Traditional Chinese medicine composition containing coptis chinensis and ginger processed pinellia and preparation method of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition containing coptis chinensis and ginger processed pinellia and a preparation method of the traditional Chinese medicine composition. Comprising the following components in parts by mass: 10-20 parts of coptis chinensis, 15-25 parts of ginger processed pinellia, 5-15 parts of celandine, 3-13 parts of cuttlebone, 1-6 parts of hedyotis diffusa, 2-9 parts of percocypris pingi, 6-14 parts of mangifera indica, 7-17 parts of cynanchum atratum, 1-9 parts of ardisia maculata, 1-10 parts of liquorice, 4-12 parts of white hyacinth bean, 12-19 parts of radix paeoniae alba, 5-15 parts of longan, 2-12 parts of red dates, 4-15 parts of rhizoma polygonati, 1-10 parts of radix polygonati officinalis, 2-8 parts of schizonepeta, 1-7 parts of pepper and 5-10 parts of pericarpium citri reticulatae. 1-5 parts of radix aucklandiae and 5-12 parts of agilawood. According to the traditional Chinese medicine composition, the coptis chinensis and the ginger processed pinellia are compounded with multiple components, active components in the traditional Chinese medicine raw materials are fully extracted through a special preparation method, the synergistic effect is achieved, and the prepared traditional Chinese medicine composition is good in gastric ulcer treatment effect and has extremely wide market prospects.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition containing coptis root and pinellia tuber and a preparation method thereof. Background Art

[0002] The number of patients with gastric ulcers in modern society is increasing, which is closely related to the changes in modern lifestyle. The following are some key factors: irregular diet: with the accelerated pace of life, many people cannot guarantee a healthy diet at regular times and in fixed quantities, and often eat out or eat fast food. These foods are often high in fat, high in salt, and lack of fiber, which increases the burden on the stomach. Increased pressure: in modern society, competition is fierce, and work and life pressure is high. Long-term mental stress and mood swings can affect the nervous system, which in turn affects gastrointestinal function and reduces the protective effect of gastric mucosa. Drug abuse: some commonly used drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), can cause damage to the gastric mucosa if used for a long time or in excessive amounts, increasing the risk of gastric ulcers. Helicobacter pylori infection: this is a common bacterial infection and one of the important causes of gastric ulcers. Close social activities in modern life may promote the spread of the bacteria. Bad living habits: including smoking, drinking, etc., these habits will directly damage the gastric mucosa and increase the risk of ulcers. Environmental and seasonal factors: such as the transition between winter and spring, temperature changes may lead to a decline in human immunity. In addition, with the prevalence of viral colds, people may overuse cold medicines, further damaging the gastric mucosa. Age distribution: Due to the combined influence of the above factors, young and middle-aged people have become a high-risk group for gastric ulcers. This group of people usually have greater life and work pressure and are more likely to have irregular living habits. In summary, the increase in gastric ulcer patients is a complex social health issue, which is closely related to the changes in modern lifestyles.

[0003] Ulcers refer to the damage or ulceration of the gastric mucosa, which is usually related to excessive gastric acid secretion, Helicobacter pylori infection, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), smoking, drinking, genetic factors, mental stress and other factors. Gastric ulcers can cause symptoms such as upper abdominal pain, fullness, acid reflux, belching, nausea, vomiting, loss of appetite, and in severe cases, complications such as bleeding and perforation may occur. In traditional Chinese medicine theory, gastric ulcers belong to the category of "epigastric pain", and their causes and pathogenesis are diverse, mainly including spleen and stomach weakness, liver qi invading the stomach, damp heat accumulation, cold and heat mixed, blood stasis blocking the collaterals, and insufficient stomach yin.

[0004] Both Coptis chinensis and Pinellia ternata are commonly used drugs in traditional Chinese medicine. They play a certain auxiliary role in the treatment of gastric ulcers, mainly through their respective medicinal properties and effects to work synergistically to achieve the purpose of harmonizing the stomach, reducing adverse reactions, removing dampness, and clearing away heat. Their potential role in the treatment of gastric ulcers.

[0005] Coptis chinensis: Nature and flavor and meridians entered: Coptis chinensis is cold in nature, bitter in taste, and enters the heart, spleen, stomach, gallbladder, and large intestine meridians.

