Traditional Chinese medicine composition, decoction and powder for treating liver cancer TACE postoperative embolism syndrome

Abstract

The invention provides a traditional Chinese medicine composition for treating liver cancer TACE postoperative embolism syndrome as well as decoction and powder thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating the liver cancer TACE postoperative embolism syndrome is prepared from the following components in parts by weight: 10 to 30 parts of radix puerariae, 10 to 20 parts of parched white peony root, 6 to 15 parts of lagotis lagosa, 7 to 18 parts of herba aconiti, 6 to 15 parts of radix scutellariae, 10 to 15 parts of vinegar-processed radix bupleuri, 3 to 15 parts of rhizoma coptidis, 10 to 15 parts of poria cocos, 4 to 8 parts of serissa serissoide, 4 to 8 parts of semen plantaginis, 4 to 8 parts of pericarpium citri reticulatae and 3 to 13 parts of radix glycyrrhizae preparata. According to the traditional Chinese medicine composition disclosed by the invention, the effects of soothing the liver, clearing heat, detoxifying, relieving pain, resolving dampness, dredging collaterals and promoting blood circulation to remove blood stasis are jointly achieved through synergistic cooperation of all the components, and the liver cancer TACE postoperative embolism syndrome can be effectively improved while gastrointestinal discomfort and liver and kidney function impairment caused by medicines for treating the liver cancer TACE postoperative embolism syndrome by western medicine are avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating embolism syndrome after TACE surgery for liver cancer, and a decoction and powder thereof. Background Art

[0002] Primary liver cancer is a common malignant tumor. Since there are no obvious symptoms in the early stage and it is not easy to be screened, most patients are already in the middle and late stages when they are diagnosed, and cannot be treated by surgical means. At present, transcatheter arterial chemoembolization (TACE) is often used for treatment of such patients. However, patients treated with TACE often experience post-TACE embolism syndrome, i.e., symptoms such as nausea and vomiting, fever, gastrointestinal discomfort, and pain in the liver area, which seriously affect the quality of life of patients with liver cancer. At present, Western medicine is often used clinically for symptomatic treatment. However, the simultaneous use of multiple drugs cannot fully relieve the symptoms, and can also cause bleeding in the patient's digestive tract, aggravate the patient's gastrointestinal discomfort symptoms, and even aggravate the patient's liver and kidney function damage. Therefore, it is very important to provide a safe, side-free drug that can be used to treat post-TACE embolism syndrome in liver cancer. Summary of the invention

[0003] In view of this, the purpose of the present invention is to provide a Chinese medicine composition and its decoction and powder for treating embolism syndrome after TACE surgery for liver cancer. Through a reasonable formula, the components can jointly achieve the effects of soothing the liver, clearing away heat, detoxifying, relieving pain, removing dampness and unblocking collaterals, and promoting blood circulation and removing blood stasis, which can effectively improve embolism syndrome after TACE surgery for liver cancer.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a traditional Chinese medicine composition for treating embolic syndrome after TACE for liver cancer. The composition comprises the following components in parts by weight: 10-30 parts of kudzu root, 10-20 parts of stir-fried white peony root, 6-15 parts of honglian, 7-18 parts of bangai, 6-15 parts of scutellaria, 10-15 parts of vinegar bupleurum, 3-15 parts of coptis, 10-15 parts of tuckahoe, 4-8 parts of serissa, 4-8 parts of plantain seed, 4-8 parts of tangerine peel and 3-13 parts of roasted liquorice.

[0006] Preferably, the composition comprises the following components in parts by weight: 15-25 parts of Pueraria root, 13-18 parts of stir-fried white peony root, 8-12 parts of Honglian, 10-16 parts of Banggao, 8-12 parts of Scutellaria baicalensis, 11-13 parts of vinegar Bupleurum, 5-10 parts of Coptis chinensis, 11-13 parts of Poria, 5-7 parts of Serissa sylvatica, 5-7 parts of Plantago seed, 5-7 parts of dried tangerine peel, and 5-10 parts of roasted Licorice root.

