A composition for treating urticaria

Abstract

The present application relates to the technical field of external medicine for treating urticaria, and discloses a composition for treating urticaria, which comprises the following components: Cudrania tricuspidata, Eucalyptus globulus, Cymbopogon citratus, Datura stramonium, Kaempferia rotunda, Sageretia theezans, Gleditsia sinensis, camphor, Gnaphalium affine and Gynura japonica. The composition is externally applied to the skin of the affected part, and has the effects of clearing heat and detoxifying, removing dampness and swelling, dispelling wind and relieving itching.

Description

Technical Field

[0001] This invention relates to the field of topical medicines for treating urticaria, and in particular to a composition for treating urticaria. Background Technology

[0002] The primary method for treating chronic urticaria in modern medicine is to remove the underlying cause. However, the causative factors and pathogenesis are currently unclear; therefore, drug therapy or desensitization therapy is often chosen to treat the symptoms, which can control the disease's progression to some extent, but has significant limitations. Western medical epidemiology shows that the incidence of chronic urticaria is 13.5%, with little difference in the incidence rate between men and women. Currently, approximately 80% of patients still have no identifiable cause.

[0003] In clinical practice, the treatment of chronic urticaria commonly relies on oral antihistamines. However, the treatment effect is limited, and relapses often occur after discontinuation of medication, frequently resulting in recurrent and persistent symptoms, and even drug resistance. High-dose antihistamines only relieve itching symptoms without reducing the number of wheals, and overdose can cause adverse reactions such as drowsiness. Oral corticosteroids for chronic urticaria have numerous and severe adverse reactions and are not suitable for long-term treatment. Summary of the Invention

[0004] In view of this, the present invention proposes a composition for treating urticaria, which to a certain extent solves the problems of numerous adverse reactions and poor efficacy of various drugs for treating urticaria. The technical solution adopted is as follows:

[0005] A composition for treating urticaria, comprising the following components:

[0006] Podophyllum hexandrum, Eucalyptus grandis, Lemongrass, Phytolacca acinosa, Kaempferia galanga, Paederia scandens, Gleditsia sinensis, Camphor, Centella asiatica and Centella asiatica.

[0007] Preferably, the components comprise the following parts by weight:

[0008] 6-9 parts of Polygonum cuspidatum, 6-9 parts of Eucalyptus grandiflora, 6-9 parts of Lemongrass, 10-18 parts of Phytolacca acinosa, 5-9 parts of Kaempferia galanga, 6-9 parts of Paederia scandens, 6-9 parts of Gleditsia sinensis, 5-9 parts of Camphor, 6-9 parts of Gynostemma pentaphyllum, and 5-9 parts of Centella asiatica.

[0009] Preferably, the composition is prepared by the following method:

[0010] The following ingredients were crushed and passed through a 160-mesh sieve: *Polygonum cuspidatum*, *Eucalyptus macrocarpa*, lemongrass, *Phytolacca acinosa*, *Kaempferia galanga*, *Paederia scandens*, *Gleditsia sinensis*, camphor, *Gnaphalium affine*, and *Centella asiatica*.

[0011] The raw material powder is mixed with 75% ethanol at a ratio of 1:10, then ultrasonically pulverized and filtered, and the filtrate is collected.

[0012] Adjust the ethanol content of the filtrate to (55-65)%, let it stand for 8-12 hours, and collect the supernatant to obtain the composition.

[0013] Preferably, the composition is any of the following forms: spray, aerosol, solution, or ointment.

[0014] The present invention also provides the use of the composition for treating urticaria in the preparation of a medicament for urticaria.

[0015] The raw medicinal materials in the composition have the following characteristics:

[0016] Polygonumperfoliatum L., properties: sour, slightly cold;

[0017] Efficacy: Clears water and airways, removes heat and toxins, eliminates dampness and toxins, and relieves cough.

[0018] Applications: Used for eczema, boils, edema, colds, whooping cough, dysentery, and snake bites.

[0019] Eucalyptus robusta Smith., properties: bitter, spicy, neutral;

[0020] Efficacy: Clears the airways, relieves miasma and eliminates dampness and toxins;

[0021] Applications: Eczema, boils, malaria, cough, sore throat, erysipelas.

[0022] Lemongrass (Cymbopogon citratus (DC.) Stapf), properties: pungent, warm, sweet;

[0023] Efficacy: Clears heat from the lungs, warms the middle burner to relieve pain, and stops diarrhea;

[0024] Applications: Headache and body aches from colds; wind-cold-dampness syndrome; cold pain in the stomach and abdomen; diarrhea; injuries from falls and blows.

