Preparation method and application of yang-strengthening pedicure cream

A yang-boosting foot therapy cream using traditional Chinese medicine principles and specific herbs applied to acupoints on the feet addresses pain management issues by dispelling cold and unblocking meridians, effectively relieving symptoms like headaches, abdominal pain, and dysmenorrhea.

CN119112843APending Publication Date: 2024-12-13HUNAN UNIV OF CHINESE MEDICINE
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Patent Information

Application Number
CN202411226112.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-03
Publication Date
2024-12-13

AI Technical Summary

Technical Problem

Existing treatments for pain management, particularly those targeting symptoms such as headache, abdominal pain, and dysmenorrhea, have limitations in efficacy and safety, and existing pain management methods fail to effectively address the symptoms of pain due to inflammation, nausea, and dysmenorrhea, and other symptoms such as cold evil blockage, leading to inadequate relief and potential side effects.

Method used

A yang-boosting foot therapy cream prepared from a blend of Evodia rutaecarpa, white pepper, cloves, bergamot, cinnamon, asarum, and cassia twig, applied to specific acupoints on the feet, utilizing traditional Chinese medicine principles to dispel cold, unblock meridians, and relieve pain.

Benefits of technology

The cream effectively relieves pain by supporting yang, dispelling cold, and unblocking meridians, providing relief for headaches, abdominal pain, low back pain, and dysmenorrhea caused by cold evil blockage without side effects.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a preparation method and application of yang-strengthening pedicure cream, and the key point of the technical scheme is that the yang-strengthening pedicure cream is prepared from the following medicinal materials in parts by weight: 3-8 parts of fructus evodiae, 3-8 parts of white pepper, 2-4 parts of clove, 2-4 parts of fingered citron, 2-4 parts of cinnamon, 1 part of asarum and 2-3 parts of cassia twig. The yang-strengthening pedicure ointment disclosed by the invention is externally applied according to the theory of treating internal diseases by external treatment in traditional Chinese medicine, has the effects of strengthening yang, dispelling cold and activating meridians to stop pain, can effectively relieve various pains caused by cold evil, and is suitable for symptoms such as headache, abdominal pain, lumbago and dysmenorrhea caused by cold evil block.
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Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and more specifically, to a preparation method and application of a yang-boosting foot therapy cream. Background Art

[0002] The comprehensive external treatment method of TCM for treating pain is a traditional method of preventing and treating diseases based on TCM theory, which uses drugs or instruments to act on the body surface or orifices. It has the characteristics of wide indications, simple operation, significant efficacy, fast effect, safety and non-toxicity. It has been deeply welcomed by the people for thousands of years. After years of development, the content of comprehensive external treatment has become increasingly rich, including acupuncture, moxibustion, massage, physical therapy, cupping, fumigation, plastering, umbilical therapy, foot massage, auricular therapy, soaking and other methods. Among these methods, foot massage is the most widely used external treatment method.

[0003] The Yellow Emperor's Classic of Internal Medicine describes the connection between foot acupuncture points and internal organs, and explains that the functions of internal organs can be regulated through foot acupuncture points. Based on the holistic concept of traditional Chinese medicine, traditional Chinese medicine theory believes that there is a specific correspondence between foot acupuncture points and internal organs of the body. This correspondence is not only reflected in the meridian system, but also in the corresponding foot "reflexology zone". The foot reflexology zone theory believes that different areas of the sole of the foot correspond to different organs and systems of the human body, as follows: the cerebellum and brainstem reflexology zone is located at the root of the big toe meat ball of both feet near the second phalanx, the head (brain) reflexology zone is located in the entire big toe meat ball of both feet, and the trigeminal nerve reflexology zone is located on the side of the big toe near the second toe of both feet. When headaches, migraines and other discomforts occur, these reflexology zones can be stimulated to relieve symptoms. The stomach reflex zone is located behind the first metatarsophalangeal joint of the soles of both feet (towards the heel); the spleen reflex zone is located between the fourth and fifth metatarsal bones of the left foot, two horizontal fingers behind the heart reflex zone (towards the heel); the celiac plexus reflex zone is located in the center of the soles of both feet, distributed near the kidney reflex zone and the stomach reflex zone; if abdominal pain occurs, the above reflex zones can be stimulated to relieve the symptoms. The lumbar reflex zone is located on the inner edge of the arch of both feet, from the cuneiform bone to the bottom of the navicular bone, connected to the thoracic reflex zone above and the sacral reflex zone below; if backache or back pain occurs, the above reflex zones can be stimulated to relieve the pain symptoms. There are two gonad reflex zones: Position 1: the center of the heel of both feet; Position 2: the triangular area in front of the calcaneal tendon below the outer ankle of both feet (symmetrical to the position of the uterine reflex zone). The sensitive point of the ovary is near the right-angle vertex of the triangle, and the sensitive point of the fallopian tube is on the hypotenuse of the triangle; the uterus reflex zone is located on the inner side of the heel bone, in the triangular area below the ankle bone; if you have symptoms of premenstrual or menstrual abdominal pain, you can start stimulating the above reflex zones about a week before your period to improve your dysmenorrhea symptoms. In clinical applications, stimulating specific areas of the sole of the foot through massage, application, etc. can achieve the purpose of dredge meridians and relieve pain.

