A detection method for identifying adulteration with the aerial stem of Isatis indigotica in compound cold medicine tablets.

Through the analysis of the content ratio of indigo and 2-benzoxazolinone and HPLC-MS detection method, the problem of doping on the ground stems and medicinal sites of isatis roots in the compound cold spirit tablets was solved, and accurate detection of doping and monitoring of medicinal quality was achieved.

CN119470735BActive Publication Date: 2025-03-25HUACHENG PHARMA FACTORY GAUNGZHOU
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Patent Information

Application Number
CN202510066538.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-16
Publication Date
2025-03-25
Estimated Expiration
2045-01-16

AI Technical Summary

Technical Problem

The prior art is difficult to effectively identify the doping of the above-ground stems and medicinal sites of the composite cold spirit tablets in the south isatis root, resulting in inconsistent quality of the medicinal materials and affecting the effectiveness of the preparation.

Method used

The content ratio of indigo and 2-benzoxazolinone was analyzed and HPLC-MS detection method was used to identify the doping of overground stems of isatis roots in the compound cold ling tablets.

Benefits of technology

Accurate detection of the doping of the above-ground stems of isatis roots in the compound cold spirit tablets is realized, providing a basis for quality monitoring, and ensuring the consistency of the quality of the medicinal materials and the effectiveness of the preparation.

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Abstract

The invention belongs to the technical field of Chinese medicine preparation detection, and specifically relates to a detection method for identifying the adulteration of the ground stems of southern isatis root in compound Ganmaoling tablets, the detection method uses indirubin and 2-benzoxazolinone as detection indicators, adopts HPLC-MS for detection, and analyzes and judges according to the ratio of the content of indirubin and 2-benzoxazolinone. The present invention uses indirubin and 2-benzoxazolinone as detection indicators, analyzes and compares the content of the ground stems and medicinal parts in the southern isatis root medicinal material, and establishes an HPLC-MS detection method for the adulteration of the ground stems of southern isatis root in compound Ganmaoling tablets, which can be used for the identification of southern isatis root simultaneously, and can provide a basis for the quality monitoring of compound Ganmaoling tablets.
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