Gentiana macrophylla detoxifying and tissue regeneration promoting gel as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to gentiana macrophylla detoxifying and tissue regeneration promoting gel as well as a preparation method and application thereof. The traditional Chinese medicine gel is prepared from the traditional Chinese medicinal materials such as silkworm larva, gentiana macrophylla, schizonepeta and aloe according to the pharmacology and compatibility principle of traditional Chinese medicines. The gentiana macrophylla detoxification and tissue regeneration promoting gel provided by the invention has a remarkable curative effect on scar hyperplasia and color sinking caused by burn and scald patients, is cheap, and is expected to bring new good news to the patients.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a white-scented macrophylla detoxifying and myogenic gel, and a preparation method and application thereof. Background Art

[0002] In today's era, burns and scalds are still a serious medical problem. The essence of burn scars is an abnormal and unhealthy tissue. It does not have the structure and physiological functions of normal skin and has lost normal tissue vitality. The formation and extent of burn scars are often directly related to a variety of factors, including the cause of injury, the nature of the burn, the infection situation, and whether the treatment is timely and appropriate. The specific evolution process is that ulcers first appear at the burn scar due to injury, or small papules first itch, enlarge into ulcers, and do not heal for a long time; if the treatment is not timely, the displacement process of epidermal hyperplasia-pseudoepithelioma-like hyperplasia-cancer may occur.

[0003] The severity of burns depends on the extent and depth of the injured tissue, and the depth of burns can be divided into first degree, second degree, and third degree. First degree burns are the least severe. The burned skin is red, painful, obviously tender, and has exudation or edema. When the injured area is gently pressed, it turns white locally, but there are no blisters. Second degree burns are deeper. Skin blisters. The bottom of the blister is red or white and filled with clear, viscous fluid. It is sensitive to tenderness and turns white when pressed. Third degree burns are the deepest, involving the dermis and deeper tissues, which may cause the skin to lose sensation because nerve endings may also be damaged. In this case, the surface wound may be white, soft, or have a black, charred leather-like appearance. Third degree burns not only destroy the structure of the skin, but also affect its normal physiological function. Although the appearance of the initial wound may be similar, the characteristics of third degree burns will gradually appear over time. Patients may feel pain in the surrounding areas because the nerve endings in these areas are still intact, while the burn site itself is painless due to nerve damage. As the wound heals, complications such as exudation and infection may occur, further aggravating the condition. Therefore, when dealing with third-degree burns, timely medical intervention is crucial.

[0004] Modern clinical technology for the treatment of hypertrophic scars after burns and scalds has the following methods:

[0005] Use elastic clothing to apply pressure to make the scar soft and white. The key to the success of compression therapy is "early", "tight" and "long". After the wound heals, pressure should be applied as soon as possible. After the scar is obvious, the effect of pressure application is not good. The pressure should be between 2.13kPa and 2.39kPa. The elastic clothing must be worn for 18 hours to 24 hours a day, for at least 4 months to 6 months, or even up to 2 years. Relaxation too early may cause the scar to rebound. Generally, after 4 to 6 months of continuous pressure application, the congestion of the scar disappears and the bulge becomes flat. After 8 to 10 months, the pressure can be terminated in most cases. The standard for terminating pressure is that the scar becomes soft and the color becomes white. This method has a long treatment cycle and puts great psychological and physiological pressure on patients.

[0006] Use laser to stimulate the proliferation of skin collagen to remove scars. Laser mainly uses the thermal principle of laser to treat scar hyperplasia, which can achieve the effect of removing scars. Laser surgery usually uses the principle of photothermal to act on the surface of the skin, which can penetrate the dermis of the skin, stimulate the proliferation of skin collagen, and achieve the effect of removing scar hyperplasia. For more serious symptoms of scar hyperplasia, multiple laser surgeries may be required to improve. This method has a long effect period and high cost.

