A traditional Chinese medicine composition for treating constipation and its preparation method

Abstract

This invention relates to a traditional Chinese medicine composition for treating constipation and its preparation method. The traditional Chinese medicine composition includes the following raw materials: stir-fried Atractylodes macrocephala, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange, licorice, and aloe vera. This traditional Chinese medicine composition can effectively treat constipation and prevent recurrence, thus achieving both symptomatic and root-cause treatment.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for treating constipation and its preparation method. Background Technology

[0002] With the acceleration of people's pace of life and changes in dietary habits, the prevalence of constipation has been increasing year by year, and constipation patients are becoming younger. The clinical manifestations of constipation include long intervals between bowel movements (no bowel movement for more than 72 hours), infrequent bowel movements (less than 3 times per week), and dry and difficult-to-pass stools. Constipation seriously affects the quality of life of patients and causes them great suffering. Elderly people often develop cardiovascular and cerebrovascular diseases such as hypertension and coronary heart disease due to the difficulty in defecation.

[0003] Currently, the main medications for treating constipation are laxatives. Although they are fast-acting, they only treat the symptoms and not the root cause, leading to frequent relapses and potential side effects with long-term use. Summary of the Invention

[0004] Based on the above description, the present invention provides a traditional Chinese medicine composition for treating constipation and its preparation method. The traditional Chinese medicine composition can effectively treat constipation and prevent recurrence, thus achieving both symptomatic and root-cause treatment.

[0005] The technical solution of the present invention to solve the above-mentioned technical problems is as follows:

[0006] A traditional Chinese medicine composition for treating constipation, the composition comprising the following raw materials: stir-fried Atractylodes macrocephala, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, Citrus aurantium, licorice and aloe vera.

[0007] Furthermore, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-32 parts of stir-fried Atractylodes macrocephala, 10-18 parts of peach kernel, 16-22 parts of Cistanche deserticola, 2-10 parts of tangerine peel, 15-18 parts of Angelica sinensis, 5-12 parts of Trichosanthes kirilowii seed, 11-15 parts of mulberry, 11-15 parts of immature bitter orange, 1-5 parts of licorice, and 5-8 parts of aloe vera.

[0008] Furthermore, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 28-30 parts of stir-fried Atractylodes macrocephala, 12-15 parts of peach kernel, 20-21 parts of Cistanche deserticola, 5-7 parts of tangerine peel, 16-17 parts of Angelica sinensis, 7-10 parts of Trichosanthes kirilowii seed, 12-13 parts of mulberry, 12-13 parts of immature bitter orange, 2-3 parts of licorice, and 6-7 parts of aloe vera.

[0009] Furthermore, the dosage form of the traditional Chinese medicine composition is an oral dosage form.

[0010] Another object of the present invention is to provide a method for preparing the above-mentioned traditional Chinese medicine composition for treating constipation:

[0011] A method for preparing a traditional Chinese medicine composition for treating constipation as described above includes the following steps:

[0012] (1) Mix and decoct the following ingredients: stir-fried Atractylodes macrocephala, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice to obtain an extract. Centrifuge the extract and concentrate the upper centrifuged liquid to obtain an extract.

[0013] (2) After grinding aloe vera into fine powder, add excipients to prepare a coating paste;

[0014] (3) The extract prepared in step (1) is spray-dried and then coated with coating slurry. After coating, the resulting particles are dried and mixed, and then filled with empty capsules to obtain the final product.

[0015] Furthermore, in step (1), the decoction is performed 1-3 times and the decoction time is 1-5 hours.

[0016] Furthermore, in step (1), the specific gravity of the extract is 1.18-1.25.

[0017] Furthermore, in step (2), the excipients include magnesium stearate, corn starch, and silicon dioxide.

[0018] Furthermore, in step (3), the material temperature for the spray drying of the extract is 60-80℃, the atomization pressure is 0.1-0.4MPa, and the feeding speed is 10-60kg / h.

[0019] Furthermore, in step (3), the temperature of the sprayed coating slurry is 45-70℃.

[0020] Furthermore, in step (3), the drying conditions for the obtained particles are: drying at 70-95℃ for 45-120 min.

[0021] Furthermore, in step (3), the filling speed is 800-3500 particles / min and the filling amount is 0.319-0.381g.