[0006] Effects: Coptis chinensis has the effects of clearing away heat and dampness, purging fire and detoxifying. In the treatment of gastric ulcers, Coptis chinensis can help clear damp heat from the stomach and relieve discomfort caused by stomach heat, such as stomach pain, acid reflux, heartburn and other symptoms. Its anti-inflammatory and antibacterial effects may help reduce stomach inflammation and fight Helicobacter pylori infection, which may cause or aggravate gastric ulcers.

[0007] Pinellia ternata: Nature and flavor: Pinellia ternata is pungent and warm in nature, and enters the spleen and stomach meridians. It is made from raw Pinellia ternata, and ginger juice is added to enhance its warming and nausea-stopping properties. Function: Pinellia ternata's role in treating gastric ulcers is mainly reflected in its effects of drying dampness and resolving phlegm, lowering adverse qi and stopping vomiting, and eliminating lumps and dispersing nodules. It can relieve symptoms such as vomiting, bloating, and fullness caused by spleen and stomach weakness or cold and dampness, help improve the digestive function of the stomach, and relieve stomach discomfort. Pinellia ternata also has a certain protective effect on the gastric mucosa, which may help the repair process of gastric ulcers.

[0008] In the treatment of gastric ulcer, the combination of Coptis chinensis and Pinellia ternata can theoretically achieve the balance of cold and heat, clearing away heat and drying dampness, warming the stomach, and has a certain auxiliary therapeutic effect on gastric ulcers caused by damp heat or cold dampness. The combination of Coptis chinensis's heat-clearing and detoxifying effects and Pinellia ternata's warming and vomiting-stopping effects can comprehensively adjust the balance of cold and heat in the stomach, promote the recovery of digestive function, alleviate gastric ulcer symptoms, and promote ulcer healing.

[0009] However, the therapeutic effect of the Chinese medicine composition containing coptis root and pinellia tuber on the market on gastric ulcer is not ideal. Summary of the invention

[0010] The invention aims to provide a Chinese medicine composition containing coptis root and rhizoma pinelliae and a preparation method thereof.

[0011] In order to achieve the above-mentioned purpose, the present invention provides the following technical scheme: a Chinese medicine composition containing coptis root and pinellia ternata, comprising the following components in parts by weight: 10-20 parts of coptis root, 15-25 parts of pinellia ternata, 5-15 parts of celandine, 3-13 parts of cuttlebone, 1-6 parts of fireweed, 2-9 parts of carp, 6-14 parts of mangosteen, 7-17 parts of small white mulberry, 1-9 parts of pearl umbrella, 1-10 parts of liquorice, 4-12 parts of white hyacinth bean, 12-19 parts of white peony root, 5-15 parts of longan, 2-12 parts of red dates, 4-15 parts of polygonatum, 1-10 parts of polygonatum, 2-8 parts of schizonepeta, 1-7 parts of pepper, 5-10 parts of tangerine peel, 1-5 parts of costus root and 5-12 parts of agarwood.

[0012] Furthermore, a traditional Chinese medicine composition containing coptis root and pinellia tuber comprises the following components in parts by mass: 15 parts of coptis root, 20 parts of pinellia tuber, 11 parts of greater celandine, 8 parts of cuttlebone, 4 parts of firethorn, 6 parts of carp, 10 parts of mangosteen, 12 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white labiata, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0013] The present invention also provides a method for preparing the Chinese medicine composition containing coptis root and pinellia tuber, comprising the following steps: (1) Crush the coptis root and the pinellia tuber and pass through a 70-mesh sieve to obtain coptis root and the pinellia tuber fine powder; (2) First, place the coptis chinensis and pinellia ternata powders at a low temperature of -27°C for 2-3 minutes, then rapidly heat them to 30°C within 2 seconds, and repeat 2-3 times; then pressurize them to 17-23 MPa, maintain for 4-5 minutes, and then release the pressure to normal pressure, and repeat 2-3 times to obtain pretreated coptis chinensis and pinellia ternata powders; (3) Mixing the pretreated coptis chinensis and pinellia ternata powders with ethanol in a mass ratio of 10:80-90, soaking at 20-25°C for 15-20h, heating to 80-90°C, heating under reflux for 1-2h, filtering, and concentrating under reduced pressure to remove ethanol, thereby obtaining coptis chinensis and pinellia ternata extracts; (4) Mix the remaining components, crush them and pass them through a 100-mesh sieve to obtain mixed micropowder: (5) subjecting the mixed micropowder to supercritical extraction, first extracting at 40-45°C, 30-35MPa, and a CO2 flow rate of 22-25L / h for 60-70min to obtain fraction A, and then further extracting at 30-35°C, 20-25MPa, and a CO2 flow rate of 22-25L / h for 20-30min to obtain fraction B; then extracting at 20-25°C, 10-15MPa, and a CO2 flow rate of 22-25L / h for 10-20min, and mixing fraction A, fraction B, and fraction C in a mass ratio of 1:1:1 to obtain a mixed micropowder extract; (6) The extracts of Coptis chinensis and Pinellia ternata are mixed with the mixed micro powder extract to obtain a Chinese medicine composition.

