Amber heat-clearing composition for treating acute infantile convulsion

Abstract

The invention relates to an amber heat-clearing composition for treating acute infantile convulsions, which is characterized in that the amber heat-clearing composition is composed of 50-70 g of rheum officinale, 50-70 g of scutellaria baicalensis, 10-30 g of agilawood, 10-30 g of coptis chinensis, 10-30 g of lapis chloriti, 10-30 g of gypsum, 5-10 g of amber and 5-15 g of cinnabar. The traditional Chinese medicine composition adopts traditional Chinese medicines with small or no toxic or side effects, the traditional Chinese medicine composition has the effects of clearing heat, purging fire, eliminating phlegm and relieving convulsion, simultaneously adopts a method of clearing liver and soothing liver to recover the functions of main channels and tendons of the liver and heal the convulsion, and is proved by clinical practice tests for many years, so that the fever abatement time of a fever child patient can be shortened, convulsion of the child patient caused by high fever is avoided, and the curative effect of the traditional Chinese medicine composition is improved. Meanwhile, the traditional Chinese medicine composition can also effectively improve upper respiratory tract infection and comprehensively treat from multiple angles, so that the convulsion of a child patient is effectively controlled, the total effective rate reaches 96.9%, the treatment effect is good, the traditional Chinese medicine composition has a certain effect on the prevention of the convulsion in the interval and later periods, and the relapse of the convulsion can be effectively avoided.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more particularly to an amber heat-clearing composition for treating acute convulsions in children. Background Art

[0002] Acute convulsions in children correspond to diseases such as high fever convulsions, tetanus, and epilepsy in modern medicine. They often develop rapidly and are dangerous, greatly threatening the lives of children. They are listed as one of the four major pediatric syndromes. Therefore, the treatment and further prevention of this disease are particularly important. Western medicine has a good therapeutic effect on the acute stage of the disease, but it has certain limitations in preventing the interphase and late stage, so traditional Chinese medicine is usually used for treatment.

[0003] Traditional Chinese medicine believes that acute convulsions are closely related to heart fire, and in treatment, emphasis should be placed on clearing and purging, especially clearing heart fire. Both Coptis chinensis and Cinnabar enter the heart meridian and can clear heart fire, and Cinnabar can calm convulsions. They are the first choice for treating convulsions, so Coptis chinensis and Cinnabar are usually combined with other drugs; in terms of drug combination, Arisaema ciliata can clear heat and calm convulsions, calm wind and resolve phlegm. "Shengji Zonglu" says Arisaema ciliata "cools the heart and calms convulsions", and "Ben Cao Hui Yan" also says that it can treat acute convulsions with phlegm in children. Arisaema ciliata and Cinnabar combined can clear and purge heart fire, remove phlegm and calm convulsions, and shorten the duration of convulsions; Phellodendron chinense has the same effect as Coptis chinensis. It has the effects of clearing away heat and dampness, purging fire and detoxifying, and the two are complementary to each other to enhance the effects of clearing, purging and detoxifying; therefore, existing prescriptions usually combine cinnabar, coptis root, and arisaema, or combine scutellaria baicalensis, cinnabar, and phellodendron; however, arisaema has great toxic side effects, and if taken for a long time, it may cause intellectual disabilities and may also cause symptoms such as oral ulcers in patients; in addition, convulsions can cause damage to the spleen and earth. If a variety of bitter and cold medicines are used together to enhance the effects of clearing, purging and detoxifying, it will aggravate the damage to the spleen and stomach, and at the same time affect the overall treatment effect. Summary of the invention

[0004] The purpose of the present invention is to provide an amber heat-clearing composition for treating acute convulsions in children. The composition mainly clears away heat and fire, calms convulsions, and eliminates phlegm, while protecting the spleen, stomach and liver. The medicine is simple and the compatibility is appropriate. It has been proved through many years of clinical practice that the composition can control convulsions in children and has a good therapeutic effect.

[0005] To achieve the above object, the present invention adopts the following technical solution:

[0006] An amber heat-clearing composition for treating acute convulsions in children, the amber heat-clearing composition consists of 50-70g of rhubarb, 50-70g of scutellaria, 10-30g of agarwood, 10-30g of coptis root, 10-30g of greenstone, 10-30g of gypsum, 5-10g of amber and 5-15g of cinnabar.

[0007] As a preferred embodiment of the present invention, the composition consists of 60g of rhubarb, 60g of scutellaria, 15g of agarwood, 15g of coptis root, 15g of celite, 15g of gypsum, 10g of amber and 10g of cinnabar.