[0007] Commonly used drugs and their mechanisms of action. For example, vitamin E cream and growth factor gel can inhibit lipid peroxidation and repair skin elasticity. Early scars should be promptly treated with new scar gel or medical silicone gel to inhibit scar hyperplasia. This method is mostly used for the treatment of early burns with low severity and has high limitations.

[0008] Based on the above, we can find that the key issues that need to be solved in the treatment of burns and scalds are pigmentation, wound ulceration and infection, and hypertrophic scars. The treatment cost of burns and scalds ranges from 5,000 yuan to 30,000 yuan. The treatment cost of severe burns is even more expensive. If the area is small, it costs 20,000 to 80,000 yuan; if the area is large, it costs 100,000 to 200,000 yuan. This has caused heavy financial pressure on patients. Summary of the invention

[0009] The technical problem to be solved by the present invention is to provide a white-scented radix gel for detoxification and myogenic growth, and a preparation method and application thereof. The invention follows the ratio rule of traditional Chinese medicine, and adopts white silkworm, gentiana macrophylla, schizonepeta tenuifolia for antipruritic effect, and aloe vera to make a gel that can reduce scars. The price is more affordable, and the medication is reasonably proportioned to alleviate the pain of the patient. The white-scented radix gel for detoxification and myogenic growth provided by the present invention has significant curative effect, is affordable, and can solve the above problems.

[0010] In order to achieve the above object, the technical solution adopted by the present invention is: a preparation method of a white-scented radix gel for detoxification and muscle regeneration, comprising the following steps:

[0011] 1) weighing 10-30 parts by weight of Bombyx batryticatus powder, extracting it two or three times with 60-100 parts by weight of ethanol, filtering the residue, and then drying to obtain a Bombyx batryticatus extract;

[0012] 2) weighing 10-30 parts of Gentiana macrophylla powder, 10-20 parts of Nepeta tenuifolia powder, and 10-30 parts of peeled aloe vera juice, and adding them to 150-260 parts of deionized water, boiling and filtering the residue, and concentrating the filtrate to 10-30 parts to obtain a Chinese medicine solution;

[0013] 3) In parts by weight, 0.1-1 parts of Carbomer-934P dry powder are added to 10-15 parts of glycerin, followed by the addition of the Bombyx batryticatus extract described in step 1) and the Chinese medicinal solution described in step 2), and 10-20 parts of sterile deionized water are added while stirring and heating, the pH value is adjusted to 7.0, and finally 0.1-1 parts of borneol powder are added to obtain the Bletilla striata detoxification and muscle-building gel.

[0014] In the above formula, Bombyx batryticatus is combined with Gentiana macrophylla to help relieve pain and spasm, reduce wind in the liver meridian, and dry and itchy skin caused by lack of nourishment of tendons and skin. Gentiana macrophylla clears dampness and heat, solves the heat pain caused by the hot evil fumigation of the patient's skin, and at the same time, with the help of the pungent and dispersing power of Bombyx batryticatus, the heat evil is dispersed. Gentiana macrophylla and Schizonepeta tenuifolia are used together to strengthen the effect of calming and purging heat, reduce swelling, relax muscles and activate collaterals, and make the circulation of qi and blood smooth. For the susceptible environment caused by exudate, the two are synchronized and synergistic, which can resist inflammation and sterilize, prevent the occurrence of redness, swelling, heat and pain and subsequent infection, resist allergy and promote skin growth, and stretch blood vessels and veins. It helps the patient recover from the disease and reduce irritability and pain. Aloe vera can not only play an antibacterial and bactericidal effect, but also can promote blood circulation and nourish the skin, regulate the local microcirculation blood volume, expand capillaries, indirectly promote the exchange of nutrients with blood, remove metabolic wastes of the body, cooperate with the body to repair the rhythm of skin damage, and improve efficiency. Borneol has the effect of clearing away heat and relieving pain, can relieve local inflammation and pain, and promote wound healing. The above formula combines the ideas of Chinese and Western medicine treatment, carefully selects materials, gives full play to the advantages of drugs, refers to the medical treasures in Chinese traditional culture, uses the past for the present, and continuously studies and innovates the proportions, and continues to develop in inheritance.