[0014] Compared with the prior art, the advantages and beneficial effects of the present invention are: The invention compounds coptis root and pinellia tuber with multiple components, and fully extracts active components in the Chinese medicine raw materials through a special preparation method, so that the prepared Chinese medicine composition has good effect on treating gastric ulcer and has extremely broad market prospects. DETAILED DESCRIPTION

[0015] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] Example 1 The present embodiment provides a traditional Chinese medicine composition containing coptis root and pinellia tuber, comprising the following components in parts by weight: 15 parts of coptis root, 20 parts of pinellia tuber, 11 parts of celandine, 8 parts of cuttlebone, 4 parts of firethorn, 6 parts of carp, 10 parts of mangosteen, 12 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white labiata, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0017] The preparation method of the Chinese medicine composition containing coptis root and pinellia tuber comprises the following steps: (1) Crush the coptis root and the pinellia tuber and pass through a 70-mesh sieve to obtain coptis root and the pinellia tuber fine powder; (2) First, place the coptis chinensis and pinellia ternata powders at a low temperature of -27°C for 2 minutes, then rapidly heat them to 30°C within 2 seconds, and repeat this process 3 times; then pressurize them to 20 MPa, maintain the pressure for 4.5 minutes, and then release the pressure to normal pressure, and repeat this process 3 times to obtain pretreated coptis chinensis and pinellia ternata powders; (3) Mixing the pretreated coptis chinensis and pinellia ternata powders with ethanol in a mass ratio of 10:87, soaking at 22°C for 17 hours, heating to 85°C, heating under reflux for 1.5 hours, filtering, and concentrating under reduced pressure to remove ethanol, thereby obtaining coptis chinensis and pinellia ternata extracts; (4) Mix the remaining components, crush them and pass them through a 100-mesh sieve to obtain mixed micropowder: (5) The mixed micropowder was subjected to supercritical extraction, firstly extracted at 42°C, 32MPa, and a CO2 flow rate of 24L / h for 65min to obtain fraction A, and then extracted at 32°C, 22MPa, and a CO2 flow rate of 24L / h for 25min to obtain fraction B; then extracted at 22°C, 13MPa, and a CO2 flow rate of 24L / h for 15min, and fraction A, fraction B, and fraction C were mixed in a mass ratio of 1:1:1 to obtain a mixed micropowder extract; (6) The extracts of Coptis chinensis and Pinellia ternata are mixed with the mixed micro powder extract to obtain a Chinese medicine composition.

[0018] Example 2 The present embodiment provides a traditional Chinese medicine composition containing coptis root and pinellia tuber, comprising the following components in parts by weight: 10 parts of coptis root, 25 parts of pinellia tuber, 5 parts of celandine, 13 parts of cuttlebone, 1 part of firethorn, 9 parts of carp, 6 parts of mangosteen, 17 parts of small white mulberry, 1 part of pearl umbrella, 10 parts of liquorice, 4 parts of white labiata, 19 parts of white peony root, 5 parts of longan, 12 parts of red dates, 4 parts of polygonatum, 10 parts of polygonatum, 2 parts of schizonepeta, 7 parts of pepper, 5 parts of tangerine peel, 5 parts of costus root and 5 parts of agarwood.