[0008] The amber heat-clearing composition provided by the invention can comprehensively clear away internal heat and expel heat pathogens; various herbs are used together to achieve the functions of clearing away heat and purging fire, removing phlegm and calming convulsions, while protecting the spleen, stomach and liver; clinical trials have shown that the amber heat-clearing composition has a good therapeutic effect on acute convulsions in children, with a total effective rate of 96.9%, so the amber heat-clearing composition can be used in the preparation of drugs for treating acute convulsions in children.

[0009] The dosage form of the drug for treating acute convulsions in children described in the present invention is an oral preparation; wherein the oral preparation is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

[0010] The present invention also provides an amber heat-clearing powder for treating acute convulsions in children, wherein the amber heat-clearing powder is composed of the following raw materials by weight: 50-70g of rhubarb, 50-70g of scutellaria, 10-30g of agarwood, 10-30g of coptis root, 10-30g of greenstone, 10-30g of gypsum, 5-10g of amber, and 5-15g of cinnabar;

[0011] The preparation method of the amber heat-clearing powder comprises the following steps:

[0012] Step 1. Mix rhubarb, scutellaria, agarwood, coptis root, chlorite, gypsum and amber, grind into fine powder and sieve;

[0013] Step 2. Grind the cinnabar powder into fine powder, mix it evenly with the medicinal powder prepared in step 1, and divide it into packages.

[0014] Advantages and beneficial effects of the present invention:

[0015] (1) The amber heat-clearing composition provided by the present invention has simple medication and proper compatibility. The rhubarb in the prescription is bitter and cold in nature, enters the spleen, stomach, large intestine, liver, and pericardium meridians, and has the functions of clearing heat, purging fire, cooling blood and detoxifying; the scutellaria baicalensis is bitter and cold in nature, enters the lung, gallbladder, spleen, large intestine, and small intestine meridians, and has the functions of clearing heat and dampness, purging fire and detoxifying, cooling blood and stopping bleeding; in addition, it also has antibacterial and antiviral effects, and has a certain inhibitory effect on a variety of pathogenic bacteria and viruses; the coptis chinensis is bitter in taste, cold in nature, clears heat and dampness, purges fire and detoxifies, enters the heart, spleen, stomach, gallbladder, and large intestine meridians, and is especially good at clearing the heart Fire, it also has obvious anti-pathogenic microorganism and anti-inflammatory effects; gypsum mainly enters the lung meridian and stomach meridian, and "Shennong's Herbal Classic" believes that it is slightly cold in nature, and has the effects of relieving muscles and clearing the surface, purging Yangming real fire, clearing the lungs and relieving asthma, promoting fluid and quenching thirst, and calming the nerves; the herbal books of the Tang Dynasty comprehensively summarized the understanding of the effects of gypsum before the Tang Dynasty, and believed that it has the effects of clearing heat and purging fire, clearing heat from the five internal organs, clearing heat and unblocking meridians, and detoxifying and expelling epidemics; gypsum used together with the above three medicines can more comprehensively clear internal heat and expel heat evil; agarwood, pungent and bitter in taste, slightly warm in nature, enters the spleen, stomach, kidney, Lung meridian, warms the middle and promotes the circulation of qi, can neutralize the bitter and cold nature of the above four herbs, and protect the spleen and stomach; in addition, "Bencao Zaixin" says that it "can treat liver depression, reduce liver qi, harmonize the spleen and stomach, eliminate dampness, promote diuresis and open the orifices", so the combination of agarwood with gypsum and bluestone is helpful to clear the liver, soothe the liver, restore the liver's function of governing the meridians and tendons, and cure convulsions; cinnabar has the effects of clearing the heart and calming the nerves, detoxifying and calming the mind, its nature and flavor are sweet, slightly cold, and it belongs to the heart meridian, "Compendium of Materia Medica" says that it "treats epilepsy, resolves fetal toxins and smallpox toxins, drives away evil spirits and malaria, and can induce sweating"; it also has sedative, hypnotic, and anti-fear effects. , anti-inflammatory effects; amber is mild in nature and sweet in taste, and it enters the heart meridian, liver meridian and bladder meridian, and has the effects of calming the nerves, promoting blood circulation and removing blood stasis, and promoting diuresis and relieving stranguria; greenstone is sweet, salty and mild in nature and enters the lung meridian, heart meridian, liver meridian, stomach meridian and large intestine meridian, and has the functions of removing phlegm and relieving qi, calming the liver and relieving shock, and digesting food and attacking accumulation. When used together with the above-mentioned medicines, it can break up phlegm and achieve the effects of removing phlegm and relieving convulsions, strengthening the spleen and protecting the stomach; the above-mentioned medicines are used together to have the functions of clearing away heat and purging fire, removing phlegm and calming the nerves, while protecting the spleen, stomach and liver, so that the child's convulsions can be controlled, and the symptoms of high fever, thirst, dry tongue and constipation in the child can be improved.

