A preparation method for promoting transdermal absorption of topical drugs, topical drug composition and application thereof

By combining Chinese medicinal materials with auxiliary ingredients, using ultrasonic extraction, high shear dispersion, high-pressure microjet emulsification and other processes to prepare external application drugs for diabetic foot, the problem of low transdermal absorption efficiency in existing treatment methods is solved, and a more efficient treatment effect of diabetic foot is achieved.

CN119385914BActive Publication Date: 2025-03-28SANYA CENT HOSPITAL (THE THIRD PEOPLES HOSPITAL OF HAINAN PROVINCE) +1
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Patent Information

Application Number
CN202510001060.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-02
Publication Date
2025-03-28
Estimated Expiration
2045-01-02

AI Technical Summary

Technical Problem

The existing treatment methods for diabetic foot are difficult to comprehensively improve complex conditions as a whole, and the transdermal absorption efficiency of external drugs is low, making it difficult to penetrate into the lesion tissue to play a therapeutic role.

Method used

A preparation method is adopted to combine Chinese medicinal materials such as Rehmannia, Citrus acacia, Salvia miltiorrhiza, Honeysuckle, and Gallblade with auxiliary components such as oat β-glucan, lauriazole ketone, and lecithin. It is prepared by ultrasonic extraction, high shear dispersion, high pressure microjet emulsification and other processes to prepare an external dosage form to promote transdermal absorption of the drug.

Benefits of technology

It significantly improves the transdermal absorption efficiency of the drug, allowing it to more effectively target the multi-cause and multi-pathological mechanisms of diabetic foot, promote healing and symptom relief, and provide more efficient, comprehensive and safe therapeutic effects.

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Abstract

The present invention provides a preparation method and its topical drug composition and application for promoting transdermal absorption of topical drugs, the composition comprises multiple Chinese medicinal raw materials such as Radix Lycii, Rhizoma Cynoglossi, Radix Astragali, and also comprises oat β-glucan, laurocapram, etc. Astragali adopts a specific honey-roasting process, and the extract of Radix Polygoni Multiflori is extracted by supercritical CO2. During preparation, part of the medicinal materials are first extracted and concentrated to obtain an extract, the remaining medicinal materials are ground into powder and added to the extract to mix, then oat β-glucan and lecithin are made into a nanoemulsion dropwise and added to the mixture, laurocapram is added and stirred through gradient temperature increase, and finally pearl powder is added to form an topical dosage form. This pharmaceutical composition is directed to the complex causes of neuropathy, vascular lesions and infections of diabetic foot, and multiple medicinal materials work together to effectively promote drug absorption and utilization. The pharmaceutical composition has the effects of clearing heat and cooling blood, benefiting the kidney and reducing blood sugar, promoting blood circulation and menstruation, removing blood stasis and stopping bleeding, promoting ulcer healing, controlling infection, relieving pain and improving nerve function, and is suitable for topical treatment of diabetic foot.
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