A cream containing multiple ceramides and a method for preparing the same

Abstract

The application relates to the field of repair skin care products, in particular to a cream containing multiple ceramides and a preparation method thereof. The cream containing multiple ceramides comprises the following components: a moisturizing agent A, a thickening agent, an antioxidant; ceramides, a dispersing agent; the ceramides comprise at least two of ceramide EOP, ceramide NS / ceramide NG, ceramide AS, ceramide NP and ceramide AP; a pH regulator, a schizophyllan, a filtrate of saccharomycopsis glycerolatium fermentation product, dipotassium glycyrrhizinate, a moisturizing agent B; water; and the preparation method comprises the following steps: mixing raw materials in the A phase with water until uniform to obtain the A phase; uniformly dissolving raw materials in the B phase to obtain the B phase; mixing the B phase with the A phase, stirring until uniform to obtain a mixture; then adding various raw materials in the C phase into the mixture, stirring until uniform to obtain a finished product. The application has the advantages of quickly repairing skin.

Description

Technical Field

[0001] This application relates to the field of restorative skincare products, and more specifically, to a face cream containing multiple ceramides and a method for preparing the same. Background Technology

[0002] Skin is in direct contact with the external environment and has a good tolerance to various physical and chemical stimuli. It can effectively block the invasion of foreign objects and pathogens and prevent the loss of tissue fluid, making it an important protective organ for the body. The outermost layer of the skin is the stratum corneum, which is composed of 20 layers of flat and interwoven keratinocytes. It is as tough as "bricks," and lipids, like "mortar," tightly connect the keratinocytes in the gaps, forming a "brick wall structure." There is also a cell membrane composed of sweat and sebum on the surface, which together constitute the skin barrier and protect the substrate.

[0003] However, currently, due to excessive exfoliation, sunburn, sensitive inflammatory damage, and over-cleansing, some users have damaged skin barriers, making their skin unable to effectively and quickly resist external stimuli and block foreign objects. This results in persistent redness, swelling, itching, and other discomfort, causing both physical and psychological distress. Therefore, it is necessary to develop a product that can quickly repair the skin. Summary of the Invention

[0004] To achieve rapid skin repair, this application provides a face cream containing multiple ceramides and a method for preparing the same.

[0005] In a first aspect, this application provides a face cream containing multiple ceramides, employing the following technical solution: A face cream containing multiple ceramides, comprising the following components by weight percentage:

[0006] Component A: 3-10% humectant A, 0.01-1% thickener, 0.01-1% antioxidant;

[0007] Component B: 0.1-2% ceramide, 0.1-3% dispersant; the ceramide includes at least two of ceramide EOP, ceramide NS / ceramide NG, ceramide AS, ceramide NP, and ceramide AP;

[0008] Component C: 0.1-1% pH adjuster, 0.1-2% schistosome, 0.5-5% filtrate of galactosomal yeast fermentation product, 0.1-2% dipotassium glycyrrhizate, 0.1-3% humectant B;

[0009] Replenish water to 100%.

[0010] By employing the aforementioned technical solution, the combined action of schistosome extract, galactosomalidase fermentation product filtrate, and dipotassium glycyrrhizate rapidly targets Langerhans cells, exhibiting a highly positive effect on macrophage activation, thereby promoting the production and function of a large amount of endothelial growth factor (VEGF). Furthermore, the synergistic effect of these three substances also promotes cell proliferation and differentiation, stimulates endothelial cells, improves endothelial function, and enhances the activity of VEGF. This increases both the quantity and activity of VEGF, thereby increasing the growth of dermal fibroblasts and collagen synthesis, promoting skin regeneration and achieving rapid repair. This rapid skin repair helps maintain the moisture retention of the stratum corneum, allowing for full absorption of active substances in face creams, resulting in excellent moisturizing effects and aiding in skin repair.

[0011] Preferably, the mass ratio of the schistosome, the galactosomal yeast fermentation product filtrate, and the dipotassium glycyrrhizate is 1:(1.5-3):(0.5-1.5), based on the mass of the schistosome.

[0012] By adopting the above technical solution, the mass ratio of schistosome extract, galactosomal yeast fermentation product filtrate, and dipotassium glycyrrhizate is further limited, resulting in a better synergistic effect among the three components. This achieves a better balance between the activity and quantity of endothelial growth factors, thereby rapidly repairing the skin.