[0022] Compared with the prior art, the technical solution of this application has the following beneficial technical effects: the traditional Chinese medicine composition of the present invention can achieve a cure rate of more than 90% in treating constipation, and the cured patients will not relapse for six months. The total effective rate of treating constipation can reach 100%, which shows that the traditional Chinese medicine composition of the present invention can effectively treat constipation and prevent the recurrence of the disease, thus playing a role in treating both the symptoms and the root cause. Detailed Implementation

[0023] Example 1:

[0024] A traditional Chinese medicine composition for treating constipation, in capsule form, is prepared from the following raw materials: 250g of stir-fried Atractylodes macrocephala, 100g of peach kernel, 160g of Cistanche deserticola, 20g of tangerine peel, 150g of Angelica sinensis, 50g of Trichosanthes kirilowii seed, 110g of mulberry, 110g of Citrus aurantium, 10g of licorice, and 50g of aloe vera.

[0025] Its preparation method includes the following steps:

[0026] (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. The decoction is done once and each time is 5 hours. The extract is centrifuged and the upper centrifuged liquid is concentrated to obtain an extract with a specific gravity of 1.20.

[0027] (2) After grinding aloe vera into fine powder, magnesium stearate, corn starch, silicon dioxide and water are added and mixed to prepare a coating slurry. The mass ratio of aloe vera fine powder, magnesium stearate, corn starch, silicon dioxide and water is 50:3:70:5:150.

[0028] (3) The extract prepared in step (1) is spray-dried. The material temperature of the extract spray drying is 60℃, the atomization pressure is 0.4MPa, the feeding speed is 10kg / h, and then a coating slurry is sprayed in for coating. The temperature of the coating slurry is 45℃. After coating, the obtained particles are dried and mixed. The drying temperature is 70℃ and the drying time is 120min. Then, the particles are filled with empty capsules. The filling speed is 1000 capsules / min and the filling amount is 0.35g.

[0029] Example 2:

[0030] A traditional Chinese medicine composition for treating constipation, in capsule form, is prepared from the following raw materials: 320g of stir-fried Atractylodes macrocephala, 180g of peach kernel, 220g of Cistanche deserticola, 100g of tangerine peel, 180g of Angelica sinensis, 120g of Trichosanthes kirilowii seed, 150g of mulberry, 150g of Citrus aurantium, 50g of licorice, and 80g of aloe vera.

[0031] Its preparation method includes the following steps:

[0032] (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. The decoction is carried out 3 times, and the decoction time is 1 hour each time. The extract is centrifuged and the upper centrifuged liquid is concentrated to obtain an extract with a specific gravity of 1.22.

[0033] (2) After grinding aloe vera into fine powder, magnesium stearate, corn starch, silicon dioxide and water are added and mixed to prepare a coating slurry. The mass ratio of aloe vera fine powder, magnesium stearate, corn starch, silicon dioxide and water is 80:3:70:5:150.

[0034] (3) The extract prepared in step (1) is spray-dried. The material temperature of the extract spray drying is 80℃, the atomization pressure is 0.1MPa, the feeding speed is 60kg / h, and then a coating slurry is sprayed in for coating. The temperature of the coating slurry is 70℃. After coating, the obtained particles are dried and mixed. The drying temperature is 95℃ and the drying time is 45min. Then, the particles are filled with empty capsules. The filling speed is 1000 capsules / min and the filling amount is 0.35g.

[0035] Example 3:

[0036] A traditional Chinese medicine composition for treating constipation, in capsule form, is prepared from the following raw materials: 280g of stir-fried Atractylodes macrocephala, 120g of peach kernel, 200g of Cistanche deserticola, 50g of tangerine peel, 160g of Angelica sinensis, 70g of Trichosanthes kirilowii seed, 120g of mulberry, 120g of immature bitter orange, 20g of licorice, and 60g of aloe vera.

[0037] Its preparation method includes the following steps:

[0038] (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. The decoction is done twice, and each decoction lasts for 2 hours. The extract is centrifuged and the upper centrifuged liquid is concentrated to obtain an extract with a specific gravity of 1.21.

[0039] (2) After grinding aloe vera into fine powder, magnesium stearate, corn starch, silicon dioxide and water are added and mixed to prepare a coating slurry. The mass ratio of aloe vera fine powder, magnesium stearate, corn starch, silicon dioxide and water is 60:3:70:5:150.

[0040] (3) The extract prepared in step (1) is spray-dried. The material temperature of the extract spray-dried is 70℃, the atomization pressure is 0.3MPa, the feeding speed is 40kg / h, and then a coating slurry is sprayed in for coating. The temperature of the coating slurry is 60℃. After coating, the resulting particles are dried and mixed. The drying temperature is 80℃ and the drying time is 60min. Then, the particles are filled with empty capsules. The filling speed is 1000 capsules / min and the filling amount is 0.35g.