[0015] On the basis of the above technical solutions, the present invention may further have the following specific options or optimization options.

[0016] Specifically, the white silkworm powder in step 1) is crushed into powder by a high-speed grinder, and the particle size is 150-300 microns.

[0017] Specifically, the filter residue in step 1) is filtered using a 200-mesh filter paper, that is, the pore size of the filter paper is 75 microns.

[0018] Specifically, the ethanol in step 1) is an ethanol aqueous solution with a mass fraction of 75-80%.

[0019] Specifically, the drying in step 1) is drying at 37 degrees Celsius.

[0020] Specifically, the aloe vera in step 2) is Caucasian aloe vera, and the gentiana powder and schizonepeta powder are crushed into powder using a high-speed grinder, with a particle size of 150-300 microns.

[0021] Specifically, the boiling in step 2) is boiling over low heat for 3 hours.

[0022] Specifically, the stirring and heating in step 3) is heated in a water bath at 45 degrees Celsius for half an hour, and the stirring speed is 1500 rpm.

[0023] Specifically, in step 3), triethanolamine is used to adjust the pH value.

[0024] Specifically, the particle size of the borneol powder in step 3) is 150-300 microns.

[0025] Specifically, the method further comprises step 4) sterilizing the white-scented radix-spinning gel by irradiating it with UV ultraviolet rays for 1-3 hours, and then bottling, packaging and performing bacteria testing, preferably irradiating it for 2 hours.

[0026] Preferably, in step 2), 10-20 parts of astragalus and 10-20 parts of codonopsis are added by weight for boiling, and the astragalus and codonopsis are crushed into powder with a high-speed grinder, and the particle size is 150-300 microns.

[0027] Preferably, in step 2), 10-20 parts of Chinese angelica and 10-20 parts of white peony root are added by weight for boiling, and the Chinese angelica and white peony root are crushed into powder with a high-speed grinder, and the particle size is 150-300 microns.

[0028] It should be noted that the filter residue is filtered using 200-mesh filter paper.

[0029] Among them, ① Thickener - Carbomer: Carbomer is a high molecular polymer, which is mainly used as a thickener to provide viscosity and improve the texture of the gel. It also acts as a stabilizer to help stabilize the gel and prevent component separation. In addition, Carbomer can be used as a controlled release agent for traditional Chinese medicine to control the release rate of the drug in the gel and enhance the moisturizing properties of the product.

[0030] ② Humectant - Glycerol: The glycerol backbone is present in lipids called glycerides. It is widely used in FDA-approved wound and burn treatments because of its antibacterial and antiviral properties. It is an excellent hygroscopic agent, antifreeze agent, lubricant, solvent and cosolvent.

[0031] ③ Permeation enhancer - borneol: Borneol has relatively little irritation to the sensory nerve endings of the human body, and can play an analgesic, mild and antiseptic role to a certain extent. Borneol is cold and heat-clearing, can clear heat and relieve pain, has antibacterial and anti-inflammatory effects, can effectively inhibit the adverse phenomena such as increased permeability of abdominal capillaries caused by acetic acid, and can also reduce the possibility of skin surface wounds being infected by bacteria, viruses and other pathogens. At the same time, it is also conducive to wound healing, soothing skin irritation, and reducing pain and itching.

[0032] In addition, the present invention also provides a white-scented macrophylla detoxifying and myogenic gel, which is prepared by adopting the preparation method of the white-scented macrophylla detoxifying and myogenic gel.