[0019] The preparation method of the Chinese medicine composition containing coptis root and pinellia tuber comprises the following steps: (1) Crush the coptis root and the pinellia tuber and pass through a 70-mesh sieve to obtain coptis root and the pinellia tuber fine powder; (2) First, place the coptis chinensis and pinellia ternata powders at a low temperature of -27°C for 2 minutes, then rapidly heat them to 30°C within 2 seconds, and repeat this process 3 times; then pressurize them to 17 MPa, maintain for 5 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain pretreated coptis chinensis and pinellia ternata powders; (3) Mixing the pretreated coptis chinensis and pinellia ternata powders with ethanol in a mass ratio of 10:89, soaking at 20°C for 20 hours, heating to 80°C, heating under reflux for 2 hours, filtering, and concentrating under reduced pressure to remove ethanol, thereby obtaining coptis chinensis and pinellia ternata extracts; (4) Mix the remaining components, crush them and pass them through a 100-mesh sieve to obtain mixed micropowder: (5) subjecting the mixed micropowder to supercritical extraction, first extracting at 40°C, 35MPa, and a CO2 flow rate of 22L / h for 70min to obtain fraction A, and then extracting at 30°C, 25MPa, and a CO2 flow rate of 22L / h for 30min to obtain fraction B; then extracting at 20°C, 15MPa, and a CO2 flow rate of 22L / h for 20min, and mixing fraction A, fraction B, and fraction C in a mass ratio of 1:1:1 to obtain a mixed micropowder extract; (6) The extracts of Coptis chinensis and Pinellia ternata are mixed with the mixed micro powder extract to obtain a Chinese medicine composition.

[0020] Example 3 This embodiment provides a traditional Chinese medicine composition containing coptis root and pinellia ternata, including the following components in parts by mass: 20 parts of coptis root, 15 parts of pinellia ternata, 15 parts of celandine, 3 parts of cuttlebone, 6 parts of fireweed, 2 parts of carp, 14 parts of mangosteen, 7 parts of small white mulberry, 9 parts of pearl umbrella, 1 part of liquorice, 12 parts of white labiata, 12 parts of white peony root, 15 parts of longan, 2 parts of red dates, 15 parts of polygonatum, 1 part of polygonatum, 8 parts of schizonepeta, 1 part of pepper, 10 parts of tangerine peel, 1 part of costus root and 12 parts of agarwood.

[0021] The preparation method of the Chinese medicine composition containing coptis root and pinellia tuber comprises the following steps: (1) Crush the coptis root and the pinellia tuber and pass through a 70-mesh sieve to obtain coptis root and the pinellia tuber fine powder; (2) First, place the coptis chinensis and pinellia ternata powders at a low temperature of -27°C for 3 minutes, then rapidly heat them to 30°C within 2 seconds, repeating twice; then pressurize them to 23 MPa, maintain for 4 minutes, then release the pressure to normal pressure, repeating three times, to obtain pretreated coptis chinensis and pinellia ternata powders; (3) Mixing the pretreated coptis chinensis and pinellia ternata powders with ethanol in a mass ratio of 10:81, soaking at 25°C for 15 h, heating to 90°C, heating under reflux for 1 h, filtering, and concentrating under reduced pressure to remove ethanol, thereby obtaining coptis chinensis and pinellia ternata extracts; (4) Mix the remaining components, crush them and pass them through a 100-mesh sieve to obtain mixed micropowder: (5) subjecting the mixed micropowder to supercritical extraction, first extracting at 45°C, 30MPa, and a CO2 flow rate of 25L / h for 60min to obtain fraction A, and then extracting at 35°C, 20MPa, and a CO2 flow rate of 25L / h for 20min to obtain fraction B; then extracting at 25°C, 10MPa, and a CO2 flow rate of 25L / h for 10min, and mixing fraction A, fraction B, and fraction C in a mass ratio of 1:1:1 to obtain a mixed micropowder extract; (6) The extracts of Coptis chinensis and Pinellia ternata are mixed with the mixed micro powder extract to obtain a Chinese medicine composition.

[0022] Comparative Example 1 The difference between this comparative example and Example 1 is that the composition ratio is different.

[0023] A traditional Chinese medicine composition containing coptis root and pinellia tuber, comprising the following components in parts by mass: 25 parts of coptis root, 10 parts of pinellia tuber, 11 parts of celandine, 8 parts of cuttlebone, 4 parts of fireweed, 6 parts of carp, 10 parts of mangosteen, 12 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white hyacinth bean, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0024] Comparative Example 2 The difference between this comparative example and Example 1 is that the composition ratio is different.