[0025] Pokeweed (Phytolacca acinosa Roxb.), properties: bitter, cold

[0026] Efficacy: Clears water passages, removes dampness and toxins, clears heat and toxins, and disperses nodules and swelling.

[0027] Applications: For edema, and externally for carbuncles.

[0028] Kaempferia galanga, properties: pungent, warm;

[0029] Efficacy: Promotes qi circulation and warms the middle jiao, aids digestion, and relieves pain;

[0030] Applications: For chest and diaphragm distension, cold pain in the epigastrium and abdomen, and indigestion.

[0031] Chicken shit vine (Paederia scandens (Lour.) Merr.), taste and properties: sweet, astringent, neutral.

[0032] Efficacy: Clears the digestive tract and urinary tract, removes heat and toxins, and eliminates dampness and toxins;

[0033] Applications: Indigestion, stomachache, biliary colic, edema, and eczema.

[0034] Gleditsia sinensis Lam., properties: warm, pungent;

[0035] Efficacy: Reduces swelling and promotes detoxification, drains pus, and kills parasites;

[0036] Applications: Used for early-stage carbuncles or boils that have formed pus but have not yet ulcerated; also used externally for scabies and leprosy.

[0037] Camphor (Cinnamomum camphora (L.) Presl.), properties: hot, pungent;

[0038] Efficacy: Removes dampness, kills insects, relieves itching, warms and disperses pain, opens the orifices and dispels foul odors;

[0039] Applications: Primarily used to treat scabies, itching, sprains, and toothache.

[0040] Abutilon indicum (L.) G. Don, properties: sweet, bland, neutral;

[0041] Efficacy: Detoxifies, clears heat toxins, removes dampness toxins, and opens the orifices;

[0042] Applications: Common cold, mumps, tinnitus, deafness, tuberculosis, and urinary tract infection.

[0043] Centella asiatica (L.) Urb., properties: bitter, pungent, cold; effects: clearing heat and promoting diuresis, detoxifying and reducing swelling.

[0044] Applications: Damp-heat jaundice, heatstroke diarrhea, urinary tract stones and hematuria, carbuncles and boils, and injuries from falls and blows.

[0045] This invention discloses a composition for treating urticaria, which has the following advantages compared with the prior art:

[0046] The components of this invention are mainly characteristic Zhuang herbs, which are widely available and economical. Among them, *Polygonum cuspidatum*, *Eucalyptus grandiflora* leaves, and *Gnaphalium affine* clear waterways, remove heat and toxins, and eliminate dampness and toxins; *Citrus reticulata*, *Paederia scandens*, and *Kaempferia galanga* clear waterways, dispel wind and dampness, warm the middle jiao, promote qi circulation, and aid digestion; *Phytolacca acinosa*, *Gleditsia sinensis* thorns, camphor, and *Centella asiatica* reduce swelling, promote detoxification, drain pus, kill parasites, and relieve itching. The combined use of these herbs achieves the effects of clearing heat and dampness, dispelling wind and relieving itching, and dispersing nodules and swellings. Detailed Implementation

[0047] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] This invention provides a composition for treating urticaria, comprising the following components in parts by weight:

[0049] 6-9 parts of Polygonum cuspidatum, 6-9 parts of Eucalyptus grandiflora, 6-9 parts of Lemongrass, 10-18 parts of Phytolacca acinosa, 5-9 parts of Kaempferia galanga, 6-9 parts of Paederia scandens, 6-9 parts of Gleditsia sinensis, 5-9 parts of Camphor, 6-9 parts of Gynostemma pentaphyllum, and 5-9 parts of Centella asiatica.

[0050] The composition was prepared by the following method using the components within the above weight range:

[0051] The following ingredients were crushed and passed through a 160-mesh sieve: *Polygonum cuspidatum*, *Eucalyptus macrocarpa*, lemongrass, *Phytolacca acinosa*, *Kaempferia galanga*, *Paederia scandens*, *Gleditsia sinensis*, camphor, *Gnaphalium affine*, and *Centella asiatica*.

[0052] After mixing the fine powder of the raw materials of the composition with 75% ethanol at a material-to-liquid ratio of 1:10, the mixture is ultrasonically pulverized, filtered, and the filtrate is collected.

[0053] The composition is obtained by adjusting the ethanol content of the filtrate to (55-65)%, allowing it to stand for 8-12 hours, and collecting the supernatant.

