

9. The preparation method according to claim 8, characterized in that: In the step S1, the mass ratio of the neutron protection compound to water is 1:10-100.

10. The preparation method according to claim 8 or 9, characterized in that: The water is deionized water.

11. The preparation method according to claim 8 or 9, characterized in that: The stabilizer is ethylene glycol.

12. Use of the radiation blocking and sterilization dual-function composite agent according to any one of claims 1 to 6 in the preparation of sterilization and nuclear radiation protection products.

13. The use according to claim 12, characterized in that The sterilization and nuclear radiation protection product is any product containing the compound, including air spray, wet wipes, and devices, equipment and systems carrying the compound.