[0033] Specifically, each 50 ml of the Bletilla striata detoxifying and muscle-regenerating gel contains extracts of the Chinese medicinal materials 20 g of Bombyx batryticatus, 20 g of Gentiana macrophylla, 20 g of Schizonepeta tenuifolia, 20 g of aloe vera, as well as 0.5 g of Carbomer-934P dry powder, 10 mL of glycerol, 15 mL of deionized water, 0.1 g of borneol, and the rest is deionized water for decocting the medicine.

[0034] For people with different physiques, we explore the particularity on the basis of universality and adjust the prescription according to their different physiques. For example: for patients with qi deficiency burns, corresponding qi-invigorating herbs are added to the original prescription, such as adding 15g of astragalus and 15g of codonopsis (filter the medicinal liquid after boiling) into the gel according to syndrome differentiation; for patients with blood deficiency burns, corresponding blood-invigorating herbs are added to the original prescription, such as adding 15g of angelica and 10g of white peony root (filter the medicinal liquid after boiling) into the gel according to syndrome differentiation.

[0035] Therefore, further, the white-scented macrophylla detoxifying and muscle-regenerating gel also includes extracts of the Chinese medicinal materials 15g of astragalus and 15g of codonopsis per 50ml.

[0036] Furthermore, the Bletilla striata detoxifying and muscle-regenerating gel also includes extracts of the Chinese medicinal materials 15g of Angelica sinensis and 10g of White Peony Root per 50ml.

[0037] The invention uses four Chinese medicinal herbs, namely, Bombyx batryticatus, Gentiana macrophylla, Nepeta tenuifolia and Aloe vera, in combination with relevant auxiliary materials to treat hypertrophic scars produced after burns and scalds. The invention can also provide patients with more suitable treatment plans according to different specific conditions, perform dialectical treatment according to actual symptoms, and flexibly mix the basic components of the gel with flavors of addition or subtraction.

[0038] In addition, the present invention also provides the use of the above-mentioned white-scented macrophylla detoxifying and tissue-regenerating gel in preparing a medicine for treating and preventing hypertrophic scars produced after burns and scalds.

[0039] The key issues that need to be solved in the clinical treatment of burns and scalds are pigmentation and wound ulceration and infection. The main active ingredients of the white-scented silk gel have the effects of reducing pigmentation, infection and inflammation. Bombyx batryticatus can reduce pigmentation, resist infection and oxidation; Gentiana macrophylla and borneol have the effects of reducing swelling and relieving pain, which are beneficial to wound healing; Nepeta tenuifolia can resist oxidation and allergy; Aloe vera has the effects of anti-inflammatory and sedation, and can increase the viscosity of the gel; Traditional Chinese medicine believes that scar hyperplasia in the human body is caused by stagnation of qi and blood, obstruction of meridians, phlegm and dampness, or a combination of the three. Therefore, we use the above four drugs and related excipients with the effects of promoting blood circulation and removing blood stasis, resolving phlegm and dispersing nodules, unblocking meridians and relieving pain, etc. to fundamentally solve the problem. Reduce the problem of scar redness and swelling caused by stagnation of qi and blood. Antipruritic and anti-inflammatory, fade pigmentation, and calm hypertrophic scars.

[0040] The essence of burn scars is an abnormal tissue that has lost its normal tissue vitality. Its structure and physiological functions do not have the characteristics of normal skin. The healing of any wound depends on the adhesion and nutrient supply of plasma, the growth of small blood vessels, the coverage of new epithelium and the apposition of wounds. As the healing process proceeds, fibrous connective tissue gradually grows into the wound, promoting the formation of small blood vessels, but then the small blood vessels will gradually occlude and decrease, leading to the formation of burn scar tissue. The use of white-scented detoxification and muscle-generating gel can maintain scar moisture, reduce capillary proliferation, inflammatory cell infiltration and collagen deposition, reduce the red appearance of scars, and promote scar softening. The use of white-scented detoxification and muscle-generating gel to create an antibacterial environment is helpful for the prognosis and treatment of patients. While resisting infection, it can also solve the many inconveniences caused by the appearance of skin burn-like scar tissue caused by burns and scalds to the patient's life, and reduce the occurrence of psychological problems such as self-loathing, depression and anxiety caused by discrimination from others. It helps to restore the physical and mental health of patients with burns and scalds and relieve the pain of patients and their families. It makes it possible for patients to return to their pre-burn state and have the courage to enjoy a better life.