[0007] Preferably, the composition comprises the following components in parts by weight: 20 parts of Pueraria root, 15 parts of stir-fried white peony root, 10 parts of Honglian, 15 parts of Banggai, 10 parts of Scutellaria baicalensis, 12 parts of vinegar Bupleurum, 6 parts of Coptis chinensis, 12 parts of Poria, 6 parts of Serissa serrata, 6 parts of Plantago seed, 6 parts of dried tangerine peel, and 6 parts of roasted licorice.

[0008] The present invention provides application of the traditional Chinese medicine composition in preparing a medicine for treating embolism syndrome after TACE surgery for liver cancer.

[0009] Preferably, the dosage form of the drug is decoction or powder.

[0010] The present invention provides a decoction for treating embolic syndrome after TACE surgery for liver cancer. The preparation method of the decoction comprises the following steps: mixing the traditional Chinese medicine composition with water, decocting for 1 to 3 times, combining the decoctions, filtering, and taking the filtrate to obtain the decoction for treating embolic syndrome after TACE surgery for liver cancer.

[0011] Preferably, the mass ratio of the Chinese medicine composition to water is 1:3-7.

[0012] Preferably, the decoction time is 15 to 40 min / time, the decoction temperature is 90 to 100° C., and the filtration is performed through 2 to 6 layers of gauze.

[0013] The present invention also provides a powder for treating embolic syndrome after TACE surgery for liver cancer. The preparation method of the powder comprises the following steps: mixing the traditional Chinese medicine composition with water, decocting for 1 to 3 times, combining the decoctions, filtering, taking the filtrate, concentrating, freeze-drying, and crushing to obtain the powder that can be used to treat embolic syndrome after TACE surgery for liver cancer.

[0014] Preferably, the concentration is reduced-pressure concentration, the concentration temperature is 35-55° C., and the volume after concentration is 2 / 5-3 / 5 of the original volume.

[0015] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a Chinese medicine composition for treating embolism syndrome after TACE surgery for liver cancer, and its decoction and powder. The Pueraria root in the formula of the present invention has the functions of relieving muscle and fever, promoting body fluid, promoting rash, and promoting yang and stopping diarrhea. When it is combined with the stir-fried white peony root which has the functions of nourishing blood and softening liver, relieving pain, and restraining yin and sweating, it can enhance the heat-clearing and detoxifying effect; Honglian has the functions of clearing heat and detoxifying, promoting dampness and calming liver, promoting blood circulation and regulating menstruation. When it is combined with the Bangga which has the functions of clearing heat and detoxifying and promoting dampness, it has the functions of soothing liver and regulating qi; Huangqin has It has the effects of clearing away heat and dampness, purging fire and detoxifying; vinegar bupleurum has the effects of soothing the liver and relieving depression, regulating qi and relieving pain. The addition of scutellaria enhances the effects of soothing the liver and regulating qi and relieving pain; coptis has the effects of clearing heat and dampness, purging fire and detoxifying; tuckahoe has the effects of penetrating dampness and promoting diuresis, benefiting the spleen and stomach, and calming the mind; lily of the valley has the effects of dispelling wind, promoting dampness, clearing heat and detoxifying; plantain has the effects of promoting diuresis and relieving stranguria, stopping diarrhea, clearing the liver and improving eyesight, clearing the lungs and resolving phlegm; tangerine peel has the effects of regulating qi, regulating the middle, drying dampness and resolving phlegm; and roasted licorice can harmonize the middle and relieve urgency, moisten the lungs, detoxify and harmonize various medicines. Tangerine peel and roasted licorice can harmonize the middle and relieve urgency, moisten the lungs, detoxify and harmonize various medicines. While harmonizing various medicines, the combination of tangerine peel and roasted licorice can achieve the effects of regulating qi and strengthening the spleen, clearing heat and detoxifying, and promoting blood circulation and removing blood stasis. The components of the present invention cooperate synergistically to achieve the purpose of treating embolic syndrome after TACE for liver cancer by soothing the liver, clearing away heat, detoxifying, relieving pain, stopping vomiting, removing dampness and unblocking collaterals, and promoting blood circulation and removing blood stasis. While avoiding gastrointestinal discomfort and liver and kidney function damage caused by Western medicine drugs for treating embolic syndrome after TACE for liver cancer, it can effectively improve embolic syndrome after TACE for liver cancer. DETAILED DESCRIPTION

