Method for weaving medical hollow fiber membranes

Abstract

The application relates to a weaving method of a medical hollow fiber membrane, and relates to the field of textiles. The medical hollow fiber membrane mentioned in the application is mainly applied in dialysis and an extracorporeal membrane oxygenation process. In order to improve the separation efficiency of the hollow fiber membrane, a weaving method of weaving into a curtain is provided. The weaving method comprises the selection of weaving structures, weaving equipment, post-weaving treatment and packaging process methods. According to the use and specification requirements of the medical hollow fiber membrane, different weaving structures and weaving equipment can be selected to weave the membrane curtain with different densities and arrangement modes, so that the technical problems of uneven arrangement and stress of the medical hollow fiber membrane are effectively solved, and the separation and oxygenation efficiency is significantly improved.

Description

Technical Field

[0001] This application relates to the field of textile technology, and in particular to a method for weaving a medical hollow fiber membrane. Background Technology

[0002] Medical hollow fiber membranes are hollow separation membranes with microporous selective permeability prepared by wet spinning or thermal phase separation. Currently, they are mainly made of two materials: PP and PMP. The micropore size of the pore wall can reach the nanometer to micrometer level. They are mainly used in medical dialysis and extracorporeal membrane oxygenation.

[0003] In medical dialysis and extracorporeal membrane oxygenation (ECMO) processes, the limited effective separation surface area of ​​a single hollow fiber membrane necessitates the encapsulation of hundreds of membranes to meet requirements. However, clinical use has revealed that when liquid flows across the surface of these freely arranged hollow fiber membranes, hydrodynamic forces cause them to bend and slip, resulting in uneven distribution and insufficient separation, significantly reducing the effective separation area. Therefore, there is an urgent need to develop a low-tension hollow fiber membrane weaving method to achieve a more rational arrangement of the membranes and significantly improve medical separation efficiency. Currently, the weaving technology for medical hollow fiber membranes is a major technical challenge in my country's medical industry. Therefore, this application, based on the mechanical properties of medical hollow fiber membranes, proposes a textile weaving method to improve the efficiency of medical separation membranes. By combining weaving techniques and low-tension weaving methods from textile technology, this application fills the technical gap in current hollow fiber membrane weaving methods for medical applications. Summary of the Invention

[0004] The purpose of this application is to provide a weaving method for medical hollow fiber membranes, which solves the technical problems of uneven distribution and stress and low filtration efficiency of medical hollow fiber membranes during hemodialysis or extracorporeal membrane oxygenation through textile weaving forming technology.

[0005] To achieve the above objectives, the technical solution adopted in this application is as follows:

[0006] A method for weaving a medical hollow fiber membrane, comprising the following steps:

[0007] S1. Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, select the usage specifications and strength properties of the hollow fiber membrane, and determine the weaving structure of the hollow fiber membrane. The weaving structure of the hollow fiber membrane includes at least one of the following: leno weave, weft-lined or warp-lined chain weave, and spaced weft-lined chain weave.

[0008] S2. Determine the weaving equipment based on the weaving structure of the hollow fiber membrane, wherein the weaving equipment includes at least one of a loom, a warp knitting machine, and a sewing machine;

[0009] S3. In response to the weaving device weaving the hollow fiber membrane, the weaving yarn and the hollow fiber membrane are arranged perpendicular to each other during the weaving process, and the tension is constant during the active unwinding and yarn feeding of the hollow fiber membrane, so as to obtain a hollow fiber membrane fabric in the form of a curtain or a tube.

[0010] S4. Based on the hemodialysis or extracorporeal membrane oxygenation requirements of the hollow fiber membrane, the hollow fiber membrane fabric is sequentially post-processed, arranged into multiple layers of curtain or tube shape, and then packaged.

[0011] In one possible implementation, in step S1:

[0012] When the hollow fiber membrane has a leno weave structure, it is formed by machine weaving. Each set of warp yarns consists of two yarns that interweave and embrace to form the weft yarn of the hollow fiber membrane.