[0013] Preferably, the ceramide is ceramide EOP, ceramide NS / ceramide NG, or ceramide AS.

[0014] When skin is irritated, its protective barrier is damaged, leading to accelerated moisture loss and intense discomfort. Therefore, this application prioritizes the use of ceramides, which have significant moisturizing properties, to provide better hydration, alleviate discomfort, and make the product more appealing to users.

[0015] Preferably, the mass ratio of ceramide EOP, ceramide NS / ceramide NG, and ceramide AS is 1:(4-7):(1-3), with the mass of ceramide EOP as the reference.

[0016] When the skin is irritated, it becomes more vulnerable and susceptible to attack by microorganisms, which can worsen redness, swelling, and other irritations. Furthermore, skin irritation may be accompanied by itching, leading to scratching and further skin damage, which intensifies the attack by microorganisms.

[0017] By employing the above-mentioned technical solutions, the combined use of specific types and proportions of ceramides, schistosomes, galactosomal yeast fermentation product filtrate, and dipotassium glycyrrhizate can promote the expression of dectin-1 receptor protein, induce an immune response, and also improve the activity and survival rate of HaCat, thereby reducing the stimulation of the face by microorganisms and providing favorable conditions for repair.

[0018] Preferably, the moisturizer A comprises one or more of glycerin, butylene glycol, hexanediol, propylene glycol, allantoin, and sodium hyaluronate.

[0019] Preferably, the moisturizer A is glycerin and butylene glycol, and the mass ratio of glycerin to butylene glycol is (3-7):(1-3).

[0020] By adopting the above technical solution, further selecting specific moisturizers and limiting their usage ratio, a good synergy with specific ceramides can be achieved, thereby improving the moisturizing effect; moreover, the selected moisturizers have lower skin irritation and are more suitable for use after the skin has been irritated.

[0021] Secondly, this application provides a method for preparing a face cream containing multiple ceramides, using the following technical solution:

[0022] A method for preparing a face cream containing multiple ceramides includes the following steps:

[0023] The raw materials in phase A are mixed with water until homogeneous to obtain phase A;

[0024] The raw materials in phase B are dissolved evenly to obtain phase B;

[0025] Mix phase B and phase A, and stir until homogeneous to obtain a mixture;

[0026] Then add the various raw materials in phase C to the mixture and stir until uniform to obtain the finished product.

[0027] Preferably, when preparing phase A and phase B, the temperature is maintained at 80-90°C; when adding phase C, the temperature is first lowered to 40-45°C before addition.

[0028] By adopting the above technical solution, and further limiting the mixing temperature in each step during the mixing process, the various raw materials can achieve a better mixing effect, thereby fully exerting their repairing and moisturizing effects.

[0029] In summary, this application has the following beneficial effects:

[0030] 1. With the combined action of schistosome, galactosomal yeast fermentation product filtrate, and dipotassium glycyrrhizate, the amount and activity of endothelial growth factor can be increased, thereby increasing the growth of skin fibroblasts and collagen synthesis, promoting skin regeneration, and achieving rapid repair.

[0031] 2. The face cream provided in this application has a good moisturizing effect on the skin and can effectively reduce discomfort.

[0032] 3. The face cream provided in this application can reduce the irritation of microorganisms on the face and help provide good repair conditions. Attached Figure Description

[0033] Figure 1 These are images of volunteers' faces taken using a skin imaging device, and the corresponding product used is Example 1.

[0034] The first row, from left to right, shows the state diagrams for 0h, 15min, and 0.5h.

[0035] The second row, from left to right, shows the state diagrams for 1h, 1.5h, and 2h.

[0036] The third line is the state diagram for line 3h.

[0037] Figure 2 These are images of volunteers' faces taken using a skin imaging device, and the corresponding product used is Comparative Example 4.

[0038] The first row, from left to right, shows the state diagrams for 0h, 15min, and 0.5h.

[0039] The second row, from left to right, shows the state diagrams for 1h, 1.5h, and 2h.

[0040] The third line is the state diagram for line 3h. Detailed Implementation

[0041] The present application will be further described in detail below with reference to the accompanying drawings and embodiments.

[0042] The raw materials used in the following examples and comparative examples are all commercially available products.

[0043] Example

[0044] Example 1

[0045] A face cream containing multiple ceramides includes the following ingredients: moisturizer A, thickener, antioxidant, ceramide, dispersant, pH adjuster, schistosome, galactosomalidase fermentation product filtrate, dipotassium glycyrrhizate, moisturizer B, and water.