[0016] The present invention provides a traditional Chinese medicine composition for treating embolism syndrome after TACE surgery for liver cancer, comprising the following components in parts by weight:

[0017] 10 to 30 parts of Pueraria root, preferably 15 to 25 parts, more preferably 20 parts;

[0018] 10-20 parts of stir-fried white peony root, preferably 13-18 parts, more preferably 15 parts;

[0019] Honglian 6 to 15 parts, preferably 8 to 12 parts, more preferably 10 parts;

[0020] Bangga 7-18 parts, preferably 10-16 parts, more preferably 15 parts;

[0021] 6 to 15 parts of Scutellaria baicalensis, preferably 8 to 12 parts, more preferably 10 parts;

[0022] 10-15 parts of vinegar bupleurum, preferably 11-13 parts, more preferably 12 parts;

[0023] 3 to 15 parts of Coptis chinensis, preferably 5 to 10 parts, more preferably 6 parts;

[0024] 10-15 parts of Poria cocos, preferably 11-13 parts, more preferably 12 parts;

[0025] 4 to 8 parts of Serissa serrata, preferably 5 to 7 parts, more preferably 6 parts;

[0026] 4-8 parts of psyllium seeds, preferably 5-7 parts, more preferably 6 parts;

[0027] 4 to 8 parts of dried tangerine peel, preferably 5 to 7 parts, more preferably 6 parts;

[0028] 3 to 13 parts of roasted licorice root, preferably 5 to 10 parts, more preferably 6 parts.

[0029] In the present invention, the kudzu root is sweet, pungent and cool in nature and flavor, enters the spleen, stomach and lung meridians, and has the effects of relieving muscles and reducing fever, promoting body fluid, clearing rashes, and raising yang and stopping diarrhea.

[0030] Fried white peony root is bitter, sour, and slightly cold in nature. It enters the liver and spleen meridians. It has the effects of nourishing blood and softening the liver, relieving pain, and astringing yin and reducing sweat.

[0031] Honglian is bitter, sweet and cold in nature, and enters the lung, heart and liver meridians. It has the effects of clearing away heat and detoxifying, promoting dampness and calming the liver, promoting blood circulation and regulating menstruation.

[0032] Bangga is bitter and cool in nature, and enters the liver, stomach, and lung meridians. It has the effects of clearing away heat, detoxifying, and removing dampness.

[0033] Scutellaria baicalensis is bitter and cold in nature, and enters the lung meridian, gallbladder meridian, spleen meridian, large intestine meridian, and small intestine meridian. It has the effects of clearing away heat and dampness, purging fire and detoxifying.

[0034] Vinegar Bupleurum tastes pungent and bitter, is slightly cold in nature, and enters the liver, gallbladder, and lung meridians. It has the effects of soothing the liver and relieving depression, regulating qi and relieving pain.

[0035] Coptis chinensis is bitter and cold in nature, and enters the heart meridian, liver meridian, stomach meridian, and large intestine meridian. It has the effects of clearing away heat and dampness, purging fire and detoxifying.

[0036] Poria cocos is sweet, light and flat in nature, and enters the heart meridian, spleen meridian, lung meridian and kidney meridian. It has the effects of dissipating dampness and promoting diuresis, benefiting the spleen and stomach, and calming the mind and tranquilizing the nerves.

[0037] June snow is bitter, pungent and cool in nature, and enters the liver and spleen meridians. It has the effects of dispelling wind, promoting dampness, clearing heat and detoxifying.

[0038] Plantago seed is sweet and cold in nature, and enters the kidney meridian and bladder meridian. It has the effects of promoting diuresis and relieving stranguria, stopping diarrhea, clearing the liver and improving eyesight, and clearing the lungs and resolving phlegm.

[0039] Tangerine peel is bitter, pungent and warm in nature, and belongs to the lung meridian and spleen meridian. It has the effects of regulating qi, regulating the middle, drying dampness and resolving phlegm.

[0040] Roasted licorice root is sweet and flat in nature, and enters the spleen meridian, stomach meridian, and lung meridian. It can harmonize the middle and relieve urgency, moisten the lungs, detoxify, and harmonize various medicines.