[0025] A traditional Chinese medicine composition containing coptis root and pinellia tuber, comprising the following components in parts by mass: 30 parts of coptis root, 5 parts of pinellia tuber, 11 parts of celandine, 8 parts of cuttlebone, 4 parts of fireweed, 6 parts of carp, 10 parts of mangosteen, 12 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white hyacinth bean, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0026] Comparative Example 3 The difference between this comparative example and Example 1 is that the composition ratio is different.

[0027] A traditional Chinese medicine composition containing coptis root and ginger pinellia comprises the following components in parts by mass: 15 parts of coptis root, 20 parts of ginger pinellia, 4 parts of celandine, 8 parts of cuttlebone, 10 parts of fireweed, 6 parts of carp, 4 parts of mangosteen, 12 parts of small white mulberry, 6 parts of pearl umbrella, 11 parts of liquorice, 9 parts of white hyacinth bean, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 11 parts of costusroot and 3 parts of agarwood.

[0028] Comparative Example 4 The difference between this comparative example and Example 1 is that the composition ratio is different.

[0029] A traditional Chinese medicine composition containing coptis root and pinellia tuber, comprising the following components in parts by mass: 15 parts of coptis root, 20 parts of pinellia tuber, 2 parts of celandine, 17 parts of cuttlebone, 9 parts of pyrrosia, 6 parts of carp, 10 parts of mangosteen, 12 parts of small white mulberry, 1 part of pearl umbrella, 4 parts of liquorice, 9 parts of white hyacinth bean, 3 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 14 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0030] Comparative Example 5 The difference between this comparative example and Example 1 is that the composition ratio is different.

[0031] A traditional Chinese medicine composition containing coptis root and pinellia ternata comprises the following components in parts by mass: 30 parts of coptis root, 20 parts of pinellia ternata, 11 parts of celandine, 8 parts of cuttlebone, 4 parts of pyrrosia, 6 parts of carp, 5 parts of mangosteen, 7 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white hyacinth bean, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 7 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

[0032] Comparative Example 6 The difference between this comparative example and Example 1 is that the preparation method is different.

[0033] (1) Mix all the components, crush them and pass them through a 100-mesh sieve to obtain mixed micro powder: (2) The mixed micropowders were subjected to supercritical extraction, firstly extracted at 42°C, 32 MPa, and a CO2 flow rate of 24 L / h for 65 min to obtain fraction A, and then extracted at 32°C, 22 MPa, and a CO2 flow rate of 24 L / h for 25 min to obtain fraction B; then extracted at 22°C, 13 MPa, and a CO2 flow rate of 24 L / h for 15 min, and fraction A, fraction B, and fraction C were mixed in a mass ratio of 1:1:1 to obtain a traditional Chinese medicine composition.

[0034] Performance Testing The Chinese medicine compositions of Examples 1-3 and Comparative Examples 1-6 were made into tablets, each tablet containing 0.36 g of the Chinese medicine composition.

[0035] Case selection: As a traditional Chinese medicine preparation for the treatment of gastric ulcer, 200 patients with gastric ulcer were selected for clinical observation, with an age range of 23-63 years, an average age of 53.5 years, and a course of disease of 1-5 years, an average of 3.5 years; the patients were randomly divided into 10 groups, 20 cases in each group, including 10 males and 10 females; Each group was given a controlled diet as required.

[0036] The 9 experimental groups took the Chinese medicine compositions of Examples 1-3 and Comparative Examples 1-6 respectively. Adults took it orally 3 times a day, 2 capsules each time, 30 minutes after meals, for a course of 10 days. The control group took clarithromycin capsules orally 2 times a day, 2 capsules each time.

[0037] Efficacy determination: (1) Significant effect: gastric ulcer symptoms disappear and the body becomes stronger; (2) Effective: basic gastric ulcer symptoms disappear, but thrombocytopenia and increased gastric acid secretion occur; (3) Ineffective: no change in symptoms.

[0038] The number of people with different therapeutic effects was counted and the results are shown in Table 1.