[0046] Moisturizer A consists of glycerin and butylene glycol, thickener is carbomer, antioxidant is acetone, pH adjuster is triethanolamine, and moisturizer B is hexanediol.

[0047] The dispersant was MEA 99, purchased from Guangzhou Xufan Trading Co., Ltd.

[0048] Ceramides include ceramide EOP, ceramide NS / ceramide NG, and ceramide AS.

[0049] The CAS number of the mycotoxin used in this embodiment is 9050-67-3.

[0050] The filtrate of galactosomal yeast fermentation product used in this embodiment was purchased from Guangzhou Xufan Trading Co., Ltd., and the model was GFF95.

[0051] The CAS number of dipotassium glycyrrhizate used in this embodiment is 68797-35-3.

[0052] For specific dosage details, please refer to Table 1.

[0053] This application also provides a method for preparing a face cream containing multiple ceramides, comprising the following steps:

[0054] Step 1): Add all the raw materials in phase A and water into the reactor and mix. After homogenization for 4 minutes, heat to 80°C, stir and dissolve until uniform, and keep warm for 10 minutes. This is phase A.

[0055] Step 2): Mix all the raw materials in phase B and dissolve them evenly at 80°C to obtain phase B.

[0056] Then add it to the reactor and mix it with phase A. Stir until uniform to obtain a mixture.

[0057] Step 3): Adjust the temperature of the reactor to 45℃, then add the various raw materials in phase C, stir until uniform, and obtain the finished product.

[0058] Example 2

[0059] A face cream containing multiple ceramides differs from Example 1 in that the amount of schistosome used is 0.5 kg, the amount of galactosomalidase fermentation product filtrate used is 0.75 kg, and the amount of dipotassium glycyrrhizate used is 0.75 kg.

[0060] The dosage of ceramide EOP is 0.1 kg, the dosage of ceramide NS / ceramide NG is 0.4 kg, and the dosage of ceramide AS is 0.3 kg.

[0061] The amount of glycerin used is 3 kg, and the amount of butylene glycol used is 3 kg.

[0062] The amount of water used was 87.8 kg.

[0063] For specific dosage details, please refer to Table 1.

[0064] A method for preparing a face cream containing multiple ceramides differs from Example 1 in that the temperature in steps 1) and 2) is 90°C and the temperature in step 3) is 45°C.

[0065] Example 3

[0066] A face cream containing multiple ceramides differs from Example 1 in that the amount of schistosome used is 0.5 kg, the amount of galactosomalidase fermentation product filtrate used is 1.5 kg, and the amount of dipotassium glycyrrhizate used is 0.25 kg.

[0067] The dosage of ceramide EOP is 0.1 kg, the dosage of ceramide NS / ceramide NG is 0.7 kg, and the dosage of ceramide AS is 0.1 kg.

[0068] The amount of glycerin used is 7 kg, and the amount of butylene glycol used is 1 kg.

[0069] The amount of water used was 85.45 kg.

[0070] For specific dosage details, please refer to Table 1.

[0071] A method for preparing a face cream containing multiple ceramides differs from Example 1 in that the temperature in steps 1) and 2) is 85°C, and the temperature in step 3) is 45°C.

[0072] Table 1

[0073]

[0074] Example 4

[0075] A face cream containing multiple ceramides differs from Example 1 in that the amount of schistosome used is 0.5 kg, the amount of galactosomalidase fermentation product filtrate used is 0.1 kg, and the amount of dipotassium glycyrrhizate used is 1.3 kg.

[0076] Example 5

[0077] A face cream containing multiple ceramides differs from Example 1 in that the amount of ceramide EOP used is 0.1 kg, the amount of ceramide NS / ceramide NG used is 0.1 kg, and the amount of ceramide AS used is 0.6 kg.

[0078] Example 6

[0079] A face cream containing multiple ceramides differs from Example 1 in that the ceramide is ceramide EOP. Specifically, the amount of ceramide EOP used is 0.8 kg, the amount of ceramide NS / ceramide NG used is 0 kg, and the amount of ceramide AS used is 0 kg.

[0080] Example 7

[0081] A face cream containing multiple ceramides differs from Example 1 in that moisturizer A is glycerin, i.e., the amount of glycerin used is 7 kg, and the amount of butylene glycol used is 0 kg.