[0041] The present invention provides application of the traditional Chinese medicine composition in preparing a medicine for treating embolism syndrome after TACE surgery for liver cancer.

[0042] In the present invention, the dosage form of the drug is decoction or powder.

[0043] The present invention provides a decoction for treating embolic syndrome after TACE surgery for liver cancer. The preparation method of the decoction comprises the following steps: mixing the traditional Chinese medicine composition with water, decocting for 1 to 3 times, combining the decoctions, filtering, and taking the filtrate to obtain the decoction for treating embolic syndrome after TACE surgery for liver cancer.

[0044] In the present invention, there is no special limitation on the source of raw materials, and conventional commercial products can be used. The mass ratio of the Chinese medicine composition to water is 1:3-7, preferably 1:4-6, and more preferably 1:5. The decoction time is 15-40 min / time, preferably 20-35 min / time, and more preferably 30 min / time; the decoction temperature is 90-100°C, preferably 92-98°C, and more preferably 95°C; the filtration is 2-6 layers of gauze filtration, preferably 3-5 layers, and more preferably 4 layers.

[0045] The present invention also provides a powder for treating embolic syndrome after TACE surgery for liver cancer. The preparation method of the powder comprises the following steps: mixing the traditional Chinese medicine composition with water, decocting for 1 to 3 times, combining the decoctions, filtering, taking the filtrate, concentrating, freeze-drying, and crushing to obtain the powder that can be used to treat embolic syndrome after TACE surgery for liver cancer.

[0046] In the present invention, there is no special limitation on the source of raw materials, and conventional commercial products can be used. The mass ratio of the Chinese medicine composition to water is 1:3-7, preferably 1:4-6, and more preferably 1:5, the decoction time is 15-40 min / time, preferably 20-35 min / time, and more preferably 30 min / time; the decoction temperature is 90-100°C, preferably 92-98°C, and more preferably 95°C; the filtration is 2-6 layers of gauze filtration, preferably 3-5 layers, and more preferably 4 layers; the concentration is reduced pressure concentration, and the concentration temperature is 35-55°C, preferably 40-50°C, and more preferably 45°C; the volume after concentration is 2 / 5-3 / 5 of the original volume, preferably 9 / 20-11 / 20, and more preferably 1 / 2, and the crushed particle size is less than 80 μm.

[0047] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0048] Example 1

[0049] Weigh 200g of Puerariae Radix, 150g of Radix Paeoniae Alba, 100g of Rhizoma Honglian, 150g of Rhizoma Banggai, 100g of Radix Scutellariae, 120g of Radix Bupleuri with Vinegar, 60g of Rhizoma Coptidis, 120g of Poriae, 60g of Semen Juneni, 60g of Semen Plantaginis, 60g of Pericarpium Citri Reticulatae, 60g of Radix Glycyrrhizae Preparata, and mix to obtain a Chinese medicine composition, mix the Chinese medicine composition with 6.2kg of water, boil over high heat, simmer for 30min over low heat, collect the decoction, and obtain the first decoction. Add 6.2kg of water again to the Chinese medicine residue, boil over high heat, simmer for 30min over low heat, collect the decoction, and obtain the second decoction. Combine the two decoctions, filter with 4 layers of gauze, take the filtrate, and obtain a decoction that can be used for treating embolic syndrome after TACE for liver cancer.

[0050] Example 2

[0051] Weigh 200g of Pueraria root, 150g of stir-fried white peony root, 100g of Honglian, 150g of Bangga, 100g of Scutellaria baicalensis, 120g of vinegar Bupleurum, 60g of Coptis chinensis, 120g of Poria, 60g of Serissa serrulatae, 60g of Plantago seed, 60g of dried orange peel, and 60g of Radix Glycyrrhizae Preparata to obtain a Chinese medicine composition, mix the Chinese medicine composition with 6.2kg of water, boil over high heat, simmer over low heat for 30min, collect the decoction, and obtain the first decoction. Add 6.2kg of water again to the Chinese medicine residue, boil over high heat, simmer over low heat for 30min, collect the decoction, and obtain the second decoction. Combine the two decoctions, filter with 4 layers of gauze, take the filtrate, put the filtrate into a vacuum concentration device, set the temperature to 45°C, concentrate it to 1 / 2 of the original filtrate volume, and obtain a concentrated solution. Freeze-dry the concentrated solution, and grind it into a powder with a particle size of 80 μm using a grinder to obtain a powder that can be used to treat embolism syndrome after TACE for liver cancer.