[0013] In one possible implementation, in step S1:

[0014] When the hollow fiber membrane has a weft-backed or warp-backed chain structure, a knitted warp-knitting forming process is used, with the hollow fiber membrane as the padding yarn and medical-grade low-elastic yarn as the binding yarn, and the weaving structure is a chain structure.

[0015] In one possible implementation, in step S1:

[0016] When the hollow fiber membrane has an intermittent weft-backed chain structure, a warp-knitted double needle bed forming process is adopted, with the hollow fiber membrane serving as the backing yarn and the binding yarn completing the intermittent chain structure weaving process through the front and rear needle beds.

[0017] In one possible implementation, the hollow fiber membrane woven with a double needle bed has a sandwich structure, and the number of hollow fiber membranes arranged in a certain volume space is doubled.

[0018] In one possible implementation, the chain organization includes both open chaining and closed chaining.

[0019] In one possible implementation, step S4, the post-treatment of the hollow fiber membrane fabric includes at least washing, sterilization, coagulation coating, and heat setting.

[0020] In one possible implementation, step S4, arranging the hollow fiber membrane fabric in a multi-layered curtain or tubular shape and encapsulating it, includes:

[0021] The hollow fiber membrane fabric, which is in the form of a curtain or a tube, is cut and folded into multiple layers of curtain or rolled into multiple layers of tube and then sealed in a shell.

[0022] The beneficial effects of the technical solution provided in this application include at least the following: Hollow fiber membranes are woven using textile weaving technology, with the weaving yarn and the hollow fiber membrane arranged perpendicularly to each other during the weaving process. The tension remains constant during the active unwinding and yarn feeding of the hollow fiber membrane, resulting in a curtain-like or tubular hollow fiber membrane fabric. This achieves the weaving of medical hollow fiber membranes into curtain-like or tubular shapes, solving the problem of uniform arrangement in the packaging of hollow fiber membranes. It also solves the technical problem of low oxygenation and separation efficiency caused by uneven stress on the hollow fiber membrane under blood flow during the packaging and use of medical hollow fiber membranes. Furthermore, based on the oxygenation requirements of hollow fiber membranes for hemodialysis or extracorporeal membrane oxygenation, the hollow fiber membrane fabric undergoes sequential post-processing, multi-layer curtain-like or tubular arrangement, and packaging, resulting in a uniform arrangement of the hollow fiber membrane. This increases the surface area available for oxygenation or dialysis, significantly improving the separation and oxygenation efficiency of the hollow fiber membrane. Attached Figure Description

[0023] The accompanying drawings are provided to further illustrate the present application and form part of the specification. They are used together with the embodiments of the present application to explain the application and do not constitute a limitation thereof. In the drawings:

[0024] Figure 1 shows a flowchart of a method for weaving a medical hollow fiber membrane according to an exemplary embodiment of this application;

[0025] Figure 2 shows a three-dimensional view of the woven leno fabric in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0026] Figure 3 shows a two-dimensional diagram of the weft insertion and (one-needle) closed-loop braided (closed-loop) tissue in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0027] Figure 4 shows a three-dimensional diagram of the weft insertion and (one-needle) closed-loop braided (closed-loop) tissue in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0028] Figure 5 shows a two-dimensional diagram of the weft and warp (two-needle) braided chain structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0029] Figure 6 shows a three-dimensional diagram of the weft and warp (two-needle) braided chain structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0030] Figure 7 shows a two-dimensional diagram of the weft insertion and (one-needle) braided (open) structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0031] Figure 8 shows a three-dimensional diagram of the weft insertion and (one-needle) braided chain (opening) structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0032] Figure 9 shows a two-dimensional diagram of the spaced weft braided chain structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0033] Figure 10 shows a three-dimensional front view of the spaced weft braided chain structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0034] Figure 11 shows a three-dimensional left view of the spaced weft braided structure in a weaving method for a medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0035] Figure 12 shows a physical diagram of the weft insertion and (one-needle) braided chain (open) structure in the weaving method of the medical hollow fiber membrane provided in an exemplary embodiment of this application;