[0004] According to traditional Chinese medicine, cold evil belongs to yin evil, which has the characteristics of coldness, condensation, and contraction. This cold nature can easily damage the body's yang energy, leading to a decline in body function, and can easily cause poor circulation of qi and blood, obstruction of meridians, and lead to "pain due to obstruction", thus causing various symptoms of pain. For example, "Suwen·Jutonglun" mentions: "Cold enters the meridians and delays, weeps but does not flow, stays outside the meridians and blood is scarce, stays inside the meridians and qi is blocked, so pain occurs suddenly". This statement reveals the pathogenesis of pain caused by cold evil blocking qi and blood, and also suggests the pathogenic basis of "pain due to obstruction" caused by cold evil invading the body.

[0005] Modern medicine usually treats various pain syndromes including medication, physical therapy, nerve block, nerve stimulation therapy, surgery and psychotherapy, and medication is one of the most common methods of pain management. It relies on different types of drugs, such as nonsteroidal anti-inflammatory drugs, opioids, antidepressants and anticonvulsants, to relieve pain, reduce inflammation and change the transmission of pain signals. However, medication also has obvious disadvantages, such as potential side effects (including gastrointestinal reactions, dependence, addiction, etc.), different efficacy due to individual differences, and possible drug resistance and drug interactions caused by long-term use. When treating various pain syndromes caused by cold evil blockage, traditional Chinese medicine mostly uses Chinese herbal decoctions, which have the disadvantages of inconvenient decoction of prescriptions, high prices of some drugs, poor efficacy due to improper medication methods, and insufficient dosage.

[0006] Therefore, the present invention is based on the theory of meridians and reflex zones in traditional Chinese medicine, and uses a traditional Chinese medicine external treatment method, namely, foot acupoint application, to propose a preparation method and application of a yang-boosting foot therapy cream. Summary of the invention

[0007] In order to solve the above problems, the purpose of the present invention is to provide a yang-boosting foot therapy cream, which has the effects of supporting yang and dispelling cold, unblocking meridians and relieving pain, and is suitable for people with headaches, abdominal pain, low back pain and dysmenorrhea caused by cold evil obstruction.

[0008] The second purpose of the present invention is to provide a method for preparing a yang-boosting foot therapy cream, so as to prepare a yang-boosting foot therapy cream that has the effects of supporting yang and dispelling cold, unblocking meridians and relieving pain, and can treat symptoms such as headache, abdominal pain, low back pain and dysmenorrhea caused by cold evil obstruction.

[0009] The third purpose of the present invention is to provide a yang-boosting foot therapy cream for use in treating headaches, abdominal pain, low back pain, dysmenorrhea and other symptoms caused by cold evil obstruction.

[0010] In order to achieve the above object, the technical solution adopted by the present invention is:

[0011] A yang-boosting foot therapy cream is prepared from the following medicinal materials in parts by weight: 3-8 parts of evodia rutaecarpa, 3-8 parts of white pepper, 2-4 parts of cloves, 2-4 parts of bergamot, 2-4 parts of cinnamon bark, 1 part of asarum, and 2-3 parts of cassia twig.

[0012] Furthermore, the yang-boosting foot therapy cream is made of the following medicinal materials in parts by weight: 6-7 parts of Evodia rutaecarpa, 6-7 parts of white pepper, 2-3 parts of cloves, 3-4 parts of bergamot, 3-4 parts of cinnamon, 1 part of asarum; and 2-3 parts of cassia twig.

[0013] Furthermore, the yang-boosting foot therapy cream is made of the following medicinal materials in parts by weight: 5 parts of Evodia rutaecarpa, 5 parts of white pepper, 3 parts of cloves, 3 parts of bergamot, 3 parts of cinnamon, 1 part of asarum; and 2 parts of cassia twig.