[0016] (2) The amber heat-clearing composition provided by the present invention adopts a traditional Chinese medicine with little or no toxic side effects. It clears away heat, relieves fire, eliminates phlegm and calms the nerves. At the same time, it uses the method of clearing the liver and soothing the liver to restore the liver's main meridian and tendon functions, so that the convulsions are cured. This prescription has been proven through many years of clinical practice that it can shorten the fever-reducing time of children with fever and prevent convulsions caused by high fever in children. At the same time, it can also effectively improve upper respiratory tract infections. Comprehensive treatment from multiple angles and in all aspects can effectively control convulsions in children. The total effective rate is 96.9%, with good therapeutic effect. It also has a certain effect on the prevention of the interval and late stages of convulsions, and can effectively avoid the recurrence of high fever convulsions. DETAILED DESCRIPTION

[0017] The present invention discloses an amber heat-clearing composition for treating acute convulsions in children. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the scope of protection of the present invention.

[0018] Example 1

[0019] The present embodiment provides an amber heat-clearing composition for treating acute convulsions in children, the composition consisting of 60g of rhubarb, 60g of scutellaria, 15g of agarwood, 15g of coptis root, 15g of greenstone, 15g of gypsum, 10g of amber, and 10g of cinnabar.

[0020] The amber heat-clearing composition provided in this embodiment can be made into an oral preparation when actually used; the oral preparation includes powders, granules, tablets, capsules, oral liquids or pills, etc. Among the above dosage forms, powders have the advantage of being simple and easy to prepare, so powders are preferred.

[0021] Specifically, the preparation method of the powder (Amber Heat-clearing Powder) comprises the following steps:

[0022] Step 1. Mix rhubarb, scutellaria, agarwood, coptis root, chlorite, gypsum and amber, grind into fine powder and sieve;

[0023] Step 2. Grind the cinnabar powder into fine powder, mix it evenly with the medicinal powder prepared in step 1, and divide it into packages.

[0024] It should be noted that the amber heat-clearing powder provided in this embodiment can be appropriately added or subtracted according to the severity of the child's symptoms during clinical medication; for example, the dosage of greenstone can be appropriately increased for children with a history of convulsions, and the dosage of gypsum and agarwood can be appropriately increased for children with constipation; of course, the dosage of each raw material of the above powder needs to be controlled within the following range no matter how it is added or subtracted:

[0025] Rhubarb 50-70g, Scutellaria 50-70g, Aquilaria 10-30g, Coptis chinensis 10-30g, Greenstone 10-30g, Gypsum 10-30g, Amber 5-10g, Cinnabar 5-15g.

[0026] The rhubarb in the amber heat-clearing composition provided by the present invention has the functions of clearing heat, purging fire, cooling blood and detoxifying; the scutellaria has the functions of clearing heat and drying dampness, purging fire and detoxifying, cooling blood and stopping bleeding; in addition, it also has antibacterial and antiviral effects, and has a certain inhibitory effect on various pathogenic bacteria and viruses; coptis chinensis is good at clearing heart fire, and it also has obvious anti-pathogenic microorganism and anti-inflammatory effects; gypsum has the effects of clearing heat, purging fire, clearing heat from the five internal organs, clearing the lungs and relieving asthma, promoting fluid production and quenching thirst, and calming the nerves; gypsum is used in combination with the above three medicines, which can more comprehensively clear internal heat and expel heat evil; agarwood warms the middle and promotes qi circulation, can neutralize the bitter and cold nature of the above four medicines, and protect the spleen and stomach; at the same time The combination of gypsum and bluestone helps to clear the liver, soothe the liver, restore the liver's main meridian function, and cure convulsions; cinnabar has the effects of clearing the heart and calming the nerves, detoxifying and calming the nerves; amber has the effects of calming the nerves and calming the nerves, promoting blood circulation and removing blood stasis, and promoting diuresis and relieving stranguria; bluestone has the functions of falling phlegm and lowering qi, calming the liver and calming the nerves, and digesting food and attacking accumulation. When used in combination with the above-mentioned medicines, it can break up phlegm and achieve the effects of removing phlegm and calming convulsions, strengthening the spleen and protecting the stomach; the above-mentioned medicines are used in combination to clear away heat and purge fire, remove phlegm and calm the nerves, and protect the spleen, stomach and liver at the same time. This prescription has been used in Jilin Children's Hospital for many years. The following clinical data will illustrate the therapeutic effect of the amber heat-clearing composition of the present invention, as follows:

[0027] 1. Clinical data

[0028] A total of 64 children with febrile seizures (meeting the diagnostic criteria for febrile seizures in children in Chinese Pediatrics, with a body temperature of more than 38°C, clinical symptoms and related laboratory tests indicating the presence of febrile seizures, and age <10 years old) admitted to Jilin Children's Hospital from October 2020 to December 2022 were selected as the research subjects. They were randomly divided into a study group and a control group, with 32 cases in each group; the study group had 14 males and 18 females; aged 7 months to 6 years, with a body temperature of 38.6-40.7°C during the attack; the control group had 16 males and 16 females; aged 5 months to 7 years, with a body temperature of 38.5-40.8°C during the attack. There was no statistically significant difference in the general data between the two groups, and they were comparable. Exclusion criteria: seizures caused by metabolic abnormalities and central nervous system infections; those with combined organ dysfunction; those with combined severe nervous system abnormalities; those with acute infections or autoimmune diseases; those who were allergic to the therapeutic drugs used in this study.

[0029] 2. Treatment Methods

[0030] After admission, both groups of children received symptomatic treatments such as oxygen inhalation and antipyretic treatment. Those with bacterial infection were given symptomatic antibiotic treatment. For antipyretic treatment, oral pediatric ibuprofen suspension (taken according to the dosage instructions) was taken.

[0031] The control group was given diazepam injection (Southwest Pharmaceutical Co., Ltd., specification: 2ml: 10mg), 30 days to 5 years old, intravenous injection, 0.2-0.5mg every 2-5 minutes, the maximum limit is 5mg. For those over 5 years old, 1mg every 2-5 minutes, the maximum limit is 10mg. If necessary, the treatment can be repeated after 2-4 hours.

[0032] The study group took the above-mentioned Amber Qingre San orally on the basis of the treatment of the control group: for children under 1 year old, 0.5 g at a time, twice a day; for children aged 2 to 3 years old, 1 g at a time, twice a day; for children aged 4 to 6 years old, 2 g at a time, twice a day; for children aged 7 years old, 3.5 g at a time, twice a day, for 7 consecutive days.

[0033] 3. Observation indicators

[0034] The time of disappearance of clinical symptoms in the two groups of children was compared, and the total clinical efficacy of the two groups of children was statistically analyzed; the time of disappearance of clinical symptoms specifically included: time of fever reduction, number of convulsion recurrence (referring to the number of convulsions of the children during the treatment period), and time of relief of respiratory symptoms (such as nasal congestion, runny nose, sore throat, cough, etc.). The evaluation criteria for the total clinical efficacy are as follows:

[0035] Markedly effective: Body temperature basically returned to normal within 24 hours of treatment, no obvious convulsions occurred, and clinical symptoms were significantly relieved;

[0036] Effective: Body temperature basically returned to normal within 72 hours of treatment, the number of convulsions was significantly reduced, and clinical symptoms were partially relieved;

[0037] Ineffective: After 72 hours of treatment, the child's body temperature and number of convulsions showed no significant improvement, which did not meet the above conditions.

[0038] Total effective rate = (markedly effective + effective) / total number of cases × 100%.

[0039] 4. Treatment Outcomes

[0040] 4.1 Comparison of the time of disappearance of clinical symptoms between the two groups of children is shown in Table 1.

[0041] Table 1 shows the comparison of the disappearance time of clinical symptoms between the two groups of children [n=32, ]

[0042]

[0043]

[0044] Compared with the control group, a P<0.05, b P<0.01.

[0045] 4.2 Comparison of the overall clinical efficacy between the two groups of children is shown in Table 2.

[0046] Table 2 is a comparison of the total effective rate of the two groups of children [n = 32, n (%)]

[0047] Group Number of cases Significant effect efficient invalid Total Effectiveness Research Group 32 21 10 1 <![CDATA[96.9% * ]]> Control group 32 16 7 9 71.9％

[0048] Compared with the control group: * P<0.05.

[0049] After treatment with the present invention, the above 64 children were followed up once every 3 months. The follow-up results of the two groups were compared as follows: the two groups were followed up for 1 year. No convulsions occurred in the study group, while convulsions occurred (1.08±0.24) times in the control group. The study group was significantly better than the control group, and the difference was statistically significant (P<0.05).