[0039] Table 1 Performance test results Significant effect efficient invalid Example 1 12 6 2 Example 2 11 6 3 Example 3 10 7 3 Comparative Example 1 8 8 4 Comparative Example 2 9 8 3 Comparative Example 3 8 7 5 Comparative Example 4 9 8 3 Comparative Example 5 9 7 4 Comparative Example 6 8 6 6 Control group 12 5 3

[0040] As can be seen from the table, there are significant differences in the comprehensive therapeutic effects of Examples 1 to 3 and the control group. The total effective rate of Examples 1 to 3 is significantly higher than that of the control group. As can be seen from Comparative Examples 1-6, the therapeutic effect decreases to varying degrees when the number of components is changed.

[0041] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition containing coptis root and pinellia tuber, characterized in that: The invention comprises the following components in parts by weight: 10-20 parts of coptis root, 15-25 parts of pinellia tuber, 5-15 parts of celandine, 3-13 parts of cuttlebone, 1-6 parts of pyriferum, 2-9 parts of carp, 6-14 parts of mangosteen, 7-17 parts of small white mulberry, 1-9 parts of pearl umbrella, 1-10 parts of liquorice, 4-12 parts of white hyacinth bean, 12-19 parts of white peony root, 5-15 parts of longan, 2-12 parts of red dates, 4-15 parts of polygonatum, 1-10 parts of polygonatum, 2-8 parts of schizonepeta, 1-7 parts of pepper, 5-10 parts of tangerine peel, 1-5 parts of costusroot and 5-12 parts of agarwood.

2. The Chinese medicine composition containing coptis root and pinellia tuber according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 15 parts of coptis root, 20 parts of pinellia tuber, 11 parts of celandine, 8 parts of cuttlebone, 4 parts of fire thread hemp, 6 parts of carp, 10 parts of mango nail, 12 parts of small white mulberry, 6 parts of pearl umbrella, 4 parts of liquorice, 9 parts of white hyacinth, 14 parts of white peony root, 8 parts of longan, 7 parts of red dates, 12 parts of polygonatum, 5 parts of polygonatum, 4 parts of schizonepeta, 3 parts of pepper, 9 parts of tangerine peel, 3 parts of costus root and 11 parts of agarwood.

3. A method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 1 or 2, characterized in that: The following steps are involved: (1) Crush the coptis root and the pinellia tuber and sieve them to obtain coptis root and the pinellia tuber fine powder; (2) First, place the coptis chinensis and pinellia ternata powders at a low temperature of -27°C for 2-3 minutes, then rapidly heat them to 30°C within 2 seconds, and repeat 2-3 times; then pressurize them to 17-23 MPa, maintain for 4-5 minutes, and then release the pressure to normal pressure, and repeat 2-3 times to obtain pretreated coptis chinensis and pinellia ternata powders; (3) mixing the pretreated coptis chinensis and pinellia ternata powders in a mass ratio of 10:80-90 with ethanol, soaking the mixture, heating the mixture to 80-90°C, heating under reflux for 1-2h, filtering, and concentrating under reduced pressure to remove the ethanol, thereby obtaining coptis chinensis and pinellia ternata extracts; (4) Mix the remaining components, crush and sieve to obtain mixed micro powder: (5) subjecting the mixed micropowder to supercritical extraction, first extracting at 40-45°C and 30-35MPa for 60-70min to obtain fraction A, then further extracting at 30-35°C and 20-25MPa for 20-30min to obtain fraction B; then extracting at 20-25°C and 10-15MPa for 10-20min, mixing fraction A, fraction B and fraction C in a mass ratio of 1:1:1 to obtain a mixed micropowder extract; (6) The extracts of Coptis chinensis and Pinellia ternata are mixed with the mixed micro powder extract to obtain a Chinese medicine composition.

4. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: Crush the coptis root and pinellia tuber and pass through a 70-mesh sieve.

5. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: The soaking time is 15-20h.

6. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: Mix the remaining ingredients, grind them and pass through a 100 mesh sieve.

7. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: First, extract for 60-70 min at 40-45°C, 30-35 MPa, and CO2 flow rate of 22-25 L / h to obtain fraction A.

8. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: Continue to extract for 20-30 min at 30-35°C, 20-25 MPa, and CO2 flow rate of 22-25 L / h to obtain fraction B.

9. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: Then extract for 10-20 min at 20-25°C, 10-15 MPa, and a CO2 flow rate of 22-25 L / h to obtain fraction C.

10. The method for preparing the Chinese medicine composition containing coptis root and pinellia tuber according to claim 3, characterized in that: The soaking temperature is 20-25℃.