[0014] To achieve the above second purpose, the technical solution adopted by the present invention is: the yang-boosting foot therapy cream is prepared by the following method:

[0015] S1: Weigh each medicinal material according to the weight specified in the prescription, mix all the medicinal materials and then crush them, add appropriate amount of water to boil and filter, boil and concentrate the filtrate into a paste; cool and set aside;

[0016] S2: Weigh an appropriate amount of tartaric acid, add water and stir until completely dissolved, then add polyvinyl pyrrolidone PVPK90 equivalent to 0.8%-1.2% of the total weight of the original medicinal material, fully dissolve, and let it stand and swell overnight to form a gel, which is phase A;

[0017] S3. Weigh appropriate amounts of medical-grade sodium polyacrylate, aluminum glycolate and kaolin, mix them thoroughly with an appropriate amount of glycerin, and stir evenly to form phase B;

[0018] S4: Add the paste prepared in step S1 and phase A prepared in step S2 to phase B prepared in step S3 at the same time, heat to soften and mix evenly to form an ointment; and apply the heated and softened ointment on a backing material, cut the backing material into a patch according to a preset size, and package the patch in a composite film bag and seal it for storage.

[0019] Preferably, in step S1, the relative density of the paste is 1.21-1.35.

[0020] Preferably, in step S2, the mass concentration of the polyvinyl pyrrolidone PVPK90 in phase A is 0.5%-2%, and the mass ratio of the tartaric acid to the polyvinyl pyrrolidone PVPK90 is 1:10-15.

[0021] Preferably, the amount of the medical grade sodium polyacrylate is 1%-3% of the total mass of the original medicinal material.

[0022] Preferably, the mass ratio of the medical-grade sodium polyacrylate, aluminum glycolate, kaolin and glycerol is 20-30:1:1:100-120.

[0023] Preferably, the medical grade sodium polyacrylate is any one or more of sodium polyacrylate NP600, sodium polyacrylate NP700 and sodium polyacrylate NP800.

[0024] The invention also provides a yang-boosting foot therapy cream which has the effects of supporting yang, dispelling cold, unblocking meridians and relieving pain, and is suitable for people suffering from headache, abdominal pain, back pain and dysmenorrhea caused by cold evil obstruction.

[0025] Preferably, the drug dosage form is an external preparation, which is applied to the Yongquan acupoint on the sole of the patient's foot; at the same time, according to the patient's physical condition and the location of pain, it is supplemented with external application on other acupoints on the foot.

[0026] It should be noted that the method of using the foot massage cream is to change the dressing once a day, 15 days as a course of treatment, rest for 3 to 5 days before the next course of treatment, and generally 3 to 5 courses of treatment can be continued.

[0027] It should be noted that the pharmacological effects of some of the raw materials in the formula of the present invention are as follows:

[0028] Evodia rutaecarpa: Nature and flavor and meridians: pungent, bitter, hot; slightly toxic. Enters the liver, spleen, stomach, and kidney meridians. Functions and indications: dispels cold and relieves pain, relieves adverse reactions and stops vomiting, and helps yang and stops diarrhea. Used for headaches caused by the yin meridians, abdominal pain caused by cold hernia, cold and damp beriberi, abdominal pain during menstruation, abdominal distension and pain, vomiting and acid regurgitation, and diarrhea at dawn.

[0029] White pepper: Nature and flavor and meridians: pungent, hot; enters the stomach meridian and large intestine meridian. Functions and indications: warms the middle, relieves qi, eliminates phlegm, and detoxifies. Indications: cold phlegm and food accumulation, cold pain in the abdomen, nausea, vomiting of clear water, diarrhea, cold dysentery. And detoxifies food.

[0030] Clove: Nature and flavor and meridians: pungent, warm. Enters the spleen, stomach, lung, and kidney meridians. Functions and indications: warms the middle and lowers adverse reactions, tonifies the kidney and helps yang. Used for spleen and stomach deficiency and cold, hiccups and vomiting, loss of appetite, vomiting and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency.

[0031] Citron: Nature and flavor and meridians: pungent, bitter, sour, warm. Enters the liver, spleen, stomach, and lung meridians. Functions and indications: soothes the liver and regulates qi, harmonizes the stomach and relieves pain, dries dampness and resolves phlegm. Used for liver and stomach qi stagnation, chest and flank pain, fullness in the stomach, loss of appetite and vomiting, and cough with excessive phlegm.

[0032] Cinnamon: Nature and flavor and meridians: pungent, sweet, very hot. Enters the kidney, spleen, heart, and liver meridians. Functions and indications: replenishes fire and yang, guides fire back to the origin, dispels cold and relieves pain, warms and dredges the meridians. Used for impotence, cold uterus, cold pain in the waist and knees, asthma due to kidney deficiency, floating of false yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, abdominal pain due to cold hernia, dysmenorrhea and amenorrhea.

[0033] Asarum: Nature and flavor and meridians: pungent, warm. Enters the heart, lung, and kidney meridians. Functions and indications: dispels cold, dispels wind and relieves pain, clears the orifices, warms the lungs and transforms fluid. Used for colds, headaches, toothaches, nasal congestion and runny nose, allergic rhinitis, sinusitis, rheumatic arthralgia, phlegm and fluid asthma and cough.