[0050] Typical cases:

[0051] 1. Wan Moumou, female, 4 years old, first diagnosed on May 12, 2021. The child had 3 high fever convulsions in the past, 1 in May 2019, 1 in March 2020, and 1 in December 2020, with a body temperature ≥39℃ during the attack; Chief complaint: cough, sore throat, fever for 2 days, 1 convulsion, the highest temperature was 39.4℃, after taking "pediatric ibuprofen suspension" orally, before the fever subsided, the child convulsed once, accompanied by convulsions of the limbs, clenched teeth, and unconsciousness, which lasted for about 25 seconds and then eased, and then the fever subsided, and it recurred from time to time. Today, she came to our outpatient clinic for treatment. At present, the child occasionally coughs, the sputum is slightly yellow, there is no chills and fever, no nasal congestion and runny nose, the stool is once every 2-3 days, the texture is sticky, the urine is short and red, and she has suffered from upper respiratory tract infection 3 times and bronchial pneumonia once in the past year. Physical examination: red throat, swollen tonsils, negative heart and lung auscultation; routine blood examination: high white blood cell and neutrophil indexes. Western medicine diagnosis: high fever convulsions; Chinese medicine diagnosis: acute convulsions. Treatment: Oral administration of the above-mentioned Amber Heat-clearing Powder, 2g at a time, twice a day, for 7 consecutive days. On May 19, 2021, the second visit, the child had a fever 3 times during the medication. The highest temperature on the first day of medication was 38.9℃. The child no longer had a fever in the afternoon of the second day, no more convulsions, the cough had subsided, there were no respiratory symptoms, and the bowel movement was once a day; during the follow-up of 1 year, 3 upper respiratory tract infection symptoms occurred, and no high fever convulsions occurred again.

[0052] 2. Li Moumou, male, 2.5 years old, first diagnosed on October 5, 2022. The child had 2 high fever convulsions in the past, 1 in August 2020 and 1 in June 2021, with a body temperature ≥39℃ during the attack; Chief complaint: cough, fever for 1d, convulsion once, the highest temperature was 39.7℃, after taking "pediatric ibuprofen suspension" orally, before the fever subsided, the child convulsed once, accompanied by convulsions of the limbs, clenched teeth, and unconsciousness, which lasted for about 15s and then eased, and then the fever subsided. Come to our outpatient clinic for treatment today, now: cough, white sputum, no chills and fever, no nasal congestion and runny nose, stool once every 3 days, sticky, short and red urine, suffered from upper respiratory tract infection twice in the past year, blood routine examination: lymphocyte index is high. Western medicine diagnosis: high fever convulsion; Chinese medicine diagnosis: acute convulsion. Treatment: Oral administration of Amber Heat-clearing Powder, 1g at a time, twice a day, for 7 consecutive days. On October 12, 2022, the second visit showed that the child had fever twice during medication, with the highest temperature on the first day of medication being 38.6℃. On the second day, he no longer had fever, no convulsions, the cough had subsided, there were no respiratory symptoms, and he had bowel movements once a day. During the follow-up for 1 year, he had 2 upper respiratory tract infection symptoms, but no high fever convulsions occurred again.

[0053] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An amber heat-clearing composition for treating acute convulsions in children, characterized in that: The amber heat-clearing composition consists of 50-70g of rhubarb, 50-70g of scutellaria, 10-30g of agarwood, 10-30g of coptis root, 10-30g of greenstone, 10-30g of gypsum, 5-10g of amber and 5-15g of cinnabar.

2. The amber heat-clearing composition for treating acute convulsions in children according to claim 1, characterized in that: The composition consists of 60g of rhubarb, 60g of scutellaria, 15g of agarwood, 15g of coptis root, 15g of greenstone, 15g of gypsum, 10g of amber and 10g of cinnabar.

3. Use of the amber heat-clearing composition according to claim 1 or 2 in the preparation of a medicine for treating acute convulsions in children.

4. The use according to claim 3, characterized in that: The dosage form of the drug for treating acute convulsions in children is an oral preparation, which is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

5. A kind of amber heat-clearing powder for treating acute convulsions in children, characterized in that: The amber heat-clearing powder is composed of the following raw materials by weight: 50-70g of rhubarb, 50-70g of scutellaria, 10-30g of agarwood, 10-30g of coptis root, 10-30g of green stone, 10-30g of gypsum, 5-10g of amber, and 5-15g of cinnabar; The preparation method of the amber heat-clearing powder comprises the following steps: Step 1. Mix rhubarb, scutellaria, agarwood, coptis root, chloranthus, gypsum and amber, grind into fine powder and sieve; Step 2. Grind the cinnabar powder into fine powder, mix it evenly with the medicinal powder prepared in step 1, and package it.

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