Toremifene citrate liposome, preparation method and preparation

Encapsulation of toremiphen citrate through liposome technology solves the problem of its inability to dissolve in water, improves the bioavailability of oral administration and the stability of the preparation, and achieves high drug loading and high encapsulation rate.

CN117224487BActive Publication Date: 2025-08-08SHANDONG NEW TIME PHARMA CO LTD +1
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Patent Information

Application Number
CN202311278248.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-10-07
Publication Date
2025-08-08
Estimated Expiration
2043-10-07

AI Technical Summary

Technical Problem

Toremiphen citrate is difficult to dissolve in water, resulting in low bioavailability of oral administration, limiting its widespread clinical application.

Method used

Using liposome technology, toremifene citrate is encapsulated in a lipid carrier. By selecting lipid materials and optimizing preparation methods, toremifene citrate liposomes with high drug loading, high encapsulation rate, and high stability are prepared, and a preparation is formed with pharmaceutically acceptable excipients to improve dissolution and stability.

Benefits of technology

The high drug loading and high encapsulation rate of toremiphen citrate were achieved, which improved the bioavailability of oral administration, enhanced the stability and dissolution of the preparation, and reduced the impurity content.

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Abstract

The present invention belongs to the technical field of pharmaceutical preparations and specifically relates to a toremifene citrate liposome, a preparation method, and a preparation. The present invention encapsulates toremifene citrate in a lipid carrier composed of toremifene citrate, peanut lecithin, cholesterol, and calcium propionate. The preparation method is optimized to provide a toremifene citrate liposome with high drug loading, high encapsulation efficiency, and high stability. The liposome is then further prepared with pharmaceutically acceptable excipients into a toremifene citrate preparation, which improves oral bioavailability, reduces impurity content, and improves the stability of the preparation.
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