[0082] Comparative Example

[0083] Comparative Example 1

[0084] A face cream containing multiple ceramides differs from Example 1 in that the mycotoxin is replaced with yeast β-glucan, with the amount of mycotoxin used being 0 kg and the amount of yeast β-glucan used being 0.5 kg.

[0085] Comparative Example 2

[0086] A face cream containing multiple ceramides differs from Example 1 in that the galactosomal yeast fermentation product filtrate is replaced with yeast / soybean protein fermentation product, with 0 kg of galactosomal yeast fermentation product filtrate and 1 kg of yeast / soybean protein fermentation product.

[0087] Comparative Example 3

[0088] A face cream containing multiple ceramides differs from Example 1 in that dipotassium glycyrrhizate is replaced with glycyrrhizin flavonoids, with 0 kg of dipotassium glycyrrhizate and 0.3 kg of glycyrrhizin flavonoids.

[0089] Comparative Example 4

[0090] A face cream containing multiple ceramides differs from Example 1 in that the amount of schistosome used is 0.1 kg, the amount of galactosomalidase fermentation product filtrate used is 0.1 kg, and the amount of dipotassium glycyrrhizate used is 1.6 kg.

[0091] Performance testing

[0092] 1. Subjects: Forty-four female volunteers aged 28-35 were selected and divided into 11 groups of 4 volunteers each. Each group of volunteers was assigned to one example or comparative sample of face cream.

[0093] One day before the test, the volunteers did not experience any obvious redness, dryness, peeling, or other signs of skin sensitivity.

[0094] Exclusion criteria: Exclude those with primary diseases that may be accompanied by sensitive skin; exclude those who have used glucocorticoids, immunosuppressants, and antihistamines within one week prior to the current use or trial; exclude those with other serious diseases; exclude other special circumstances.

[0095] When selecting volunteers, try to choose those with similar qualifications and exclude those with significant differences.

[0096] 2. Tested products: face creams from Examples 1-7 and Comparative Examples 1-4.

[0097] 3. Test items:

[0098] A. Repair performance test:

[0099] 1) Histamine stimulation: Dissolve histamine in a 2% solution, then apply 2 drops to the arm using a dropper and take a picture using a miravex ANTERA 3D skin imager. Record the average redness at 0h.

[0100] When obvious redness, swelling and itching appear on the skin, apply 2g of the test product to the irritated area and spread it evenly.

[0101] Using 0h as the baseline, record the average redness values ​​at 0.5h, 1h, and 2h.

[0102] B. Moisturizing test: Conducted simultaneously with the repair performance test, the moisture content of volunteers' arms was measured using Delfin ModularCore (DMC) Software before histamine stimulation (before application); then, after applying the test product, the moisture content was measured again (after application); and then, based on the post-application baseline, the moisture content was measured 4 hours after application.

[0103] A facial image taken by a skin imaging device of one of the volunteers using Example 1 is shown below. Figure 1 .

[0104] One of the volunteers used as a reference was a facial image taken with a skin imaging device. Figure 2 .

[0105] The test results are detailed in Table 2.

[0106] Table 2

[0107]

[0108] During the testing, volunteers began to experience redness and swelling approximately 15 minutes after histamine stimulation, with little individual variation.

[0109] Comparative Examples 1-3 were face creams prepared by arbitrarily replacing one of the following ingredients in Example 1: schistosome extract, galactosomalidase fermentation product filtrate, and dipotassium glycyrrhizate. According to the comparison of test data between Example 1 and Comparative Examples 1-3 in Table 2, volunteers using both Comparative Examples 1-3 and Example 1 showed significant redness and swelling after 0.5 hours. However, at 1 hour, the degree of redness and swelling in the volunteers of Example 1 was similar to that at 0.5 hours, with no significant increase in the severity. In contrast, the volunteers of Comparative Examples 1-3 showed significantly more severe redness and swelling at 1 hour compared to 0.5 hours, without effective relief. At 2 hours, the redness and swelling in the volunteers using Example 1 had completely disappeared, returning to their pre-histamine-stimulated state. In contrast, the volunteers using Comparative Examples 1-3 still showed severe redness and swelling at 2 hours, with no significant improvement compared to the 1-hour test. This application indicates that the face cream provided requires the combined use of schistosome extract, galactosomal yeast ferment filtrate, and dipotassium glycyrrhizate to achieve a good effect in rapidly repairing the skin; none of these ingredients can be omitted.