[0041] Example 4:

[0042] A traditional Chinese medicine composition for treating constipation, in capsule form, is prepared from the following raw materials: 300g of stir-fried Atractylodes macrocephala, 150g of peach kernel, 210g of Cistanche deserticola, 70g of tangerine peel, 170g of Angelica sinensis, 100g of Trichosanthes kirilowii seed, 130g of mulberry, 130g of Citrus aurantium, 30g of licorice, and 70g of aloe vera.

[0043] Its preparation method includes the following steps:

[0044] (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. The decoction is done twice, and each decoction lasts for 2 hours. The extract is centrifuged and the upper centrifuged liquid is concentrated to obtain an extract with a specific gravity of 1.21.

[0045] (2) After grinding aloe vera into fine powder, magnesium stearate, corn starch, silicon dioxide and water are added and mixed to prepare a coating slurry. The mass ratio of aloe vera fine powder, magnesium stearate, corn starch, silicon dioxide and water is 70:3:70:5:150.

[0046] (3) The extract prepared in step (1) is spray-dried. The material temperature of the extract spray-dried is 70℃, the atomization pressure is 0.3MPa, the feeding speed is 40kg / h, and then a coating slurry is sprayed in for coating. The temperature of the coating slurry is 60℃. After coating, the resulting particles are dried and mixed. The drying temperature is 80℃ and the drying time is 60min. Then, the particles are filled with empty capsules. The filling speed is 1000 capsules / min and the filling amount is 0.35g.

[0047] Example 5:

[0048] A traditional Chinese medicine composition for treating constipation, in capsule form, is prepared from the following raw materials: 290g of stir-fried Atractylodes macrocephala, 130g of peach kernel, 205g of Cistanche deserticola, 60g of tangerine peel, 165g of Angelica sinensis, 80g of Trichosanthes kirilowii seed, 125g of mulberry, 125g of immature bitter orange, 25g of licorice, and 65g of aloe vera.

[0049] Its preparation method includes the following steps:

[0050] (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. The decoction is done twice, and each decoction lasts for 2 hours. The extract is centrifuged and the upper centrifuged liquid is concentrated to obtain an extract with a specific gravity of 1.21.

[0051] (2) After grinding aloe vera into fine powder, magnesium stearate, corn starch, silicon dioxide and water are added and mixed to prepare a coating slurry. The mass ratio of aloe vera fine powder, magnesium stearate, corn starch, silicon dioxide and water is 65:3:70:5:150.

[0052] (3) The extract prepared in step (1) is spray-dried. The material temperature of the extract spray-dried is 70℃, the atomization pressure is 0.3MPa, the feeding speed is 40kg / h, and then a coating slurry is sprayed in for coating. The temperature of the coating slurry is 60℃. After coating, the resulting particles are dried and mixed. The drying temperature is 80℃ and the drying time is 60min. Then, the particles are filled with empty capsules. The filling speed is 1000 capsules / min and the filling amount is 0.35g.

[0053] Comparative Example 1:

[0054] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain stir-fried Atractylodes macrocephala.

[0055] Comparative Example 2:

[0056] A traditional Chinese medicine composition differs from Example 5 only in that it does not contain peach kernels.

[0057] Comparative Example 3:

[0058] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain Cistanche deserticola.

[0059] Comparative Example 4:

[0060] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain dried tangerine peel.

[0061] Comparative Example 5:

[0062] A traditional Chinese medicine composition differs from Example 5 only in that it does not contain angelica.

[0063] Comparative Example 6:

[0064] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain Trichosanthes kirilowii seeds.

[0065] Comparative Example 7:

[0066] A traditional Chinese medicine composition, differing from Example 5 only in that mulberry was not added.

[0067] Comparative Example 8:

[0068] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain Citrus aurantium.

[0069] Comparative Example 9:

[0070] A traditional Chinese medicine composition, differing from Example 5 only in that licorice was not added.

[0071] Comparative Example 10:

[0072] A traditional Chinese medicine composition, differing from Example 5 only in that it does not contain aloe vera.

[0073] Efficacy test:

[0074] 1. Four hundred and fifty patients aged 40-60 years with severe constipation were randomly selected. The selection criteria were prolonged intervals between bowel movements (more than 100 hours without defecation) and fewer than two bowel movements per week. Of the 450 patients, 253 were male and 197 were female. They were randomly divided into 15 groups of 30 patients each. There were no statistically significant differences among the 450 patients in terms of age, gender, or severity of constipation, making them comparable.