[0041] Compared with the prior art, the invention has the beneficial effects of: using a combination of traditional Chinese and Western medicine, developing a new Chinese medicine scar removal gel made of Chinese medicines such as Bombyx Batryticatus, Gentiana macrophylla, Nepeta tenuifolia, and Aloe vera with auxiliary materials to solve the problems of pigmentation, wound ulceration and infection, and hypertrophic scars. The white-scented macrophylla detoxification and muscle-regeneration gel provided by the invention is expected to reduce pigmentation, smooth hypertrophic scars, reduce joint deformation, prevent scar rebound and regeneration, and make the skin closer to its natural state. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 The present invention provides a preparation process flow chart of the Bletilla striata myogenic gel.

[0043] Figure 2 The invention provides an interaction diagram of the Chinese medicinal ingredients-disease-gene targets of the Bletilla striata myogenic gel.

[0044] Figure 3The present invention provides a diagram for analyzing the interaction between key gene targets in network pharmacology in the myogenic gel using the Radix Glehniae.

[0045] Figure 4 It is the effect confirmation of the basic experiment of the mouse model provided by one embodiment of the present invention; wherein, the upper left picture is the picture of the third-degree burn wound of mice in the un-dressing group for 10 days, the upper middle picture is the picture of the third-degree burn wound of mice in the un-dressing group for 12 days, the upper right picture is the picture of the third-degree burn wound of mice in the un-dressing group for 14 days, the lower left picture is the picture of the third-degree burn wound of mice in the group treated with Bletilla striata interpretation muscle growth gel for 10 days, the lower middle picture is the picture of the third-degree burn wound of mice in the group treated with Bletilla striata interpretation muscle growth gel for 12 days, and the lower right picture is the picture of the third-degree burn wound of mice in the group treated with Bletilla striata interpretation muscle growth gel for 14 days.

[0046] Figure 5 It is a HE staining picture provided by an embodiment of the present invention; wherein, the left picture is a burn model, the middle picture is a 21-day treatment group of Bombyx Batryticatus + Gentiana macrophylla + Aloe Vera gel, and the right picture is a 21-day treatment group without changing the dressing. DETAILED DESCRIPTION

[0047] In order to better understand the present invention, the content of the present invention is further explained below in conjunction with the accompanying drawings and specific embodiments, but the content of the present invention is not limited to the following embodiments.

[0048] Embodiment 1:

[0049] Preparation process of 50mL white radix macrophylla detoxification and muscle regeneration gel (process flow)

[0050] Step 1: Weigh 20 g of Bombyx batryticatus, crush it into powder with a high-speed grinder, extract it twice with 100 ml 80% ethanol, filter the residue, and then dry the ethanol at low temperature to obtain a Bombyx batryticatus extract;

[0051] Step 2: Add 20g of Gentiana macrophylla, 15g of Nepeta tenuifolia powder, and 20g of peeled and squeezed juice of Aloe vera to 200mL of deionized water, boil and filter the residue, and concentrate the filtrate to 25mL to obtain a Chinese medicine solution;

[0052] Step 3: Add 0.5 g of Carbomer-934P dry powder to 10 ml of glycerol, add the Bombyx batryticatus extract and the Chinese medicine solution in steps 1 and 2, heat in a water bath, add 15 ml of sterile deionized water while heating and stirring, adjust the pH value to 7.0 with triethanolamine, and finally add 0.1 g of borneol powder.

[0053] Step 4: Sterilize the gel with UV rays for several hours.

[0054] Step 5: Bottling (PET plastic material).

[0055] Step 6: Packaging

[0056] Step 7: Random sampling and bacterial testing.