[0110] In terms of moisturizing, the test results showed that volunteers using the product in Example 1 experienced a significant improvement in skin hydration after application. Even 4 hours after application, their skin remained at a good level of hydration, demonstrating a good improvement compared to before application. In contrast, volunteers in Comparative Examples 1-3, while experiencing an improvement in skin hydration after application, saw their skin hydration return to its pre-application state after 4 hours, failing to maintain long-lasting and effective moisturizing.

[0111] Users with irritated skin can quickly reduce redness and swelling within 2 hours after using the face cream product of this application. After application, the skin's moisturization is effectively improved and can be maintained for up to 4 hours. Throughout the rapid repair process, users have a good skin feel and low irritation.

[0112] In addition, Comparative Example 4, which was based on Example 1, had its dosage and ratio of schistosome extract, galactosomalidone fermentation product filtrate, and dipotassium glycyrrhizate disrupted. Volunteers used this face cream, which had its balance arbitrarily disrupted. In the repair performance test, although the redness and swelling were not as severe as in Comparative Examples 1-3, the repair effect was far inferior to that of Example 1. Volunteers in Comparative Example 4 still showed relatively obvious redness and swelling after 2 hours of testing.

[0113] In addition, Example 4, which is based on Example 1, modifies the ratio of schistosome extract, galactosomalid fermentation product filtrate, and dipotassium glycyrrhizate, but the amount of each ingredient is still within a certain limited range. After using the face cream of Example 4, although the effect was not as good as that of Example 1, it showed better relief, repair, and moisturizing effects than Comparative Example 4 in the 1-hour and 2-hour tests.

[0114] This indicates that not only is it necessary to select specific mycotoxin, galactosomal yeast fermentation product filtrate, and dipotassium glycyrrhizate, but it is also necessary to further strictly limit the dosage and ratio of the three components in order to produce a product with significant repair and moisturizing effects.

[0115] A comparison of the test data from Examples 1 and 5-6 in Table 2 shows that after changing the specific types and proportions of ceramides used, the volunteers using the corresponding products did not experience the same repair and moisturizing effects as those in Example 1. This is likely related to the specific combination of certain ceramides with schistosome extract, galactosomalidase fermentation product filtrate, and dipotassium glycyrrhizate.

[0116] According to the comparison of the test data of Example 1 and Example 7 in Table 2, it can be seen that selecting specific types and proportions of moisturizers can further improve the moisturizing effect and improve the user experience.

[0117] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A face cream containing multiple ceramides, characterized in that, By mass percentage, it includes the following components: Phase A: 3-10% humectant A, 0.01-1% thickener, 0.01-1% antioxidant; Phase B: 0.1-2% ceramide, 0.1-3% dispersant; Phase C: 0.1-1% pH adjuster, 0.1-2% schistosome, 0.5-5% filtrate of galactosomal yeast fermentation product, 0.1-2% dipotassium glycyrrhizate, 0.1-3% humectant B; Replenish water to 100%; The mass ratio of schistoxin, galactosomal yeast fermentation product filtrate, and dipotassium glycyrrhizate is 1:(1.5-3):(0.5-1.5), based on the mass of schistoxin. The ceramide is ceramide EOP, ceramide NS / ceramide NG, and ceramide AS, and the mass ratio of ceramide EOP, ceramide NS / ceramide NG, and ceramide AS is 1:(4-7):(1-3), with the mass of ceramide EOP as the basis; The method for preparing the face cream containing multiple ceramides includes the following steps: The raw materials in phase A are mixed with water until homogeneous to obtain phase A; The raw materials in phase B are dissolved evenly to obtain phase B; Mix phase B and phase A, and stir until homogeneous to obtain a mixture; Then add the various raw materials in phase C to the mixture and stir until uniform to obtain the finished product; When preparing phases A and B, the temperature is maintained at 80-90℃; when adding phase C, the temperature is first lowered to 40-45℃ before adding it.

2. The face cream containing multiple ceramides according to claim 1, characterized in that: The moisturizer A includes one or more of the following: glycerin, butylene glycol, hexanediol, propylene glycol, allantoin, and sodium hyaluronate.

3. The face cream containing multiple ceramides according to claim 2, characterized in that: The moisturizer A is glycerin and butylene glycol, with a mass ratio of glycerin to butylene glycol of (3-7):(1-3).

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