A rapidly degradable polyethylene glycol hydrogel and application thereof

CN117736565BActive Publication Date: 2026-10-16SHANGHAI RUINING BIOTECH CO LTD
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Patent Information

Application Number
CN202211119504.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-14
Publication Date
2026-10-16
Estimated Expiration
2042-09-14

AI Technical Summary

Technical Problem

然而这些凝胶降解时间普遍偏慢，在体内停留数周到数个月会引发持续的炎症反应，限制了其更广泛的应用

Benefits of technology

[0010] Advantages of this invention: This invention achieves rapidly degradable injectable hydrogels with degradation times ranging from 2 hours to several days by adjusting the polyethylene glycol chain structure, molecular weight, and the proportion of polyamine crosslinking agents. The polyethylene glycol hydrogel can rapidly gel on object surfaces and rapidly degrade in vivo and on the body surface. It exhibits good biocompatibility and high strength, and has potential medical applications in areas such as rapid in vivo organ and blood vessel hemostasis, wound repair on the body surface, organ sealing, blood vessel occlusion, drug release, coatings for medical implants, and tissue anti-adhesion.

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Abstract

The application provides a fast-degradable polyethylene glycol hydrogel, which is formed by in-situ crosslinking of single-arm polyethylene glycol with a molecular weight of 1250-5000 Da and 4-8-arm benzaldehyde-terminated star-shaped multi-arm polyethylene glycol with a molecular weight of 600-10000 Da, and the benzaldehyde and the star-shaped multi-arm polyethylene glycol are connected by an ester bond, an ether bond, an amide bond, an urethane bond, an imine bond or a urea bond. The polyethylene glycol hydrogel has the advantages of fast gelation on the surface of an object, good biocompatibility, high strength, and fast degradation in the body and on the surface of the body for 2 hours to several days.
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