[0057] Embodiment 2:

[0058] Preparation process of 50mL white radix macrophylla detoxification and muscle regeneration gel (process flow)

[0059] Step 1: Weigh 20 g of Bombyx batryticatus, crush it into powder with a high-speed grinder, extract it twice with 120 ml 80% ethanol, filter the residue, and then dry the ethanol at low temperature to obtain a Bombyx batryticatus extract;

[0060] Step 2: Add 20g of Gentiana macrophylla powder, 15g of Nepeta tenuifolia powder, 15g of Astragalus membranaceus powder, 15g of Codonopsis pilosula powder, and 20g of peeled and squeezed juice of Aloe vera to 260mL of deionized water, boil and filter the residue, and concentrate the filtrate to 25mL to obtain a Chinese medicine solution;

[0061] Step 3: Add 0.5 g of Carbomer-934P dry powder to 15 ml of glycerol, add the Bombyx batryticatus extract and the Chinese medicine solution in steps 1 and 2, heat in a water bath, add 10 ml of sterile deionized water while heating and stirring, adjust the pH value to 7.0 with triethanolamine, and finally add 0.1 g of borneol powder.

[0062] Step 4: Sterilize the gel with UV rays for several hours.

[0063] Step 5: Bottling (PET plastic material).

[0064] Step 6: Packaging

[0065] Step 7: Random sampling and bacterial testing.

[0066] Embodiment 3:

[0067] Preparation process of 50mL white radix macrophylla detoxification and muscle regeneration gel (process flow)

[0068] Step 1: Weigh 20 g of Bombyx batryticatus, crush it into powder with a high-speed grinder, extract it three times with 100 ml of 75% ethanol, filter the residue, and then dry the ethanol at low temperature to obtain a Bombyx batryticatus extract;

[0069] Step 2: Add 20g of Gentiana macrophylla powder, 15g of Nepeta tenuifolia powder, 15g of Angelica sinensis powder, 10g of White Peony Root powder, and 20g of peeled and squeezed juice of Aloe vera to 200mL of deionized water, boil and filter the residue, and concentrate the filtrate to 20mL to obtain a Chinese medicine solution;

[0070] Step 3: Add 0.3 g of Carbomer-934P dry powder to 10 ml of glycerol, add the Bombyx batryticatus extract and the Chinese medicine solution in steps 1 and 2, heat in a water bath, add 20 ml of sterile deionized water while heating and stirring, adjust the pH to 7.0 with triethanolamine, and finally add 0.1 g of borneol powder.

[0071] Step 4: Sterilize the gel with UV rays for several hours.

[0072] Step 5: Bottling (PET plastic material).

[0073] Step 6: Packaging

[0074] Step 7: Random sampling and bacterial testing.

[0075] Embodiment 4:

[0076] A mouse model of deep third-degree burns was constructed, with a burn area of ​​1.5 cm × 4 cm, accounting for about 9%-12% of its body surface area. After the model was established (for pathological analysis), the medicine (Baijiao Detoxification and Myogenic Gel) was changed every two days. On the 21st day, the skin tissue was taken for HE staining. The purpose of the experiment was to preliminarily explore the optimal ratio of related drugs in Baijiao Detoxification and Myogenic Gel and its therapeutic effect. The following is a display of some of the results. Figure 4 This is a third-degree burn animal model, in which the epidermis and dermis are completely destroyed. Figure 4 As shown, after changing the dressing every 2 days, it was found that the treatment groups treated with the Bletilla striata detoxification and muscle-generating gel generated in Example 1 (10, 12, and 14 days after burns) dissolved and fell off earlier than the experimental control group without medication, and formed granulation wounds earlier. On the 12th day, most of the eschar on the wounds of the mice in the Bletilla striata detoxification and muscle-generating gel treatment group had fallen off, while on the 12th day, the eschar on the wounds of the mice in the group not applying medication had not fallen off significantly. On the 14th day, large-area granulation wounds were formed on the wounds of the mice in the Bletilla striata detoxification and muscle-generating gel treatment group, while on the 14th day, the eschar on the wounds of the mice in the group not applying medication partially fell off, and no local small-area granulation wounds were formed. (The area of ​​the burn wound of each mouse is 1.5 cm×4 cm. Due to the ductility of the mouse skin and the posture during grasping, the size of the burn area of ​​each mouse may be visually inconsistent, but the actual burn area is the same.) In the attached Figure 5 In the HE staining image, the small rectangular frame is the epidermis. The thicker and smoother it is, the better the wound healing effect. After changing the dressing every 2 days, it was found that the recovery of the dermis in the group treated with the Bletilla striata detoxification and muscle regeneration gel (21 days after burn) was better than that in the control group without medication. The staining results show that the Bletilla striata gel has a more significant effect in treating third-degree burns after adding Bombyx batryticatus. The above theoretical basis and preliminary experimental results show that the Bletilla striata gel has great prospects and application value in solving the problems of wound healing and scar hyperplasia after burns.