[0034] Cinnamon twig: Nature and flavor and meridians: pungent, sweet, warm. Enters the heart, lung, and bladder meridians. Functions and indications: sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, balancing and descending qi. Used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0035] The present invention has the following beneficial effects:

[0036] 1. The selected drugs in the yang-boosting foot therapy cream of the present invention, evodia rutaecarpa and white pepper are pungent and hot in nature and flavor, and have the effects of warming the middle, dispelling cold and relieving pain; cloves are pungent and warm in nature and flavor, can help yang and warm the middle, and assist evodia rutaecarpa and white pepper in strengthening the effects of dispelling cold and relieving pain; bergamot can regulate qi, harmonize the stomach and relieve pain, and can comb out the pain caused by qi stagnation due to cold evil blocking; cinnamon is pungent, sweet and hot in nature and flavor, and has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispelling cold and relieving pain, and warming and unblocking the meridians; asarum is pungent and warm, good at running around, and has the effects of opening the orifices, dispelling cold and relieving pain; cassia twig can resolve the cold evil on the skin surface, warm and unblock the meridians, and help yang and transform qi. All the drugs are used together to play the effects of supporting yang, dispelling cold, unblocking meridians and relieving pain.

[0037] 2. The acupoints selected for the ointment acupoint application of the present invention are mainly Yongquan. In clinical use, other acupoints on the foot are supplemented according to the patient's physique and pain site. Yongquan is the starting acupoint of the kidney meridian and the place where the kidney meridian qi flows outward. Applying Yongquan acupoint can warm the meridians and promote the local harmony of qi and blood, so as to achieve the effect of eliminating cold evil and relieving pain.

[0038] 3. The Yang-boosting foot therapy cream of the present invention adopts the theory of external treatment of internal diseases in traditional Chinese medicine for external application. It has the effects of supporting Yang and dispelling cold, unblocking meridians and relieving pain. It can effectively relieve various pains caused by cold evil, and is suitable for headaches, abdominal pain, low back pain and dysmenorrhea caused by cold evil blockage.

[0039] 4. The present invention is based on the theory of meridians and reflex zones in traditional Chinese medicine, and uses the external treatment method of traditional Chinese medicine, foot acupoint application, to prepare a yang-boosting foot therapy cream. According to the principle of "external treatment of internal diseases", the yang-boosting foot therapy cream uses pungent and warm, running, and meridian-dredging drugs to be applied to relevant acupoints, so that the drugs can penetrate the skin and enter the acupoints and meridians, and through the running of qi and blood in the meridians, the "return to the meridians" and functional effects of the drugs are exerted, directly reaching the relevant internal organs, which can dispel cold evil, support yang and dispel cold, dredge the meridians and relieve pain, and relieve symptoms. DETAILED DESCRIPTION

[0040] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0041] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0042] Embodiment 1:

[0043] A preparation method of a yang-boosting foot therapy cream, specifically comprising:

[0044] S1: According to the prescription, weigh 5 parts of Evodia rutaecarpa, 5 parts of white pepper, 3 parts of cloves, 3 parts of bergamot, 3 parts of cinnamon, 1 part of asarum, and 2 parts of cassia twig; mix all the above medicinal materials and crush them, add 12 times of water and boil for 3 times, each time boiling for 45 minutes, filter, boil the filtrate and concentrate it into a paste with a relative density of 1.21, cool it for later use.

[0045] S2: Weigh an appropriate amount of tartaric acid, add water and stir until completely dissolved, then add polyvinyl pyrrolidone PVPK90 equivalent to 0.8% of the total mass of the original medicinal material, fully dissolve, and let it swell overnight to form a gel as phase A, wherein the mass ratio of tartaric acid to polyvinyl pyrrolidone PVPK90 is 1:10, and the mass concentration of polyvinyl pyrrolidone PVPK90 in phase A is 0.8%.

[0046] S3. Weigh medical-grade sodium polyacrylate NP700, aluminum glyoxylate and kaolin, mix them thoroughly into an appropriate amount of glycerol, and stir evenly to prepare phase B, wherein the mass of medical-grade sodium polyacrylate NP700 is 1% of the total mass of the original medicinal material, and the mass ratio of medical-grade sodium polyacrylate NP700, aluminum glyoxylate, kaolin and glycerol is 20:1:1:100.

[0047] S4: Add the paste prepared in step S1 and phase A prepared in step S2 to phase B prepared in step S3 at the same time, heat to soften and mix evenly to form an ointment; and apply the heated and softened ointment on a backing material, cut the backing material into a patch according to a preset size, and package the patch in a composite film bag and seal it for storage.