[0052] Example 3

[0053] Weigh 300g of Puerariae Radix, 100g of Paeonia lactiflora, 60g of Rhizoma Honglian, 70g of Rhizoma Banggai, 150g of Radix Scutellariae, 100g of Radix Bupleuri with Vinegar, 30g of Rhizoma Coptidis, 100g of Poriae, 40g of Semen Juneni, 40g of Semen Plantaginis, 40g of Pericarpium Citri Reticulatae, 30g of Radix Glycyrrhizae Preparata to mix, obtain a Chinese medicine composition, mix the Chinese medicine composition with 3.18kg of water, boil over high heat, simmer for 15min over low heat, collect the decoction, and obtain the first decoction. 3.18kg of water is added to the Chinese medicine residue again, boil over high heat, simmer for 15min over low heat, collect the decoction, and obtain the second decoction. Combine the two decoctions, filter with 3 layers of gauze, take the filtrate, and obtain a decoction that can be used for treating embolic syndrome after TACE for liver cancer.

[0054] Example 4

[0055] Weigh 100g of Puerariae Radix, 200g of Radix Paeoniae Alba, 150g of Rhizoma Honglian, 180g of Rhizoma Banggai, 60g of Radix Scutellariae, 150g of Radix Bupleuri with Vinegar, 150g of Rhizoma Coptidis, 150g of Poriae, 80g of Semen Juneni, 80g of Semen Plantaginis, 80g of Pericarpium Citri Reticulatae, 130g of Radix Glycyrrhizae Preparata to mix, obtain a Chinese medicine composition, mix the Chinese medicine composition with 10.57kg of water, boil over high heat, decocted on low heat for 40min, collect the decoction, and obtain the first decoction. Add 6.2kg of water again to the Chinese medicine residue, boil over high heat, decocted on low heat for 40min, collect the decoction, and obtain the second decoction. Combine the two decoctions, filter with 6 layers of gauze, take the filtrate, and obtain a decoction that can be used for treating embolic syndrome after TACE for liver cancer.

[0056] Comparative Example 1

[0057] The method described in Example 1 was adopted, except that in this comparative example, the kudzu root in the formula was replaced with cimicifuga to obtain a decoction.

[0058] Comparative Example 2

[0059] The method described in Example 1 was adopted, except that in this comparative example, the roasted licorice root in the formula was omitted to obtain a decoction.

[0060] Comparative Example 3

[0061] The method described in Example 1 was adopted, except that, in this comparative example, 100 g of astragalus was added to the formula to obtain a decoction.

[0062] Experimental example

[0063] Male SD rats in good physical condition weighing 300-350 g were selected. After one week of adaptive feeding, the rats' drinking water was replaced with 0.01% N-diethylnitrosamine solution. After 10 weeks of chemical induction, the rats were scanned to confirm the formation of liver cancer. Rats with tumor diameters of 4 mm or more were selected as the standard for successful model construction and TACE treatment was performed. The rats treated with TACE were randomly divided into 7 groups, each with 10 rats, namely, Example 1, Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3, a control group and a blank control group, wherein the control group was gavaged with bicyclol at 10 mg / 100 g·d, the Example 1 group was gavaged with the decoction of Example 1 at 10 mL / 100 g·d, the Example 2 group was gavaged with the powder of Example 2 at 10 mg / 100 g·d, the Comparative Example 1 was gavaged with the decoction of Comparative Example 1 at 10 mL / 100 g·d, the Comparative Example 2 was gavaged with the decoction of Comparative Example 2 at 10 mL / 100 g·d, the Comparative Example 3 was gavaged with the decoction of Comparative Example 3 at 10 mL / 100 g·d, and the blank control group was gavaged with normal saline at 10 mL / 100 g·d, and the drugs were continuously administered for 4 weeks, and the state of the mice after surgery was observed, and the animal toxicity reactions were recorded, including poisoning symptoms, the onset time of symptoms, severity, duration and death. If abnormalities were found, histopathological examination was performed.