[0075] 2. Instructions for use:

[0076] Patients in groups 1-5 took the Chinese medicine compositions of Examples 1-5 respectively, and patients in groups 6-15 took the Chinese medicine compositions of Comparative Examples 1-10 respectively. The dosage was 3 pills twice a day for 2 consecutive weeks.

[0077] 3. Assessment of therapeutic effect:

[0078] Cured: Constipation symptoms disappear, bowel movements return to normal (1-2 bowel movements per day or once every two days), and there is no recurrence after six months of observation;

[0079] Effective: Symptoms significantly improved (bowdown interval greater than 48 hours and less than 60 hours);

[0080] Ineffective: No change in symptoms.

[0081] 4. Treatment results:

[0082] The overall effective rate = total effective number / total number of cases × 100%, the cure rate = number of cured cases / total number of cases × 100%, and the total effective number = number of cured cases + number of effective cases. The treatment results are shown in Table 1 below.

[0083] Table 1: Treatment Results

[0084]

[0085]

[0086] As shown in Table 1, the traditional Chinese medicine composition of the present invention has a cure rate of over 90% for treating constipation, and cured patients do not relapse for six months. The total effective rate can reach 100%, indicating that the traditional Chinese medicine composition can effectively treat constipation and prevent recurrence, thus achieving both symptomatic and root-cause treatment.

[0087] Meanwhile, comparing Example 5 with Comparative Examples 1-8, it can be seen that when any one of the following is missing from the Chinese herbal composition: stir-fried Atractylodes macrocephala, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, and immature bitter orange, the overall effective rate and cure rate of the Chinese herbal composition for treating constipation will decrease significantly. This indicates that stir-fried Atractylodes macrocephala, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, and immature bitter orange can synergistically improve the fundamental curative effect on constipation.

[0088] Comparing Example 5 with Comparative Examples 9-10, it can be seen that when either licorice or aloe is missing from the traditional Chinese medicine composition, the overall effective rate and cure rate of the traditional Chinese medicine composition for treating constipation will decrease, indicating that licorice and aloe can synergistically improve the symptomatic treatment effect on constipation.

[0089] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating constipation, characterized in that: The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 25-32 parts of stir-fried Atractylodes macrocephala, 10-18 parts of peach kernel, 16-22 parts of Cistanche deserticola, 2-10 parts of tangerine peel, 15-18 parts of Angelica sinensis, 5-12 parts of Trichosanthes kirilowii seed, 11-15 parts of mulberry, 11-15 parts of immature bitter orange, 1-5 parts of licorice, and 5-8 parts of aloe vera.

2. The traditional Chinese medicine composition for treating constipation according to claim 1, characterized in that: The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 28-30 parts of stir-fried Atractylodes macrocephala, 12-15 parts of peach kernel, 20-21 parts of Cistanche deserticola, 5-7 parts of tangerine peel, 16-17 parts of Angelica sinensis, 7-10 parts of Trichosanthes kirilowii seed, 12-13 parts of mulberry, 12-13 parts of immature bitter orange, 2-3 parts of licorice, and 6-7 parts of aloe vera.

3. The traditional Chinese medicine composition for treating constipation according to claim 1, characterized in that: The dosage form of the traditional Chinese medicine composition is an oral preparation.

4. A method for preparing a traditional Chinese medicine composition for treating constipation as described in any one of claims 1 to 3, characterized in that: Includes the following steps: (1) Stir-fry Atractylodes macrocephala with wheat bran, peach kernel, Cistanche deserticola, tangerine peel, Angelica sinensis, Trichosanthes kirilowii seed, mulberry, immature bitter orange and licorice together and decoct to obtain an extract. Centrifuge the extract and concentrate the upper centrifuged liquid to obtain an extract. (2) After grinding aloe vera into fine powder, add excipients to prepare a coating paste; (3) The extract prepared in step (1) is spray-dried and then coated with coating slurry. After coating, the resulting particles are dried and mixed, and then filled with empty capsules to obtain the final product.

5. The preparation method according to claim 4, characterized in that: In step (1), the decoction is performed 1-3 times and the decoction time is 1-5 hours.

6. The preparation method according to claim 4, characterized in that: In step (1), the specific gravity of the extract is 1.18-1.

25.

7. The preparation method according to claim 4, characterized in that: In step (2), the excipients include magnesium stearate, corn starch and silicon dioxide.

8. The preparation method according to claim 4, characterized in that: In step (3), the material temperature for the spray drying of the extract is 60-80℃, the atomization pressure is 0.1-0.4MPa, and the feeding speed is 10-60kg / h.

9. The preparation method according to claim 4, characterized in that: In step (3), the temperature of the sprayed coating slurry is 45-70℃.

Images