[0048] The Yang-boosting foot massage cream described in this embodiment has the effects of supporting Yang and activating collaterals, can effectively relieve various pains caused by cold evil, and is suitable for headaches, abdominal pain, low back pain, dysmenorrhea and the like caused by cold evil obstruction.

[0049] Embodiment 2:

[0050] A preparation method of a yang-boosting foot therapy cream, specifically comprising:

[0051] S1. According to the prescription, weigh 8 parts of Evodia rutaecarpa, 8 parts of white pepper, 4 parts of cloves, 4 parts of bergamot, 4 parts of cinnamon, 1 part of asarum, and 3 parts of cassia twig; mix all the above medicinal materials and crush them, add 10 times water and boil twice, each time boiling for 30 minutes, filter, boil the filtrate and concentrate it into a paste with a relative density of 1.35, cool it for later use.

[0052] S2: Weigh an appropriate amount of tartaric acid, add water and stir until completely dissolved, then add polyvinyl pyrrolidone PVPK90 equivalent to 1.2% of the total mass of the original medicinal material, fully dissolve, and let it stand and swell overnight to form a gel as phase A, wherein the mass ratio of tartaric acid to polyvinyl pyrrolidone PVPK90 is 1:15, and the mass concentration of polyvinyl pyrrolidone PVPK90 in phase A is 1.8%.

[0053] S3. Weigh medical-grade sodium polyacrylate (the mass ratio of sodium polyacrylate NP600: sodium polyacrylate NP700 is 1:1), aluminum glycolate and kaolin, mix them thoroughly into an appropriate amount of glycerol, and stir evenly as phase B, wherein the mass of medical-grade sodium polyacrylate is 2.5% of the total mass of the original medicinal material, and the mass ratio of medical-grade sodium polyacrylate, aluminum glycolate, kaolin and glycerol is 20:1:1:120.

[0054] S4: Add the paste prepared in step S1 and phase A prepared in step S2 to phase B prepared in step S3 at the same time, heat to soften and mix evenly to form an ointment; and apply the heated and softened ointment on a backing material, cut the backing material into a patch according to a preset size, and package the patch in a composite film bag and seal it for storage.

[0055] The dosage of warming yang drugs in the Yang-boosting foot therapy cream prepared in this embodiment is relatively large. Among them, cinnamon bark replenishes fire and helps yang, and guides fire back to the origin. Combined with drugs such as Evodia rutaecarpa, Asarum, and Clove, it helps warm the kidney yang and replenish spleen yang. It is mostly suitable for people with cold pain in the waist and knees and dysmenorrhea caused by cold stagnation.

[0056] Embodiment three:

[0057] A preparation method of a yang-boosting foot therapy cream, specifically comprising:

[0058] S1. Weigh 3 parts of Evodia rutaecarpa, 3 parts of white pepper, 2 parts of cloves, 2 parts of bergamot, 2 parts of cinnamon, 1 part of asarum, and 2 parts of cassia twig according to the prescription; mix all the above medicinal materials and crush them, add 15 times water and boil twice, each time boiling for 30 minutes, filter, boil the filtrate and concentrate it into a paste with a relative density of 1.30, cool it for later use.

[0059] S2: Weigh an appropriate amount of tartaric acid, add water and stir until completely dissolved, then add polyvinyl pyrrolidone PVPK90 equivalent to 1% of the total mass of the original medicinal material, fully dissolve, and let it stand and swell overnight to form a gel as phase A, wherein the mass ratio of tartaric acid to polyvinyl pyrrolidone PVPK90 is 1:12, and the mass concentration of polyvinyl pyrrolidone PVPK90 in phase A is 1.2%.

[0060] S3. Weigh medical-grade sodium polyacrylate NP800, aluminum glycolate and kaolin, mix them thoroughly into an appropriate amount of glycerol, and stir evenly to prepare phase B, wherein the mass of medical-grade sodium polyacrylate NP800 is 1.5% of the total mass of the original medicinal material, and the mass ratio of medical-grade sodium polyacrylate NP800, aluminum glycolate, kaolin and glycerol is 30:1:1:110.

[0061] S4: Add the paste prepared in step S1 and phase A prepared in step S2 to phase B prepared in step S3 at the same time, heat to soften and mix evenly to form an ointment; and apply the heated and softened ointment on a backing material, cut the backing material into a patch according to a preset size, and package the patch in a composite film bag and seal it for storage.

[0062] The Yang-boosting foot therapy cream prepared in this embodiment has a small dosage, weaker efficacy and slower momentum, and is suitable for use by the elderly, children, weak physiques or those with long-term illness and physical weakness.