[0064] No animal death occurred within 4 weeks of continuous administration. The behavior, mental state and defecation of rats after administration were observed. It was found that the rats after TACE surgery, using the products of Example 1 and Example 2, had normal behavior, good mental state, and normal defecation, while the blank control group rats without any medicaments showed apathy, less stool, and a significant decrease in weight. The reason for this may be that the symptoms of post-TACE embolism syndrome appeared after TACE surgery, and no other drugs were given to assist in treatment, which led to the occurrence of this situation in the blank control group rats. The control group rats using bicyclol had better mental state and defecation than the blank control group, but they were not active and occasionally had less stool. The reason for this may be that bicyclol has the effect of protecting the liver and improving liver function, thus alleviating some symptoms of post-TACE embolism syndrome. The rats using the products of Comparative Examples 1, Comparative Examples 2 and Comparative Examples 3 showed varying degrees of apathy and less stool. During the administration process, no other changes and poisoning changes were observed, indicating that this product had no toxic side effects on the animal body. The decoction or powder of the present invention can effectively improve the symptoms of embolism syndrome after TACE surgery.

[0065] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating embolic syndrome after TACE for liver cancer, characterized in that: The invention comprises the following components in parts by weight: 10-30 parts of kudzu root, 10-20 parts of stir-fried white peony root, 6-15 parts of honglian, 7-18 parts of bangai, 6-15 parts of scutellaria, 10-15 parts of vinegar bupleurum, 3-15 parts of coptis root, 10-15 parts of poria, 4-8 parts of serissa, 4-8 parts of plantain seed, 4-8 parts of tangerine peel and 3-13 parts of roasted liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 15-25 parts of kudzu root, 13-18 parts of stir-fried white peony root, 8-12 parts of honglian, 10-16 parts of bangai, 8-12 parts of scutellaria, 11-13 parts of vinegar bupleurum, 5-10 parts of coptis root, 11-13 parts of poria, 5-7 parts of serissa, 5-7 parts of plantain seed, 5-7 parts of tangerine peel, and 5-10 parts of roasted licorice.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 20 parts of kudzu root, 15 parts of stir-fried white peony root, 10 parts of honglian, 15 parts of bangai, 10 parts of scutellaria, 12 parts of vinegar bupleurum, 6 parts of coptis root, 12 parts of tuckahoe, 6 parts of sericea, 6 parts of plantain seed, 6 parts of tangerine peel and 6 parts of roasted liquorice.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a drug for treating embolic syndrome after TACE surgery for liver cancer.

5. The use according to claim 4, characterized in that: The dosage form of the medicine is decoction or powder.

6. A decoction for treating embolism syndrome after TACE surgery for liver cancer, characterized in that: The preparation method of the decoction comprises the following steps: mixing the Chinese medicine composition according to any one of claims 1 to 3 with water, decocting for 1 to 3 times, combining the decoctions, filtering, and taking the filtrate to obtain a decoction that can be used to treat embolic syndrome after TACE surgery for liver cancer.

7. The decoction according to claim 6, characterized in that The mass ratio of the Chinese medicine composition to water is 1:3-7.

8. The decoction according to claim 6, characterized in that The decoction time is 15 to 40 minutes per time, the decoction temperature is 90 to 100° C., and the filtration is performed through 2 to 6 layers of gauze.

9. A powder for treating embolic syndrome after TACE surgery for liver cancer, characterized in that: The preparation method of the powder comprises the following steps: mixing the Chinese medicine composition according to any one of claims 1 to 3 with water, decocting for 1 to 3 times, combining the decoctions, filtering, taking the filtrate, concentrating, freeze-drying, and crushing to obtain a powder that can be used to treat embolic syndrome after TACE surgery for liver cancer.

10. The powder according to claim 9, characterized in that The concentration is reduced pressure concentration, the concentration temperature is 35-55° C., and the volume after concentration is 2 / 5-3 / 5 of the original volume.