[0036] Figure 13 shows a physical diagram of the weft insertion and (one-needle) closed-loop braided (closed-loop) structure in the weaving method of the medical hollow fiber membrane provided in an exemplary embodiment of this application; in the figure: 1, binding yarn; 2, hollow fiber membrane. Detailed Implementation

[0037] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0038] In this specification, identical components are represented by the same reference numerals. It should be noted that the terms "front," "rear," "left," "right," "upper," and "lower" used in the following description refer to directions in the accompanying drawings, while the terms "bottom surface" and "top surface," "inner" and "outer" refer to directions towards or away from a specific component, respectively. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this specification, "multiple" means two or more.

[0039] First, a brief introduction to the terms used in the embodiments of this application:

[0040] Medical hollow fiber membranes are fibrous membranes with a self-supporting structure. They are commonly used in hemodialysis, blood gas separation, and exchange. Primarily made from polysulfone and dimethylacetamide, these membranes are processed into hollow fiber filaments and then coated with a highly permeable polymer, giving them selective permeation properties. The outer diameter of the hollow fiber membrane is typically 400-600 μm, and the inner diameter is 200-300 μm. The fibers are bundled into bundles of 2-10 meters and housed within a high-pressure resistant shell. One end of the fiber bundle is sealed, and the other end is bonded together with a specially formulated epoxy resin.

[0041] The present application will be further described below with reference to the accompanying drawings and embodiments.

[0042] Example 1:

[0043] Figure 1 shows a flowchart of a method for weaving a medical hollow fiber membrane according to an exemplary embodiment of this application. The method for weaving the medical hollow fiber membrane includes the following steps:

[0044] Step S1: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, select the usage specifications and strength properties of hollow fiber membranes, and determine the weave structure of hollow fiber membranes.

[0045] In this embodiment of the application, hollow fiber membrane is used as the weaving object. The weaving structure of the hollow fiber membrane includes at least one of the following in the textile field: leno weave in weaving technology, weft-backed or warp-backed chain weave in knitting technology, and spaced weft-backed chain weave.

[0046] In the embodiments of this application, when the woven structure of the hollow fiber membrane is leno fabric, a machine-woven forming process is adopted to meet the requirements of blood flow field. Each set of warp yarns consists of two yarns (the width is determined according to medical needs), which are interwoven and embraced to form the weft yarn of the hollow fiber membrane.

[0047] In the embodiments of this application, when the woven structure of the hollow fiber membrane is a weft-lined or warp-lined chain structure, a knitted warp-knitting forming process is adopted, with the hollow fiber membrane as the padding yarn and the medical-grade low-elastic yarn as the binding yarn, and the woven structure is a chain structure.

[0048] In this embodiment, when the hollow fiber membrane has an intermittent weft-backed chain knitting structure, a warp-knitted double-needle-bed forming process is used. The hollow fiber membrane serves as the backing yarn, and the binding yarn completes the intermittent chain knitting process through the front and rear needle beds. The hollow fiber membrane woven with a double-needle bed has a sandwich structure, doubling the number of hollow fiber strands within a given volume, which further improves the working efficiency of the hollow fiber membrane.

[0049] It is worth mentioning that the above-mentioned chain weaving organization includes two methods: open chain weaving and closed chain weaving.

[0050] Step S2: Determine the weaving equipment based on the weaving structure of the hollow fiber membrane.

[0051] Optionally, the weaving equipment includes at least one of the following: a loom, a braiding machine, a warp knitting machine, and a sewing machine.

[0052] In the embodiments of this application, the hollow fiber membranes used for hemodialysis or extracorporeal membrane oxygenation have different requirements for outer diameter, mechanical properties, and density, so the selection of weaving structure, weft feeding method, and weaving machine is different.

[0053] In this embodiment of the application, the weaving parameters of the weaving equipment are set according to the required parameters such as diameter and porosity of the hollow fiber membrane, including weaving speed, weaving density, and weaving structure.