[0063] The application of the Fuyang foot therapy cream prepared in the above-mentioned embodiments 1 to 3 is as follows: apply the Fuyang foot therapy cream to the Yongquan acupoint in the center of the foot; at the same time, apply other acupoints on the foot according to the patient's physique and the location of pain. Change the dressing once a day, 15 days as a course of treatment, rest for 3 to 5 days before the next course of treatment, and generally 3 to 5 courses of treatment can be continued.

[0064] Test example:

[0065] To prove that the ointment for yang-boosting foot therapy in the present invention has the effects of yang-boosting, dispelling cold, unblocking meridians and relieving pain, it can effectively relieve various pains caused by cold pathogens, and is suitable for headaches, abdominal pain, low back pain and dysmenorrhea caused by cold pathogens. The inventors have conducted a large number of clinical trials on the yang-boosting foot therapy ointment prepared in Example 1, and now select some clinical trial reports as follows.

[0066] Case 1: Long, female, 30 years old. Main complaint: headache recurred for more than one month. The patient reported that in the past month, whenever the weather turned cold or she caught a cold, her headache worsened, mainly on the forehead and both sides, aggravated by cold and relieved by heat. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for half a month, the frequency and intensity of the patient's headache were significantly reduced. After continuing to use it for two months, the patient's cold headache symptoms disappeared.

[0067] Case 2: Mr. Li, male, 45 years old. Main complaint: Abdominal pain recurred for 3 weeks. The patient reported that in the past three weeks, whenever he ate raw or cold food or got cold, he had obvious abdominal pain, mainly around the navel, which was relieved by heat, accompanied by diarrhea and loose stools. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for half a month, the frequency of abdominal pain and diarrhea of ​​the patient was significantly reduced, and after one month of use, the patient's abdominal pain symptoms were significantly relieved.

[0068] Case 3: Wang, female, 50 years old. Main complaint: waist pain for more than half a year. The patient reported that she had waist pain without obvious cause half a year ago, which worsened on rainy days or after catching a cold. The pain was mainly in the waist and both sides, accompanied by limb weakness, especially at night. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for one month, the patient's waist pain was alleviated and the frequency of attacks was reduced; after continuous use for three months, the patient's waist pain symptoms basically disappeared.

[0069] Case 4: Sheng, female, 22 years old. Chief complaint: severe abdominal pain during menstruation for more than 2 years. The patient reported that about two years ago, she began to experience severe abdominal pain two days before each menstruation. The pain was severe and unbearable, and it was relieved by heat. The menstrual volume was small, dark in color, with blood clots, and she was afraid of cold limbs during menstruation and liked warmth. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for one month, the abdominal pain before menstruation was relieved, and the blood clots during menstruation were reduced compared with before; after continuing to use it for four months, the patient's abdominal pain symptoms before and during menstruation were significantly relieved, the menstrual volume and color were basically normal, and the symptoms of fear of cold disappeared completely.

[0070] Case 5: Xiao, female, 35 years old. Main complaint: abdominal cold pain recurred for more than 3 years. The patient reported that she had abdominal cold pain after catching a cold about 3 years ago, and the symptoms disappeared after taking medicine. After that, she felt that the abdominal cold pain was aggravated every time she ate raw or cold food, accompanied by loose diarrhea, and liked warmth and pressure. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for one month, the abdominal pain was relieved compared with before; after continuing to use it for two months, the abdominal pain basically disappeared, bowel sounds were normal, and bowel movements were regular.

[0071] Case 6: Chen, male, 27 years old. Chief complaint: recurrent upper abdominal cold pain for more than 2 months. The patient reported that he had recurrent upper abdominal cold pain after eating a lot of raw and cold food about 2 months ago, accompanied by abdominal distension, loose stools, poor appetite, watery mouth, chills and cold limbs. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for half a month, the abdominal cold pain was significantly relieved, the abdominal distension basically disappeared, and there were occasional loose stools; after continuing to use it for three months, the symptoms of abdominal cold pain and loose stools basically disappeared.

[0072] Case 7: Xie, female, 19 years old. Chief complaint: abdominal pain during menstruation for 3 years, aggravated for 3 days after recurrence. The patient reported that after catching a cold about 3 years ago, she had cold and painful lower abdomen during menstruation or before menstruation and refused to press it, the skin temperature of both kidney areas decreased, the waist was cold and painful, and the pain was relieved by heat, the menstrual flow was small, dark in color and with blood clots. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for two months, the pain before and during menstruation was significantly relieved, and the blood clots were reduced compared with before; after continuing to use it for three months, the patient's dysmenorrhea symptoms were significantly relieved, and the menstrual flow and color were basically normal.

[0073] Case 8: Wu, female, 45 years old. Main complaint: headache recurred for 5 years, and the next attack was aggravated for 1 day. The patient complained that she had a headache after catching a cold about 5 years ago, mainly at the top of the head, aggravated by cold, relieved by warmth, painful like a needle prick, accompanied by nausea and vomiting. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for one month, the frequency of headache attacks decreased, and the feeling of nausea and vomiting disappeared; after continuing to use it for one month, the headache was significantly relieved.

