A rhenium complex having an aggregation-induced emission property and a preparation method and application thereof

By preparing rhenium complexes with aggregation-induced emission properties, the problem of poor treatment efficacy of hypoxic solid tumors in photodynamic therapy was solved, achieving efficient destruction of cancer cells under light conditions and demonstrating significant anti-tumor activity.

CN117486941BActive Publication Date: 2026-06-16SHENZHEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN UNIV
Filing Date
2023-09-21
Publication Date
2026-06-16

AI Technical Summary

⚠Technical Problem

In existing photodynamic therapy, photosensitizers that generate singlet oxygen via an oxygen-dependent pathway are not very effective in treating hypoxic solid tumors.

⚗Method used

A rhenium complex with aggregation-induced emission properties was developed, which can generate a large number of singlet oxygen, superoxide anions and hydroxyl radicals under 465 nm light irradiation, disrupting the intracellular redox balance and leading to cancer cell death.

🎯Benefits of technology

Under light conditions, rhenium complexes can effectively destroy cancer cells, showing significant anti-tumor activity, especially for hypoxic solid tumors.

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Abstract

This invention discloses a rhenium complex with aggregation-induced emission properties, its preparation method, and its application. The structural formula of the rhenium complex is shown below: First, 4-methoxy-N-(4-methoxyphenyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxane-2-yl)phenyl)aniline and 3,8-dibromo-1,10-phenanthroline are reacted to obtain the ligand TP; then, rhenium pentacarbonyl chloride is added and reacted to obtain the rhenium complex. The rhenium complex prepared by this invention produces a singlet state under illumination at a wavelength of 465 nm. 1 Compared to the dark group, the rhenium complex reduced the IC50 of B16 cells by more than 31.25 times under light conditions, which will have important application prospects in the treatment of melanoma cells.
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