[0054] Step S3: In response to the weaving equipment weaving the hollow fiber membrane, the weaving yarn and the hollow fiber membrane are arranged perpendicular to each other during the weaving process, and the tension is constant during the active unwinding and yarn feeding of the hollow fiber membrane, resulting in a curtain-shaped hollow fiber membrane fabric.

[0055] In this embodiment, the hollow fiber membrane is fed into the weaving mechanism via an active yarn feeding and constant tension yarn feeding process. Based on preset weaving parameters, the hollow fiber membrane is woven through motion control of the weaving machine. During the weaving process, by controlling the motion trajectory of the weaving machine and the tension of the hollow fiber membrane, a hollow fiber structure with consistency and stability is ensured. During the weaving process, the warp and weft insertion methods of the hollow fiber membrane and binding yarns are arbitrary; from the perspective of the finished product, there is no distinction between warp and weft yarns, and the density between the binding yarns in the weaving process can be adjusted according to the application requirements.

[0056] Optionally, the warp and weft densities can be adjusted arbitrarily within a specified range according to the medical application requirements of the hollow fiber membrane. Warp density (specifically referring to binding yarn): 5-30 mm / thread, weft density (specifically referring to hollow fiber membrane): 5-30 threads / cm.

[0057] In the embodiments of this application, the binding yarn uses low-elasticity yarns of different fineness that meet medical grade requirements and is adapted to hollow fiber membranes of different specifications, which can effectively prevent blood clotting and meet weaving requirements.

[0058] In this embodiment, the active unwinding of the hollow fiber membrane is based on the demand for the hollow fiber membrane by the weaving mechanism. A servo motor controls the coil of the hollow fiber membrane, actively unwinding it according to different machine speeds. Maintaining constant tension during yarn feeding means that no tension fluctuation occurs as the hollow fiber membrane is unwound from the coil and fed into the weaving mechanism. An active tension buffer device (such as a tension spring or tension plate) is installed during yarn feeding.

[0059] Step S4: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, the hollow fiber membrane fabric is sequentially post-processed, arranged into multiple layers of curtain or tube shape, and then packaged.

[0060] In the embodiments of this application, the post-processing of hollow fiber membrane fabric includes at least cleaning, sterilization, coagulation coating, and heat setting to ensure that the final hollow fiber membrane meets the standards for medical applications.

[0061] In this embodiment of the application, the hollow fiber membrane fabric is arranged in a multi-layer curtain or tubular shape and then packaged, which includes: cutting the hollow fiber membrane fabric in the curtain or tubular shape, folding it into a multi-layer curtain shape or rolling it into a multi-layer tubular shape and packaging it in a shell.

[0062] In summary, based on the actual conditions of medical dialysis and extracorporeal membrane oxygenation, and the requirements for volume, density, and number of membrane filaments after hollow fiber membrane weaving, this application proposes woven leno fabric, knitted weft-inserted or warp-inserted chain fabric, and spaced weft-inserted chain fabric. Although these are only terms in the field of textile technology, they protect the essence of their structure (the vertical arrangement of binding yarns and padding yarns and the binding structure). The weaving process can be realized through various weaving equipment (such as weaving equipment, warp knitting machines, sewing machines, etc.).

[0063] Next, based on the medical application requirements of hollow fiber membranes, the warp and weft densities can be adjusted arbitrarily within a specified range. Warp density (binding yarn): 5-30 mm / thread, weft density (hollow fiber membrane): 5-30 threads / cm. Therefore, there are three implementation methods as in Examples 2 to 4.

[0064] Example 2:

[0065] This embodiment provides a method for weaving medical hollow fiber membranes. This method is suitable for applications where the density requirement of the woven hollow fiber membrane is low (5-15 strands / cm). The method includes the following steps:

[0066] Step S1: Based on the oxygenation requirements of hemodialysis or extracorporeal membrane oxygenation (volume, density, and separated products after weaving) of hollow fiber membrane, select the usage specifications and strength properties of hollow fiber membrane, and determine that the weaving structure of hollow fiber membrane is woven gauze.