[0074] Case 9: Gao, male, 12 years old. Main complaint: upper abdominal cold pain for 2 weeks. The patient reported that he had upper abdominal cold pain after being caught in the rain 2 weeks ago, which was paroxysmal and aggravated. He liked warmth and massage, and was relieved by heat, accompanied by chills and diarrhea. After using the yang-boosting foot therapy cream prepared in Example 3 of the present invention for one and a half months, the upper abdominal cold pain was basically relieved.

[0075] Case 10: An, female, 52 years old. Chief complaint: cold pain in the waist accompanied by heaviness for more than 1 year. The patient complained that she caught a cold while swimming in the river 1 year ago and developed cold pain in the waist, accompanied by heaviness, which worsened in rainy weather, and it was difficult to turn to the side. There was obvious local coldness, accompanied by heaviness in the lower limbs. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for half a month, the heaviness in the waist disappeared, and the frequency of low back pain was lower than before; after continuing to use it for one month, the low back pain was significantly relieved.

[0076] Case 11: Yao, male, 69 years old. Main complaint: headache recurred for 1 year, and worsened for 2 days. The patient reported that he had a headache after catching a cold 1 year ago, and the headache recurred, mainly in the forehead, aggravated by wind and cold, accompanied by nasal congestion and clear runny nose. After using the Fuyang foot therapy cream prepared in Example 3 of the present invention for one month, the headache was less severe than before; after continuing to use it for two months, the headache was significantly relieved.

[0077] Case 12: He, male, 28 years old. Main complaint: repeated attacks of headache for more than 3 months. The patient reported that he drank a lot of ice water after exercise about 3 months ago, and then had a severe headache, which was relieved after hot compress, and recurred after catching a cold. The headache was severe, mainly in the forehead and temples, and it was triggered by cold, and nausea and vomiting of water. After using the Fuyang foot therapy cream prepared in Example 1 of the present invention for half a month, the vomiting symptoms disappeared and the headache was relieved; after continuing to use it for one month, the headache was significantly relieved.

[0078] Case 13: Lin, female, 45 years old. Chief complaint: cold pain in the waist and lower limbs for more than 2 years. The patient reported that she accidentally fell into the water about 2 months ago, and then she developed pain in the waist and lower limbs. The cold pain was severe and aggravated by cold, accompanied by numbness of the lower limbs. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for one month, the numbness of the lower limbs was significantly improved; after continuing to use it for two months, the degree of cold pain in the waist and lower limbs was alleviated, and the frequency of attacks decreased; after continuing to use it for two months, the cold pain in the waist and lower limbs disappeared

[0079] Case 14: Li, female, 16 years old. Main complaint: progressively worsening menstrual abdominal pain for 3 years. The patient reported that she usually likes to eat raw and cold foods. After her menarche, she experienced severe cold pain in her lower abdomen during menstruation, which was slightly relieved by heat. The pain worsened with age, and the menstrual volume was small, dark and clotted, accompanied by cold hands and feet. After using the Fuyang foot therapy cream prepared in Example 2 of the present invention for two months, the menstrual pain was relieved compared with before; after continuing to use it for three months, the pain symptoms were basically controlled and did not affect normal life.

[0080] Case 15: Huang, male, 72 years old. Chief complaint: recurrent lower abdominal cold pain accompanied by diarrhea for more than 2 years. The patient reported that he usually likes to eat raw and cold food. About 2 years ago, he had persistent abdominal pain without obvious cause. He likes warmth and pressure, and has diarrhea after eating cold food, accompanied by cold body and limbs. After using the Fuyang foot therapy cream prepared in Example 3 of the present invention for one month, the diarrhea was significantly relieved; after continuing to use it for one month, the abdominal pain was significantly relieved, and there was occasional discomfort after eating raw and cold food; after continuing to use it for two months, the abdominal pain and other symptoms basically disappeared.

[0081] In summary, the acupoint application of the yang-boosting foot therapy cream in the present invention is based on the principle of "external treatment of internal diseases", selects acupoints according to different physical constitutions and pain sites, and applies pungent, warm, moving, and menstruation-promoting drugs to relevant acupoints, so that the drugs can penetrate the skin pores and enter the acupoint meridians, and through the circulation of qi and blood in the meridians, the "channel" and functional effects of the drugs are exerted, directly reaching the relevant internal organs, which can dispel cold evil, support yang and dispel cold, dredge meridians and relieve pain, and relieve various pain symptoms caused by the blockage of cold evil.