[0054] It should be noted that thorough extraction of herbal components is crucial. Crushing and sieving various herbal components (Polygonum cuspidatum, Eucalyptus grandiflora, Lemongrass, Phytolacca acinosa, Kaempferia galanga, Paederia scandens, Gleditsia sinensis, Camphor, Centella asiatica, and Centella asiatica) helps increase the surface area, thereby improving the effective contact area during ethanol extraction and enhancing the extraction efficiency. Ethanol is a commonly used solvent with good solubility for many plant components, facilitating the effective dissolution of active compounds in the herbal components into the liquid for efficient extraction. Ultrasonic pulverization further breaks down plant cell walls, releasing the active ingredients within the cells and improving extraction efficiency. This increases the solubility of the solute, making it easier for ethanol to extract. The filtration step helps remove plant residues and other impurities, obtaining a relatively clear liquid and improving the purity of the composition. Adjusting the ethanol content of the filtrate to 55%-65% helps improve the stability and shelf life of the composition. The settling process allows residual insoluble substances to precipitate, making the composition clearer.

[0055] Example 1

[0056] The raw materials used in this embodiment include: 6g of Polygonum aviculare, 6g of Eucalyptus grandis leaves, 6g of Lemongrass, 10g of Phytolacca acinosa, 5g of Kaempferia galanga, 6g of Paederia scandens, 6g of Gleditsia sinensis thorns, 5g of camphor, 6g of Gynostemma pentaphyllum and 5g of Centella asiatica.

[0057] Weigh each ingredient according to the above formula ratio and grind them into fine powder. After passing through a 160-mesh sieve, mix the powder with a 75% ethanol solution at a material-to-liquid ratio of 1:10. Use an ultrasonic grinder to sonicate for 1 hour. Filter the mixture with filter paper and collect the filtrate. Add ethanol to make the alcohol content reach 55%-65%. Stir well, let stand overnight, collect the supernatant to obtain the composition, and store it in a sealed container under cold.

[0058] Example 2

[0059] The raw materials used in this embodiment include: 9g of Polygonum aviculare, 6g of Eucalyptus grandis leaves, 6g of Lemongrass, 18g of Phytolacca acinosa, 5g of Kaempferia galanga, 9g of Paederia scandens, 6g of Gleditsia sinensis thorns, 5g of camphor, 6g of Gynostemma pentaphyllum and 9g of Centella asiatica.

[0060] Weigh each ingredient according to the above formula ratio and grind them into fine powder. After passing through a 160-mesh sieve, mix the powder with a 75% ethanol solution at a material-to-liquid ratio of 1:10. Use an ultrasonic grinder to sonicate for 1 hour. Filter the mixture with filter paper and collect the filtrate. Add ethanol to make the alcohol content reach 55%-65%. Stir well, let stand overnight, collect the supernatant to obtain the composition, and store it in a sealed container under cold.

[0061] Example 3

[0062] The raw materials used in this embodiment include: 6g of Polygonum aviculare, 9g of Eucalyptus grandis leaves, 9g of Lemongrass, 10g of Phytolacca acinosa, 9g of Kaempferia galanga, 6g of Paederia scandens, 9g of Gleditsia sinensis thorns, 5g of camphor, 6g of Gynostemma pentaphyllum and 9g of Centella asiatica.

[0063] Weigh each ingredient according to the above formula ratio and grind them into fine powder. After passing through a 160-mesh sieve, mix the powder with a 75% ethanol solution at a material-to-liquid ratio of 1:10. Use an ultrasonic grinder to sonicate for 1 hour. Filter the mixture with filter paper and collect the filtrate. Add ethanol to make the alcohol content reach 55%-65%. Stir well, let stand overnight, collect the supernatant to obtain the composition, and store it in a sealed container under cold.

[0064] Example 4

[0065] The raw materials used in this embodiment include: 8g of Polygonum aviculare, 6g of Eucalyptus grandis leaves, 7g of Lemongrass, 15g of Phytolacca acinosa, 7g of Kaempferia galanga, 8g of Paederia scandens, 7g of Gleditsia sinensis thorns, 8g of camphor, 6g of Gynostemma pentaphyllum and 5g of Centella asiatica.

[0066] Weigh each ingredient according to the above formula ratio and grind them into fine powder. After passing through a 160-mesh sieve, mix the powder with a 75% ethanol solution at a material-to-liquid ratio of 1:10. Use an ultrasonic grinder to sonicate for 1 hour. Filter the mixture with filter paper and collect the filtrate. Add ethanol to make the alcohol content reach 55%-65%. Stir well, let stand overnight, collect the supernatant to obtain the composition, and store it in a sealed container under cold.

[0067] The compositions prepared in the above examples, after being dispensed, are applied to the affected area three or four times a day. The following is a record of the efficacy of the compositions prepared in Examples 1-4 above for urticaria.