[0067] Step S2: Based on the braided structure of the hollow fiber membrane, the braiding equipment is determined to be a rapier loom;

[0068] Step S3: In response to the rapier loom weaving the hollow fiber membrane with a woven leno weave structure, the binding yarn is 30-75D medical low-elasticity yarn, and the hollow fiber membrane is the weft yarn; the hollow fiber membrane enters the weaving mechanism of the rapier loom as the weft yarn, and multiple sets of warp yarns are bound at a specified density (5-30mm / yarn). Each set of warp yarns consists of two weaving yarns crossing each other vertically in a plane perpendicular to the weft yarn, forming a symmetrical cross binding. The tension is constant during the active unwinding and yarn feeding of the hollow fiber membrane. Finally, the hollow fiber membrane fabric is woven into a curtain-like structure as shown in Figure 2. In the figure: 1 is the binding yarn, and 2 is the hollow fiber membrane.

[0069] Step S4: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, the hollow fiber membrane fabric is sequentially cleaned, sterilized, coated with a coagulation coating, and heat-set. Finally, it is cut to the required length according to the usage requirements, arranged in a multi-layer curtain or tube shape, and placed into the encapsulation shell.

[0070] Example 3:

[0071] This embodiment provides a method for weaving a medical hollow fiber membrane. This method employs a knitting process, which offers advantages such as high density (12-30 fibers / cm), small volume, and strong binding of the woven hollow fiber membrane. The method includes the following steps:

[0072] Step S1: Based on the oxygenation requirements of hemodialysis or extracorporeal membrane oxygenation (volume, density, and separated products after weaving) of hollow fiber membrane, select the usage specifications and strength properties of hollow fiber membrane, and determine that the weaving structure of hollow fiber membrane is the weft-knitted chain structure in knitting technology.

[0073] Step S2: The weaving structure based on the hollow fiber membrane is a weft-lined chain knitting structure in knitting technology. The weaving equipment is determined to be an industrial warp knitting machine.

[0074] Step S3: In response to the industrial warp knitting machine weaving a hollow fiber membrane with a weft-backed chain knitting structure, the binding yarn is 45D~70D medical low-elasticity yarn, and the hollow fiber membrane is the weft yarn; the hollow fiber membrane enters the weaving mechanism of the warp knitting machine as the weft yarn, and multiple sets of warp yarns are bound in the warp direction at a specified density (5-30mm / thread). The hollow fiber membrane is woven and formed through the chain knitting structure. The tension is constant during the active unwinding and yarn feeding of the hollow fiber membrane. Finally, it is woven into a curtain-like hollow fiber membrane fabric as shown in Figures 3 to 7. In the figures: 1 is the binding yarn, and 2 is the hollow fiber membrane;

[0075] Optionally, an industrial warp knitting machine can be selected, and the knitting structure can be changed to a weft-inserted and (one-needle) closed chain knitting (closed) structure, a weft-inserted and heavy warp (two-needle) chain knitting structure, or a weft-inserted and (one-needle) chain knitting (open) structure, as shown in Figures 3 to 8. In the figures: 1 is the binding yarn, and 2 is the hollow fiber membrane.

[0076] Step S4: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, the hollow fiber membrane fabric is sequentially cleaned, sterilized, coated with a coagulation coating, and heat-set. Finally, it is cut to the required length according to the usage requirements, arranged in a multi-layer curtain or tube shape, and placed into the encapsulation shell.

[0077] Example 4:

[0078] This embodiment provides a method for weaving a medical hollow fiber membrane. This method employs a knitting process, which offers advantages such as high oxygenation efficiency, high density (12-30 fibers / cm), small volume, and strong binding after weaving. The method includes the following steps:

[0079] Step S1: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, select the usage specifications and strength properties of hollow fiber membranes, and determine that the weaving structure of hollow fiber membranes is the spaced weft knitting chain structure in knitting technology.