[0082] The selected drugs in the Yang-boosting foot therapy cream are Evodia rutaecarpa and white pepper, which are pungent and hot in nature and have the effects of warming the middle, dispelling cold and relieving pain; cloves are pungent and warm in nature and can help warm the middle, and assist Evodia rutaecarpa and white pepper in strengthening the effects of dispelling cold and relieving pain; bergamot can regulate qi, harmonize the stomach and relieve pain, and can sort out the pain caused by qi stagnation due to cold evil blockage; cinnamon is pungent, sweet and hot in nature and has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispelling cold and relieving pain, and warming and unblocking the meridians; asarum is pungent and warm, good at moving around, and has the effects of opening the orifices, dispelling cold and relieving pain; cassia twig can resolve the cold evil on the skin surface, warm and unblock the meridians, and help yang and transform qi. All the drugs are used together to play the effects of supporting yang, dispelling cold, unblocking meridians and relieving pain, effectively relieving multiple pains in the body caused by cold evil blockage, and can be used to treat headaches, abdominal pain, low back pain and dysmenorrhea caused by cold evil blockage.

[0083] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A yang-boosting foot therapy cream, It is characterized in that The yang-boosting foot therapy cream is prepared from the following medicinal materials in parts by weight: 3-8 parts of Evodia rutaecarpa, 3-8 parts of white pepper, 2-4 parts of cloves, 2-4 parts of bergamot, 2-4 parts of cinnamon bark, 1 part of asarum; and 2-3 parts of cassia twig.

2. A yang-boosting foot therapy cream according to claim 1, It is characterized in that The yang-boosting foot therapy cream is prepared from the following medicinal materials in parts by weight: 6-7 parts of Evodia rutaecarpa, 6-7 parts of white pepper, 2-3 parts of cloves, 3-4 parts of bergamot, 3-4 parts of cinnamon, 1 part of asarum; and 2-3 parts of cassia twig.

3. A yang-boosting foot therapy cream according to claim 1, It is characterized in that The yang-boosting foot therapy cream is made of the following medicinal materials in parts by weight: 5 parts of Evodia rutaecarpa, 5 parts of white pepper, 3 parts of cloves, 3 parts of bergamot, 3 parts of cinnamon bark, 1 part of asarum; and 2 parts of cassia twig.

4. A method for preparing the yang-boosting foot therapy cream according to any one of claims 1 to 3, It is characterized in that The yang-boosting foot therapy cream is prepared by the following method: S1: Weigh each medicinal material according to the weight stated in the prescription, mix all the medicinal materials and then crush them, add appropriate amount of water to boil and filter, boil and concentrate the filtrate into a paste, cool and set aside; S2: Weigh an appropriate amount of tartaric acid, add water and stir until completely dissolved, then add polyvinyl pyrrolidone PVPK90 equivalent to 0.8%-1.2% of the total weight of the original medicinal material, fully dissolve, and let it stand and swell overnight to form a gel, which is phase A; S3. Weigh appropriate amounts of medical-grade sodium polyacrylate, aluminum glycolate and kaolin, mix them thoroughly with an appropriate amount of glycerin, and stir evenly to form phase B; S4: Add the paste prepared in step S1 and phase A prepared in step S2 to phase B prepared in step S3 at the same time, heat to soften and mix evenly to form an ointment; and apply the heated and softened ointment on a backing material, cut the backing material into a patch according to a preset size, and package the patch in a composite film bag and seal it for storage.

5. The preparation method of the yang-boosting foot therapy cream according to claim 4, It is characterized in that In step S1, the relative density of the paste is 1.21-1.

35.

6. The preparation method of the yang-boosting foot therapy cream according to claim 4, It is characterized in that In step S2, the mass concentration of the polyvinyl pyrrolidone PVPK90 in phase A is 0.5%-2%, and the mass ratio of the tartaric acid to the polyvinyl pyrrolidone PVPK90 is 1:10-15.

7. The preparation method of the yang-boosting foot therapy cream according to claim 4, It is characterized in that The dosage of the medical grade sodium polyacrylate is 1%-3% relative to the total weight of the original medicinal material.

8. The method for preparing the Fuyang foot therapy cream according to claim 4, wherein the mass ratio of the medical-grade sodium polyacrylate, aluminum glycolate, kaolin and glycerol is 20-30:1:1:100-120.

9. The preparation method of the yang-boosting foot therapy cream according to claim 4, It is characterized in that The medical grade sodium polyacrylate is any one or more of sodium polyacrylate NP600, sodium polyacrylate NP700 and sodium polyacrylate NP800.

10. The Yang-boosting foot therapy cream according to any one of claims 1 to 3 has the effects of supporting Yang and dispelling cold, unblocking meridians and relieving pain, and is suitable for people suffering from headaches, abdominal pain, low back pain, dysmenorrhea and the like caused by cold evil obstruction.