[0077] Experiments have shown that Bombyx Batryticatus + Gentiana macrophylla + Aloe Vera gel has obvious therapeutic effects on treating burns and scalds and lightening pigmentation.

[0078] In summary, the white-scented radix-detoxifying and muscle-regenerating gel provided by the present invention adopts the combination of traditional Chinese and Western medicine, and ancient books and modern science and technology to obtain the best efficacy group; finally, it is planned to use four Chinese medicines, Bombyx batryticatus, Gentiana macrophylla, Nepeta tenuifolia, and Aloe vera, in combination with traditional Chinese and Western medicine to treat hypertrophic scars produced after burns and scalds. Bombyx batryticatus can reduce pigmentation, resist infection and resist oxidation; Gentiana macrophylla has the effects of reducing swelling and relieving pain, which is beneficial to wound healing; Nepeta tenuifolia has the effects of anti-oxidation and anti-allergy; Aloe vera has the effects of anti-inflammatory and sedation, and can increase the viscosity of the gel; Vaseline can form a thin film on the skin surface, making it difficult for water to evaporate and keeping the skin moist. It can also block the contact between bacteria in the air and the skin, thereby reducing the possibility of infection.

[0079] At the same time, compared with traditional Chinese medicine black plasters and rubber plasters, gel ointment has a large drug loading capacity, good skin biocompatibility, fast absorption, easy use, and no stain on clothing. The basic prescription dosage is (per 50mL gel drug dosage) 20g of white silkworm, 15g of gentiana, 15g of schizonepeta, and 20g of peeled Caucasian aloe. For people with different physiques, we will make different proportions, so as to explore the particularity on the basis of universality, adjust the prescription according to different physiques, and flexibly proportion based on the characteristics of a class of people as the dialectical key points.

[0080] In today's era, burns and scalds are a serious medical problem. Using white spherical gel to create an antibacterial environment is simple, convenient and has a lower cost than other methods. It helps the patient's prognosis and treatment. While resisting infection, it can also solve the many inconveniences caused by the appearance of skin burn-like scar tissue caused by burns and scalds, and reduce the occurrence of psychological problems such as self-loathing, depression and anxiety caused by discrimination from others. It helps the recovery of the physical and mental health of patients with burns and scalds, and alleviates the pain of patients and their families. It gives patients hope to return to their pre-burn state and muster up the courage to enjoy a better life.