[0080] Step S2: The weaving structure based on the hollow fiber membrane is a spaced weft-lined chain knitting structure in knitting technology. The weaving equipment is determined to be an industrial double needle bed warp knitting machine.

[0081] Step S3: In response to the double-needle bed warp knitting machine knitting a hollow fiber membrane with an interleaved weft knitting structure, the binding yarn is 35-60D medical low-elasticity yarn, and the hollow fiber membrane is the weft yarn; the hollow fiber membrane enters the knitting mechanism of the double-needle bed warp knitting machine as the weft yarn, and multiple sets of binding yarns are bound in the warp direction of the front and rear needle beds at a specified density (5-30mm / thread). The knitting and forming process of the hollow fiber membrane is completed through the knitting structure, and the tension is constant during the active unwinding and yarn feeding process of the hollow fiber membrane. Finally, the hollow fiber membrane fabric is woven into a curtain-like structure as shown in Figures 9 to 11. In the figures: 1 is the binding yarn, and 2 is the hollow fiber membrane;

[0082] Optionally, by using a spaced-weft knitted chain structure and an industrial double-needle bed warp knitting machine, spaced-weft knitted chain fabrics of different lengths with a sandwich structure appearance can be knitted by setting the interval distance between the front and rear needle beds of the machine.

[0083] Step S4: Based on the hemodialysis or extracorporeal membrane oxygenation requirements of hollow fiber membranes, the hollow fiber membrane fabric is sequentially cleaned, sterilized, coated with a coagulation coating, and heat-set. Finally, it is cut to the required length according to the usage requirements, arranged in a multi-layer curtain or tube shape, and placed into the encapsulation shell.

[0084] In summary, the sandwich-structured spaced-weft knitted chain fabric produced by using an industrial double-needle bed warp knitting machine, compared with other structures, can uniformly arrange twice the number of hollow fiber membranes in the same space, significantly improving the efficiency of hollow fiber membranes in hemodialysis or extracorporeal membrane oxygenation.

[0085] Example 5:

[0086] To better understand this application, the weft-lined chain structure (open) from Example 3 is selected for weaving in conjunction with Examples 1 to 4. The finished product is shown in Figure 12. In the figure: 1 is the binding yarn, and 2 is the hollow fiber membrane. The weaving process is as follows:

[0087] Step S1: Select the extracorporeal membrane oxygenation requirements of the hollow fiber membrane. Select a hollow fiber membrane with an outer diameter of 420um, an inner diameter of 390um, a strength of 92cN, a weaving density of 22 threads / cm, a binding yarn density of 10mm, and a weaving structure of the hollow fiber membrane that is a weft-lined chain knitting structure (open).

[0088] Step S2: The weaving equipment uses an industrial warp knitting machine for weaving;

[0089] Step S3: In response to the industrial warp knitting machine, the hollow fiber membrane with an open weft-lined chain structure is woven. The binding yarn is 45D medical low-elasticity yarn, and the hollow fiber membrane is the weft yarn. During the active unwinding and yarn feeding process, the hollow fiber membrane enters the weaving mechanism of the warp knitting machine with constant tension, and is finally woven into a curtain-shaped hollow fiber membrane fabric as shown in Figure 12. In the figure: 1 is the binding yarn, and 2 is the hollow fiber membrane.

[0090] Step S4: The woven hollow fiber membrane fabric (as shown in Figure 12) is post-processed and packaged. The post-processing includes cleaning, sterilization, coagulation coating, and heat setting. The packaging involves cutting the fabric to the required length, arranging it in a multi-layered curtain or tubular shape, and then placing it into the packaging shell.