[0068] Typical cases: Among the 60 patients treated with this composition, there were 36 males and 24 females, with the shortest course of disease being 2 months and the longest being 10 years.

[0069] Efficacy assessment: A four-level standard was adopted: Cure: Clinical improvement rate ≥ 95%; Significant effect: Clinical improvement rate < 95%; Effective: Clinical improvement rate < 60%; Ineffective: Clinical improvement rate < 20%. Treatment efficacy statistics are shown in Table 1.

[0070] Table 1. Statistical Table of Treatment Effects

[0071]

[0072] Typical clinical cases

[0073] Case 1

[0074] Patient A, male, 30 years old, had suffered from urticaria for one year, mainly manifested as dense red patches, wheals, and intense itching on his arms and back. He had previously taken antihistamines and various topical steroid medications multiple times, but the symptoms frequently recurred. After using this medication three times daily for about two weeks, his symptoms lessened, and after four weeks of continuous use, he was essentially cured.

[0075] Case 2

[0076] Patient B, female, 25 years old, had been suffering from urticaria for 2 months, mainly manifested as numerous wheals, redness, swelling, and itching on the skin of her limbs and trunk. She had previously used topical medications, but the effect was not obvious. After using this medication 3 times a day, she saw initial improvement after one week, and the itching symptoms basically disappeared after two weeks of use. After one month, her condition was cured and there was no recurrence.

[0077] Case 3

[0078] Patient C, a 41-year-old male, had been suffering from urticaria for 2 years. He experienced recurrent skin redness and itching, with two wheals appearing on his limbs, and occasional symptoms. He used this medication three times a day and paid attention to his diet. After two weeks, his condition improved. After continuing to take the medication for another two weeks, he did not experience any symptoms. During a follow-up visit, there was no recurrence.

[0079] Case 4

[0080] Patient D, female, 49 years old, had suffered from urticaria for many years. She frequently developed dense red patches, wheals, and unbearable itching on her trunk. She had sought medical treatment for several years but could not get rid of the condition. After using this medicine three times a day, she was basically cured after three weeks. A year later, she occasionally experienced mild itching. She continued to use this medicine for another week and has not experienced any symptoms since.

[0081] Case 5

[0082] Patient E, a 60-year-old male, had been suffering from urticaria for half a year. He experienced severe itching and could not sleep well every night. He also developed red patches and wheals on his body. After using this medication, his skin basically returned to normal after one week. After taking the medication for two weeks, his condition was cured and he has not relapsed since stopping the medication.

[0083] Case 6

[0084] Patient F, female, 36 years old, had urticaria for 5 months, with recurrent itching and wheals on the skin of the limbs and trunk. She used this medicine 3 times a day, and the itching symptoms disappeared after two weeks. She continued to use it for another week to consolidate the treatment. After stopping the medication, there was no recurrence.

[0085] In summary, the composition of this invention has a stable effect in relieving wind and itching, and when applied topically to the affected skin, it has a cooling and detoxifying effect.

[0086] It has the effects of reducing swelling, dispelling wind, and relieving itching. Its secret lies in the fact that, stimulated by the alcohol extract, it can penetrate the surface of the skin to a great extent to counteract skin allergic reactions, quickly eliminate the patient's itching symptoms, relieve the patient from the torment of itching, and reduce the psychological burden of suffering.

[0087] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A topical composition for treating urticaria, characterized in that, Made from the following components: 6-9 parts of Polygonum cuspidatum, 6-9 parts of Eucalyptus grandis, 6-9 parts of Lemongrass, 10-18 parts of Phytolacca acinosa, 5-9 parts of Kaempferia galanga, 6-9 parts of Paederia scandens, 6-9 parts of Gleditsia sinensis, 5-9 parts of Camphor, 6-9 parts of Gynostemma pentaphyllum and 5-9 parts of Centella asiatica. The topical composition is any of the following forms: spray, aerosol, solution, or ointment.

2. The topical composition for treating urticaria according to claim 1, characterized in that, The topical composition is prepared by the following method: The following ingredients were crushed and passed through a 160-mesh sieve to obtain fine powder: Eucalyptus grandis, Eucalyptus globulus, Phytolacca acinosa, Kaempferia galanga, Paederia scandens, Gleditsia sinensis, camphor, Gynostemma pentaphyllum, and Centella asiatica. The raw material powder is mixed with 75% ethanol at a ratio of 1:10, then ultrasonically pulverized and filtered, and the filtrate is collected. Adjust the ethanol content of the filtrate to 55-65%, let it stand for 8-12 hours, and collect the supernatant to obtain the external composition.

3. Use of the topical composition for treating urticaria according to claim 1 in the preparation of a medicament for urticaria.

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