[0081] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for preparing a white-scented radix gel for detoxification and muscle regeneration, characterized in that: The following steps are involved: 1) Weighing 10-30 parts of Bombyx batryticatus powder by weight, extracting it two or three times with 60-100 parts of ethanol by weight, filtering the residue, and drying to obtain a Bombyx batryticatus extract; 2) weighing 10-30 parts of Gentiana macrophylla powder, 10-20 parts of Nepeta tenuifolia powder, and 10-30 parts of peeled aloe vera juice, and adding them to 150-260 parts of deionized water, boiling and filtering the residue, and concentrating the filtrate to 10-30 parts to obtain a Chinese medicine solution; 3) In parts by weight, 0.1-1 parts of Carbomer-934P dry powder are added to 10-15 parts of glycerin, followed by the addition of the Bombyx batryticatus extract described in step 1) and the Chinese medicinal solution described in step 2), and 10-20 parts of sterile deionized water are added while stirring and heating, the pH value is adjusted to 7.0, and finally 0.1-1 parts of borneol powder are added to obtain the Bletilla striata detoxification and muscle-building gel.

2. The method for preparing the white-scented radix polygoni multiflori detoxifying and myogenic gel according to claim 1, characterized in that: In step 1), the Bombyx batryticatus powder is crushed into powder by a high-speed pulverizer, and the particle size is 150-300 microns. The filtering residue is filtered by using a 200-mesh filter paper, that is, the filter paper has a pore size of 75 microns. The ethanol is an ethanol aqueous solution with a mass fraction of 75-80%, and the drying is drying at 37 degrees Celsius. In step 2), the aloe vera is Caucasian aloe, the gentiana powder and the schizonepeta powder are crushed into powder by a high-speed pulverizer, and the particle size is 150-300 microns. The boiling is boiling on a low heat for 3 hours. In step 3), the stirring and heating is heated in a pot at 45 degrees Celsius for half an hour, the stirring speed is 1500 revolutions per minute, triethanolamine is used to adjust the pH value, and the particle size of the borneol powder is 150-300 microns.

3. The method for preparing a white-scented radix-spinach detoxifying and myogenic gel according to claim 2, characterized in that: The method also includes step 4) sterilizing the white-scented giant root detoxifying and muscle-regenerating gel by irradiating it with UV ultraviolet rays for 1-3 hours, and then bottling, packaging and conducting bacteria testing.

4. The method for preparing the white-scented radix polygoni multiflori detoxifying and myogenic gel according to claim 2, characterized in that: In step 2), 10-20 parts of astragalus and 10-20 parts of codonopsis are added by weight for boiling, and the astragalus and codonopsis are crushed into powder with a high-speed grinder, and the particle size is 150-300 microns.

5. The method for preparing the white-scented macrophylla detoxifying and myogenic gel according to claim 2, characterized in that: In step 2), 10-20 parts of Chinese angelica and 10-20 parts of white peony root are added by weight for boiling, and the Chinese angelica and white peony root are crushed into powder by a high-speed grinder with a particle size of 150-300 microns.

6. A white-rooted radix-spleen-detoxifying and muscle-regenerating gel, characterized in that: The gel is prepared by the method for preparing the white-scented macrophylla detoxifying and muscle-regenerating gel described in any one of claims 1 to 3.

7. The white-scented macrophylla detoxifying and muscle-regenerating gel according to claim 6, characterized in that: Each 50mL contains extracts of Chinese medicinal materials: 20g Bombyx Batryticatus, 20g Gentiana Macrophylla, 20g Nepeta Tenuifolia, 20g Aloe Vera, 0.5g Carbomer-934P dry powder, 10mL glycerol, 15mL deionized water, 0.1g borneol, and the rest is deionized water for decocting the medicine.

8. The white-scented macrophylla detoxifying and muscle-regenerating gel according to claim 7, characterized in that: Each 50ml also contains extracts of the Chinese medicinal materials 15g of Astragalus and 15g of Codonopsis.

9. The white-scented macrophylla detoxifying and muscle-regenerating gel according to claim 7, characterized in that: Each 50ml also contains extracts of the Chinese medicinal materials 15g of angelica and 10g of white peony root.

10. Use of the Bletilla striata detoxifying and myogenic gel according to any one of claims 6 to 9 in the preparation of a medicament for treating and preventing hypertrophic scars resulting from burns and scalds.

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