[0091] Example 6:

[0092] To better understand this application, the weft-lined chain structure (closed-loop) from Example 3 is selected for weaving in conjunction with Examples 1 to 4. The finished product is shown in Figure 13. In the figure: 1 is the binding yarn, and 2 is the hollow fiber membrane. The weaving process is as follows:

[0093] Step S1: Select the extracorporeal membrane oxygenation requirements of the hollow fiber membrane. Select a hollow fiber membrane with an outer diameter of 410 μm, an inner diameter of 380 μm, a strength of 85 cN, a weaving density of 20 threads / cm, a binding yarn density of 9 mm, and a weaving structure of the hollow fiber membrane that is a closed-loop knitting structure using knitting technology.

[0094] Step S2: The weaving equipment is the same as in Example 5, except that the machine configuration file for the weaving mechanism is changed to a closed-loop weft-inserted chain weave structure.

[0095] Step S3: In response to the industrial warp knitting machine weaving a hollow fiber membrane with a closed weft-lined chain structure, the binding yarn is 50D medical low-elasticity yarn, and the hollow fiber membrane is the weft yarn; the hollow fiber membrane enters the weaving mechanism of the warp knitting machine with constant tension during the active unwinding and yarn feeding process, and is finally woven into a curtain-shaped hollow fiber membrane fabric as shown in Figure 13. In the figure: 1 is the binding yarn, and 2 is the hollow fiber membrane;

[0096] Step S4: The woven hollow fiber membrane fabric (as shown in Figure 13) is post-processed and packaged. The post-processing includes cleaning, sterilization, coagulation coating, and heat setting. The packaging involves cutting the fabric to the required length, arranging it in a multi-layered curtain or tubular shape, and then placing it into the packaging shell.

[0097] Effect verification:

[0098] Measurements were performed on the hollow fiber membrane fabrics woven in Examples 5 and 6: the outer diameter of the woven hollow fiber membrane was >380 μm, the inner diameter was >380 μm, the strength was >78 cN, the hollow fiber membrane density was >20 fibers / cm, and there was slight deformation at the binding yarn on the outer surface. However, no obvious leakage was observed in the membrane lung oxygenation test, meeting medical requirements. The above description is merely a preferred embodiment of this application. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of this application, and these improvements and modifications should also be considered within the scope of protection of this application.

Claims

1. A method for weaving a medical hollow fiber membrane, characterized in that, Includes the following steps: S1. Based on the requirements of hemodialysis or extracorporeal membrane oxygenation using hollow fiber membranes, select the specifications and strength properties of the hollow fiber membrane, and determine the weave structure of the hollow fiber membrane. The hollow fiber membrane has an intermittent weft-backed chain structure, which is formed by warp knitting double needle bed forming process. The hollow fiber membrane is used as the weft yarn, and the binding yarn completes the intermittent chain structure weaving process through the front and rear needle beds. The binding yarn is 35-60D medical low elastic yarn. The hollow fiber membrane woven with double needle bed has a sandwich structure, which doubles the number of hollow fiber membranes in a certain volume space. S2. Determine the weaving equipment based on the weaving structure of the hollow fiber membrane, wherein the weaving equipment includes a warp knitting machine; S3. In response to the weaving device weaving the hollow fiber membrane, the binding yarn and the hollow fiber membrane are arranged perpendicular to each other during the weaving process, and the tension is constant during the active unwinding and yarn feeding of the hollow fiber membrane, to obtain a hollow fiber membrane fabric in the form of a curtain or a tube. S4. Based on the hemodialysis or extracorporeal membrane oxygenation requirements of the hollow fiber membrane, the hollow fiber membrane fabric is sequentially post-processed, arranged into multiple layers of curtain or tube shape, and then packaged.

2. The method for weaving a medical hollow fiber membrane according to claim 1, characterized in that, In step S4, the post-treatment of the hollow fiber membrane fabric includes at least washing, sterilization, coagulation coating, and heat setting.

3. The method for weaving a medical hollow fiber membrane according to claim 1, characterized in that, In step S4, the hollow fiber membrane fabric is arranged in multiple layers in a curtain or tube shape and then encapsulated, including: The hollow fiber membrane fabric, which is in the form of a curtain or a tube, is cut and folded into multiple layers of curtain or rolled into multiple layers of tube and then encapsulated in a shell.

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